BR112018010650A8 - pró-fármacos de um inibidor de jak composto para o tratamento da doença inflamatória gastrointestinal - Google Patents

pró-fármacos de um inibidor de jak composto para o tratamento da doença inflamatória gastrointestinal

Info

Publication number
BR112018010650A8
BR112018010650A8 BR112018010650A BR112018010650A BR112018010650A8 BR 112018010650 A8 BR112018010650 A8 BR 112018010650A8 BR 112018010650 A BR112018010650 A BR 112018010650A BR 112018010650 A BR112018010650 A BR 112018010650A BR 112018010650 A8 BR112018010650 A8 BR 112018010650A8
Authority
BR
Brazil
Prior art keywords
jak inhibitor
prodrugs
compound
treatment
inflammatory disease
Prior art date
Application number
BR112018010650A
Other languages
English (en)
Other versions
BR112018010650A2 (pt
Inventor
D Long Daniel
A A Wilton Donna
Loo Mandy
J Brassil Patrick
Hudson Ryan
Original Assignee
Theravance Biopharma R&D Ip Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Theravance Biopharma R&D Ip Llc filed Critical Theravance Biopharma R&D Ip Llc
Publication of BR112018010650A2 publication Critical patent/BR112018010650A2/pt
Publication of BR112018010650A8 publication Critical patent/BR112018010650A8/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/16—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing two or more hetero rings
    • C12P17/165—Heterorings having nitrogen atoms as the only ring heteroatoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Epidemiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

a invenção proporciona compostos que são pró-fármacos de um agente inibidor de jak para a distribuição direcionada do inibidor de jak ao trato gastrointestinal de um mamífero. a invenção também proporciona composições farmacêuticas compreendendo os compostos, métodos de utilização dos compostos para tratar doenças inflamatórias gastrointestinais e processos e intermediários úteis para preparar os compostos.
BR112018010650A 2015-11-24 2016-11-22 pró-fármacos de um inibidor de jak composto para o tratamento da doença inflamatória gastrointestinal BR112018010650A8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562259273P 2015-11-24 2015-11-24
US62/259,273 2015-11-24
PCT/US2016/063254 WO2017091544A1 (en) 2015-11-24 2016-11-22 Prodrugs of a jak inhibitor compound for treatment of gastrointestinal inflammatory disease

Publications (2)

Publication Number Publication Date
BR112018010650A2 BR112018010650A2 (pt) 2018-11-13
BR112018010650A8 true BR112018010650A8 (pt) 2019-02-26

Family

ID=57518004

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112018010650A BR112018010650A8 (pt) 2015-11-24 2016-11-22 pró-fármacos de um inibidor de jak composto para o tratamento da doença inflamatória gastrointestinal

Country Status (32)

Country Link
US (3) US10435428B2 (pt)
EP (1) EP3380486B1 (pt)
JP (2) JP6778747B2 (pt)
KR (1) KR20180080330A (pt)
CN (1) CN108290918B (pt)
AU (1) AU2016359494B2 (pt)
BR (1) BR112018010650A8 (pt)
CA (1) CA3003283A1 (pt)
CL (1) CL2018001345A1 (pt)
CO (1) CO2018005327A2 (pt)
CY (1) CY1122918T1 (pt)
DK (1) DK3380486T3 (pt)
EA (1) EA035816B1 (pt)
ES (1) ES2784523T3 (pt)
HR (1) HRP20200561T1 (pt)
HU (1) HUE049775T2 (pt)
IL (1) IL259076B (pt)
LT (1) LT3380486T (pt)
ME (1) ME03757B (pt)
MX (1) MX2018006282A (pt)
MY (1) MY189979A (pt)
NZ (1) NZ742574A (pt)
PH (1) PH12018501037A1 (pt)
PL (1) PL3380486T3 (pt)
PT (1) PT3380486T (pt)
RS (1) RS60237B1 (pt)
SG (1) SG11201803686UA (pt)
SI (1) SI3380486T1 (pt)
TW (1) TWI703147B (pt)
UA (1) UA121270C2 (pt)
WO (1) WO2017091544A1 (pt)
ZA (1) ZA201802967B (pt)

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US20220401436A1 (en) 2019-11-08 2022-12-22 INSERM (Institute National de la Santé et de la Recherche Médicale) Methods for the treatment of cancers that have acquired resistance to kinase inhibitors
US20210139857A1 (en) * 2019-11-13 2021-05-13 New York University Intestinal organoid co-culture systems and methods for treating or preventing a disease or disorder associated with immune response-mediated tissue injury
WO2021148581A1 (en) 2020-01-22 2021-07-29 Onxeo Novel dbait molecule and its use
TW202207918A (zh) * 2020-05-14 2022-03-01 美商施萬生物製藥研發Ｉｐ有限責任公司 腸道選擇性ｊａｋ３抑制劑的投與
CN113943312A (zh) * 2020-07-17 2022-01-18 轶诺(浙江)药业有限公司 一类肠道裂解型共药及其制备和用途
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Also Published As

Publication number Publication date
NZ742574A (en) 2018-11-30
SI3380486T1 (sl) 2020-07-31
IL259076B (en) 2021-05-31
PL3380486T3 (pl) 2020-07-27
UA121270C2 (uk) 2020-04-27
ZA201802967B (en) 2019-04-24
PH12018501037A1 (en) 2019-01-28
CN108290918B (zh) 2021-06-08
JP2019501133A (ja) 2019-01-17
US10961267B2 (en) 2021-03-30
AU2016359494A1 (en) 2018-06-14
ES2784523T3 (es) 2020-09-28
MY189979A (en) 2022-03-22
BR112018010650A2 (pt) 2018-11-13
CO2018005327A2 (es) 2018-05-31
AU2016359494B2 (en) 2021-01-07
US10435428B2 (en) 2019-10-08
US20170145044A1 (en) 2017-05-25
WO2017091544A1 (en) 2017-06-01
PT3380486T (pt) 2020-05-22
EA035816B1 (ru) 2020-08-14
IL259076A (en) 2018-06-28
SG11201803686UA (en) 2018-06-28
EA201891248A1 (ru) 2018-10-31
EP3380486B1 (en) 2020-02-19
HRP20200561T1 (hr) 2020-06-26
KR20180080330A (ko) 2018-07-11
EP3380486A1 (en) 2018-10-03
CL2018001345A1 (es) 2018-06-22
US20190389895A1 (en) 2019-12-26
TW201720827A (zh) 2017-06-16
CY1122918T1 (el) 2021-10-29
CN108290918A (zh) 2018-07-17
JP2020196742A (ja) 2020-12-10
RS60237B1 (sr) 2020-06-30
ME03757B (me) 2021-04-20
LT3380486T (lt) 2020-05-11
JP6778747B2 (ja) 2020-11-04
HUE049775T2 (hu) 2020-10-28
TWI703147B (zh) 2020-09-01
DK3380486T3 (da) 2020-05-18
CA3003283A1 (en) 2017-06-01
US11608354B2 (en) 2023-03-21
US20210179655A1 (en) 2021-06-17
MX2018006282A (es) 2019-01-21

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