CA2786071C - Modulation of angiopoietin-like 3 expression - Google Patents

Modulation of angiopoietin-like 3 expression Download PDF

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Publication number
CA2786071C
CA2786071C CA2786071A CA2786071A CA2786071C CA 2786071 C CA2786071 C CA 2786071C CA 2786071 A CA2786071 A CA 2786071A CA 2786071 A CA2786071 A CA 2786071A CA 2786071 C CA2786071 C CA 2786071C
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modified oligonucleotide
compound
modified
levels
linked nucleosides
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French (fr)
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CA2786071A1 (en
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Rosanne M. Crooke
Mark J. Graham
Richard Lee
Kenneth W. Dobie
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Ionis Pharmaceuticals Inc
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Ionis Pharmaceuticals Inc
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1136—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against growth factors, growth regulators, cytokines, lymphokines or hormones
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    • G01N33/5023—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects on expression patterns
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    • C12N2310/32—Chemical structure of the sugar
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CA2786071A 2010-01-08 2011-01-07 Modulation of angiopoietin-like 3 expression Active CA2786071C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US29360410P 2010-01-08 2010-01-08
US61/293,604 2010-01-08
PCT/US2011/020606 WO2011085271A2 (en) 2010-01-08 2011-01-07 Modulation of angiopoietin-like 3 expression

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CA2786071A1 CA2786071A1 (en) 2011-07-14
CA2786071C true CA2786071C (en) 2021-01-12

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CA2786071A Active CA2786071C (en) 2010-01-08 2011-01-07 Modulation of angiopoietin-like 3 expression

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US (5) US8653047B2 (enExample)
EP (2) EP2521556B1 (enExample)
JP (4) JP5822845B2 (enExample)
CN (3) CN106146591B (enExample)
AU (1) AU2011203986C1 (enExample)
CA (1) CA2786071C (enExample)
DK (1) DK2521556T3 (enExample)
ES (1) ES2677969T3 (enExample)
WO (1) WO2011085271A2 (enExample)

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