SG194671A1 - Modulation of apolipoprotein ciii (apociii) expression - Google Patents

Modulation of apolipoprotein ciii (apociii) expression Download PDF

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Publication number
SG194671A1
SG194671A1 SG2013079959A SG2013079959A SG194671A1 SG 194671 A1 SG194671 A1 SG 194671A1 SG 2013079959 A SG2013079959 A SG 2013079959A SG 2013079959 A SG2013079959 A SG 2013079959A SG 194671 A1 SG194671 A1 SG 194671A1
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Singapore
Prior art keywords
animal
compound
hdl
seq
levels
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SG2013079959A
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English (en)
Inventor
Adam Mullick
Rosanne M Crooke
Mark J Graham
Kenneth W Dobie
Thomas A Bell
Richard Lee
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Isis Pharmaceuticals Inc
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47072800&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SG194671(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Isis Pharmaceuticals Inc filed Critical Isis Pharmaceuticals Inc
Publication of SG194671A1 publication Critical patent/SG194671A1/en

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
    • A61K48/0058Nucleic acids adapted for tissue specific expression, e.g. having tissue specific promoters as part of a contruct
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088Compounds having three or more nucleosides or nucleotides
    • AHUMAN NECESSITIES
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088Compounds having three or more nucleosides or nucleotides
    • A61K31/713Double-stranded nucleic acids or oligonucleotides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
    • A61K48/0066Manipulation of the nucleic acid to modify its expression pattern, e.g. enhance its duration of expression, achieved by the presence of particular introns in the delivered nucleic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
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    • A61P3/06Antihyperlipidemics
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    • A61P9/06Antiarrhythmics
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    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • A61P9/12Antihypertensives
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00Preparations for use in therapy
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    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/11Antisense
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    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/30Chemical structure
    • C12N2310/31Chemical structure of the backbone
    • C12N2310/315Phosphorothioates
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    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/30Chemical structure
    • C12N2310/32Chemical structure of the sugar
    • C12N2310/3212'-O-R Modification
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    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/30Chemical structure
    • C12N2310/34Spatial arrangement of the modifications
    • C12N2310/341Gapmers, i.e. of the type ===---===
    • CCHEMISTRY; METALLURGY
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    • C12N2310/30Chemical structure
    • C12N2310/34Spatial arrangement of the modifications
    • C12N2310/346Spatial arrangement of the modifications having a combination of backbone and sugar modifications
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    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/30Chemical structure
    • C12N2310/35Nature of the modification
    • C12N2310/351Conjugate

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  • Life Sciences & Earth Sciences (AREA)
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  • Engineering & Computer Science (AREA)
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  • Pharmacology & Pharmacy (AREA)
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  • Diabetes (AREA)
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  • Pain & Pain Management (AREA)
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  • Neurosurgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Urology & Nephrology (AREA)
SG2013079959A 2011-04-27 2012-04-27 Modulation of apolipoprotein ciii (apociii) expression SG194671A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161479817P 2011-04-27 2011-04-27
US201261595009P 2012-02-03 2012-02-03
PCT/US2012/035694 WO2012149495A1 (en) 2011-04-27 2012-04-27 Modulation of apolipoprotein ciii (apociii) expression

Publications (1)

Publication Number Publication Date
SG194671A1 true SG194671A1 (en) 2013-12-30

Family

ID=47072800

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SG10201606174RA SG10201606174RA (en) 2011-04-27 2012-04-27 Modulation of apolipoprotein ciii (apociii) expression
SG2013079959A SG194671A1 (en) 2011-04-27 2012-04-27 Modulation of apolipoprotein ciii (apociii) expression

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SG10201606174RA SG10201606174RA (en) 2011-04-27 2012-04-27 Modulation of apolipoprotein ciii (apociii) expression

Country Status (17)

Country Link
US (4) US9157082B2 (enExample)
EP (2) EP3357497B1 (enExample)
JP (3) JP6203707B2 (enExample)
KR (3) KR20190062511A (enExample)
CN (3) CN107714715A (enExample)
AU (3) AU2012249324B2 (enExample)
BR (1) BR112013027479A8 (enExample)
CA (1) CA2834232A1 (enExample)
DK (2) DK2701713T3 (enExample)
ES (2) ES2663635T3 (enExample)
IL (1) IL229010A0 (enExample)
MY (1) MY162715A (enExample)
NZ (1) NZ710192A (enExample)
RU (2) RU2603076C9 (enExample)
SG (2) SG10201606174RA (enExample)
UA (1) UA115309C2 (enExample)
WO (1) WO2012149495A1 (enExample)

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