HK1199036A1 - 2,4-difluoro-2-methyl substituted nucleoside derivatives as inhibitors of hcv rna replication hcv rna 24--2- - Google Patents
2,4-difluoro-2-methyl substituted nucleoside derivatives as inhibitors of hcv rna replication hcv rna 24--2-Info
- Publication number
- HK1199036A1 HK1199036A1 HK14112520.8A HK14112520A HK1199036A1 HK 1199036 A1 HK1199036 A1 HK 1199036A1 HK 14112520 A HK14112520 A HK 14112520A HK 1199036 A1 HK1199036 A1 HK 1199036A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- hcv rna
- difluoro
- inhibitors
- methyl substituted
- substituted nucleoside
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
- A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/606—Nucleosides; Nucleotides; Nucleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Birds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161577707P | 2011-12-20 | 2011-12-20 | |
PCT/EP2012/075779 WO2013092481A1 (en) | 2011-12-20 | 2012-12-17 | 2',4'-difluoro-2'-methyl substituted nucleoside derivatives as inhibitors of hcv rna replication |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1199036A1 true HK1199036A1 (en) | 2015-06-19 |
Family
ID=47504913
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK14112520.8A HK1199036A1 (en) | 2011-12-20 | 2014-12-12 | 2,4-difluoro-2-methyl substituted nucleoside derivatives as inhibitors of hcv rna replication hcv rna 24--2- |
HK15101204.3A HK1200836A1 (en) | 2011-12-20 | 2015-02-04 | 2,4-difluoro-2-methyl substituted nucleoside derivatives as inhibitors of hcv rna replication hcv rna 24--2- |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK15101204.3A HK1200836A1 (en) | 2011-12-20 | 2015-02-04 | 2,4-difluoro-2-methyl substituted nucleoside derivatives as inhibitors of hcv rna replication hcv rna 24--2- |
Country Status (32)
Country | Link |
---|---|
US (1) | US9108999B2 (xx) |
EP (1) | EP2794629B1 (xx) |
JP (1) | JP5982007B2 (xx) |
KR (1) | KR101765997B1 (xx) |
CN (1) | CN104011061B (xx) |
AU (1) | AU2012357940B2 (xx) |
BR (1) | BR112014013661B1 (xx) |
CA (1) | CA2856179C (xx) |
CL (1) | CL2014001562A1 (xx) |
CO (1) | CO6960551A2 (xx) |
CR (1) | CR20140238A (xx) |
CY (1) | CY1119056T1 (xx) |
DK (1) | DK2794629T3 (xx) |
EA (1) | EA024297B1 (xx) |
ES (1) | ES2636448T3 (xx) |
HK (2) | HK1199036A1 (xx) |
HU (1) | HUE033727T2 (xx) |
IL (1) | IL232505B (xx) |
LT (1) | LT2794629T (xx) |
MA (1) | MA35750B1 (xx) |
MX (1) | MX350809B (xx) |
MY (1) | MY171577A (xx) |
PE (1) | PE20141423A1 (xx) |
PH (1) | PH12014501134B1 (xx) |
PL (1) | PL2794629T3 (xx) |
PT (1) | PT2794629T (xx) |
RS (1) | RS56212B1 (xx) |
SG (1) | SG11201403364PA (xx) |
SI (1) | SI2794629T1 (xx) |
UA (1) | UA111761C2 (xx) |
WO (1) | WO2013092481A1 (xx) |
ZA (1) | ZA201404273B (xx) |
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US9211300B2 (en) * | 2012-12-19 | 2015-12-15 | Idenix Pharmaceuticals Llc | 4′-fluoro nucleosides for the treatment of HCV |
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US9187515B2 (en) | 2013-04-01 | 2015-11-17 | Idenix Pharmaceuticals Llc | 2′,4′-fluoro nucleosides for the treatment of HCV |
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SG11201509424VA (en) * | 2013-05-16 | 2015-12-30 | Riboscience Llc | 4'-fluor0-2'-methyl substituted nucleoside derivatives |
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KR102314960B1 (ko) | 2013-10-11 | 2021-10-19 | 얀센 바이오파마, 인코퍼레이트. | 치환된 뉴클레오사이드, 뉴클레오타이드 및 이의 유사체 |
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2012
- 2012-12-17 EP EP12810206.8A patent/EP2794629B1/en active Active
- 2012-12-17 MX MX2014007023A patent/MX350809B/es active IP Right Grant
- 2012-12-17 CA CA2856179A patent/CA2856179C/en active Active
- 2012-12-17 US US14/365,416 patent/US9108999B2/en active Active
- 2012-12-17 HU HUE12810206A patent/HUE033727T2/en unknown
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