KR102539587B1 - Tmprss6 발현을 조절하기 위한 화합물 및 방법들 - Google Patents

Tmprss6 발현을 조절하기 위한 화합물 및 방법들 Download PDF

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KR102539587B1
KR102539587B1 KR1020177030957A KR20177030957A KR102539587B1 KR 102539587 B1 KR102539587 B1 KR 102539587B1 KR 1020177030957 A KR1020177030957 A KR 1020177030957A KR 20177030957 A KR20177030957 A KR 20177030957A KR 102539587 B1 KR102539587 B1 KR 102539587B1
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certain embodiments
antisense
compound
modified
tmprss6
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KR20170129263A (ko
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슐링 구오
마리암 아그하잔
에릭 이. 스웨이지
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아이오니스 파마수티컬즈, 인코포레이티드
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    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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KR1020177030957A 2015-04-03 2016-04-04 Tmprss6 발현을 조절하기 위한 화합물 및 방법들 Active KR102539587B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562142986P 2015-04-03 2015-04-03
US62/142,986 2015-04-03
PCT/US2016/025883 WO2016161429A1 (en) 2015-04-03 2016-04-04 Compounds and methods for modulating tmprss6 expression

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KR20170129263A KR20170129263A (ko) 2017-11-24
KR102539587B1 true KR102539587B1 (ko) 2023-06-01

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US (4) US10415038B2 (enExample)
EP (1) EP3277817A4 (enExample)
JP (3) JP6833705B2 (enExample)
KR (1) KR102539587B1 (enExample)
CN (1) CN107429250B (enExample)
AU (1) AU2016244106B2 (enExample)
CA (1) CA2978100C (enExample)
HK (1) HK1249140A1 (enExample)
IL (2) IL253509B2 (enExample)
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JP2021523227A (ja) 2018-05-04 2021-09-02 ストーク セラピューティクス，インク． コレステリルエステル蓄積症の処置のための方法及び組成物
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CA3173647A1 (en) 2020-05-11 2021-11-18 Isabel AZNAREZ Opa1 antisense oligomers for treatment of conditions and diseases
JP2023130528A (ja) * 2020-06-24 2023-09-21 田辺三菱製薬株式会社 Ｐｌｐ１発現を調節するための化合物、方法及び医薬組成物
US12152243B2 (en) 2020-09-17 2024-11-26 Quelltx, Inc. Therapeutic compositions for treating pain via multiple targets
MX2023012834A (es) * 2021-04-27 2023-11-08 Silence Therapeutics Gmbh Inhibidor de la matriptasa-2 para el tratamiento de trastornos mieloproliferativos.
US20240209377A1 (en) * 2021-04-28 2024-06-27 Q-State Biosciences, Inc. Therapeutic compositions for treating pain via multiple targets
CN115247173B (zh) * 2021-11-11 2025-11-11 南京启真基因工程有限公司 构建tmprss6基因突变的缺铁性贫血猪核移植供体细胞的基因编辑系统及其应用
TWI868755B (zh) 2022-06-24 2025-01-01 丹麥商諾佛 儂迪克股份有限公司 抑制跨膜絲胺酸蛋白酶６（ｔｍｐｒｓｓ６）表現的組成物及方法
CN117136236B (zh) * 2022-09-29 2024-03-15 广州必贝特医药股份有限公司 用于抑制TMPRSS6基因表达的siRNA或其盐、药物及其应用
WO2024060649A1 (zh) * 2022-09-29 2024-03-28 广州必贝特医药股份有限公司 用于抑制TMPRSS6基因表达的siRNA或其盐、药物及其应用
WO2024200512A1 (en) 2023-03-27 2024-10-03 Silence Therapeutics Gmbh Compounds and compositions for use in stem cell transplantation
WO2025148896A1 (en) * 2024-01-08 2025-07-17 Shanghai Argo Biopharmaceutical Co., Ltd. Compositions and methods for inhibiting expression of transmembrane serine protease 6 (tmprss6)
WO2025206092A1 (ja) * 2024-03-27 2025-10-02 田辺三菱製薬株式会社 Ｍｙｏｒｅｇｕｌｉｎ発現を調節するための化合物及び医薬組成物

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