JP2014516516A5 - - Google Patents
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- JP2014516516A5 JP2014516516A5 JP2014508166A JP2014508166A JP2014516516A5 JP 2014516516 A5 JP2014516516 A5 JP 2014516516A5 JP 2014508166 A JP2014508166 A JP 2014508166A JP 2014508166 A JP2014508166 A JP 2014508166A JP 2014516516 A5 JP2014516516 A5 JP 2014516516A5
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- pharmaceutical composition
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- modified oligonucleotide
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- Prior art date
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- 239000008194 pharmaceutical composition Substances 0.000 claims 40
- 239000002777 nucleoside Substances 0.000 claims 16
- 108091034117 Oligonucleotide Proteins 0.000 claims 15
- 241001465754 Metazoa Species 0.000 claims 11
- 150000001875 compounds Chemical class 0.000 claims 11
- 125000003835 nucleoside group Chemical group 0.000 claims 10
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 claims 8
- 208000024172 Cardiovascular disease Diseases 0.000 claims 7
- 208000024891 symptom Diseases 0.000 claims 7
- OPTASPLRGRRNAP-UHFFFAOYSA-N cytosine Chemical compound NC=1C=CNC(=O)N=1 OPTASPLRGRRNAP-UHFFFAOYSA-N 0.000 claims 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 6
- 208000035475 disorder Diseases 0.000 claims 6
- 239000003814 drug Substances 0.000 claims 6
- 229940079593 drug Drugs 0.000 claims 6
- 150000003833 nucleoside derivatives Chemical class 0.000 claims 6
- 230000000291 postprandial effect Effects 0.000 claims 6
- 108010004103 Chylomicrons Proteins 0.000 claims 5
- 208000006575 hypertriglyceridemia Diseases 0.000 claims 5
- 230000008685 targeting Effects 0.000 claims 5
- 206010033645 Pancreatitis Diseases 0.000 claims 4
- 229940104302 cytosine Drugs 0.000 claims 3
- 230000002265 prevention Effects 0.000 claims 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- KEWSCDNULKOKTG-UHFFFAOYSA-N 4-cyano-4-ethylsulfanylcarbothioylsulfanylpentanoic acid Chemical compound CCSC(=S)SC(C)(C#N)CCC(O)=O KEWSCDNULKOKTG-UHFFFAOYSA-N 0.000 claims 2
- 206010002383 Angina Pectoris Diseases 0.000 claims 2
- 102100037637 Cholesteryl ester transfer protein Human genes 0.000 claims 2
- 208000032928 Dyslipidaemia Diseases 0.000 claims 2
- 101000880514 Homo sapiens Cholesteryl ester transfer protein Proteins 0.000 claims 2
- 101001094647 Homo sapiens Serum paraoxonase/arylesterase 1 Proteins 0.000 claims 2
- 208000017170 Lipid metabolism disease Diseases 0.000 claims 2
- 102100035476 Serum paraoxonase/arylesterase 1 Human genes 0.000 claims 2
- 239000003529 anticholesteremic agent Substances 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 230000007423 decrease Effects 0.000 claims 2
- 201000011110 familial lipoprotein lipase deficiency Diseases 0.000 claims 2
- 230000009395 genetic defect Effects 0.000 claims 2
- 210000003205 muscle Anatomy 0.000 claims 2
- RYYWUUFWQRZTIU-UHFFFAOYSA-K thiophosphate Chemical compound [O-]P([O-])([O-])=S RYYWUUFWQRZTIU-UHFFFAOYSA-K 0.000 claims 2
- 150000003626 triacylglycerols Chemical class 0.000 claims 2
- LRSASMSXMSNRBT-UHFFFAOYSA-N 5-methylcytosine Chemical group CC1=CNC(=O)N=C1N LRSASMSXMSNRBT-UHFFFAOYSA-N 0.000 claims 1
- 206010000060 Abdominal distension Diseases 0.000 claims 1
- 206010002329 Aneurysm Diseases 0.000 claims 1
- 201000001320 Atherosclerosis Diseases 0.000 claims 1
- 206010008479 Chest Pain Diseases 0.000 claims 1
- 208000000059 Dyspnea Diseases 0.000 claims 1
- 206010013975 Dyspnoeas Diseases 0.000 claims 1
- 229940121710 HMGCoA reductase inhibitor Drugs 0.000 claims 1
- 208000035150 Hypercholesterolemia Diseases 0.000 claims 1
- 208000031226 Hyperlipidaemia Diseases 0.000 claims 1
- 206010020772 Hypertension Diseases 0.000 claims 1
- 206010028813 Nausea Diseases 0.000 claims 1
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 claims 1
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 206010033799 Paralysis Diseases 0.000 claims 1
- 206010037660 Pyrexia Diseases 0.000 claims 1
- 208000005392 Spasm Diseases 0.000 claims 1
- 208000001871 Tachycardia Diseases 0.000 claims 1
- 208000012886 Vertigo Diseases 0.000 claims 1
- 230000000692 anti-sense effect Effects 0.000 claims 1
- 239000003472 antidiabetic agent Substances 0.000 claims 1
- 229940125708 antidiabetic agent Drugs 0.000 claims 1
- 239000003524 antilipemic agent Substances 0.000 claims 1
- 206010003119 arrhythmia Diseases 0.000 claims 1
- 230000006793 arrhythmia Effects 0.000 claims 1
- 125000002619 bicyclic group Chemical group 0.000 claims 1
- 208000006218 bradycardia Diseases 0.000 claims 1
- 230000036471 bradycardia Effects 0.000 claims 1
- 150000001720 carbohydrates Chemical class 0.000 claims 1
- 235000014633 carbohydrates Nutrition 0.000 claims 1
- 208000026106 cerebrovascular disease Diseases 0.000 claims 1
- 230000000295 complement effect Effects 0.000 claims 1
- 208000029078 coronary artery disease Diseases 0.000 claims 1
- 229960004042 diazoxide Drugs 0.000 claims 1
- -1 diazoxide salt Chemical class 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 229940125753 fibrate Drugs 0.000 claims 1
- 235000021323 fish oil Nutrition 0.000 claims 1
- 229940127208 glucose-lowering drug Drugs 0.000 claims 1
- 208000030175 lameness Diseases 0.000 claims 1
- 231100000682 maximum tolerated dose Toxicity 0.000 claims 1
- 230000008693 nausea Effects 0.000 claims 1
- 229960003512 nicotinic acid Drugs 0.000 claims 1
- 235000001968 nicotinic acid Nutrition 0.000 claims 1
- 239000011664 nicotinic acid Substances 0.000 claims 1
- 150000007523 nucleic acids Chemical group 0.000 claims 1
- 238000007911 parenteral administration Methods 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 208000013220 shortness of breath Diseases 0.000 claims 1
- 238000007920 subcutaneous administration Methods 0.000 claims 1
- 230000035900 sweating Effects 0.000 claims 1
- 230000006794 tachycardia Effects 0.000 claims 1
- 231100000889 vertigo Toxicity 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161479817P | 2011-04-27 | 2011-04-27 | |
| US61/479,817 | 2011-04-27 | ||
| US201261595009P | 2012-02-03 | 2012-02-03 | |
| US61/595,009 | 2012-02-03 | ||
| PCT/US2012/035694 WO2012149495A1 (en) | 2011-04-27 | 2012-04-27 | Modulation of apolipoprotein ciii (apociii) expression |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016138210A Division JP2017008059A (ja) | 2011-04-27 | 2016-07-13 | アポリポタンパク質ｃｉｉｉ（ａｐｏｃｉｉｉ）発現の調節 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014516516A JP2014516516A (ja) | 2014-07-17 |
| JP2014516516A5 true JP2014516516A5 (enExample) | 2014-12-25 |
| JP6203707B2 JP6203707B2 (ja) | 2017-09-27 |
Family
ID=47072800
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014508166A Active JP6203707B2 (ja) | 2011-04-27 | 2012-04-27 | アポリポタンパク質ｃｉｉｉ（ａｐｏｃｉｉｉ）発現の調節 |
| JP2016138210A Pending JP2017008059A (ja) | 2011-04-27 | 2016-07-13 | アポリポタンパク質ｃｉｉｉ（ａｐｏｃｉｉｉ）発現の調節 |
| JP2018128233A Pending JP2018168184A (ja) | 2011-04-27 | 2018-07-05 | アポリポタンパク質ｃｉｉｉ（ａｐｏｃｉｉｉ）発現の調節 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016138210A Pending JP2017008059A (ja) | 2011-04-27 | 2016-07-13 | アポリポタンパク質ｃｉｉｉ（ａｐｏｃｉｉｉ）発現の調節 |
| JP2018128233A Pending JP2018168184A (ja) | 2011-04-27 | 2018-07-05 | アポリポタンパク質ｃｉｉｉ（ａｐｏｃｉｉｉ）発現の調節 |
Country Status (17)
| Country | Link |
|---|---|
| US (4) | US9157082B2 (enExample) |
| EP (2) | EP2701713B1 (enExample) |
| JP (3) | JP6203707B2 (enExample) |
| KR (3) | KR20190062511A (enExample) |
| CN (3) | CN107854478A (enExample) |
| AU (3) | AU2012249324B2 (enExample) |
| BR (1) | BR112013027479A8 (enExample) |
| CA (1) | CA2834232A1 (enExample) |
| DK (2) | DK2701713T3 (enExample) |
| ES (2) | ES2663635T3 (enExample) |
| IL (1) | IL229010A0 (enExample) |
| MY (1) | MY162715A (enExample) |
| NZ (1) | NZ710192A (enExample) |
| RU (2) | RU2603076C9 (enExample) |
| SG (2) | SG194671A1 (enExample) |
| UA (1) | UA115309C2 (enExample) |
| WO (1) | WO2012149495A1 (enExample) |
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| EP3187182B1 (en) | 2008-09-02 | 2021-03-03 | Amarin Pharmaceuticals Ireland Limited | Pharmaceutical composition comprising eicosapentaenoic acid and nicotinic acid and methods of using same |
| MX377553B (es) | 2009-04-29 | 2025-03-10 | Amarin Pharma Inc | Composicion farmaceutica estable y metodos de uso de la misma. |
| CN107233337A (zh) | 2009-04-29 | 2017-10-10 | 阿马里纳药物爱尔兰有限公司 | 含有epa和心血管剂的药物组合物以及使用其的方法 |
| BRPI1011883A2 (pt) | 2009-06-15 | 2016-09-13 | Amarin Pharma Inc | uso de composições para redução de triglicerídeos sem elevar os níveis de o ldl-c em um paciente sob o tratamento concomitante com estatina |
| NZ599061A (en) | 2009-09-23 | 2014-05-30 | Amarin Pharmaceuticals Ie Ltd | Pharmaceutical composition comprising omega-3 fatty acid and hydroxy-derivative of a statin and methods of using same |
| NZ744990A (en) | 2010-11-29 | 2019-10-25 | Amarin Pharmaceuticals Ie Ltd | Low eructation composition and methods for treating and/or preventing cardiovascular disease in a subject with fish allergy/hypersensitivity |
| US11712429B2 (en) | 2010-11-29 | 2023-08-01 | Amarin Pharmaceuticals Ireland Limited | Low eructation composition and methods for treating and/or preventing cardiovascular disease in a subject with fish allergy/hypersensitivity |
| SG194671A1 (en) | 2011-04-27 | 2013-12-30 | Isis Pharmaceuticals Inc | Modulation of apolipoprotein ciii (apociii) expression |
| US11291643B2 (en) | 2011-11-07 | 2022-04-05 | Amarin Pharmaceuticals Ireland Limited | Methods of treating hypertriglyceridemia |
| WO2013070735A1 (en) | 2011-11-07 | 2013-05-16 | Amarin Pharmaceuticals Ireland Limited | Methods of treating hypertriglyceridemia |
| EP2792746A4 (en) * | 2011-12-12 | 2015-09-16 | Nat Cerebral & Cardiovascular Ct | OLIGONUCLEOTIDE AND THERAPEUTIC FOR HYPERLIPIDEMIA WITH THIS AS AN ACTIVE SUBSTANCE |
| EP2800469B1 (en) | 2012-01-06 | 2021-08-25 | Amarin Pharmaceuticals Ireland Limited | Compositions and methods for lowering levels of high-sensitivity (hs-crp) in a subject |
| US9603826B2 (en) | 2012-06-29 | 2017-03-28 | Amarin Pharmaceuticals Ireland Limited | Methods of reducing the risk of a cardiovascular event in a subject on statin therapy |
| WO2014074552A2 (en) | 2012-11-06 | 2014-05-15 | Amarin Pharmaceuticals Ireland Limited | Compositions and methods for lowering triglycerides without raising ldl-c levels in a subject on concomitant statin therapy |
| US20140187633A1 (en) | 2012-12-31 | 2014-07-03 | Amarin Pharmaceuticals Ireland Limited | Methods of treating or preventing nonalcoholic steatohepatitis and/or primary biliary cirrhosis |
| US9814733B2 (en) | 2012-12-31 | 2017-11-14 | A,arin Pharmaceuticals Ireland Limited | Compositions comprising EPA and obeticholic acid and methods of use thereof |
| US9452151B2 (en) | 2013-02-06 | 2016-09-27 | Amarin Pharmaceuticals Ireland Limited | Methods of reducing apolipoprotein C-III |
| US9624492B2 (en) | 2013-02-13 | 2017-04-18 | Amarin Pharmaceuticals Ireland Limited | Compositions comprising eicosapentaenoic acid and mipomersen and methods of use thereof |
| KR20200123263A (ko) * | 2013-02-14 | 2020-10-28 | 아이오니스 파마수티컬즈, 인코포레이티드 | 지질단백질 리파제 결핍 (lpld) 모집단에서 아포지질단백질 c-iii (apociii) 발현의 조절 |
| US9662307B2 (en) | 2013-02-19 | 2017-05-30 | The Regents Of The University Of Colorado | Compositions comprising eicosapentaenoic acid and a hydroxyl compound and methods of use thereof |
| CA2902491A1 (en) | 2013-02-25 | 2014-08-28 | Imetabolic Biopharma, Llc | A polipoprotein c3 (apociii) antagonists and methods of their use to remove apociii inhibition of lipoprotein lipase (lpl) |
| US9283201B2 (en) | 2013-03-14 | 2016-03-15 | Amarin Pharmaceuticals Ireland Limited | Compositions and methods for treating or preventing obesity in a subject in need thereof |
| US20140271841A1 (en) | 2013-03-15 | 2014-09-18 | Amarin Pharmaceuticals Ireland Limited | Pharmaceutical composition comprising eicosapentaenoic acid and derivatives thereof and a statin |
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| US10966968B2 (en) | 2013-06-06 | 2021-04-06 | Amarin Pharmaceuticals Ireland Limited | Co-administration of rosiglitazone and eicosapentaenoic acid or a derivative thereof |
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| EP3656386A1 (en) | 2013-06-21 | 2020-05-27 | Ionis Pharmaceuticals, Inc. | Compounds and methods for modulating apolipoprotein c-iii expression for improving a diabetic profile |
| WO2015021141A1 (en) * | 2013-08-06 | 2015-02-12 | Amarin Pharmaceuticals Ireland Limited | Methods of treating a cardiovascular disorder in a subject on apo-c3 modulating therapy |
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| WO2016069446A1 (en) * | 2014-10-28 | 2016-05-06 | Omthera Pharmaceuticals Inc | Methods for modulating plasma levels of lipoproteins |
| AU2016222548A1 (en) * | 2015-02-27 | 2017-07-27 | Ionis Pharmaceuticals, Inc. | Modulation of apolipoprotein C-III (ApoCIII) expression in lipodystrophy populations |
| MA46427A (fr) | 2015-10-09 | 2018-08-15 | Wave Life Sciences Ltd | Compositions d'oligonucléotides et procédés associés |
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| JP7376952B2 (ja) | 2018-09-30 | 2023-11-09 | スーチョウ リボ ライフ サイエンス カンパニー、リミテッド | ｓｉＲＮＡ複合体及びその調製方法と使用 |
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| JP7610848B2 (ja) | 2019-05-22 | 2025-01-09 | スーチョウ リボ ライフ サイエンス カンパニー、リミテッド | 核酸、薬物組成物及び複合体ならびに調製方法と使用 |
| CN113286888B (zh) | 2019-05-22 | 2023-12-22 | 苏州瑞博生物技术股份有限公司 | 核酸、药物组合物与缀合物及制备方法和用途 |
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| CN113795582B (zh) | 2019-05-24 | 2024-05-24 | 苏州瑞博生物技术股份有限公司 | 核酸、药物组合物与缀合物及制备方法和用途 |
| CA3160676A1 (en) | 2019-11-12 | 2021-05-20 | Amarin Pharmaceuticals Ireland Limited | Methods of reducing the risk of cardiovascular events in a subject with atrial fibrillation and/or atrial flutter |
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| CN114934074A (zh) * | 2022-06-01 | 2022-08-23 | 北京大学 | 一种ApoC3基因敲除仓鼠模型的构建方法 |
| CN121159702B (zh) * | 2025-08-31 | 2026-03-20 | 广东工业大学 | 一种重组质粒纳米抗体突变体m1及其制备方法与应用 |
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