MD4666B1 - Inhibitori ai Syk - Google Patents

Inhibitori ai Syk Download PDF

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Publication number
MD4666B1
MD4666B1 MDA20160078A MD20160078A MD4666B1 MD 4666 B1 MD4666 B1 MD 4666B1 MD A20160078 A MDA20160078 A MD A20160078A MD 20160078 A MD20160078 A MD 20160078A MD 4666 B1 MD4666 B1 MD 4666B1
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MD
Moldova
Prior art keywords
compounds
syk inhibitors
syk
formula
compositions
Prior art date
Application number
MDA20160078A
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English (en)
Russian (ru)
Other versions
MD20160078A2 (ro
MD4666C1 (ro
Inventor
Питер А. Бломгрен
Кевин С. Карри
Джеффри И. Кропф
Сёнг Х. Ли
Дженнифер Р. Ло
Скотт А. Митчелл
Аарон С. ШМИТТ
Цзинь-Мин СЮН
Цзяньцзюнь Сюй
Чжундун Чжао
Сундарамуртхи СУАМИНАТХАН
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Gilead Sciences Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=52350364&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MD4666(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Gilead Sciences Inc. filed Critical Gilead Sciences Inc.
Publication of MD20160078A2 publication Critical patent/MD20160078A2/ro
Publication of MD4666B1 publication Critical patent/MD4666B1/ro
Publication of MD4666C1 publication Critical patent/MD4666C1/ro

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    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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Abstract

Invenţia se referă la compuşi care sunt inhibitori ai Syk şi la utilizarea acestora în tratamentul diferitor stări de boală, inclusiv al cancerului şi stărilor inflamatorii. În exemplele de realizare particulare, structura compuşilor este prezentată prin formula I:I,în care R1, R2, R3 şi R4 sunt astfel cum sunt definiţi în descrierea invenţiei. Invenţia se referă, de asemenea, la compoziţii farmaceutice care includ un compus cu formula I sau săruri acceptabile farmaceutic, sau co-cristale ale acestuia, precum şi la metode de utilizare a acestor compuşi şi compoziţii pentru tratarea stărilor mediate de Syk.
MDA20160078A 2013-12-23 2014-12-22 Inhibitori ai Syk MD4666C1 (ro)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361920407P 2013-12-23 2013-12-23
PCT/US2014/071842 WO2015100217A1 (en) 2013-12-23 2014-12-22 Syk inhibitors

Publications (3)

Publication Number Publication Date
MD20160078A2 MD20160078A2 (ro) 2017-01-31
MD4666B1 true MD4666B1 (ro) 2019-12-31
MD4666C1 MD4666C1 (ro) 2021-01-31

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MDA20160078A MD4666C1 (ro) 2013-12-23 2014-12-22 Inhibitori ai Syk

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US (5) US9968601B2 (ro)
EP (2) EP3087075B1 (ro)
JP (3) JP6243062B2 (ro)
KR (3) KR102146477B1 (ro)
CN (2) CN105934434B (ro)
AP (1) AP2016009274A0 (ro)
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AU (3) AU2014370010B2 (ro)
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MD (1) MD4666C1 (ro)
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NO3183247T3 (ro) 2018-04-28
TW201940488A (zh) 2019-10-16
NZ721175A (en) 2017-05-26
TWI735853B (zh) 2021-08-11
EP3087075A1 (en) 2016-11-02
SMT201800193T1 (it) 2018-05-02
US12263163B2 (en) 2025-04-01
HK1251563A1 (zh) 2019-02-01
CR20160287A (es) 2016-09-19
HK1256999A1 (en) 2019-10-11
LT3087075T (lt) 2018-04-10
EP3342773A1 (en) 2018-07-04
ZA201800913B (en) 2022-07-27
CA2875877A1 (en) 2015-06-23
CU20160097A7 (es) 2017-02-02
SI3087075T1 (en) 2018-06-29
MX2016008456A (es) 2017-01-11
DK3087075T3 (en) 2018-03-19
SI3342773T1 (sl) 2021-04-30
EP3342773B9 (en) 2021-06-09
SV2016005229A (es) 2017-07-28
US10828299B2 (en) 2020-11-10
KR20160102041A (ko) 2016-08-26
CA2875877C (en) 2021-10-26
PT3087075T (pt) 2018-04-09
MX392440B (es) 2025-03-24
TWI662037B (zh) 2019-06-11

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