JP5822845B2 - アンジオポエチン様３発現の調節 - Google Patents

アンジオポエチン様３発現の調節 Download PDF

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Publication number
JP5822845B2
JP5822845B2 JP2012548193A JP2012548193A JP5822845B2 JP 5822845 B2 JP5822845 B2 JP 5822845B2 JP 2012548193 A JP2012548193 A JP 2012548193A JP 2012548193 A JP2012548193 A JP 2012548193A JP 5822845 B2 JP5822845 B2 JP 5822845B2
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certain embodiments
angptl3
modified
antisense
oligonucleotide
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Japanese (ja)
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JP2013516489A5 (enExample
JP2013516489A (ja
Inventor
クルック，ロザンヌ・エム
グラハム，マーク・ジェイ
リー，リチャード
ドビー，ケネス・ダブリュー
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Ionis Pharmaceuticals Inc
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Ionis Pharmaceuticals Inc
Isis Pharmaceuticals Inc
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    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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    • A—HUMAN NECESSITIES
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1136—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against growth factors, growth regulators, cytokines, lymphokines or hormones
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    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
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    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G01N33/5023—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects on expression patterns
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    • C12N2310/11—Antisense
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/32—Chemical structure of the sugar
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    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/323—Chemical structure of the sugar modified ring structure
    • C12N2310/3231—Chemical structure of the sugar modified ring structure having an additional ring, e.g. LNA, ENA
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    • C12N2310/341—Gapmers, i.e. of the type ===---===
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  • Urology & Nephrology (AREA)
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JP2012548193A 2010-01-08 2011-01-07 アンジオポエチン様３発現の調節 Expired - Fee Related JP5822845B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US29360410P 2010-01-08 2010-01-08
US61/293,604 2010-01-08
PCT/US2011/020606 WO2011085271A2 (en) 2010-01-08 2011-01-07 Modulation of angiopoietin-like 3 expression

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2015156939A Division JP6440592B2 (ja) 2010-01-08 2015-08-07 アンジオポエチン様３発現の調節

Publications (3)

Publication Number Publication Date
JP2013516489A JP2013516489A (ja) 2013-05-13
JP2013516489A5 JP2013516489A5 (enExample) 2013-08-08
JP5822845B2 true JP5822845B2 (ja) 2015-11-25

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JP2012548193A Expired - Fee Related JP5822845B2 (ja) 2010-01-08 2011-01-07 アンジオポエチン様３発現の調節
JP2015156939A Expired - Fee Related JP6440592B2 (ja) 2010-01-08 2015-08-07 アンジオポエチン様３発現の調節
JP2017098842A Pending JP2017165765A (ja) 2010-01-08 2017-05-18 アンジオポエチン様３発現の調節
JP2020032712A Pending JP2020100654A (ja) 2010-01-08 2020-02-28 アンジオポエチン様３発現の調節

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JP2015156939A Expired - Fee Related JP6440592B2 (ja) 2010-01-08 2015-08-07 アンジオポエチン様３発現の調節
JP2017098842A Pending JP2017165765A (ja) 2010-01-08 2017-05-18 アンジオポエチン様３発現の調節
JP2020032712A Pending JP2020100654A (ja) 2010-01-08 2020-02-28 アンジオポエチン様３発現の調節

Country Status (9)

Country Link
US (5) US8653047B2 (enExample)
EP (2) EP2521556B1 (enExample)
JP (4) JP5822845B2 (enExample)
CN (3) CN111700901A (enExample)
AU (1) AU2011203986C1 (enExample)
CA (1) CA2786071C (enExample)
DK (1) DK2521556T3 (enExample)
ES (1) ES2677969T3 (enExample)
WO (1) WO2011085271A2 (enExample)

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US10023861B2 (en) 2011-08-29 2018-07-17 Ionis Pharmaceuticals, Inc. Oligomer-conjugate complexes and their use
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NZ720286A (en) 2013-12-24 2022-12-23 Ionis Pharmaceuticals Inc Modulation of angiopoietin-like 3 expression
JPWO2015108046A1 (ja) 2014-01-15 2017-03-23 株式会社新日本科学 抗アレルギー作用を有するキラル核酸アジュバンド及び抗アレルギー剤
JPWO2015108048A1 (ja) 2014-01-15 2017-03-23 株式会社新日本科学 抗腫瘍作用を有するキラル核酸アジュバンド及び抗腫瘍剤
WO2015108047A1 (ja) 2014-01-15 2015-07-23 株式会社新日本科学 免疫誘導活性を有するキラル核酸アジュバンド及び免疫誘導活性剤
KR20230152178A (ko) 2014-01-16 2023-11-02 웨이브 라이프 사이언시스 리미티드 키랄 디자인
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US20180245077A1 (en) * 2015-03-20 2018-08-30 Protiva Biotherapeutics, Inc. Compositions and methods for treating hypertriglyceridemia
RU2017137410A (ru) 2015-04-03 2019-05-06 Ионис Фармасьютикалз, Инк. Соединения и способы модулирования экспрессии tmprss6
EA201792263A1 (ru) 2015-04-13 2018-08-31 Элнилэм Фармасьютикалз, Инк. КОМПОЗИЦИИ НА ОСНОВЕ iRNA ПРОТИВ АНГИОПОЭТИН-ПОДОБНОГО БЕЛКА 3 (ANGPTL3) И СПОСОБЫ ИХ ПРИМЕНЕНИЯ
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