|
CH445129A
(fr)
|
1964-04-29 |
1967-10-15 |
Nestle Sa |
Procédé pour la préparation de composés d'inclusion à poids moléculaire élevé
|
|
US3459731A
(en)
|
1966-12-16 |
1969-08-05 |
Corn Products Co |
Cyclodextrin polyethers and their production
|
|
US3426011A
(en)
|
1967-02-13 |
1969-02-04 |
Corn Products Co |
Cyclodextrins with anionic properties
|
|
US3453257A
(en)
|
1967-02-13 |
1969-07-01 |
Corn Products Co |
Cyclodextrin with cationic properties
|
|
US3453259A
(en)
|
1967-03-22 |
1969-07-01 |
Corn Products Co |
Cyclodextrin polyol ethers and their oxidation products
|
|
US4235871A
(en)
|
1978-02-24 |
1980-11-25 |
Papahadjopoulos Demetrios P |
Method of encapsulating biologically active materials in lipid vesicles
|
|
DE3650699T2
(de)
|
1985-03-15 |
1999-04-15 |
Antivirals Inc., Portland, Oreg. |
Immunotestmittel für Polynukleotid und Verfahren
|
|
US5166315A
(en)
|
1989-12-20 |
1992-11-24 |
Anti-Gene Development Group |
Sequence-specific binding polymers for duplex nucleic acids
|
|
US5217866A
(en)
|
1985-03-15 |
1993-06-08 |
Anti-Gene Development Group |
Polynucleotide assay reagent and method
|
|
US5521063A
(en)
|
1985-03-15 |
1996-05-28 |
Antivirals Inc. |
Polynucleotide reagent containing chiral subunits and methods of use
|
|
US5034506A
(en)
|
1985-03-15 |
1991-07-23 |
Anti-Gene Development Group |
Uncharged morpholino-based polymers having achiral intersubunit linkages
|
|
US5506337A
(en)
|
1985-03-15 |
1996-04-09 |
Antivirals Inc. |
Morpholino-subunit combinatorial library and method
|
|
US4737323A
(en)
|
1986-02-13 |
1988-04-12 |
Liposome Technology, Inc. |
Liposome extrusion method
|
|
KR0166088B1
(ko)
|
1990-01-23 |
1999-01-15 |
. |
수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도
|
|
US5714331A
(en)
|
1991-05-24 |
1998-02-03 |
Buchardt, Deceased; Ole |
Peptide nucleic acids having enhanced binding affinity, sequence specificity and solubility
|
|
US5719262A
(en)
|
1993-11-22 |
1998-02-17 |
Buchardt, Deceased; Ole |
Peptide nucleic acids having amino acid side chains
|
|
US5539082A
(en)
|
1993-04-26 |
1996-07-23 |
Nielsen; Peter E. |
Peptide nucleic acids
|
|
CA2140343A1
(en)
|
1992-07-17 |
1994-02-03 |
Sean M. Sullivan |
Method and reagent for treatment of animal diseases
|
|
NZ266386A
(en)
|
1993-05-11 |
1997-11-24 |
Univ North Carolina |
Use of antisense rna oligonucleotides in regulating gene expression
|
|
US5820873A
(en)
|
1994-09-30 |
1998-10-13 |
The University Of British Columbia |
Polyethylene glycol modified ceramide lipids and liposome uses thereof
|
|
US5885613A
(en)
|
1994-09-30 |
1999-03-23 |
The University Of British Columbia |
Bilayer stabilizing components and their use in forming programmable fusogenic liposomes
|
|
US5753613A
(en)
|
1994-09-30 |
1998-05-19 |
Inex Pharmaceuticals Corporation |
Compositions for the introduction of polyanionic materials into cells
|
|
IL115849A0
(en)
|
1994-11-03 |
1996-01-31 |
Merz & Co Gmbh & Co |
Tangential filtration preparation of liposomal drugs and liposome product thereof
|
|
US6794499B2
(en)
|
1997-09-12 |
2004-09-21 |
Exiqon A/S |
Oligonucleotide analogues
|
|
US7572582B2
(en)
|
1997-09-12 |
2009-08-11 |
Exiqon A/S |
Oligonucleotide analogues
|
|
WO1999042091A2
(en)
|
1998-02-19 |
1999-08-26 |
Massachusetts Institute Of Technology |
Use of polycations as endosomolytic agents
|
|
US6683173B2
(en)
|
1998-04-03 |
2004-01-27 |
Epoch Biosciences, Inc. |
Tm leveling methods
|
|
US6210892B1
(en)
|
1998-10-07 |
2001-04-03 |
Isis Pharmaceuticals, Inc. |
Alteration of cellular behavior by antisense modulation of mRNA processing
|
|
JP2000125448A
(ja)
|
1998-10-14 |
2000-04-28 |
Yazaki Corp |
電気接続箱
|
|
JP2000256547A
(ja)
|
1999-03-10 |
2000-09-19 |
Sumitomo Dow Ltd |
耐熱性プラスチックカード用樹脂組成物
|
|
US7084125B2
(en)
|
1999-03-18 |
2006-08-01 |
Exiqon A/S |
Xylo-LNA analogues
|
|
CA2372085C
(en)
|
1999-05-04 |
2009-10-27 |
Exiqon A/S |
L-ribo-lna analogues
|
|
JP2000325085A
(ja)
|
1999-05-21 |
2000-11-28 |
Masafumi Matsuo |
デュシェンヌ型筋ジストロフィー治療剤
|
|
WO2001047496A1
(en)
|
1999-12-29 |
2001-07-05 |
Mixson A James |
Histidine copolymer and methods for using same
|
|
US7070807B2
(en)
|
1999-12-29 |
2006-07-04 |
Mixson A James |
Branched histidine copolymers and methods for using same
|
|
US6653467B1
(en)
|
2000-04-26 |
2003-11-25 |
Jcr Pharmaceutical Co., Ltd. |
Medicament for treatment of Duchenne muscular dystrophy
|
|
US6727355B2
(en)
|
2000-08-25 |
2004-04-27 |
Jcr Pharmaceuticals Co., Ltd. |
Pharmaceutical composition for treatment of Duchenne muscular dystrophy
|
|
EP1191097A1
(en)
|
2000-09-21 |
2002-03-27 |
Leids Universitair Medisch Centrum |
Induction of exon skipping in eukaryotic cells
|
|
WO2003020739A2
(en)
|
2001-09-04 |
2003-03-13 |
Exiqon A/S |
Novel lna compositions and uses thereof
|
|
KR100464261B1
(ko)
|
2002-01-24 |
2005-01-03 |
주식회사 파나진 |
Ｐｎａ 올리고머를 합성하기 위한 신규한 단량체 및 그의제조방법
|
|
KR20030084444A
(ko)
|
2002-04-26 |
2003-11-01 |
주식회사 파나진 |
Ｐｎａ 올리고머를 합성하기 위한 신규한 단량체 및 그의제조방법
|
|
US7569575B2
(en)
|
2002-05-08 |
2009-08-04 |
Santaris Pharma A/S |
Synthesis of locked nucleic acid derivatives
|
|
CA2504554A1
(en)
|
2002-11-05 |
2004-05-27 |
Isis Pharmaceuticals, Inc. |
2'-substituted oligomeric compounds and compositions for use in gene modulations
|
|
ES2509140T3
(es)
|
2002-11-25 |
2014-10-17 |
Masafumi Matsuo |
Fármacos de ácido nucleico ENA que modifican el corte y empalme en precursores de ARNm
|
|
AU2003225410A1
(en)
|
2003-03-21 |
2004-10-11 |
Academisch Ziekenhuis Leiden |
Modulation of exon recognition in pre-mrna by interfering with the secondary rna structure
|
|
US7211668B2
(en)
|
2003-07-28 |
2007-05-01 |
Panagene, Inc. |
PNA monomer and precursor
|
|
HRP20110352T1
(hr)
|
2004-06-28 |
2011-06-30 |
The University Of Western Australia |
Antisens olinukleotidi za induciranje zaobilaženja egzona i postupci njihove upotrebe
|
|
WO2006112705A2
(en)
|
2005-04-22 |
2006-10-26 |
Academisch Ziekenhuis Leiden |
Modulation of exon recognition in pre-mrna by interfering with the binding of sr proteins and by interfering with secondary rna structure.
|
|
US8067571B2
(en)
|
2005-07-13 |
2011-11-29 |
Avi Biopharma, Inc. |
Antibacterial antisense oligonucleotide and method
|
|
CA2629323A1
(en)
|
2005-11-10 |
2007-05-24 |
The University Of North Carolina At Chapel Hill |
Splice switching oligomers for tnf superfamily receptors and their use in treatment of disease
|
|
WO2007133105A1
(en)
|
2006-05-17 |
2007-11-22 |
Svetlana Anatolevna Sokolova |
Transport means
|
|
CN101790385A
(zh)
|
2007-07-12 |
2010-07-28 |
普罗森那技术公司 |
用于使化合物靶向多种选定器官、组织或肿瘤细胞的分子
|
|
CA2704049A1
(en)
|
2007-10-26 |
2009-04-30 |
Academisch Ziekenhuis Leiden |
Means and methods for counteracting muscle disorders
|
|
CA2704261C
(en)
|
2007-11-15 |
2015-05-26 |
Avi Biopharma, Inc. |
Method of synthesis of morpholino oligomers
|
|
US8299206B2
(en)
|
2007-11-15 |
2012-10-30 |
Avi Biopharma, Inc. |
Method of synthesis of morpholino oligomers
|
|
US8076476B2
(en)
|
2007-11-15 |
2011-12-13 |
Avi Biopharma, Inc. |
Synthesis of morpholino oligomers using doubly protected guanine morpholino subunits
|
|
WO2009127230A1
(en)
|
2008-04-16 |
2009-10-22 |
Curevac Gmbh |
MODIFIED (m)RNA FOR SUPPRESSING OR AVOIDING AN IMMUNOSTIMULATORY RESPONSE AND IMMUNOSUPPRESSIVE COMPOSITION
|
|
EP2119783A1
(en)
|
2008-05-14 |
2009-11-18 |
Prosensa Technologies B.V. |
Method for efficient exon (44) skipping in Duchenne Muscular Dystrophy and associated means
|
|
US8084601B2
(en)
|
2008-09-11 |
2011-12-27 |
Royal Holloway And Bedford New College Royal Holloway, University Of London |
Oligomers
|
|
WO2010048586A1
(en)
|
2008-10-24 |
2010-04-29 |
Avi Biopharma, Inc. |
Multiple exon skipping compositions for dmd
|
|
SI2607484T1
(sl)
|
2008-10-27 |
2016-11-30 |
Biomarin Technologies B.V. |
Metode in sredstva za učinkovito preskakovanje eksona 45 v pre-mRNA Duchennove mišične distrofije
|
|
ES2616051T3
(es)
|
2008-12-02 |
2017-06-09 |
Wave Life Sciences Japan, Inc. |
Método para la síntesis de ácidos nucleicos modificados en el átomo de fósforo
|
|
DK2417257T3
(da)
|
2009-04-10 |
2016-06-06 |
Ass Inst De Myologie |
Tricyclo-dna-antisense-oligonukleotider, sammensætninger, og fremgangsmåder til behandlingen af sygdom
|
|
EP2421971B1
(en)
|
2009-04-24 |
2016-07-06 |
BioMarin Technologies B.V. |
Oligonucleotide comprising an inosine for treating dmd
|
|
CA2767253A1
(en)
|
2009-07-06 |
2011-01-13 |
Ontorii, Inc. |
Novel nucleic acid prodrugs and methods of use thereof
|
|
EP2479182B8
(en)
|
2009-09-16 |
2016-07-13 |
Wave Life Sciences Japan, Inc. |
Novel protecting group for synthesizing rna and derivative thereof
|
|
KR102113306B1
(ko)
|
2009-11-12 |
2020-05-21 |
더 유니버시티 오브 웨스턴 오스트레일리아 |
안티센스 분자 및 이를 이용한 질환 치료방법
|
|
TWI541024B
(zh)
|
2010-09-01 |
2016-07-11 |
日本新藥股份有限公司 |
反義核酸
|
|
EP2620428B1
(en)
|
2010-09-24 |
2019-05-22 |
Wave Life Sciences Ltd. |
Asymmetric auxiliary group
|
|
US9078911B2
(en)
|
2011-02-08 |
2015-07-14 |
The Charlotte-Mecklenburg Hospital Authority |
Antisense oligonucleotides
|
|
CA2834128A1
(en)
*
|
2011-05-05 |
2012-11-08 |
Sarepta Therapeutics, Inc. |
Peptide oligonucleotide conjugates
|
|
PT2581448E
(pt)
|
2011-10-13 |
2015-05-21 |
Institut National De La Santé Et De La Rech Médicale (Inserm) |
Dna triciclo-fosforotioato
|
|
CN104024414A
(zh)
|
2011-12-28 |
2014-09-03 |
日本新药株式会社 |
反义核酸
|
|
NZ627896A
(en)
|
2012-01-27 |
2016-11-25 |
Biomarin Technologies B V |
Rna modulating oligonucleotides with improved characteristics for the treatment of duchenne and becker muscular dystrophy
|
|
DE102012101676A1
(de)
|
2012-02-29 |
2013-08-29 |
Klaus-Dieter Rösler |
Verfahren und Vorrichtung zum Bearbeiten von Formularen mit einer Datenverarbeitungsanlage
|
|
JP6460983B2
(ja)
|
2012-07-03 |
2019-01-30 |
バイオマリン テクノロジーズ ベー．フェー． |
筋ジストロフィー患者の治療のためのオリゴヌクレオチド
|
|
US9598458B2
(en)
|
2012-07-13 |
2017-03-21 |
Wave Life Sciences Japan, Inc. |
Asymmetric auxiliary group
|
|
US9982257B2
(en)
|
2012-07-13 |
2018-05-29 |
Wave Life Sciences Ltd. |
Chiral control
|
|
CN111440796A
(zh)
|
2012-12-20 |
2020-07-24 |
萨雷普塔医疗公司 |
用于治疗肌营养不良症的改良的外显子跳跃组合物
|
|
NZ731587A
(en)
|
2013-03-14 |
2021-07-30 |
Sarepta Therapeutics Inc |
Exon skipping compositions for treating muscular dystrophy
|
|
KR20230074606A
(ko)
|
2013-03-14 |
2023-05-30 |
사렙타 쎄러퓨틱스 인코퍼레이티드 |
근육 이영양증의 치료를 위한 엑손 스키핑 조성물
|
|
WO2015108046A1
(ja)
|
2014-01-15 |
2015-07-23 |
株式会社新日本科学 |
抗アレルギー作用を有するキラル核酸アジュバンド及び抗アレルギー剤
|
|
US10144933B2
(en)
|
2014-01-15 |
2018-12-04 |
Shin Nippon Biomedical Laboratories, Ltd. |
Chiral nucleic acid adjuvant having immunity induction activity, and immunity induction activator
|
|
EP3095459A4
(en)
|
2014-01-15 |
2017-08-23 |
Shin Nippon Biomedical Laboratories, Ltd. |
Chiral nucleic acid adjuvant having antitumor effect and antitumor agent
|
|
DK3094728T3
(da)
|
2014-01-16 |
2022-05-16 |
Wave Life Sciences Ltd |
Kiralt design
|
|
HUE042283T2
(hu)
|
2014-03-12 |
2019-06-28 |
Nippon Shinyaku Co Ltd |
Antiszensz nukleinsav
|
|
SI3159409T1
(sl)
|
2014-06-17 |
2020-02-28 |
Nippon Shinyaku Co., Ltd. |
Protismiselna nukleinska kislina za uporabo pri zdravljenju Duchennove mišične distrofije
|
|
AU2015338923B2
(en)
|
2014-11-02 |
2021-10-21 |
Arcturus Therapeutics, Inc. |
Messenger UNA molecules and uses thereof
|
|
MA43072A
(fr)
|
2015-07-22 |
2018-05-30 |
Wave Life Sciences Ltd |
Compositions d'oligonucléotides et procédés associés
|
|
BR112018007066A2
(pt)
*
|
2015-10-09 |
2018-10-23 |
Sarepta Therapeutics Inc |
composições e métodos para tratamento da distrofia muscular de duchene e distúrbios relacionados
|
|
CN114533900A
(zh)
|
2015-10-09 |
2022-05-27 |
波涛生命科学有限公司 |
寡核苷酸组合物及其方法
|
|
MA45270A
(fr)
|
2016-05-04 |
2017-11-09 |
Wave Life Sciences Ltd |
Compositions d'oligonucléotides et procédés associés
|
|
MA45290A
(fr)
|
2016-05-04 |
2019-03-13 |
Wave Life Sciences Ltd |
Procédés et compositions d'agents biologiquement actifs
|
|
ES2928486T3
(es)
*
|
2016-12-19 |
2022-11-18 |
Sarepta Therapeutics Inc |
Conjugados de oligómeros con omisión de exón para la distrofia muscular
|
|
WO2020214763A1
(en)
*
|
2019-04-18 |
2020-10-22 |
Sarepta Therapeutics, Inc. |
Compositions for treating muscular dystrophy
|