BR112013016856A2 - composto, uso de um composto, composição farmacêutica e produto farmacêutico - Google Patents

composto, uso de um composto, composição farmacêutica e produto farmacêutico

Info

Publication number
BR112013016856A2
BR112013016856A2 BR112013016856A BR112013016856A BR112013016856A2 BR 112013016856 A2 BR112013016856 A2 BR 112013016856A2 BR 112013016856 A BR112013016856 A BR 112013016856A BR 112013016856 A BR112013016856 A BR 112013016856A BR 112013016856 A2 BR112013016856 A2 BR 112013016856A2
Authority
BR
Brazil
Prior art keywords
compound
alkyl
optionally substituted
pharmaceutical
inhibitory effect
Prior art date
Application number
BR112013016856A
Other languages
English (en)
Inventor
Hall Adrian
Madin Andrew
Louise Shuker Nicola
Dimopoulos Paschalis
Kita Yoichi
Original Assignee
Eisai R&D Man Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai R&D Man Co Ltd filed Critical Eisai R&D Man Co Ltd
Publication of BR112013016856A2 publication Critical patent/BR112013016856A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
    • C07D513/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/04—1,3-Thiazines; Hydrogenated 1,3-thiazines
    • C07D279/08—1,3-Thiazines; Hydrogenated 1,3-thiazines condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Abstract

composto, uso de um composto, composição farmacêutica e produto farmacêutico a presente invenção diz respeito a um derivado de aminodi-hidrotiazina fundida da fórmula (i): em que r é hidrogênio ou alquila c~ 1~-~ 6~, opcionalmente substituídos por um até cinco átomos de halógeno; n é 0,1,2 ou 3; ar é fenila ou um grupo heteroaromático de 5 ou 6 membros que contêm de 1,2, ou 3 átomos n, ar este que é opcionalmente substituído por um até três substituintes selecionados de hal, hidroxila, -cn, alquila c~ 1-~ 6~, alquila c~ 1~-~ 6~ e alcóxi c~ 1~-~ 6~ são opcionalmente substituídos por um até três átomos de halógeno; e seus sais farmaceuticamente aceitáveis; composto este que tem um efeito inibidor da produção a<225> ou um efeito inibidor de bace1 e é útil como um agente profilático ou terapêutico para uma doença neurodegenarativa causada por a<225> e tipificada pela demência do tipo de alzheimer.
BR112013016856A 2011-01-06 2012-01-05 composto, uso de um composto, composição farmacêutica e produto farmacêutico BR112013016856A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1100181.5A GB201100181D0 (en) 2011-01-06 2011-01-06 Fused aminodihydrothiazine derivatives
PCT/EP2012/050122 WO2012093148A1 (en) 2011-01-06 2012-01-05 Fused aminodihydrothiazine derivatives

Publications (1)

Publication Number Publication Date
BR112013016856A2 true BR112013016856A2 (pt) 2017-08-01

Family

ID=43663873

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112013016856A BR112013016856A2 (pt) 2011-01-06 2012-01-05 composto, uso de um composto, composição farmacêutica e produto farmacêutico

Country Status (12)

Country Link
US (1) US8822455B2 (pt)
EP (1) EP2661267A1 (pt)
JP (1) JP2014501769A (pt)
KR (1) KR20130131399A (pt)
CN (1) CN103429244A (pt)
AU (1) AU2012204890A1 (pt)
BR (1) BR112013016856A2 (pt)
CA (1) CA2822777A1 (pt)
GB (1) GB201100181D0 (pt)
MX (1) MX2013007490A (pt)
RU (1) RU2013136542A (pt)
WO (1) WO2012093148A1 (pt)

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CA2711655C (en) 2008-01-18 2013-03-05 Eisai R&D Management Co., Ltd. Condensed aminodihydrothiazine derivative
US8637504B2 (en) 2008-06-13 2014-01-28 Shionogi & Co., Ltd. Sulfur-containing heterocyclic derivative having beta secretase inhibitory activity
JPWO2010047372A1 (ja) 2008-10-22 2012-03-22 塩野義製薬株式会社 Ｂａｃｅ１阻害活性を有する２−アミノピリミジン−４−オンおよび２−アミノピリジン誘導体
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GB0912778D0 (en) 2009-07-22 2009-08-26 Eisai London Res Lab Ltd Fused aminodihydro-oxazine derivatives
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JP5816630B2 (ja) 2010-10-29 2015-11-18 塩野義製薬株式会社 ナフチリジン誘導体
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GB201101139D0 (en) 2011-01-21 2011-03-09 Eisai Ltd Fused aminodihydrothiazine derivatives
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Also Published As

Publication number Publication date
CA2822777A1 (en) 2012-07-12
JP2014501769A (ja) 2014-01-23
WO2012093148A1 (en) 2012-07-12
RU2013136542A (ru) 2015-02-20
AU2012204890A1 (en) 2013-08-01
GB201100181D0 (en) 2011-02-23
US8822455B2 (en) 2014-09-02
US20140011802A1 (en) 2014-01-09
MX2013007490A (es) 2013-08-15
CN103429244A (zh) 2013-12-04
KR20130131399A (ko) 2013-12-03
EP2661267A1 (en) 2013-11-13

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]