JP2019501133A5 - - Google Patents
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- JP2019501133A5 JP2019501133A5 JP2018526682A JP2018526682A JP2019501133A5 JP 2019501133 A5 JP2019501133 A5 JP 2019501133A5 JP 2018526682 A JP2018526682 A JP 2018526682A JP 2018526682 A JP2018526682 A JP 2018526682A JP 2019501133 A5 JP2019501133 A5 JP 2019501133A5
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- JP
- Japan
- Prior art keywords
- compound
- pharmaceutically acceptable
- acceptable salt
- formula
- compound according
- Prior art date
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- 0 C[C@](CCN(C1)C(CC#N)=O)[C@]1N(C)c1c(cc[n]2C(N(C)CCN(C)C(OCc(cc3)cc(*)c3O[C@@]([C@]([C@@]([C@@]3O)O)O)O[C@@]3C(O)=O)=O)=O)c2ncn1 Chemical compound C[C@](CCN(C1)C(CC#N)=O)[C@]1N(C)c1c(cc[n]2C(N(C)CCN(C)C(OCc(cc3)cc(*)c3O[C@@]([C@]([C@@]([C@@]3O)O)O)O[C@@]3C(O)=O)=O)=O)c2ncn1 0.000 description 6
- NKJXNCPMTBJPHR-BEFAXECRSA-N C[C@H](CCN(C1)C(CC#N)=O)[C@H]1N(C)c1ncnc2c1cc[n]2C(Oc(cc1)ccc1[N+]([O-])=O)=O Chemical compound C[C@H](CCN(C1)C(CC#N)=O)[C@H]1N(C)c1ncnc2c1cc[n]2C(Oc(cc1)ccc1[N+]([O-])=O)=O NKJXNCPMTBJPHR-BEFAXECRSA-N 0.000 description 4
- UJLAWZDWDVHWOW-YPMHNXCESA-N C[C@H](CCN(C1)C(CC#N)=O)[C@H]1N(C)c1c(cc[nH]2)c2ncn1 Chemical compound C[C@H](CCN(C1)C(CC#N)=O)[C@H]1N(C)c1c(cc[nH]2)c2ncn1 UJLAWZDWDVHWOW-YPMHNXCESA-N 0.000 description 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562259273P | 2015-11-24 | 2015-11-24 | |
| US62/259,273 | 2015-11-24 | ||
| PCT/US2016/063254 WO2017091544A1 (en) | 2015-11-24 | 2016-11-22 | Prodrugs of a jak inhibitor compound for treatment of gastrointestinal inflammatory disease |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020141651A Division JP2020196742A (ja) | 2015-11-24 | 2020-08-25 | 胃腸炎症性腸疾患の処置のための、ｊａｋ阻害剤化合物のプロドラッグ |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019501133A JP2019501133A (ja) | 2019-01-17 |
| JP2019501133A5 true JP2019501133A5 (enExample) | 2019-11-14 |
| JP6778747B2 JP6778747B2 (ja) | 2020-11-04 |
Family
ID=57518004
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018526682A Active JP6778747B2 (ja) | 2015-11-24 | 2016-11-22 | 胃腸炎症性腸疾患の処置のための、ｊａｋ阻害剤化合物のプロドラッグ |
| JP2020141651A Pending JP2020196742A (ja) | 2015-11-24 | 2020-08-25 | 胃腸炎症性腸疾患の処置のための、ｊａｋ阻害剤化合物のプロドラッグ |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020141651A Pending JP2020196742A (ja) | 2015-11-24 | 2020-08-25 | 胃腸炎症性腸疾患の処置のための、ｊａｋ阻害剤化合物のプロドラッグ |
Country Status (33)
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3371184A1 (en) | 2015-11-03 | 2018-09-12 | Topivert Pharma Limited | 4,5,6,7-tetrahydro-1h-imidazo[4,5-c]pyridine and 1,4,5,6,7,8-hexahydroimidazo[4,5-d]azepine derivatives as janus kinase inhibitors |
| PT3371185T (pt) | 2015-11-03 | 2020-12-28 | Topivert Pharma Ltd | Derivados de 4,5,6,7-tetrahidro-1h-imidazo[4,5-c]piridina e 1,4,5,6,7,8-hexahidroimidazo[4,5-d]azepina como inibidores de janus quinase |
| US10435428B2 (en) | 2015-11-24 | 2019-10-08 | Theravance Biopharma R&D Ip, Llc | Prodrugs of a JAK inhibitor compound for treatment of gastrointestinal inflammatory disease |
| FR3060567B1 (fr) * | 2016-12-19 | 2019-05-24 | Ecole Normale Superieure De Lyon | Substrat de glycosidase fluorogene et procede de detection associe |
| WO2018165250A1 (en) * | 2017-03-08 | 2018-09-13 | Theravance Biopharma R&D Ip, Llc | Glucuronide prodrugs of tofacitinib |
| JP2020520955A (ja) | 2017-05-23 | 2020-07-16 | セラヴァンス バイオファーマ アール＆ディー アイピー， エルエルシー | ヤヌスキナーゼ阻害剤のグルクロニドプロドラッグ |
| EP3609903A1 (en) * | 2017-05-23 | 2020-02-19 | Theravance Biopharma R&D IP, LLC | Thiocarbamate prodrugs of tofacitinib |
| JP2020522514A (ja) * | 2017-06-05 | 2020-07-30 | フラッグシップ パイオニアリング イノベーションズ ブイ， インコーポレイテッド | マルチバイオティック剤及びその使用方法 |
| CN111989137A (zh) | 2018-01-05 | 2020-11-24 | 赛博克萨1公司 | 用于治疗涉及酸性或缺氧性患病组织的疾病的化合物、组合物和方法 |
| WO2019182322A1 (ko) * | 2018-03-20 | 2019-09-26 | 삼진제약주식회사 | 신규 염, 이의 제조 방법 및 이를 포함하는 약학 조성물 |
| US12171764B2 (en) | 2018-06-20 | 2024-12-24 | Biora Therapeutics, Inc. | Treatment of a disease of the gastrointestinal tract with a JAK or other kinase inhibitor |
| WO2020034987A1 (zh) * | 2018-08-15 | 2020-02-20 | 江苏豪森药业集团有限公司 | 含有葡糖苷酸衍生物jak抑制剂的前药及其制备方法和应用 |
| EP3847158A1 (en) * | 2018-09-06 | 2021-07-14 | Arena Pharmaceuticals, Inc. | Compounds useful in the treatment of autoimmune and inflammatory disorders |
| CN109134564B (zh) * | 2018-09-21 | 2022-03-11 | 合肥锐思生物医药有限公司 | 乳果糖糖苷衍生物、其制备方法及其用途 |
| EA202191354A1 (ru) * | 2018-11-15 | 2021-08-11 | Янссен Байотек, Инк. | Способы и композиции для прогнозирования ответа на терапию воспалительного заболевания кишечника |
| US11596632B2 (en) | 2018-12-19 | 2023-03-07 | Incyte Corporation | JAK1 pathway inhibitors for the treatment of gastrointestinal disease |
| EP3942045A1 (en) | 2019-03-21 | 2022-01-26 | Onxeo | A dbait molecule in combination with kinase inhibitor for the treatment of cancer |
| KR20220052918A (ko) | 2019-07-10 | 2022-04-28 | 싸이브렉사 2, 인크. | 치료제로서의 사이토톡신의 펩티드 접합체 |
| PH12022550037A1 (en) | 2019-07-10 | 2023-04-12 | Cybrexa 3 Inc | Peptide conjugates of microtubule-targeting agents as therapeutics |
| EP4054579A1 (en) | 2019-11-08 | 2022-09-14 | Institut National de la Santé et de la Recherche Médicale (INSERM) | Methods for the treatment of cancers that have acquired resistance to kinase inhibitors |
| US20210139857A1 (en) * | 2019-11-13 | 2021-05-13 | New York University | Intestinal organoid co-culture systems and methods for treating or preventing a disease or disorder associated with immune response-mediated tissue injury |
| WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
| US20230107927A1 (en) * | 2020-02-28 | 2023-04-06 | First Wave Bio, Inc. | Methods of treating iatrogenic autoimmune colitis |
| JP2023528239A (ja) * | 2020-05-14 | 2023-07-04 | テラバンス バイオファーマ アールアンドディー アイピー リミテッド ライアビリティ カンパニー | 腸管選択的ｊａｋ３阻害剤の投与 |
| CN113943312A (zh) * | 2020-07-17 | 2022-01-18 | 轶诺(浙江)药业有限公司 | 一类肠道裂解型共药及其制备和用途 |
| WO2022087313A1 (en) * | 2020-10-22 | 2022-04-28 | Progenity, Inc. | Methods of treating and predicting non-response to anti-tnf treatment in subjects with gastrointestinal tract diseases |
| US20240307396A1 (en) * | 2021-06-07 | 2024-09-19 | The Regents Of The University Of California | Compositions and methods for treating celiac disease |
| IL309840A (en) * | 2021-07-20 | 2024-02-01 | Coval Biopharma Shanghai Co Ltd | An external antidialectic coupling compound drug, and a method of preparation therefor and use thereof |
| US20230381185A1 (en) * | 2022-05-14 | 2023-11-30 | 3-D Matrix, Ltd. | Novel formulations for oral administration of therapeutic agents to the gastrointestinal tract |
| CN115073543B (zh) * | 2022-07-20 | 2022-11-15 | 北京普祺医药科技股份有限公司 | 一种jak抑制剂的化合物前药及其制备与应用 |
| CN117567460A (zh) * | 2022-08-08 | 2024-02-20 | 明慧医药（杭州）有限公司 | 一种前药化合物及其制备方法和用途 |
| AU2023326364A1 (en) | 2022-08-17 | 2025-03-06 | Transcend Therapeutics, Inc. | Phenethylamines and cathinones precursors |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1993022334A1 (en) | 1992-05-04 | 1993-11-11 | Sri International | Pharmaceutical compositions and methods for colonic delivery of corticosteroids |
| US5811388A (en) | 1995-06-07 | 1998-09-22 | Cibus Pharmaceutical, Inc. | Delivery of drugs to the lower GI tract |
| EA006227B1 (ru) | 1999-12-10 | 2005-10-27 | Пфайзер Продактс Инк. | СОЕДИНЕНИЯ ПИРРОЛО[2,3-d]ПИРИМИДИНА |
| MX2012004180A (es) | 2009-10-09 | 2012-07-17 | Incyte Corp | Derivados de hidroxil, ceto y glucuronido de 3-(4-7h-pirrolo[2,3-d ]pirimidin-a-il)-1h-pirazol-1-il)-3-ciclopentilpropanonitrilo. |
| WO2011079249A2 (en) | 2009-12-23 | 2011-06-30 | Glycomyr, Inc. | Use of vitamin d glycosides and sulfates for treatment of disease |
| US20120289571A1 (en) | 2009-12-31 | 2012-11-15 | Enzon Pharmaceuticals, Inc. | Polymeric conjugates of aromatic amine containing compounds including releasable urea linker |
| EP2531508A1 (en) * | 2010-02-05 | 2012-12-12 | Pfizer Inc. | Pyrrolo [ 2, 3 - d]pyrimidine urea compounds as jak inhibitors |
| US20130109720A1 (en) | 2011-11-01 | 2013-05-02 | Hoffmann-La Roche Inc. | Indole inhibitors of crac |
| CA2913752A1 (en) * | 2013-05-31 | 2014-12-04 | Cerulean Pharma Inc. | Cyclodextrin-based polymers for therapeutic delivery |
| EP3169348B1 (en) * | 2014-06-24 | 2019-07-31 | Institut National de la Sante et de la Recherche Medicale (INSERM) | Pharmaceutical compositions comprising agonists of orexin-1 receptor ox1r for the treatment of inflammatory bowel diseases |
| US10435428B2 (en) | 2015-11-24 | 2019-10-08 | Theravance Biopharma R&D Ip, Llc | Prodrugs of a JAK inhibitor compound for treatment of gastrointestinal inflammatory disease |
| CA3008909C (en) | 2015-12-23 | 2023-10-03 | The University Of British Columbia | Lipid-linked prodrugs |
| CN106496233B (zh) | 2016-09-26 | 2018-05-15 | 东南大学 | 吡咯并嘧啶类化合物、其制备方法及其用途 |
-
2016
- 2016-11-22 US US15/358,462 patent/US10435428B2/en active Active
- 2016-11-22 JP JP2018526682A patent/JP6778747B2/ja active Active
- 2016-11-22 KR KR1020187017879A patent/KR20180080330A/ko not_active Withdrawn
- 2016-11-22 SI SI201630741T patent/SI3380486T1/sl unknown
- 2016-11-22 PT PT168088763T patent/PT3380486T/pt unknown
- 2016-11-22 MY MYPI2018701637A patent/MY189979A/en unknown
- 2016-11-22 MX MX2018006282A patent/MX383107B/es unknown
- 2016-11-22 PL PL16808876T patent/PL3380486T3/pl unknown
- 2016-11-22 EP EP16808876.3A patent/EP3380486B1/en active Active
- 2016-11-22 WO PCT/US2016/063254 patent/WO2017091544A1/en not_active Ceased
- 2016-11-22 AU AU2016359494A patent/AU2016359494B2/en not_active Ceased
- 2016-11-22 ME MEP-2020-126A patent/ME03757B/me unknown
- 2016-11-22 RS RS20200508A patent/RS60237B1/sr unknown
- 2016-11-22 EA EA201891248A patent/EA035816B1/ru unknown
- 2016-11-22 LT LTEP16808876.3T patent/LT3380486T/lt unknown
- 2016-11-22 HR HRP20200561TT patent/HRP20200561T1/hr unknown
- 2016-11-22 NZ NZ742574A patent/NZ742574A/en not_active IP Right Cessation
- 2016-11-22 SM SM20200242T patent/SMT202000242T1/it unknown
- 2016-11-22 DK DK16808876.3T patent/DK3380486T3/da active
- 2016-11-22 ES ES16808876T patent/ES2784523T3/es active Active
- 2016-11-22 CA CA3003283A patent/CA3003283A1/en not_active Abandoned
- 2016-11-22 BR BR112018010650A patent/BR112018010650A8/pt not_active IP Right Cessation
- 2016-11-22 SG SG11201803686UA patent/SG11201803686UA/en unknown
- 2016-11-22 CN CN201680068165.XA patent/CN108290918B/zh active Active
- 2016-11-22 UA UAA201806963A patent/UA121270C2/uk unknown
- 2016-11-22 TW TW105138180A patent/TWI703147B/zh not_active IP Right Cessation
- 2016-11-22 HU HUE16808876A patent/HUE049775T2/hu unknown
-
2018
- 2018-05-01 IL IL259076A patent/IL259076B/en active IP Right Grant
- 2018-05-07 ZA ZA2018/02967A patent/ZA201802967B/en unknown
- 2018-05-15 PH PH12018501037A patent/PH12018501037A1/en unknown
- 2018-05-18 CL CL2018001345A patent/CL2018001345A1/es unknown
- 2018-05-22 CO CONC2018/0005327A patent/CO2018005327A2/es unknown
-
2019
- 2019-08-29 US US16/555,222 patent/US10961267B2/en active Active
-
2020
- 2020-05-13 CY CY20201100447T patent/CY1122918T1/el unknown
- 2020-08-25 JP JP2020141651A patent/JP2020196742A/ja active Pending
-
2021
- 2021-02-22 US US17/249,126 patent/US11608354B2/en active Active
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