JP2018511307A5 - - Google Patents
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- JP2018511307A5 JP2018511307A5 JP2017546624A JP2017546624A JP2018511307A5 JP 2018511307 A5 JP2018511307 A5 JP 2018511307A5 JP 2017546624 A JP2017546624 A JP 2017546624A JP 2017546624 A JP2017546624 A JP 2017546624A JP 2018511307 A5 JP2018511307 A5 JP 2018511307A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- wing segment
- modified oligonucleotide
- linked nucleosides
- modified
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000001875 compounds Chemical class 0.000 claims description 69
- 239000002777 nucleoside Substances 0.000 claims description 52
- 108091034117 Oligonucleotide Proteins 0.000 claims description 51
- 125000003835 nucleoside group Chemical group 0.000 claims description 37
- 150000003833 nucleoside derivatives Chemical class 0.000 claims description 15
- RYYWUUFWQRZTIU-UHFFFAOYSA-K thiophosphate Chemical compound [O-]P([O-])([O-])=S RYYWUUFWQRZTIU-UHFFFAOYSA-K 0.000 claims description 13
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 12
- LRSASMSXMSNRBT-UHFFFAOYSA-N 5-methylcytosine Chemical group CC1=CNC(=O)N=C1N LRSASMSXMSNRBT-UHFFFAOYSA-N 0.000 claims description 11
- OPTASPLRGRRNAP-UHFFFAOYSA-N cytosine Chemical group NC=1C=CNC(=O)N=1 OPTASPLRGRRNAP-UHFFFAOYSA-N 0.000 claims description 9
- 208000007502 anemia Diseases 0.000 claims description 8
- 230000000295 complement effect Effects 0.000 claims description 8
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 8
- UYTPUPDQBNUYGX-UHFFFAOYSA-N guanine Chemical compound O=C1NC(N)=NC2=C1N=CN2 UYTPUPDQBNUYGX-UHFFFAOYSA-N 0.000 claims description 8
- RWQNBRDOKXIBIV-UHFFFAOYSA-N thymine Chemical group CC1=CNC(=O)NC1=O RWQNBRDOKXIBIV-UHFFFAOYSA-N 0.000 claims description 8
- OVRNDRQMDRJTHS-KEWYIRBNSA-N N-acetyl-D-galactosamine Chemical compound CC(=O)N[C@H]1C(O)O[C@H](CO)[C@H](O)[C@@H]1O OVRNDRQMDRJTHS-KEWYIRBNSA-N 0.000 claims description 7
- 239000000203 mixture Substances 0.000 claims description 7
- 241001465754 Metazoa Species 0.000 claims description 6
- 229910052742 iron Inorganic materials 0.000 claims description 6
- MBLBDJOUHNCFQT-UHFFFAOYSA-N N-acetyl-D-galactosamine Natural products CC(=O)NC(C=O)C(O)C(O)C(O)CO MBLBDJOUHNCFQT-UHFFFAOYSA-N 0.000 claims description 5
- 229930024421 Adenine Natural products 0.000 claims description 4
- GFFGJBXGBJISGV-UHFFFAOYSA-N Adenine Chemical compound NC1=NC=NC2=C1N=CN2 GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 claims description 4
- 206010053138 Congenital aplastic anaemia Diseases 0.000 claims description 4
- 208000002903 Thalassemia Diseases 0.000 claims description 4
- 102000004338 Transferrin Human genes 0.000 claims description 4
- 108090000901 Transferrin Proteins 0.000 claims description 4
- 238000009825 accumulation Methods 0.000 claims description 4
- 229960000643 adenine Drugs 0.000 claims description 4
- 239000003085 diluting agent Substances 0.000 claims description 4
- 201000010099 disease Diseases 0.000 claims description 4
- 208000035475 disorder Diseases 0.000 claims description 4
- 239000003937 drug carrier Substances 0.000 claims description 4
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 4
- 229940113082 thymine Drugs 0.000 claims description 4
- 239000012581 transferrin Substances 0.000 claims description 4
- 150000003839 salts Chemical class 0.000 claims description 3
- XJOTXKZIRSHZQV-RXHOOSIZSA-N (3S)-3-amino-4-[[(2S,3R)-1-[[(2S)-1-[[(2S)-1-[(2S)-2-[[(2S,3S)-1-[[(1R,6R,12R,17R,20S,23S,26R,31R,34R,39R,42S,45S,48S,51S,59S)-51-(4-aminobutyl)-31-[[(2S)-6-amino-1-[[(1S,2R)-1-carboxy-2-hydroxypropyl]amino]-1-oxohexan-2-yl]carbamoyl]-20-benzyl-23-[(2S)-butan-2-yl]-45-(3-carbamimidamidopropyl)-48-(hydroxymethyl)-42-(1H-imidazol-4-ylmethyl)-59-(2-methylsulfanylethyl)-7,10,19,22,25,33,40,43,46,49,52,54,57,60,63,64-hexadecaoxo-3,4,14,15,28,29,36,37-octathia-8,11,18,21,24,32,41,44,47,50,53,55,58,61,62,65-hexadecazatetracyclo[32.19.8.26,17.212,39]pentahexacontan-26-yl]amino]-3-methyl-1-oxopentan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxo-3-phenylpropan-2-yl]amino]-3-(1H-imidazol-4-yl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-4-oxobutanoic acid Chemical compound CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@@H](N)CC(O)=O)[C@@H](C)O)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@@H]2CSSC[C@@H]3NC(=O)[C@@H]4CSSC[C@H](NC(=O)[C@H](Cc5ccccc5)NC(=O)[C@@H](NC1=O)[C@@H](C)CC)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](Cc1cnc[nH]1)NC3=O)C(=O)NCC(=O)N[C@@H](CCSC)C(=O)N2)C(=O)NCC(=O)N4)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(O)=O XJOTXKZIRSHZQV-RXHOOSIZSA-N 0.000 claims description 2
- 102100033051 40S ribosomal protein S19 Human genes 0.000 claims description 2
- 208000033932 Blackfan-Diamond anemia Diseases 0.000 claims description 2
- 201000004449 Diamond-Blackfan anemia Diseases 0.000 claims description 2
- 201000004939 Fanconi anemia Diseases 0.000 claims description 2
- 208000025499 G6PD deficiency Diseases 0.000 claims description 2
- 206010018444 Glucose-6-phosphate dehydrogenase deficiency Diseases 0.000 claims description 2
- 206010018910 Haemolysis Diseases 0.000 claims description 2
- 208000018565 Hemochromatosis Diseases 0.000 claims description 2
- 208000031953 Hereditary hemorrhagic telangiectasia Diseases 0.000 claims description 2
- 101000798696 Homo sapiens Transmembrane protease serine 6 Proteins 0.000 claims description 2
- 201000003793 Myelodysplastic syndrome Diseases 0.000 claims description 2
- 208000008601 Polycythemia Diseases 0.000 claims description 2
- 102100032452 Transmembrane protease serine 6 Human genes 0.000 claims description 2
- 208000027418 Wounds and injury Diseases 0.000 claims description 2
- 208000005980 beta thalassemia Diseases 0.000 claims description 2
- 125000002619 bicyclic group Chemical group 0.000 claims description 2
- 210000004027 cell Anatomy 0.000 claims description 2
- 230000001684 chronic effect Effects 0.000 claims description 2
- 230000006378 damage Effects 0.000 claims description 2
- 229910003460 diamond Inorganic materials 0.000 claims description 2
- 239000010432 diamond Substances 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims description 2
- 210000003617 erythrocyte membrane Anatomy 0.000 claims description 2
- 208000008605 glucosephosphate dehydrogenase deficiency Diseases 0.000 claims description 2
- 230000008588 hemolysis Effects 0.000 claims description 2
- 102000018511 hepcidin Human genes 0.000 claims description 2
- 229940066919 hepcidin Drugs 0.000 claims description 2
- 108060003558 hepcidin Proteins 0.000 claims description 2
- 208000014674 injury Diseases 0.000 claims description 2
- 210000000056 organ Anatomy 0.000 claims description 2
- 208000007056 sickle cell anemia Diseases 0.000 claims description 2
- 208000011580 syndromic disease Diseases 0.000 claims description 2
- 238000002560 therapeutic procedure Methods 0.000 claims description 2
- 210000001519 tissue Anatomy 0.000 claims description 2
- 229940126836 transmembrane protease serine 6 synthesis reducer Drugs 0.000 claims description 2
- HWPZZUQOWRWFDB-UHFFFAOYSA-N 1-methylcytosine Chemical compound CN1C=CC(N)=NC1=O HWPZZUQOWRWFDB-UHFFFAOYSA-N 0.000 claims 1
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical group P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 claims 1
- 239000002953 phosphate buffered saline Substances 0.000 claims 1
- 210000002966 serum Anatomy 0.000 description 2
- 229940104302 cytosine Drugs 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562142986P | 2015-04-03 | 2015-04-03 | |
| US62/142,986 | 2015-04-03 | ||
| PCT/US2016/025883 WO2016161429A1 (en) | 2015-04-03 | 2016-04-04 | Compounds and methods for modulating tmprss6 expression |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021015452A Division JP7037681B2 (ja) | 2015-04-03 | 2021-02-03 | Ｔｍｐｒｓｓ６発現を調節するための化合物及び方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018511307A JP2018511307A (ja) | 2018-04-26 |
| JP2018511307A5 true JP2018511307A5 (enExample) | 2019-05-16 |
| JP6833705B2 JP6833705B2 (ja) | 2021-02-24 |
Family
ID=57007353
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017546624A Active JP6833705B2 (ja) | 2015-04-03 | 2016-04-04 | Ｔｍｐｒｓｓ６発現を調節するための化合物及び方法 |
| JP2021015452A Active JP7037681B2 (ja) | 2015-04-03 | 2021-02-03 | Ｔｍｐｒｓｓ６発現を調節するための化合物及び方法 |
| JP2022033166A Withdrawn JP2022104917A (ja) | 2015-04-03 | 2022-03-04 | Ｔｍｐｒｓｓ６発現を調節するための化合物及び方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021015452A Active JP7037681B2 (ja) | 2015-04-03 | 2021-02-03 | Ｔｍｐｒｓｓ６発現を調節するための化合物及び方法 |
| JP2022033166A Withdrawn JP2022104917A (ja) | 2015-04-03 | 2022-03-04 | Ｔｍｐｒｓｓ６発現を調節するための化合物及び方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (4) | US10415038B2 (enExample) |
| EP (1) | EP3277817A4 (enExample) |
| JP (3) | JP6833705B2 (enExample) |
| KR (1) | KR102539587B1 (enExample) |
| CN (1) | CN107429250B (enExample) |
| AU (1) | AU2016244106B2 (enExample) |
| CA (1) | CA2978100C (enExample) |
| HK (1) | HK1249140A1 (enExample) |
| IL (2) | IL253509B2 (enExample) |
| MX (1) | MX2017012426A (enExample) |
| RU (1) | RU2017137410A (enExample) |
| WO (1) | WO2016161429A1 (enExample) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201410693D0 (en) | 2014-06-16 | 2014-07-30 | Univ Southampton | Splicing modulation |
| EP3201339A4 (en) | 2014-10-03 | 2018-09-19 | Cold Spring Harbor Laboratory | Targeted augmentation of nuclear gene output |
| KR20220105174A (ko) | 2015-10-09 | 2022-07-26 | 유니버시티 오브 사우스앰톤 | 유전자 발현의 조절 및 탈조절된 단백질 발현의 스크리닝 |
| WO2017106377A1 (en) | 2015-12-14 | 2017-06-22 | Cold Spring Harbor Laboratory | Antisense oligomers for treatment of autosomal dominant mental retardation-5 and dravet syndrome |
| US11096956B2 (en) | 2015-12-14 | 2021-08-24 | Stoke Therapeutics, Inc. | Antisense oligomers and uses thereof |
| KR20240035631A (ko) | 2017-08-25 | 2024-03-15 | 스톡 테라퓨틱스, 인크. | 병태 및 질환 치료용 안티센스 올리고머 |
| AU2019218987B2 (en) | 2018-02-12 | 2025-04-24 | Ionis Pharmaceuticals, Inc. | Modified compounds and uses thereof |
| TWI840345B (zh) * | 2018-03-02 | 2024-05-01 | 美商Ionis製藥公司 | Irf4表現之調節劑 |
| WO2019213016A1 (en) * | 2018-04-30 | 2019-11-07 | The Children's Hospital Of Philadelphia | Methods of improving anemias by combining agents |
| WO2019213525A1 (en) | 2018-05-04 | 2019-11-07 | Stoke Therapeutics, Inc. | Methods and compositions for treatment of cholesteryl ester storage disease |
| EP3598995A1 (en) * | 2018-07-26 | 2020-01-29 | Silence Therapeutics GmbH | Products and compositions |
| WO2020132521A1 (en) * | 2018-12-20 | 2020-06-25 | Praxis Precision Medicines, Inc. | Compositions and methods for the treatment of kcnt1 related disorders |
| KR20230022409A (ko) | 2020-05-11 | 2023-02-15 | 스톡 테라퓨틱스, 인크. | 병태 및 질환의 치료를 위한 opa1 안티센스 올리고머 |
| JP2023130528A (ja) * | 2020-06-24 | 2023-09-21 | 田辺三菱製薬株式会社 | Ｐｌｐ１発現を調節するための化合物、方法及び医薬組成物 |
| JP2023542889A (ja) | 2020-09-17 | 2023-10-12 | キュー－ステート バイオサイエンシーズ， インコーポレイテッド | 複数の標的を介して疼痛を処置するための治療用組成物 |
| CA3216859A1 (en) | 2021-04-27 | 2022-11-03 | Silence Therapeutics Gmbh | Sirna targeting tmprss6 for the treatment of myeloproliferative disorders |
| US20240209377A1 (en) * | 2021-04-28 | 2024-06-27 | Q-State Biosciences, Inc. | Therapeutic compositions for treating pain via multiple targets |
| CN115247173B (zh) * | 2021-11-11 | 2025-11-11 | 南京启真基因工程有限公司 | 构建tmprss6基因突变的缺铁性贫血猪核移植供体细胞的基因编辑系统及其应用 |
| TWI868755B (zh) | 2022-06-24 | 2025-01-01 | 丹麥商諾佛 儂迪克股份有限公司 | 抑制跨膜絲胺酸蛋白酶６（ｔｍｐｒｓｓ６）表現的組成物及方法 |
| CN117136236B (zh) * | 2022-09-29 | 2024-03-15 | 广州必贝特医药股份有限公司 | 用于抑制TMPRSS6基因表达的siRNA或其盐、药物及其应用 |
| WO2024060649A1 (zh) * | 2022-09-29 | 2024-03-28 | 广州必贝特医药股份有限公司 | 用于抑制TMPRSS6基因表达的siRNA或其盐、药物及其应用 |
| WO2024200512A1 (en) | 2023-03-27 | 2024-10-03 | Silence Therapeutics Gmbh | Compounds and compositions for use in stem cell transplantation |
| TW202527968A (zh) * | 2024-01-08 | 2025-07-16 | 大陸商上海舶望製藥有限公司 | 用於抑制跨膜絲氨酸蛋白酶6（tmprss6）表達的組合物和方法 |
| WO2025206092A1 (ja) * | 2024-03-27 | 2025-10-02 | 田辺三菱製薬株式会社 | Ｍｙｏｒｅｇｕｌｉｎ発現を調節するための化合物及び医薬組成物 |
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-
2016
- 2016-04-04 MX MX2017012426A patent/MX2017012426A/es unknown
- 2016-04-04 EP EP16774409.3A patent/EP3277817A4/en active Pending
- 2016-04-04 HK HK18108870.8A patent/HK1249140A1/zh unknown
- 2016-04-04 US US15/562,843 patent/US10415038B2/en active Active
- 2016-04-04 WO PCT/US2016/025883 patent/WO2016161429A1/en not_active Ceased
- 2016-04-04 AU AU2016244106A patent/AU2016244106B2/en active Active
- 2016-04-04 CA CA2978100A patent/CA2978100C/en active Active
- 2016-04-04 JP JP2017546624A patent/JP6833705B2/ja active Active
- 2016-04-04 RU RU2017137410A patent/RU2017137410A/ru not_active Application Discontinuation
- 2016-04-04 CN CN201680015815.4A patent/CN107429250B/zh active Active
- 2016-04-04 KR KR1020177030957A patent/KR102539587B1/ko active Active
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2017
- 2017-07-16 IL IL253509A patent/IL253509B2/en unknown
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2019
- 2019-08-01 US US16/528,925 patent/US20200190522A1/en not_active Abandoned
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2021
- 2021-02-03 JP JP2021015452A patent/JP7037681B2/ja active Active
- 2021-09-24 US US17/484,386 patent/US20220259600A1/en not_active Abandoned
- 2021-09-26 IL IL286669A patent/IL286669A/en unknown
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2022
- 2022-03-04 JP JP2022033166A patent/JP2022104917A/ja not_active Withdrawn
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2023
- 2023-07-25 US US18/358,591 patent/US20240026364A1/en active Pending
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