BR112013024059A2 - compostos de bis(fluoroalquil)-1,4-benzodiazepinona - Google Patents
compostos de bis(fluoroalquil)-1,4-benzodiazepinonaInfo
- Publication number
- BR112013024059A2 BR112013024059A2 BR112013024059A BR112013024059A BR112013024059A2 BR 112013024059 A2 BR112013024059 A2 BR 112013024059A2 BR 112013024059 A BR112013024059 A BR 112013024059A BR 112013024059 A BR112013024059 A BR 112013024059A BR 112013024059 A2 BR112013024059 A2 BR 112013024059A2
- Authority
- BR
- Brazil
- Prior art keywords
- compounds
- fluoroalkyl
- bis
- ch2ch2cf3
- ch2cf3
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
- C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
- C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
- C07D243/24—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
resumo patente de invenção: "compostos de bis(fluoroalquil)-1,4-benzodiazepinona". a invenção refere-se a compostos de fórmula (i) ou profármacos dos mesmos; (i) em que: r1 é -ch2cf3 ou -ch2ch2cf3; r2 é -ch2cf3, -ch2ch2cf3, ou -ch2ch2ch2cf3; r3 é h ou -ch3; cada ra é independentemente f, cl, -cn, -och3, e/ou -nhch2ch2och3; e z é zero, 1, ou 2. da mesma forma refere-se aos métodos de usar tal composto para inibir o receptor de notch, e composições farmacêuticas compreendendo tais compostos. estes compostos são úteis no tratamento, prevenção, ou retardo do progresso de doenças ou distúrbios em uma variedade de áreas terapêuticas, tal como câncer.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161466238P | 2011-03-22 | 2011-03-22 | |
US61/466,238 | 2011-03-22 | ||
PCT/US2012/030021 WO2012129353A1 (en) | 2011-03-22 | 2012-03-22 | Bis(fluoroalkyl)-1,4-benzodiazepinone compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
BR112013024059A2 true BR112013024059A2 (pt) | 2016-12-06 |
BR112013024059B1 BR112013024059B1 (pt) | 2022-01-25 |
Family
ID=45894701
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112013024059-8A BR112013024059B1 (pt) | 2011-03-22 | 2012-03-22 | Compostos de bis(fluoroalquil)-1,4-benzodiazepinona, combinação e uso de ditos compostos |
Country Status (32)
Country | Link |
---|---|
US (2) | US8629136B2 (pt) |
EP (1) | EP2688873B1 (pt) |
JP (1) | JP5873923B2 (pt) |
KR (1) | KR101948347B1 (pt) |
CN (1) | CN103717576B (pt) |
AR (1) | AR085471A1 (pt) |
AU (1) | AU2012230904B2 (pt) |
BR (1) | BR112013024059B1 (pt) |
CA (1) | CA2830902C (pt) |
CL (1) | CL2013002690A1 (pt) |
CO (1) | CO6771446A2 (pt) |
CY (1) | CY1116423T1 (pt) |
DK (1) | DK2688873T3 (pt) |
EA (1) | EA022530B1 (pt) |
ES (1) | ES2534080T3 (pt) |
HK (1) | HK1189218A1 (pt) |
HR (1) | HRP20150273T1 (pt) |
IL (1) | IL228534A (pt) |
MA (1) | MA35036B1 (pt) |
MX (1) | MX2013010420A (pt) |
MY (1) | MY161233A (pt) |
PE (1) | PE20140626A1 (pt) |
PL (1) | PL2688873T3 (pt) |
PT (1) | PT2688873E (pt) |
RS (1) | RS53843B1 (pt) |
SG (1) | SG193555A1 (pt) |
SI (1) | SI2688873T1 (pt) |
SM (1) | SMT201500091B (pt) |
TN (1) | TN2013000372A1 (pt) |
TW (1) | TWI530489B (pt) |
UY (1) | UY33961A (pt) |
WO (1) | WO2012129353A1 (pt) |
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EP1996182A4 (en) | 2006-02-27 | 2009-08-12 | Univ Johns Hopkins | CANCER TREATMENT WITH GAMMA SECRETASE INHIBITORS |
CA2645756C (en) | 2006-03-27 | 2013-12-31 | F. Hoffmann-La Roche Ag | Malonamide derivatives as gamma secretase inhibitors |
EP2069317A2 (en) | 2006-09-20 | 2009-06-17 | F. Hoffmann-Roche AG | 4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]diazepine derivatives |
KR101136260B1 (ko) | 2007-08-14 | 2012-04-19 | 일라이 릴리 앤드 캄파니 | 감마-세크레타제 억제제로서의 아제핀 유도체 |
MA33076B1 (fr) | 2008-01-11 | 2012-03-01 | Hoffmann La Roche | Utilisation d'un inhibiteur de la gamma-secretase pour le traitement du cancer |
US8637493B2 (en) | 2009-11-12 | 2014-01-28 | University Of Massachusetts | Methods for treating glioblastoma |
US20120225860A1 (en) | 2011-03-02 | 2012-09-06 | John Frederick Boylan | Method for administration of a gamma secretase inhibitor |
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