EA035816B1 - Пролекарства jak-ингибирующего соединения для лечения воспалительного заболевания желудочно-кишечного тракта - Google Patents

Пролекарства jak-ингибирующего соединения для лечения воспалительного заболевания желудочно-кишечного тракта Download PDF

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Publication number
EA035816B1
EA035816B1 EA201891248A EA201891248A EA035816B1 EA 035816 B1 EA035816 B1 EA 035816B1 EA 201891248 A EA201891248 A EA 201891248A EA 201891248 A EA201891248 A EA 201891248A EA 035816 B1 EA035816 B1 EA 035816B1
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Eurasian Patent Office
Prior art keywords
compound
pharmaceutically acceptable
methyl
acceptable salt
formula
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EA201891248A
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English (en)
Russian (ru)
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EA201891248A1 (ru
Inventor
Райан Хадсон
Дэниэл Д. Лонг
Донна А.А. Уилтон
Менди Лу
Патрик Дж. Брэссил
Original Assignee
ТЕРЕВАНС БАЙОФАРМА Ар энд Ди АйПи, ЭлЭлСи
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Publication of EA201891248A1 publication Critical patent/EA201891248A1/ru
Publication of EA035816B1 publication Critical patent/EA035816B1/ru

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26Acyclic or carbocyclic radicals, substituted by hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/549Sugars, nucleosides, nucleotides or nucleic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00Processes for the preparation of sugar derivatives
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/16Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing two or more hetero rings
    • C12P17/165Heterorings having nitrogen atoms as the only ring heteroatoms

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
EA201891248A 2015-11-24 2016-11-22 Пролекарства jak-ингибирующего соединения для лечения воспалительного заболевания желудочно-кишечного тракта EA035816B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562259273P 2015-11-24 2015-11-24
PCT/US2016/063254 WO2017091544A1 (en) 2015-11-24 2016-11-22 Prodrugs of a jak inhibitor compound for treatment of gastrointestinal inflammatory disease

Publications (2)

Publication Number Publication Date
EA201891248A1 EA201891248A1 (ru) 2018-10-31
EA035816B1 true EA035816B1 (ru) 2020-08-14

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EA201891248A EA035816B1 (ru) 2015-11-24 2016-11-22 Пролекарства jak-ингибирующего соединения для лечения воспалительного заболевания желудочно-кишечного тракта

Country Status (33)

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US (3) US10435428B2 (enExample)
EP (1) EP3380486B1 (enExample)
JP (2) JP6778747B2 (enExample)
KR (1) KR20180080330A (enExample)
CN (1) CN108290918B (enExample)
AU (1) AU2016359494B2 (enExample)
BR (1) BR112018010650A8 (enExample)
CA (1) CA3003283A1 (enExample)
CL (1) CL2018001345A1 (enExample)
CO (1) CO2018005327A2 (enExample)
CY (1) CY1122918T1 (enExample)
DK (1) DK3380486T3 (enExample)
EA (1) EA035816B1 (enExample)
ES (1) ES2784523T3 (enExample)
HR (1) HRP20200561T1 (enExample)
HU (1) HUE049775T2 (enExample)
IL (1) IL259076B (enExample)
LT (1) LT3380486T (enExample)
ME (1) ME03757B (enExample)
MX (1) MX383107B (enExample)
MY (1) MY189979A (enExample)
NZ (1) NZ742574A (enExample)
PH (1) PH12018501037A1 (enExample)
PL (1) PL3380486T3 (enExample)
PT (1) PT3380486T (enExample)
RS (1) RS60237B1 (enExample)
SG (1) SG11201803686UA (enExample)
SI (1) SI3380486T1 (enExample)
SM (1) SMT202000242T1 (enExample)
TW (1) TWI703147B (enExample)
UA (1) UA121270C2 (enExample)
WO (1) WO2017091544A1 (enExample)
ZA (1) ZA201802967B (enExample)

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CA3159348A1 (en) 2019-11-08 2021-05-14 Inserm (Institut National De La Sante Et De La Recherche Medicale) Methods for the treatment of cancers that have acquired resistance to kinase inhibitors
US20210139857A1 (en) * 2019-11-13 2021-05-13 New York University Intestinal organoid co-culture systems and methods for treating or preventing a disease or disorder associated with immune response-mediated tissue injury
WO2021148581A1 (en) 2020-01-22 2021-07-29 Onxeo Novel dbait molecule and its use
US20230107927A1 (en) * 2020-02-28 2023-04-06 First Wave Bio, Inc. Methods of treating iatrogenic autoimmune colitis
WO2021231272A1 (en) * 2020-05-14 2021-11-18 Theravance Biopharma R&D Ip, Llc Administration of gut-selective jak3 inhibitor
CN113943312A (zh) * 2020-07-17 2022-01-18 轶诺(浙江)药业有限公司 一类肠道裂解型共药及其制备和用途
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Publication number Publication date
AU2016359494B2 (en) 2021-01-07
CO2018005327A2 (es) 2018-05-31
EP3380486A1 (en) 2018-10-03
MY189979A (en) 2022-03-22
CY1122918T1 (el) 2021-10-29
JP2019501133A (ja) 2019-01-17
UA121270C2 (uk) 2020-04-27
KR20180080330A (ko) 2018-07-11
BR112018010650A2 (pt) 2018-11-13
EA201891248A1 (ru) 2018-10-31
US20210179655A1 (en) 2021-06-17
MX383107B (es) 2025-03-13
JP6778747B2 (ja) 2020-11-04
US10435428B2 (en) 2019-10-08
SG11201803686UA (en) 2018-06-28
US20190389895A1 (en) 2019-12-26
TW201720827A (zh) 2017-06-16
LT3380486T (lt) 2020-05-11
PT3380486T (pt) 2020-05-22
IL259076A (en) 2018-06-28
SI3380486T1 (sl) 2020-07-31
NZ742574A (en) 2018-11-30
AU2016359494A1 (en) 2018-06-14
DK3380486T3 (da) 2020-05-18
BR112018010650A8 (pt) 2019-02-26
US20170145044A1 (en) 2017-05-25
WO2017091544A1 (en) 2017-06-01
ES2784523T3 (es) 2020-09-28
PH12018501037A1 (en) 2019-01-28
ME03757B (me) 2021-04-20
RS60237B1 (sr) 2020-06-30
MX2018006282A (es) 2019-01-21
US10961267B2 (en) 2021-03-30
SMT202000242T1 (it) 2020-07-08
ZA201802967B (en) 2019-04-24
CL2018001345A1 (es) 2018-06-22
IL259076B (en) 2021-05-31
CA3003283A1 (en) 2017-06-01
US11608354B2 (en) 2023-03-21
HUE049775T2 (hu) 2020-10-28
CN108290918B (zh) 2021-06-08
PL3380486T3 (pl) 2020-07-27
TWI703147B (zh) 2020-09-01
CN108290918A (zh) 2018-07-17
EP3380486B1 (en) 2020-02-19
HRP20200561T1 (hr) 2020-06-26
JP2020196742A (ja) 2020-12-10

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