JP2010531879A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2010531879A5 JP2010531879A5 JP2010514847A JP2010514847A JP2010531879A5 JP 2010531879 A5 JP2010531879 A5 JP 2010531879A5 JP 2010514847 A JP2010514847 A JP 2010514847A JP 2010514847 A JP2010514847 A JP 2010514847A JP 2010531879 A5 JP2010531879 A5 JP 2010531879A5
- Authority
- JP
- Japan
- Prior art keywords
- corresponds
- composition
- disorder
- group
- phch
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 claims description 27
- 150000001875 compounds Chemical class 0.000 claims description 19
- 208000019901 Anxiety disease Diseases 0.000 claims description 17
- 150000003839 salts Chemical class 0.000 claims description 11
- 230000036506 anxiety Effects 0.000 claims description 10
- 208000027534 Emotional disease Diseases 0.000 claims description 9
- 208000021384 Obsessive-Compulsive disease Diseases 0.000 claims description 6
- 206010041250 Social phobia Diseases 0.000 claims description 6
- JNODQFNWMXFMEV-UHFFFAOYSA-N latrepirdine Chemical compound C1N(C)CCC2=C1C1=CC(C)=CC=C1N2CCC1=CC=C(C)N=C1 JNODQFNWMXFMEV-UHFFFAOYSA-N 0.000 claims description 6
- 208000019906 panic disease Diseases 0.000 claims description 6
- 208000019899 phobic disease Diseases 0.000 claims description 6
- 208000028173 post-traumatic stress disease Diseases 0.000 claims description 6
- 208000011688 Generalised anxiety disease Diseases 0.000 claims description 5
- 208000029364 generalized anxiety disease Diseases 0.000 claims description 5
- RDMFHRSPDKWERA-UHFFFAOYSA-N 5H-Pyrido[4,3-b]indole Chemical class C1=NC=C2C3=CC=CC=C3NC2=C1 RDMFHRSPDKWERA-UHFFFAOYSA-N 0.000 claims description 4
- 206010034912 Phobia Diseases 0.000 claims description 4
- 239000002253 acid Substances 0.000 claims description 4
- 230000037396 body weight Effects 0.000 claims description 4
- 239000008194 pharmaceutical composition Substances 0.000 claims description 4
- 239000002249 anxiolytic agent Substances 0.000 claims description 2
- 230000000949 anxiolytic effect Effects 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 208000019022 Mood disease Diseases 0.000 claims 1
- 208000000810 Separation Anxiety Diseases 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 238000000034 method Methods 0.000 description 5
- 239000002552 dosage form Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000012377 drug delivery Methods 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 239000012729 immediate-release (IR) formulation Substances 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU2007124175/15A RU2338533C1 (ru) | 2007-06-28 | 2007-06-28 | СРЕДСТВО, ОБЛАДАЮЩЕЕ АНКСИОЛИТИЧЕСКИМ ДЕЙСТВИЕМ, НА ОСНОВЕ ГИДРИРОВАННЫХ ПИРИДО(4,3-b)ИНДОЛОВ (ВАРИАНТЫ), ФАРМАКОЛОГИЧЕСКОЕ СРЕДСТВО НА ЕГО ОСНОВЕ И СПОСОБ ЕГО ПРИМЕНЕНИЯ |
| PCT/US2008/008121 WO2009005771A1 (en) | 2007-06-28 | 2008-06-27 | A drug demonstrating anxiolytic effect based on hydrogenated pyrido (4, 3-b) indoles, its pharmacological compound and application method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010531879A JP2010531879A (ja) | 2010-09-30 |
| JP2010531879A5 true JP2010531879A5 (enExample) | 2011-08-11 |
Family
ID=40226421
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010514847A Pending JP2010531879A (ja) | 2007-06-28 | 2008-06-27 | 水素化ピリド［４，３−ｂ］インドールに基づく抗不安作用を示す薬物、その薬理学的な化合物および適用方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20120101121A1 (enExample) |
| EP (1) | EP2161995A4 (enExample) |
| JP (1) | JP2010531879A (enExample) |
| AU (1) | AU2008271026A1 (enExample) |
| CA (1) | CA2691812A1 (enExample) |
| RU (1) | RU2338533C1 (enExample) |
| WO (1) | WO2009005771A1 (enExample) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090221627A1 (en) | 2007-09-20 | 2009-09-03 | Alexey Aksinenko | Fluoro-containing derivatives of hydrogenated pyrido[4,3-b]indoles with neuroprotective and cognition enhancing properties, process for preparing, and use |
| RU2007139634A (ru) | 2007-10-25 | 2009-04-27 | Сергей Олегович Бачурин (RU) | Новые тиазол-, триазол- или оксадиазол-содержащие тетрациклические соединения |
| RU2544856C2 (ru) | 2008-01-25 | 2015-03-20 | Сергей Олегович Бачурин | НОВЫЕ ПРОИЗВОДНЫЕ 2,3,4,5-ТЕТРАГИДРО-1-ПИРИДО[4,3-b]ИНДОЛА И СПОСОБЫ ИХ ПРИМЕНЕНИЯ |
| CN104387382A (zh) | 2008-03-24 | 2015-03-04 | 梅迪维新技术公司 | 吡啶并[3,4-b]吲哚和应用方法 |
| WO2009120720A1 (en) | 2008-03-24 | 2009-10-01 | Medivation Technologies,Inc. | Bridged heterocyclic compounds and methods of use |
| US8907097B2 (en) | 2008-10-31 | 2014-12-09 | Medivation Technologies, Inc. | Pyrido[4,3-b]indoles containing rigid moieties |
| AU2009308708B2 (en) | 2008-10-31 | 2015-11-19 | Medivation Technologies, Inc. | Azepino [4, 5-b] indoles and methods of use |
| RU2011137419A (ru) | 2009-02-11 | 2013-03-20 | Суновион Фармасьютикалз Инк. | Обратные агонисты и антагонисты гистамина н3 и способы их применения |
| EP2424366B1 (en) | 2009-04-29 | 2016-02-17 | Medivation Technologies, Inc. | Pyrido [4, 3-b]indoles and methods of use |
| EP2424364A4 (en) | 2009-04-29 | 2012-12-19 | Medivation Technologies Inc | PYRIDO [4.3-B] INDOLES AND METHODS OF USE |
| JP5869484B2 (ja) | 2009-09-23 | 2016-02-24 | メディベイション テクノロジーズ， インコーポレイテッド | 架橋複素環化合物およびその使用 |
| WO2011038163A1 (en) | 2009-09-23 | 2011-03-31 | Medivation Technologies, Inc. | Pyrido[3,4-b]indoles and methods of use |
| US8859561B2 (en) | 2009-09-23 | 2014-10-14 | Medivation Technologies, Inc. | Pyrido[4,3-b]indoles and methods of use |
| RU2428185C1 (ru) * | 2009-12-29 | 2011-09-10 | Учреждение Российской Академии Наук Институт Физиологически Активных Веществ Ран (Ифав Ран) | ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ ДЛЯ ЛЕЧЕНИЯ НЕЙРОДЕГЕНЕРАТИВНЫХ ЗАБОЛЕВАНИЙ НА ОСНОВЕ ГИДРИРОВАННОГО ПИРИДО(4,3-b)ИНДОЛА, СПОСОБ ЕЕ ПОЛУЧЕНИЯ И ФАРМАКОЛОГИЧЕСКОЕ СРЕДСТВО НА ЕЕ ОСНОВЕ |
| US9034865B2 (en) | 2010-02-18 | 2015-05-19 | Medivation Technologies, Inc. | Pyrido [4,3-B] indole and pyrido [3,4-B] indole derivatives and methods of use |
| WO2011103460A1 (en) | 2010-02-18 | 2011-08-25 | Medivation Technologies, Inc. | Fused tetracyclic pyrido[4,3-b]indole and pyrido[3,4-b]ondole derivatives and methods of use |
| US9040519B2 (en) | 2010-02-18 | 2015-05-26 | Medivation Technologies, Inc. | Fused tetracyclic pyrido [4,3-B] indole and pyrido [3,4-B] indole derivatives and methods of use |
| US9187471B2 (en) | 2010-02-19 | 2015-11-17 | Medivation Technologies, Inc. | Pyrido [4,3-b] indole and pyrido [3,4-b] indole derivatives and methods of use |
| WO2012112961A1 (en) * | 2011-02-18 | 2012-08-23 | Medivation Technologies, Inc. | Compounds and methods of treating hypertension |
| US20140155384A1 (en) | 2011-02-18 | 2014-06-05 | Medivation Technologies, Inc. | Compounds and methods of treating diabetes |
| US9035056B2 (en) | 2011-02-18 | 2015-05-19 | Medivation Technologies, Inc. | Pyrido[4,3-b]indole and pyrido[3,4-b]indole derivatives and methods of use |
| BR112013021126A2 (pt) | 2011-02-18 | 2019-09-24 | Medivation Technologies Inc | método para reduzir a pressão sanguínea, método para aumentar o fluxo sanguíneo renal ou diminuir a reabsorção de sódio, método para tratar uma doença, kit, composto e composição farmacêutica |
| US20150315188A1 (en) * | 2012-08-22 | 2015-11-05 | Medivation Technologies, Inc. | Compounds and methods for treatment of hypertension |
| SG10202107367SA (en) | 2016-12-31 | 2021-08-30 | Bioxcel Therapeutics Inc | Use of sublingual dexmedetomidine for the treatment of agitation |
| ES3004544T3 (en) | 2018-06-27 | 2025-03-12 | Bioxcel Therapeutics Inc | Film formulations containing dexmedetomidine and methods of producing them |
| US20240024288A1 (en) | 2019-07-19 | 2024-01-25 | Bioxcel Therapeutics, Inc. | Non-sedating dexmedetomidine treatment regimens |
| US11806334B1 (en) | 2023-01-12 | 2023-11-07 | Bioxcel Therapeutics, Inc. | Non-sedating dexmedetomidine treatment regimens |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3718657A (en) * | 1970-12-03 | 1973-02-27 | Abbott Lab | Certain-2-substituted-1,2,3,4-tetrahydro-beta or gamma carbolines |
| RU2106864C1 (ru) * | 1995-10-23 | 1998-03-20 | Николай Серафимович Зефиров | Средство для лечения болезни альцгеймера |
| US6147085A (en) * | 1999-04-01 | 2000-11-14 | Neurogen Corporation | Aminoalkyl substituted 9H-pyridino[2,3-b] indole and 9H-pyrimidino[4,5-b] indole derivatives |
-
2007
- 2007-06-28 RU RU2007124175/15A patent/RU2338533C1/ru not_active IP Right Cessation
-
2008
- 2008-06-27 EP EP08779878A patent/EP2161995A4/en not_active Withdrawn
- 2008-06-27 US US12/667,035 patent/US20120101121A1/en not_active Abandoned
- 2008-06-27 CA CA002691812A patent/CA2691812A1/en not_active Abandoned
- 2008-06-27 JP JP2010514847A patent/JP2010531879A/ja active Pending
- 2008-06-27 WO PCT/US2008/008121 patent/WO2009005771A1/en not_active Ceased
- 2008-06-27 AU AU2008271026A patent/AU2008271026A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2010511701A5 (enExample) | ||
| US20220184222A1 (en) | Bicycle toxin conjugates and uses thereof | |
| RU2653408C2 (ru) | Способы лечения биполярного расстройства | |
| JP2013501731A5 (enExample) | ||
| JP2010511616A5 (enExample) | ||
| TW200522952A (en) | Pyrido[2,3-d]pyrimidine-2,4-diamines as pde 2 inhibitors | |
| RU2006101999A (ru) | Средство для лечения шизофрении на основе гидрированных пиридо(4,3-b)индолов (варианты), фармакологическое средство на его основе и способ его применения | |
| WO2006119958A2 (en) | Use of flibanserin in the treatment of chronic pain | |
| JP2012521429A5 (enExample) | ||
| JP2014517050A5 (enExample) | ||
| JPH03148221A (ja) | 記憶および学習憎進または認知もしくは精神障害治療用のｄ―シクロセリンおよびｄ―アラニン含有組成物 | |
| JP2016517434A5 (enExample) | ||
| JP2018520189A5 (enExample) | ||
| JP2014196328A (ja) | ニコチン性アセチルコリンα７受容体アゴニストの組合せ剤 | |
| JP2019515908A5 (enExample) | ||
| JP2022526763A5 (enExample) | ||
| CA2671470A1 (en) | Powder formulation for valganciclovir | |
| JP2004518653A (ja) | 不安障害を治療する方法 | |
| WO2008116890A2 (en) | Pharmaceutical compositions comprising flibanserin and a further agent in the treatment of sexual disorders | |
| IL318548A (en) | Methods for treating muscular dystrophy with casimersen | |
| JP2015531373A5 (enExample) | ||
| WO2023186963A1 (en) | Combination of nitrous oxide and 5-ht2a receptor agonists | |
| JP2011518168A5 (enExample) | ||
| JP5674923B2 (ja) | アンチセンスオリゴヌクレオチドを含む医薬組成物およびそれを使用する方法 | |
| JP2015057409A (ja) | 多形膠芽腫の治療のためのマシテンタンを含有する組み合わせ剤 |