JP6778747B2 - 胃腸炎症性腸疾患の処置のための、ｊａｋ阻害剤化合物のプロドラッグ - Google Patents

胃腸炎症性腸疾患の処置のための、ｊａｋ阻害剤化合物のプロドラッグ Download PDF

Info

Publication number
JP6778747B2
JP6778747B2 JP2018526682A JP2018526682A JP6778747B2 JP 6778747 B2 JP6778747 B2 JP 6778747B2 JP 2018526682 A JP2018526682 A JP 2018526682A JP 2018526682 A JP2018526682 A JP 2018526682A JP 6778747 B2 JP6778747 B2 JP 6778747B2
Authority
JP
Japan
Prior art keywords
compound
methyl
pharmaceutically acceptable
formula
acceptable salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2018526682A
Other languages
English (en)
Japanese (ja)
Other versions
JP2019501133A (ja
JP2019501133A5 (enExample
Inventor
ライアン ハドソン，
ライアン ハドソン，
ダニエル ディー． ロング，
ダニエル ディー． ロング，
ドナ エー．エー． ウィルトン，
ドナ エー．エー． ウィルトン，
マンディー ルー，
マンディー ルー，
パトリック ジェイ． ブラシル，
パトリック ジェイ． ブラシル，
Original Assignee
セラヴァンス バイオファーマ アール＆ディー アイピー， エルエルシー
セラヴァンス バイオファーマ アール＆ディー アイピー， エルエルシー
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by セラヴァンス バイオファーマ アール＆ディー アイピー， エルエルシー, セラヴァンス バイオファーマ アール＆ディー アイピー， エルエルシー filed Critical セラヴァンス バイオファーマ アール＆ディー アイピー， エルエルシー
Publication of JP2019501133A publication Critical patent/JP2019501133A/ja
Publication of JP2019501133A5 publication Critical patent/JP2019501133A5/ja
Application granted granted Critical
Publication of JP6778747B2 publication Critical patent/JP6778747B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/16—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing two or more hetero rings
    • C12P17/165—Heterorings having nitrogen atoms as the only ring heteroatoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2018526682A 2015-11-24 2016-11-22 胃腸炎症性腸疾患の処置のための、ｊａｋ阻害剤化合物のプロドラッグ Active JP6778747B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562259273P 2015-11-24 2015-11-24
US62/259,273 2015-11-24
PCT/US2016/063254 WO2017091544A1 (en) 2015-11-24 2016-11-22 Prodrugs of a jak inhibitor compound for treatment of gastrointestinal inflammatory disease

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2020141651A Division JP2020196742A (ja) 2015-11-24 2020-08-25 胃腸炎症性腸疾患の処置のための、ｊａｋ阻害剤化合物のプロドラッグ

Publications (3)

Publication Number Publication Date
JP2019501133A JP2019501133A (ja) 2019-01-17
JP2019501133A5 JP2019501133A5 (enExample) 2019-11-14
JP6778747B2 true JP6778747B2 (ja) 2020-11-04

Family

ID=57518004

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2018526682A Active JP6778747B2 (ja) 2015-11-24 2016-11-22 胃腸炎症性腸疾患の処置のための、ｊａｋ阻害剤化合物のプロドラッグ
JP2020141651A Pending JP2020196742A (ja) 2015-11-24 2020-08-25 胃腸炎症性腸疾患の処置のための、ｊａｋ阻害剤化合物のプロドラッグ

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2020141651A Pending JP2020196742A (ja) 2015-11-24 2020-08-25 胃腸炎症性腸疾患の処置のための、ｊａｋ阻害剤化合物のプロドラッグ

Country Status (33)

Country Link
US (3) US10435428B2 (enExample)
EP (1) EP3380486B1 (enExample)
JP (2) JP6778747B2 (enExample)
KR (1) KR20180080330A (enExample)
CN (1) CN108290918B (enExample)
AU (1) AU2016359494B2 (enExample)
BR (1) BR112018010650A8 (enExample)
CA (1) CA3003283A1 (enExample)
CL (1) CL2018001345A1 (enExample)
CO (1) CO2018005327A2 (enExample)
CY (1) CY1122918T1 (enExample)
DK (1) DK3380486T3 (enExample)
EA (1) EA035816B1 (enExample)
ES (1) ES2784523T3 (enExample)
HR (1) HRP20200561T1 (enExample)
HU (1) HUE049775T2 (enExample)
IL (1) IL259076B (enExample)
LT (1) LT3380486T (enExample)
ME (1) ME03757B (enExample)
MX (1) MX383107B (enExample)
MY (1) MY189979A (enExample)
NZ (1) NZ742574A (enExample)
PH (1) PH12018501037A1 (enExample)
PL (1) PL3380486T3 (enExample)
PT (1) PT3380486T (enExample)
RS (1) RS60237B1 (enExample)
SG (1) SG11201803686UA (enExample)
SI (1) SI3380486T1 (enExample)
SM (1) SMT202000242T1 (enExample)
TW (1) TWI703147B (enExample)
UA (1) UA121270C2 (enExample)
WO (1) WO2017091544A1 (enExample)
ZA (1) ZA201802967B (enExample)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK3712152T3 (da) 2015-11-03 2021-03-22 Topivert Pharma Ltd 4,5,6,7-tetrahydro-1h-imidazo[4,5-c]pyridin og 1,4,5,6,7,8-hexahydroimidazo[4,5-d]azepinderivater som janus kinase-inhibitorer
EP3371185B1 (en) 2015-11-03 2020-09-30 Topivert Pharma Limited 4,5,6,7-tetrahydro-1h-imidazo[4,5-c]pyridine and 1,4,5,6,7,8-hexahydroimidazo[4,5-d]azepine derivatives as janus kinase inhibitors
EA035816B1 (ru) 2015-11-24 2020-08-14 ТЕРЕВАНС БАЙОФАРМА Ар энд Ди АйПи, ЭлЭлСи Пролекарства jak-ингибирующего соединения для лечения воспалительного заболевания желудочно-кишечного тракта
FR3060567B1 (fr) * 2016-12-19 2019-05-24 Ecole Normale Superieure De Lyon Substrat de glycosidase fluorogene et procede de detection associe
US10472366B2 (en) 2017-03-08 2019-11-12 Theravance Biopharma R&D Ip, Llc Glucuronide prodrugs of tofacitinib
JP2020520955A (ja) 2017-05-23 2020-07-16 セラヴァンス バイオファーマ アール＆ディー アイピー， エルエルシー ヤヌスキナーゼ阻害剤のグルクロニドプロドラッグ
WO2018217699A1 (en) * 2017-05-23 2018-11-29 Theravance Biopharma R&D Ip, Llc Thiocarbamate prodrugs of tofacitinib
SG11201910198UA (en) * 2017-06-05 2019-11-28 Flagship Pioneering Innovations V Inc Multibiotic agents and methods of using the same
PE20211305A1 (es) 2018-01-05 2021-07-20 Cybrexa 1 Inc Compuestos, composiciones y metodos para tratar enfermedades que involucren tejidos con enfermedades acidas o hipoxicas
WO2019182322A1 (ko) * 2018-03-20 2019-09-26 삼진제약주식회사 신규 염, 이의 제조 방법 및 이를 포함하는 약학 조성물
US12171764B2 (en) 2018-06-20 2024-12-24 Biora Therapeutics, Inc. Treatment of a disease of the gastrointestinal tract with a JAK or other kinase inhibitor
CN111094314B (zh) * 2018-08-15 2022-08-12 江苏豪森药业集团有限公司 含有葡糖苷酸衍生物jak抑制剂的前药及其制备方法和应用
CN119751336A (zh) * 2018-09-06 2025-04-04 艾尼纳制药公司 可用于治疗自身免疫性病症和炎性病症的化合物
CN109134564B (zh) * 2018-09-21 2022-03-11 合肥锐思生物医药有限公司 乳果糖糖苷衍生物、其制备方法及其用途
CA3119294A1 (en) * 2018-11-15 2020-05-22 Janssen Biotech, Inc. Methods and compositions for prediction of response to a therapy of inflammatory bowel disease
CN113692278A (zh) 2018-12-19 2021-11-23 因赛特公司 用于治疗胃肠道疾病的jak1途径抑制剂
AU2020242287A1 (en) 2019-03-21 2021-09-02 INSERM (Institut National de la Santé et de la Recherche Médicale) A Dbait molecule in combination with kinase inhibitor for the treatment of cancer
CR20220057A (es) 2019-07-10 2022-07-19 Cybrexa 3 Inc Conjugados peptídicos de agentes dirigidos a microtúbulos como terapéuticos
CR20220058A (es) 2019-07-10 2022-07-19 Cybrexa 2 Inc Conjugados peptídicos de citotoxinas como terapéuticos
KR20220098759A (ko) 2019-11-08 2022-07-12 인쎄름 (엥스띠뛰 나씨오날 드 라 쌍떼 에 드 라 흐쉐르슈 메디깔) 키나제 억제제에 대해 내성을 획득한 암의 치료 방법
WO2021097074A1 (en) * 2019-11-13 2021-05-20 New York University Intestinal organoid co-culture systems and methods for treating or preventing a disease or disorder associated with immune response-mediated tissue injury
WO2021148581A1 (en) 2020-01-22 2021-07-29 Onxeo Novel dbait molecule and its use
US20230107927A1 (en) * 2020-02-28 2023-04-06 First Wave Bio, Inc. Methods of treating iatrogenic autoimmune colitis
EP4149462A4 (en) 2020-05-14 2024-04-24 Theravance Biopharma R&D IP, LLC Administration of gut-selective jak3 inhibitor
CN113943312A (zh) * 2020-07-17 2022-01-18 轶诺(浙江)药业有限公司 一类肠道裂解型共药及其制备和用途
WO2022087313A1 (en) * 2020-10-22 2022-04-28 Progenity, Inc. Methods of treating and predicting non-response to anti-tnf treatment in subjects with gastrointestinal tract diseases
EP4351584A4 (en) * 2021-06-07 2025-04-23 The Regents of the University of California COMPOSITIONS AND METHODS FOR TREATING CELIAC DISEASE
IL309840A (en) * 2021-07-20 2024-02-01 Coval Biopharma Shanghai Co Ltd An external antidialectic coupling compound drug, and a method of preparation therefor and use thereof
JP2025516712A (ja) * 2022-05-14 2025-05-30 株式会社スリー・ディー・マトリックス 消化管への治療剤の経口投与のための新規な製剤
CN115073543B (zh) * 2022-07-20 2022-11-15 北京普祺医药科技股份有限公司 一种jak抑制剂的化合物前药及其制备与应用
CN117567460A (zh) * 2022-08-08 2024-02-20 明慧医药（杭州）有限公司 一种前药化合物及其制备方法和用途
KR20250107797A (ko) 2022-08-17 2025-07-14 트랜센드 테라퓨틱스 인코퍼레이티드 페네틸아민 및 카티논 전구체

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993022334A1 (en) 1992-05-04 1993-11-11 Sri International Pharmaceutical compositions and methods for colonic delivery of corticosteroids
US5811388A (en) 1995-06-07 1998-09-22 Cibus Pharmaceutical, Inc. Delivery of drugs to the lower GI tract
AU777911B2 (en) 1999-12-10 2004-11-04 Pfizer Products Inc. Pyrrolo(2,3-d)pyrimidine compounds
CA2777114C (en) 2009-10-09 2018-10-23 Incyte Corporation Hydroxyl, keto, and glucuronide derivatives of 3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl)-3-cyclopentylpropanenitrile
EP2515913A2 (en) 2009-12-23 2012-10-31 Glycomyr Inc. Use of vitamin d glycosides and sulfates for treatment of disease
CN102724967A (zh) 2009-12-31 2012-10-10 安龙制药公司 包括可释放的脲连接体的含芳香胺化合物的聚合缀合物
CN102822177A (zh) * 2010-02-05 2012-12-12 美国辉瑞有限公司 吡咯并[2,3-d]嘧啶脲化合物
US20130109720A1 (en) 2011-11-01 2013-05-02 Hoffmann-La Roche Inc. Indole inhibitors of crac
CA2913752A1 (en) * 2013-05-31 2014-12-04 Cerulean Pharma Inc. Cyclodextrin-based polymers for therapeutic delivery
EP3169348B1 (en) * 2014-06-24 2019-07-31 Institut National de la Sante et de la Recherche Medicale (INSERM) Pharmaceutical compositions comprising agonists of orexin-1 receptor ox1r for the treatment of inflammatory bowel diseases
EA035816B1 (ru) 2015-11-24 2020-08-14 ТЕРЕВАНС БАЙОФАРМА Ар энд Ди АйПи, ЭлЭлСи Пролекарства jak-ингибирующего соединения для лечения воспалительного заболевания желудочно-кишечного тракта
WO2017106957A1 (en) 2015-12-23 2017-06-29 The University Of British Columbia Lipid-linked prodrugs
CN106496233B (zh) 2016-09-26 2018-05-15 东南大学 吡咯并嘧啶类化合物、其制备方法及其用途

Also Published As

Publication number Publication date
EP3380486B1 (en) 2020-02-19
NZ742574A (en) 2018-11-30
SI3380486T1 (sl) 2020-07-31
JP2020196742A (ja) 2020-12-10
PT3380486T (pt) 2020-05-22
LT3380486T (lt) 2020-05-11
KR20180080330A (ko) 2018-07-11
SMT202000242T1 (it) 2020-07-08
ME03757B (me) 2021-04-20
MY189979A (en) 2022-03-22
HRP20200561T1 (hr) 2020-06-26
JP2019501133A (ja) 2019-01-17
ZA201802967B (en) 2019-04-24
TWI703147B (zh) 2020-09-01
AU2016359494B2 (en) 2021-01-07
HUE049775T2 (hu) 2020-10-28
US11608354B2 (en) 2023-03-21
WO2017091544A1 (en) 2017-06-01
CA3003283A1 (en) 2017-06-01
CL2018001345A1 (es) 2018-06-22
CN108290918A (zh) 2018-07-17
CY1122918T1 (el) 2021-10-29
US10435428B2 (en) 2019-10-08
UA121270C2 (uk) 2020-04-27
TW201720827A (zh) 2017-06-16
RS60237B1 (sr) 2020-06-30
IL259076A (en) 2018-06-28
IL259076B (en) 2021-05-31
PL3380486T3 (pl) 2020-07-27
US20210179655A1 (en) 2021-06-17
US20190389895A1 (en) 2019-12-26
MX2018006282A (es) 2019-01-21
US20170145044A1 (en) 2017-05-25
EA035816B1 (ru) 2020-08-14
EP3380486A1 (en) 2018-10-03
US10961267B2 (en) 2021-03-30
ES2784523T3 (es) 2020-09-28
EA201891248A1 (ru) 2018-10-31
CN108290918B (zh) 2021-06-08
BR112018010650A8 (pt) 2019-02-26
BR112018010650A2 (pt) 2018-11-13
MX383107B (es) 2025-03-13
CO2018005327A2 (es) 2018-05-31
AU2016359494A1 (en) 2018-06-14
SG11201803686UA (en) 2018-06-28
PH12018501037A1 (en) 2019-01-28
DK3380486T3 (da) 2020-05-18

Similar Documents

Publication Publication Date Title
JP6778747B2 (ja) 胃腸炎症性腸疾患の処置のための、ｊａｋ阻害剤化合物のプロドラッグ
JP6942853B2 (ja) Ｊａｋキナーゼ阻害剤としてのナフチリジン化合物
US10233174B2 (en) Thiocarbamate prodrugs of tofacitinib
EP2882751B1 (en) Deuterated ibrutinib
JP2019514903A (ja) Ｊａｋキナーゼ阻害剤としてのピリミジン化合物
US10745405B2 (en) Glucuronide prodrugs of Janus kinase inhibitors
EP3448847A1 (en) Crystalline forms of n-[2-(3-hydroxy-3-methylbutyl)-6-(2-hydroxypropan-2-yl)-2h-indazol-5-yl]-6-(trifluoromethyl)pyridine-2-carboxamide
CN114026086A (zh) 3-(5-甲基-1,3-噻唑-2-基)-n-{(1r)-1-[2-(三氟甲基)嘧啶-5-基]乙基}苯甲酰胺的类似物
US11878965B2 (en) Inhibitors of peptidylarginine deiminases
HK1254120B (en) Prodrugs of a jak inhibitor compound for treatment of gastrointestinal inflammatory disease
HK1254120A1 (en) Prodrugs of a jak inhibitor compound for treatment of gastrointestinal inflammatory disease
HK40061390A (en) Analogues of 3-(5-methyl-1,3-thiazol-2-yl)-n-{(1r)-1-[2-(trifluoro-methyl)pyrimidin-5-yl]ethyl}benzamide
WO2011159920A1 (en) [5,6]-dihydro-2h-pyran-2-one derivatives
HK1262051A1 (en) [8-(phenylsulfonyl)-3,8-diazabicyclo[3.2.1]oct-3-yl](1h-1,2,3-triazol-4-yl)methanones

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20191002

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20191002

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20200612

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20200825

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20200928

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20201012

R150 Certificate of patent or registration of utility model

Ref document number: 6778747

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250