KR102539587B1 - Tmprss6 발현을 조절하기 위한 화합물 및 방법들 - Google Patents

Tmprss6 발현을 조절하기 위한 화합물 및 방법들 Download PDF

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KR102539587B1
KR102539587B1 KR1020177030957A KR20177030957A KR102539587B1 KR 102539587 B1 KR102539587 B1 KR 102539587B1 KR 1020177030957 A KR1020177030957 A KR 1020177030957A KR 20177030957 A KR20177030957 A KR 20177030957A KR 102539587 B1 KR102539587 B1 KR 102539587B1
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certain embodiments
antisense
compound
modified
tmprss6
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KR20170129263A (ko
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슐링 구오
마리암 아그하잔
에릭 이. 스웨이지
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아이오니스 파마수티컬즈, 인코포레이티드
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    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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KR1020177030957A 2015-04-03 2016-04-04 Tmprss6 발현을 조절하기 위한 화합물 및 방법들 Active KR102539587B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562142986P 2015-04-03 2015-04-03
US62/142,986 2015-04-03
PCT/US2016/025883 WO2016161429A1 (en) 2015-04-03 2016-04-04 Compounds and methods for modulating tmprss6 expression

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KR20170129263A KR20170129263A (ko) 2017-11-24
KR102539587B1 true KR102539587B1 (ko) 2023-06-01

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US (4) US10415038B2 (enExample)
EP (1) EP3277817A4 (enExample)
JP (3) JP6833705B2 (enExample)
KR (1) KR102539587B1 (enExample)
CN (1) CN107429250B (enExample)
AU (1) AU2016244106B2 (enExample)
CA (1) CA2978100C (enExample)
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IL (2) IL253509B2 (enExample)
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WO2017106377A1 (en) 2015-12-14 2017-06-22 Cold Spring Harbor Laboratory Antisense oligomers for treatment of autosomal dominant mental retardation-5 and dravet syndrome
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TWI840345B (zh) * 2018-03-02 2024-05-01 美商Ionis製藥公司 Irf4表現之調節劑
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US20220056455A1 (en) * 2018-12-20 2022-02-24 Praxis Precision Medicines, Inc. Compositions and methods for the treatment of kcnt1 related disorders
EP4150092A4 (en) 2020-05-11 2024-11-06 Stoke Therapeutics, Inc. OPA1 ANTISENSE OLIGOMERS FOR THE TREATMENT OF DISEASES AND CONDITIONS
JP2023130528A (ja) * 2020-06-24 2023-09-21 田辺三菱製薬株式会社 Ｐｌｐ１発現を調節するための化合物、方法及び医薬組成物
WO2022061108A2 (en) 2020-09-17 2022-03-24 Q-State Biosciences, Inc. Therapeutic compositions for treating pain via multiple targets
AU2022265493A1 (en) 2021-04-27 2023-09-21 Silence Therapeutics Gmbh Sirna targeting tmprss6 for the treatment of myeloproliferative disorders
JP2024519204A (ja) * 2021-04-28 2024-05-09 キュー－ステート バイオサイエンシーズ， インコーポレイテッド 複数の標的を介して疼痛を処置するための治療組成物
CN115247173B (zh) * 2021-11-11 2025-11-11 南京启真基因工程有限公司 构建tmprss6基因突变的缺铁性贫血猪核移植供体细胞的基因编辑系统及其应用
TWI868755B (zh) 2022-06-24 2025-01-01 丹麥商諾佛 儂迪克股份有限公司 抑制跨膜絲胺酸蛋白酶６（ｔｍｐｒｓｓ６）表現的組成物及方法
WO2024060649A1 (zh) * 2022-09-29 2024-03-28 广州必贝特医药股份有限公司 用于抑制TMPRSS6基因表达的siRNA或其盐、药物及其应用
CN117136236B (zh) * 2022-09-29 2024-03-15 广州必贝特医药股份有限公司 用于抑制TMPRSS6基因表达的siRNA或其盐、药物及其应用
CN120981247A (zh) 2023-03-27 2025-11-18 赛伦斯治疗有限责任公司 用于干细胞移植的化合物和组合物
WO2025148896A1 (en) * 2024-01-08 2025-07-17 Shanghai Argo Biopharmaceutical Co., Ltd. Compositions and methods for inhibiting expression of transmembrane serine protease 6 (tmprss6)
WO2025206092A1 (ja) * 2024-03-27 2025-10-02 田辺三菱製薬株式会社 Ｍｙｏｒｅｇｕｌｉｎ発現を調節するための化合物及び医薬組成物

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