ME03757B - Prolekovi jaki inhibitornih jedinjenja za lečenje gastorintestinalne inflamatorne bolesti - Google Patents
Prolekovi jaki inhibitornih jedinjenja za lečenje gastorintestinalne inflamatorne bolestiInfo
- Publication number
- ME03757B ME03757B MEP-2020-126A MEP2020126A ME03757B ME 03757 B ME03757 B ME 03757B ME P2020126 A MEP2020126 A ME P2020126A ME 03757 B ME03757 B ME 03757B
- Authority
- ME
- Montenegro
- Prior art keywords
- compound
- pharmaceutically acceptable
- acceptable salt
- formula
- iii
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title claims 28
- 239000000651 prodrug Substances 0.000 title claims 3
- 229940002612 prodrug Drugs 0.000 title claims 3
- 208000018522 Gastrointestinal disease Diseases 0.000 title 1
- 229940122245 Janus kinase inhibitor Drugs 0.000 title 1
- 208000010643 digestive system disease Diseases 0.000 title 1
- 208000018685 gastrointestinal system disease Diseases 0.000 title 1
- 230000002757 inflammatory effect Effects 0.000 title 1
- 150000003839 salts Chemical class 0.000 claims 19
- 229910052739 hydrogen Inorganic materials 0.000 claims 7
- 239000001257 hydrogen Substances 0.000 claims 7
- 238000000034 method Methods 0.000 claims 6
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 6
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 5
- 208000017189 Gastrointestinal inflammatory disease Diseases 0.000 claims 4
- 150000002431 hydrogen Chemical class 0.000 claims 4
- 239000004012 Tofacitinib Substances 0.000 claims 3
- 125000003545 alkoxy group Chemical group 0.000 claims 3
- 125000000217 alkyl group Chemical group 0.000 claims 3
- -1 cyano, hydroxy Chemical group 0.000 claims 3
- 125000005843 halogen group Chemical group 0.000 claims 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 3
- UJLAWZDWDVHWOW-YPMHNXCESA-N tofacitinib Chemical compound C[C@@H]1CCN(C(=O)CC#N)C[C@@H]1N(C)C1=NC=NC2=C1C=CN2 UJLAWZDWDVHWOW-YPMHNXCESA-N 0.000 claims 3
- 229960001350 tofacitinib Drugs 0.000 claims 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 2
- 125000003277 amino group Chemical group 0.000 claims 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 210000002429 large intestine Anatomy 0.000 claims 2
- 125000006239 protecting group Chemical group 0.000 claims 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 2
- UNILWMWFPHPYOR-KXEYIPSPSA-M 1-[6-[2-[3-[3-[3-[2-[2-[3-[[2-[2-[[(2r)-1-[[2-[[(2r)-1-[3-[2-[2-[3-[[2-(2-amino-2-oxoethoxy)acetyl]amino]propoxy]ethoxy]ethoxy]propylamino]-3-hydroxy-1-oxopropan-2-yl]amino]-2-oxoethyl]amino]-3-[(2r)-2,3-di(hexadecanoyloxy)propyl]sulfanyl-1-oxopropan-2-yl Chemical compound O=C1C(SCCC(=O)NCCCOCCOCCOCCCNC(=O)COCC(=O)N[C@@H](CSC[C@@H](COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)NCC(=O)N[C@H](CO)C(=O)NCCCOCCOCCOCCCNC(=O)COCC(N)=O)CC(=O)N1CCNC(=O)CCCCCN\1C2=CC=C(S([O-])(=O)=O)C=C2CC/1=C/C=C/C=C/C1=[N+](CC)C2=CC=C(S([O-])(=O)=O)C=C2C1 UNILWMWFPHPYOR-KXEYIPSPSA-M 0.000 claims 1
- 206010009900 Colitis ulcerative Diseases 0.000 claims 1
- 208000011231 Crohn disease Diseases 0.000 claims 1
- 102000053187 Glucuronidase Human genes 0.000 claims 1
- 108010060309 Glucuronidase Proteins 0.000 claims 1
- 229940076838 Immune checkpoint inhibitor Drugs 0.000 claims 1
- 102000037984 Inhibitory immune checkpoint proteins Human genes 0.000 claims 1
- 108091008026 Inhibitory immune checkpoint proteins Proteins 0.000 claims 1
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 1
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 125000001309 chloro group Chemical group Cl* 0.000 claims 1
- 206010009887 colitis Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 229930182480 glucuronide Natural products 0.000 claims 1
- 150000008134 glucuronides Chemical class 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 239000012274 immune-checkpoint protein inhibitor Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/16—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing two or more hetero rings
- C12P17/165—Heterorings having nitrogen atoms as the only ring heteroatoms
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Epidemiology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Saccharide Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562259273P | 2015-11-24 | 2015-11-24 | |
| PCT/US2016/063254 WO2017091544A1 (en) | 2015-11-24 | 2016-11-22 | Prodrugs of a jak inhibitor compound for treatment of gastrointestinal inflammatory disease |
| EP16808876.3A EP3380486B1 (en) | 2015-11-24 | 2016-11-22 | Prodrugs of a jak inhibitor compound for treatment of gastrointestinal inflammatory disease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ME03757B true ME03757B (me) | 2021-04-20 |
Family
ID=57518004
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MEP-2020-126A ME03757B (me) | 2015-11-24 | 2016-11-22 | Prolekovi jaki inhibitornih jedinjenja za lečenje gastorintestinalne inflamatorne bolesti |
Country Status (33)
Families Citing this family (32)
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| DK3712152T3 (da) | 2015-11-03 | 2021-03-22 | Topivert Pharma Ltd | 4,5,6,7-tetrahydro-1h-imidazo[4,5-c]pyridin og 1,4,5,6,7,8-hexahydroimidazo[4,5-d]azepinderivater som janus kinase-inhibitorer |
| EP3371185B1 (en) | 2015-11-03 | 2020-09-30 | Topivert Pharma Limited | 4,5,6,7-tetrahydro-1h-imidazo[4,5-c]pyridine and 1,4,5,6,7,8-hexahydroimidazo[4,5-d]azepine derivatives as janus kinase inhibitors |
| EA035816B1 (ru) | 2015-11-24 | 2020-08-14 | ТЕРЕВАНС БАЙОФАРМА Ар энд Ди АйПи, ЭлЭлСи | Пролекарства jak-ингибирующего соединения для лечения воспалительного заболевания желудочно-кишечного тракта |
| FR3060567B1 (fr) * | 2016-12-19 | 2019-05-24 | Ecole Normale Superieure De Lyon | Substrat de glycosidase fluorogene et procede de detection associe |
| US10472366B2 (en) | 2017-03-08 | 2019-11-12 | Theravance Biopharma R&D Ip, Llc | Glucuronide prodrugs of tofacitinib |
| JP2020520955A (ja) | 2017-05-23 | 2020-07-16 | セラヴァンス バイオファーマ アール＆ディー アイピー， エルエルシー | ヤヌスキナーゼ阻害剤のグルクロニドプロドラッグ |
| WO2018217699A1 (en) * | 2017-05-23 | 2018-11-29 | Theravance Biopharma R&D Ip, Llc | Thiocarbamate prodrugs of tofacitinib |
| SG11201910198UA (en) * | 2017-06-05 | 2019-11-28 | Flagship Pioneering Innovations V Inc | Multibiotic agents and methods of using the same |
| PE20211305A1 (es) | 2018-01-05 | 2021-07-20 | Cybrexa 1 Inc | Compuestos, composiciones y metodos para tratar enfermedades que involucren tejidos con enfermedades acidas o hipoxicas |
| WO2019182322A1 (ko) * | 2018-03-20 | 2019-09-26 | 삼진제약주식회사 | 신규 염, 이의 제조 방법 및 이를 포함하는 약학 조성물 |
| US12171764B2 (en) | 2018-06-20 | 2024-12-24 | Biora Therapeutics, Inc. | Treatment of a disease of the gastrointestinal tract with a JAK or other kinase inhibitor |
| CN111094314B (zh) * | 2018-08-15 | 2022-08-12 | 江苏豪森药业集团有限公司 | 含有葡糖苷酸衍生物jak抑制剂的前药及其制备方法和应用 |
| CN119751336A (zh) * | 2018-09-06 | 2025-04-04 | 艾尼纳制药公司 | 可用于治疗自身免疫性病症和炎性病症的化合物 |
| CN109134564B (zh) * | 2018-09-21 | 2022-03-11 | 合肥锐思生物医药有限公司 | 乳果糖糖苷衍生物、其制备方法及其用途 |
| CA3119294A1 (en) * | 2018-11-15 | 2020-05-22 | Janssen Biotech, Inc. | Methods and compositions for prediction of response to a therapy of inflammatory bowel disease |
| CN113692278A (zh) | 2018-12-19 | 2021-11-23 | 因赛特公司 | 用于治疗胃肠道疾病的jak1途径抑制剂 |
| AU2020242287A1 (en) | 2019-03-21 | 2021-09-02 | INSERM (Institut National de la Santé et de la Recherche Médicale) | A Dbait molecule in combination with kinase inhibitor for the treatment of cancer |
| CR20220057A (es) | 2019-07-10 | 2022-07-19 | Cybrexa 3 Inc | Conjugados peptídicos de agentes dirigidos a microtúbulos como terapéuticos |
| CR20220058A (es) | 2019-07-10 | 2022-07-19 | Cybrexa 2 Inc | Conjugados peptídicos de citotoxinas como terapéuticos |
| KR20220098759A (ko) | 2019-11-08 | 2022-07-12 | 인쎄름 (엥스띠뛰 나씨오날 드 라 쌍떼 에 드 라 흐쉐르슈 메디깔) | 키나제 억제제에 대해 내성을 획득한 암의 치료 방법 |
| WO2021097074A1 (en) * | 2019-11-13 | 2021-05-20 | New York University | Intestinal organoid co-culture systems and methods for treating or preventing a disease or disorder associated with immune response-mediated tissue injury |
| WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
| US20230107927A1 (en) * | 2020-02-28 | 2023-04-06 | First Wave Bio, Inc. | Methods of treating iatrogenic autoimmune colitis |
| EP4149462A4 (en) | 2020-05-14 | 2024-04-24 | Theravance Biopharma R&D IP, LLC | Administration of gut-selective jak3 inhibitor |
| CN113943312A (zh) * | 2020-07-17 | 2022-01-18 | 轶诺(浙江)药业有限公司 | 一类肠道裂解型共药及其制备和用途 |
| WO2022087313A1 (en) * | 2020-10-22 | 2022-04-28 | Progenity, Inc. | Methods of treating and predicting non-response to anti-tnf treatment in subjects with gastrointestinal tract diseases |
| EP4351584A4 (en) * | 2021-06-07 | 2025-04-23 | The Regents of the University of California | COMPOSITIONS AND METHODS FOR TREATING CELIAC DISEASE |
| IL309840A (en) * | 2021-07-20 | 2024-02-01 | Coval Biopharma Shanghai Co Ltd | An external antidialectic coupling compound drug, and a method of preparation therefor and use thereof |
| JP2025516712A (ja) * | 2022-05-14 | 2025-05-30 | 株式会社スリー・ディー・マトリックス | 消化管への治療剤の経口投与のための新規な製剤 |
| CN115073543B (zh) * | 2022-07-20 | 2022-11-15 | 北京普祺医药科技股份有限公司 | 一种jak抑制剂的化合物前药及其制备与应用 |
| CN117567460A (zh) * | 2022-08-08 | 2024-02-20 | 明慧医药（杭州）有限公司 | 一种前药化合物及其制备方法和用途 |
| KR20250107797A (ko) | 2022-08-17 | 2025-07-14 | 트랜센드 테라퓨틱스 인코퍼레이티드 | 페네틸아민 및 카티논 전구체 |
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|---|---|---|---|---|
| WO1993022334A1 (en) | 1992-05-04 | 1993-11-11 | Sri International | Pharmaceutical compositions and methods for colonic delivery of corticosteroids |
| US5811388A (en) | 1995-06-07 | 1998-09-22 | Cibus Pharmaceutical, Inc. | Delivery of drugs to the lower GI tract |
| AU777911B2 (en) | 1999-12-10 | 2004-11-04 | Pfizer Products Inc. | Pyrrolo(2,3-d)pyrimidine compounds |
| CA2777114C (en) | 2009-10-09 | 2018-10-23 | Incyte Corporation | Hydroxyl, keto, and glucuronide derivatives of 3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl)-3-cyclopentylpropanenitrile |
| EP2515913A2 (en) | 2009-12-23 | 2012-10-31 | Glycomyr Inc. | Use of vitamin d glycosides and sulfates for treatment of disease |
| CN102724967A (zh) | 2009-12-31 | 2012-10-10 | 安龙制药公司 | 包括可释放的脲连接体的含芳香胺化合物的聚合缀合物 |
| CN102822177A (zh) * | 2010-02-05 | 2012-12-12 | 美国辉瑞有限公司 | 吡咯并[2,3-d]嘧啶脲化合物 |
| US20130109720A1 (en) | 2011-11-01 | 2013-05-02 | Hoffmann-La Roche Inc. | Indole inhibitors of crac |
| CA2913752A1 (en) * | 2013-05-31 | 2014-12-04 | Cerulean Pharma Inc. | Cyclodextrin-based polymers for therapeutic delivery |
| EP3169348B1 (en) * | 2014-06-24 | 2019-07-31 | Institut National de la Sante et de la Recherche Medicale (INSERM) | Pharmaceutical compositions comprising agonists of orexin-1 receptor ox1r for the treatment of inflammatory bowel diseases |
| EA035816B1 (ru) | 2015-11-24 | 2020-08-14 | ТЕРЕВАНС БАЙОФАРМА Ар энд Ди АйПи, ЭлЭлСи | Пролекарства jak-ингибирующего соединения для лечения воспалительного заболевания желудочно-кишечного тракта |
| WO2017106957A1 (en) | 2015-12-23 | 2017-06-29 | The University Of British Columbia | Lipid-linked prodrugs |
| CN106496233B (zh) | 2016-09-26 | 2018-05-15 | 东南大学 | 吡咯并嘧啶类化合物、其制备方法及其用途 |
-
2016
- 2016-11-22 EA EA201891248A patent/EA035816B1/ru unknown
- 2016-11-22 UA UAA201806963A patent/UA121270C2/uk unknown
- 2016-11-22 CN CN201680068165.XA patent/CN108290918B/zh active Active
- 2016-11-22 HR HRP20200561TT patent/HRP20200561T1/hr unknown
- 2016-11-22 MY MYPI2018701637A patent/MY189979A/en unknown
- 2016-11-22 SM SM20200242T patent/SMT202000242T1/it unknown
- 2016-11-22 PT PT168088763T patent/PT3380486T/pt unknown
- 2016-11-22 RS RS20200508A patent/RS60237B1/sr unknown
- 2016-11-22 CA CA3003283A patent/CA3003283A1/en not_active Abandoned
- 2016-11-22 KR KR1020187017879A patent/KR20180080330A/ko not_active Withdrawn
- 2016-11-22 BR BR112018010650A patent/BR112018010650A8/pt not_active IP Right Cessation
- 2016-11-22 LT LTEP16808876.3T patent/LT3380486T/lt unknown
- 2016-11-22 MX MX2018006282A patent/MX383107B/es unknown
- 2016-11-22 HU HUE16808876A patent/HUE049775T2/hu unknown
- 2016-11-22 AU AU2016359494A patent/AU2016359494B2/en not_active Ceased
- 2016-11-22 SG SG11201803686UA patent/SG11201803686UA/en unknown
- 2016-11-22 SI SI201630741T patent/SI3380486T1/sl unknown
- 2016-11-22 ES ES16808876T patent/ES2784523T3/es active Active
- 2016-11-22 EP EP16808876.3A patent/EP3380486B1/en active Active
- 2016-11-22 PL PL16808876T patent/PL3380486T3/pl unknown
- 2016-11-22 WO PCT/US2016/063254 patent/WO2017091544A1/en not_active Ceased
- 2016-11-22 DK DK16808876.3T patent/DK3380486T3/da active
- 2016-11-22 JP JP2018526682A patent/JP6778747B2/ja active Active
- 2016-11-22 TW TW105138180A patent/TWI703147B/zh not_active IP Right Cessation
- 2016-11-22 US US15/358,462 patent/US10435428B2/en active Active
- 2016-11-22 ME MEP-2020-126A patent/ME03757B/me unknown
- 2016-11-22 NZ NZ742574A patent/NZ742574A/en not_active IP Right Cessation
-
2018
- 2018-05-01 IL IL259076A patent/IL259076B/en active IP Right Grant
- 2018-05-07 ZA ZA2018/02967A patent/ZA201802967B/en unknown
- 2018-05-15 PH PH12018501037A patent/PH12018501037A1/en unknown
- 2018-05-18 CL CL2018001345A patent/CL2018001345A1/es unknown
- 2018-05-22 CO CONC2018/0005327A patent/CO2018005327A2/es unknown
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2019
- 2019-08-29 US US16/555,222 patent/US10961267B2/en active Active
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2020
- 2020-05-13 CY CY20201100447T patent/CY1122918T1/el unknown
- 2020-08-25 JP JP2020141651A patent/JP2020196742A/ja active Pending
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2021
- 2021-02-22 US US17/249,126 patent/US11608354B2/en active Active
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