BR112014013661A8 - derivados de nucleosídeos 2’,4’-difluoro-2’-metil substituídos como inibidores de replicação de hcv-rna - Google Patents

derivados de nucleosídeos 2’,4’-difluoro-2’-metil substituídos como inibidores de replicação de hcv-rna

Info

Publication number
BR112014013661A8
BR112014013661A8 BR112014013661A BR112014013661A BR112014013661A8 BR 112014013661 A8 BR112014013661 A8 BR 112014013661A8 BR 112014013661 A BR112014013661 A BR 112014013661A BR 112014013661 A BR112014013661 A BR 112014013661A BR 112014013661 A8 BR112014013661 A8 BR 112014013661A8
Authority
BR
Brazil
Prior art keywords
hcv
difluoro
inhibitors
rna replication
nucleoside derivatives
Prior art date
Application number
BR112014013661A
Other languages
English (en)
Other versions
BR112014013661B1 (pt
BR112014013661A2 (pt
Inventor
Zhang Zhuming
Zhang Jing
Original Assignee
Hoffmann La Roche
Riboscience Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche, Riboscience Llc filed Critical Hoffmann La Roche
Publication of BR112014013661A2 publication Critical patent/BR112014013661A2/pt
Publication of BR112014013661A8 publication Critical patent/BR112014013661A8/pt
Publication of BR112014013661B1 publication Critical patent/BR112014013661B1/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60—Sugars; Derivatives thereof
    • A61K8/606—Nucleosides; Nucleotides; Nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Birds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

DERIVADOS DE NUCLEOSÍDEOS 2, 4-DIFLUORO-2-METIL SUBSTITUÍDOS COMO INIBIDORES DE REPLICAÇÃO DE HCV-RNA A presente descrição refere-se aos compostos da Fórmula I: Igualmente expostas estão as composições farmacêuticas que compreendem os compostos da Fórmula I, os métodos de utilização dos compostos da Fórmula I e/ou as composições que compreendem os compostos da Fórmula I para o tratamento de HCV.
BR112014013661-0A 2011-12-20 2012-12-17 Derivados de nucleosídeos 2,4-difluoro-2-metil substituídos como inibidores de replicação de hcv-rna BR112014013661B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161577707P 2011-12-20 2011-12-20
US61/577,707 2011-12-20
PCT/EP2012/075779 WO2013092481A1 (en) 2011-12-20 2012-12-17 2',4'-difluoro-2'-methyl substituted nucleoside derivatives as inhibitors of hcv rna replication

Publications (3)

Publication Number Publication Date
BR112014013661A2 BR112014013661A2 (pt) 2017-06-13
BR112014013661A8 true BR112014013661A8 (pt) 2017-12-19
BR112014013661B1 BR112014013661B1 (pt) 2020-10-27

Family

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Family Applications (1)

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BR112014013661-0A BR112014013661B1 (pt) 2011-12-20 2012-12-17 Derivados de nucleosídeos 2,4-difluoro-2-metil substituídos como inibidores de replicação de hcv-rna

Country Status (32)

Country Link
US (1) US9108999B2 (pt)
EP (1) EP2794629B1 (pt)
JP (1) JP5982007B2 (pt)
KR (1) KR101765997B1 (pt)
CN (1) CN104011061B (pt)
AU (1) AU2012357940B2 (pt)
BR (1) BR112014013661B1 (pt)
CA (1) CA2856179C (pt)
CL (1) CL2014001562A1 (pt)
CO (1) CO6960551A2 (pt)
CR (1) CR20140238A (pt)
CY (1) CY1119056T1 (pt)
DK (1) DK2794629T3 (pt)
EA (1) EA024297B1 (pt)
ES (1) ES2636448T3 (pt)
HK (2) HK1199036A1 (pt)
HU (1) HUE033727T2 (pt)
IL (1) IL232505B (pt)
LT (1) LT2794629T (pt)
MA (1) MA35750B1 (pt)
MX (1) MX350809B (pt)
MY (1) MY171577A (pt)
PE (1) PE20141423A1 (pt)
PH (1) PH12014501134A1 (pt)
PL (1) PL2794629T3 (pt)
PT (1) PT2794629T (pt)
RS (1) RS56212B1 (pt)
SG (1) SG11201403364PA (pt)
SI (1) SI2794629T1 (pt)
UA (1) UA111761C2 (pt)
WO (1) WO2013092481A1 (pt)
ZA (1) ZA201404273B (pt)

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Publication number Publication date
MA35750B1 (fr) 2014-12-01
KR20140108290A (ko) 2014-09-05
HUE033727T2 (en) 2018-01-29
CY1119056T1 (el) 2018-01-10
MX350809B (es) 2017-09-20
JP2015500852A (ja) 2015-01-08
EP2794629B1 (en) 2017-05-24
CN104011061A (zh) 2014-08-27
PH12014501134B1 (en) 2014-07-28
DK2794629T3 (en) 2017-07-24
RS56212B1 (sr) 2017-11-30
CO6960551A2 (es) 2014-05-30
SG11201403364PA (en) 2014-07-30
US9108999B2 (en) 2015-08-18
CN104011061B (zh) 2017-06-13
EA024297B1 (ru) 2016-09-30
EA201491179A1 (ru) 2014-11-28
IL232505A0 (en) 2014-06-30
PT2794629T (pt) 2017-07-20
BR112014013661B1 (pt) 2020-10-27
MY171577A (en) 2019-10-21
ZA201404273B (en) 2015-09-30
SI2794629T1 (sl) 2017-10-30
AU2012357940B2 (en) 2017-02-16
ES2636448T3 (es) 2017-10-05
NZ625342A (en) 2016-07-29
WO2013092481A1 (en) 2013-06-27
PL2794629T3 (pl) 2018-02-28
KR101765997B1 (ko) 2017-08-07
CL2014001562A1 (es) 2014-11-14
HK1199036A1 (en) 2015-06-19
BR112014013661A2 (pt) 2017-06-13
JP5982007B2 (ja) 2016-08-31
CA2856179A1 (en) 2013-06-27
MX2014007023A (es) 2014-09-12
HK1200836A1 (en) 2015-08-14
CA2856179C (en) 2017-02-28
IL232505B (en) 2019-02-28
LT2794629T (lt) 2017-07-25
EP2794629A1 (en) 2014-10-29
CR20140238A (es) 2014-06-20
PH12014501134A1 (en) 2014-07-28
UA111761C2 (uk) 2016-06-10
US20150004135A1 (en) 2015-01-01
PE20141423A1 (es) 2014-10-16
AU2012357940A1 (en) 2014-05-29

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