DK3357497T3 - Modulation af apolipoprotein ciii (apociii) ekspression - Google Patents

Modulation af apolipoprotein ciii (apociii) ekspression Download PDF

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Publication number
DK3357497T3
DK3357497T3 DK18155337.1T DK18155337T DK3357497T3 DK 3357497 T3 DK3357497 T3 DK 3357497T3 DK 18155337 T DK18155337 T DK 18155337T DK 3357497 T3 DK3357497 T3 DK 3357497T3
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Prior art keywords
ekspression
apociii
modulation
apolipoprotein ciii
ciii
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DK18155337.1T
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English (en)
Inventor
Adam Mullick
Rosanne M Crooke
Mark J Graham
Kenneth W Dobie
Thomas A Bell
Richard Lee
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Ionis Pharmaceuticals Inc
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47072800&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK3357497(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ionis Pharmaceuticals Inc filed Critical Ionis Pharmaceuticals Inc
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Publication of DK3357497T3 publication Critical patent/DK3357497T3/da

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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
    • A61K48/0058—Nucleic acids adapted for tissue specific expression, e.g. having tissue specific promoters as part of a contruct
    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
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    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
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    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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    • A61K48/0066—Manipulation of the nucleic acid to modify its expression pattern, e.g. enhance its duration of expression, achieved by the presence of particular introns in the delivered nucleic acid
    • A—HUMAN NECESSITIES
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/341—Gapmers, i.e. of the type ===---===
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate

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DK18155337.1T 2011-04-27 2012-04-27 Modulation af apolipoprotein ciii (apociii) ekspression DK3357497T3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161479817P 2011-04-27 2011-04-27
US201261595009P 2012-02-03 2012-02-03
EP12776385.2A EP2701713B1 (en) 2011-04-27 2012-04-27 Modulation of apolipoprotein ciii (apociii) expression

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DK3357497T3 true DK3357497T3 (en) 2020-11-23

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ID=47072800

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DK12776385.2T DK2701713T3 (da) 2011-04-27 2012-04-27 Modulation af apolipoprotein ciii (apociii) ekspression
DK18155337.1T DK3357497T3 (en) 2011-04-27 2012-04-27 Modulation af apolipoprotein ciii (apociii) ekspression

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US (4) US9157082B2 (da)
EP (2) EP2701713B1 (da)
JP (3) JP6203707B2 (da)
KR (3) KR102021688B1 (da)
CN (3) CN103547271A (da)
AU (3) AU2012249324B2 (da)
BR (1) BR112013027479A8 (da)
CA (1) CA2834232A1 (da)
DK (2) DK2701713T3 (da)
ES (2) ES2833468T3 (da)
IL (1) IL229010A0 (da)
MY (1) MY162715A (da)
NZ (1) NZ710192A (da)
RU (2) RU2603076C9 (da)
SG (2) SG194671A1 (da)
UA (1) UA115309C2 (da)
WO (1) WO2012149495A1 (da)

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