SG11201403364PA - 2',4'-difluoro-2'-methyl substituted nucleoside derivatives as inhibitors of hcv rna replication - Google Patents
2',4'-difluoro-2'-methyl substituted nucleoside derivatives as inhibitors of hcv rna replicationInfo
- Publication number
- SG11201403364PA SG11201403364PA SG11201403364PA SG11201403364PA SG11201403364PA SG 11201403364P A SG11201403364P A SG 11201403364PA SG 11201403364P A SG11201403364P A SG 11201403364PA SG 11201403364P A SG11201403364P A SG 11201403364PA SG 11201403364P A SG11201403364P A SG 11201403364PA
- Authority
- SG
- Singapore
- Prior art keywords
- difluoro
- inhibitors
- hcv rna
- methyl substituted
- rna replication
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
- A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/606—Nucleosides; Nucleotides; Nucleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Birds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161577707P | 2011-12-20 | 2011-12-20 | |
| PCT/EP2012/075779 WO2013092481A1 (en) | 2011-12-20 | 2012-12-17 | 2',4'-difluoro-2'-methyl substituted nucleoside derivatives as inhibitors of hcv rna replication |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201403364PA true SG11201403364PA (en) | 2014-07-30 |
Family
ID=47504913
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201403364PA SG11201403364PA (en) | 2011-12-20 | 2012-12-17 | 2',4'-difluoro-2'-methyl substituted nucleoside derivatives as inhibitors of hcv rna replication |
Country Status (32)
| Country | Link |
|---|---|
| US (1) | US9108999B2 (en) |
| EP (1) | EP2794629B1 (en) |
| JP (1) | JP5982007B2 (en) |
| KR (1) | KR101765997B1 (en) |
| CN (1) | CN104011061B (en) |
| AU (1) | AU2012357940B2 (en) |
| BR (1) | BR112014013661B1 (en) |
| CA (1) | CA2856179C (en) |
| CL (1) | CL2014001562A1 (en) |
| CO (1) | CO6960551A2 (en) |
| CR (1) | CR20140238A (en) |
| CY (1) | CY1119056T1 (en) |
| DK (1) | DK2794629T3 (en) |
| EA (1) | EA024297B1 (en) |
| ES (1) | ES2636448T3 (en) |
| HK (2) | HK1199036A1 (en) |
| HU (1) | HUE033727T2 (en) |
| IL (1) | IL232505B (en) |
| LT (1) | LT2794629T (en) |
| MA (1) | MA35750B1 (en) |
| MX (1) | MX350809B (en) |
| MY (1) | MY171577A (en) |
| PE (1) | PE20141423A1 (en) |
| PH (1) | PH12014501134B1 (en) |
| PL (1) | PL2794629T3 (en) |
| PT (1) | PT2794629T (en) |
| RS (1) | RS56212B1 (en) |
| SG (1) | SG11201403364PA (en) |
| SI (1) | SI2794629T1 (en) |
| UA (1) | UA111761C2 (en) |
| WO (1) | WO2013092481A1 (en) |
| ZA (1) | ZA201404273B (en) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9403863B2 (en) | 2011-09-12 | 2016-08-02 | Idenix Pharmaceuticals Llc | Substituted carbonyloxymethylphosphoramidate compounds and pharmaceutical compositions for the treatment of viral infections |
| EP2852605B1 (en) | 2012-05-22 | 2018-01-31 | Idenix Pharmaceuticals LLC | 3',5'-cyclic phosphate prodrugs for hcv infection |
| EP2852604B1 (en) | 2012-05-22 | 2017-04-12 | Idenix Pharmaceuticals LLC | 3',5'-cyclic phosphoramidate prodrugs for hcv infection |
| PE20150132A1 (en) | 2012-05-22 | 2015-02-14 | Idenix Pharmaceuticals Inc | D-AMINO ACID COMPOUNDS FOR HEPATIC DISEASE |
| US9422323B2 (en) | 2012-05-25 | 2016-08-23 | Janssen Sciences Ireland Uc | Uracyl spirooxetane nucleosides |
| US9192621B2 (en) | 2012-09-27 | 2015-11-24 | Idenix Pharmaceuticals Llc | Esters and malonates of SATE prodrugs |
| AP2015008384A0 (en) | 2012-10-08 | 2015-04-30 | Univ Montpellier Ct Nat De La Rech Scient | 2'-Chloro nucleoside analogs for hcv infection |
| EP2935304A1 (en) * | 2012-12-19 | 2015-10-28 | IDENIX Pharmaceuticals, Inc. | 4'-fluoro nucleosides for the treatment of hcv |
| WO2014100498A1 (en) | 2012-12-21 | 2014-06-26 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
| PT2935303T (en) * | 2012-12-21 | 2021-04-30 | Alios Biopharma Inc | Substituted nucleosides, nucleotides and analogs thereof |
| US9339541B2 (en) | 2013-03-04 | 2016-05-17 | Merck Sharp & Dohme Corp. | Thiophosphate nucleosides for the treatment of HCV |
| EP2970358B1 (en) | 2013-03-04 | 2021-06-30 | Idenix Pharmaceuticals LLC | 3'-deoxy nucleosides for the treatment of hcv |
| JP6219414B2 (en) * | 2013-03-08 | 2017-10-25 | ナンジン・サンホーム・ファーマシューティカル・カンパニー・リミテッドＮａｎｊｉｎｇ Ｓａｎｈｏｍｅ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｃｏ．， Ｌｔｄ． | Novel nucleoside phosphoramidate compounds and uses thereof |
| US20140271547A1 (en) | 2013-03-13 | 2014-09-18 | Idenix Pharmaceuticals, Inc. | Amino acid phosphoramidate pronucleotides of 2'-cyano, azido and amino nucleosides for the treatment of hcv |
| WO2014165542A1 (en) * | 2013-04-01 | 2014-10-09 | Idenix Pharmaceuticals, Inc. | 2',4'-fluoro nucleosides for the treatment of hcv |
| US20180200280A1 (en) | 2013-05-16 | 2018-07-19 | Riboscience Llc | 4'-Fluoro-2'-Methyl Substituted Nucleoside Derivatives as Inhibitors of HCV RNA Replication |
| AU2014265293B2 (en) * | 2013-05-16 | 2019-07-18 | Riboscience Llc | 4'-Fluoro-2'-methyl substituted nucleoside derivatives |
| WO2014197578A1 (en) | 2013-06-05 | 2014-12-11 | Idenix Pharmaceuticals, Inc. | 1',4'-thio nucleosides for the treatment of hcv |
| WO2015017713A1 (en) | 2013-08-01 | 2015-02-05 | Idenix Pharmaceuticals, Inc. | D-amino acid phosphoramidate pronucleotides of halogeno pyrimidine compounds for liver disease |
| KR102314960B1 (en) * | 2013-10-11 | 2021-10-19 | 얀센 바이오파마, 인코퍼레이트. | Substituted nucleosides, nucleotides and analogs thereof |
| WO2015061683A1 (en) * | 2013-10-25 | 2015-04-30 | Idenix Pharmaceuticals, Inc. | D-amino acid phosphoramidate and d-alanine thiophosphoramidate pronucleotides of nucleoside compounds useful for the treatment of hcv |
| WO2015161137A1 (en) | 2014-04-16 | 2015-10-22 | Idenix Pharmaceuticals, Inc. | 3'-substituted methyl or alkynyl nucleosides for the treatment of hcv |
| CN106573011A (en) | 2014-06-24 | 2017-04-19 | 艾丽奥斯生物制药有限公司 | Substituted nucleosides, nucleotides and analogs thereof |
| TN2016000566A1 (en) | 2014-06-24 | 2018-04-04 | Alios Biopharma Inc | Substituted nucleosides, nucleotides and analogs thereof |
| WO2016078582A1 (en) * | 2014-11-20 | 2016-05-26 | 南京曼杰生物科技有限公司 | Novel nucleoside phosphoramidate derivatives and applications thereof |
| MA41441A (en) * | 2014-12-19 | 2017-12-12 | Alios Biopharma Inc | SUBSTITUTED NUCLEOSIDES, NUCLEOTIDES AND ANALOGUES OF THEM |
| CN108350016B (en) * | 2015-09-02 | 2021-07-27 | 艾伯维公司 | Antiviral tetrahydrofuran derivatives |
| EP3455218A4 (en) | 2016-05-10 | 2019-12-18 | C4 Therapeutics, Inc. | C3-carbon linked glutarimide degronimers for target protein degradation |
| WO2017197055A1 (en) | 2016-05-10 | 2017-11-16 | C4 Therapeutics, Inc. | Heterocyclic degronimers for target protein degradation |
| CN109562113A (en) | 2016-05-10 | 2019-04-02 | C4医药公司 | Loop coil degron body for target protein degradation |
| US10202412B2 (en) | 2016-07-08 | 2019-02-12 | Atea Pharmaceuticals, Inc. | β-D-2′-deoxy-2′-substituted-4′-substituted-2-substituted-N6-substituted-6-aminopurinenucleotides for the treatment of paramyxovirus and orthomyxovirus infections |
| WO2018013937A1 (en) | 2016-07-14 | 2018-01-18 | Atea Pharmaceuticals, Inc. | Beta-d-2'-deoxy-2'-alpha-fluoro-2'-beta-c-substituted-4'-fluoro-n6-substituted-6-amino-2-substituted purine nucleotides for the treatment of hepatitis c virus infection |
| EP3684374A4 (en) | 2017-09-21 | 2021-06-16 | Riboscience LLC | 4'-fluoro-2'-methyl substituted nucleoside derivatives as inhibitors of hcv rna replication |
| KR20200140274A (en) * | 2018-03-07 | 2020-12-15 | 에모리 유니버시티 | 4'-halogen containing nucleotide and nucleoside therapeutic compositions and uses related thereto |
Family Cites Families (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU498131B2 (en) | 1974-02-26 | 1979-02-15 | Ciba-Geigy Ag | Production of cephems by cyclization |
| US4147864A (en) | 1975-02-20 | 1979-04-03 | Ciba-Geigy Corporation | Process for the manufacture of 7β-amino-3-cephem-3-ol-4 carboxylic acid compounds |
| US4322347A (en) | 1978-04-03 | 1982-03-30 | Bristol-Myers Company | 2-Carbamoyloxymethyl-penicillin derivatives |
| WO1986006380A1 (en) | 1985-04-30 | 1986-11-06 | Takeda Chemical Industries, Ltd. | Antibacterial compounds, use and preparation thereof |
| US5807876A (en) | 1996-04-23 | 1998-09-15 | Vertex Pharmaceuticals Incorporated | Inhibitors of IMPDH enzyme |
| US6054472A (en) | 1996-04-23 | 2000-04-25 | Vertex Pharmaceuticals, Incorporated | Inhibitors of IMPDH enzyme |
| HUP0004421A3 (en) | 1996-04-23 | 2002-10-28 | Vertex Pharmaceuticals Inc Cam | Urea derivatives and pharmaceutical compositions containing them, use thereof for the treatment of deseases mediated by impdh enzyme |
| UA79749C2 (en) | 1996-10-18 | 2007-07-25 | Vertex Pharma | Inhibitors of serine proteases, particularly hepatitis c virus ns3 protease |
| GB9623908D0 (en) | 1996-11-18 | 1997-01-08 | Hoffmann La Roche | Amino acid derivatives |
| DK0966465T3 (en) | 1997-03-14 | 2003-10-20 | Vertex Pharma | Inhibitors of IMPDH enzymes |
| US6010848A (en) | 1997-07-02 | 2000-01-04 | Smithkline Beecham Corporation | Screening methods using an atpase protein from hepatitis C virus |
| ATE283865T1 (en) | 1997-08-11 | 2004-12-15 | Boehringer Ingelheim Ca Ltd | PEPTIDE ANALOGUES WITH INHIBITORY EFFECT ON HEPATITIS C |
| JP2003525200A (en) | 1998-07-27 | 2003-08-26 | イスティトゥト ディ リチェルケ ディ ビオロジア モレコラーレ ピー．アンジェレッティ ソチエタ ペル アツィオニ | Diketoacid derivatives as polymerase inhibitors |
| US6323180B1 (en) | 1998-08-10 | 2001-11-27 | Boehringer Ingelheim (Canada) Ltd | Hepatitis C inhibitor tri-peptides |
| ID27787A (en) | 1998-08-21 | 2001-04-26 | Viro Pharma Inc | COMPOUND, COMPOSITION AND METHODS FOR TREATMENT OR PREVENTION OF INFECTIONS CAUSED BY VIRUSES AND RELATED DISEASES |
| MXPA01002253A (en) | 1998-09-04 | 2003-06-04 | Viropharma Inc | Methods for treating or preventing viral infections and associated diseases. |
| BR9913935A (en) | 1998-09-25 | 2001-06-19 | Viropharma Inc | Methods of treatment and prevention of infection caused by at least one virus of the family of flaviviridae and disease associated with said infection in a living host |
| EP1964561A1 (en) | 1999-03-19 | 2008-09-03 | Vertex Pharmaceuticals Incorporated | Inhibitors of IMPDH enzyme |
| CA2389745C (en) | 1999-11-04 | 2010-03-23 | Shire Biochem Inc. | Method for the treatment or prevention of flaviviridae viral infection using nucleoside analogues |
| JP2004509066A (en) | 2000-05-10 | 2004-03-25 | スミスクライン・ビーチャム・コーポレイション | New anti-infective drug |
| US6448281B1 (en) | 2000-07-06 | 2002-09-10 | Boehringer Ingelheim (Canada) Ltd. | Viral polymerase inhibitors |
| SV2003000617A (en) | 2000-08-31 | 2003-01-13 | Lilly Co Eli | INHIBITORS OF PROTEASA PEPTIDOMIMETICA REF. X-14912M |
| US20030175950A1 (en) | 2001-05-29 | 2003-09-18 | Mcswiggen James A. | RNA interference mediated inhibition of HIV gene expression using short interfering RNA |
| US20030170891A1 (en) | 2001-06-06 | 2003-09-11 | Mcswiggen James A. | RNA interference mediated inhibition of epidermal growth factor receptor gene expression using short interfering nucleic acid (siNA) |
| EP1395571A1 (en) | 2001-06-11 | 2004-03-10 | Shire Biochem Inc. | Compounds and methods for the treatment or prevention of flavivirus infections |
| SI1401825T1 (en) | 2001-06-11 | 2010-01-29 | Virochem Pharma Inc | Thiophene derivatives as antiviral agents for flavivirus infection |
| AR035543A1 (en) | 2001-06-26 | 2004-06-16 | Japan Tobacco Inc | THERAPEUTIC AGENT FOR HEPATITIS C THAT INCLUDES A CONDENSED RING COMPOUND, CONDENSED RING COMPOUND, PHARMACEUTICAL COMPOSITION THAT UNDERSTANDS, BENZIMIDAZOL, THIAZOL AND BIFENYL COMPOUNDS USED AS INTERMEDIARY COMPARTMENTS OF COMPARTMENTS |
| JP4558314B2 (en) | 2001-07-20 | 2010-10-06 | ベーリンガー インゲルハイム （カナダ） リミテッド | Viral polymerase inhibitor |
| EP2335700A1 (en) | 2001-07-25 | 2011-06-22 | Boehringer Ingelheim (Canada) Ltd. | Hepatitis C virus polymerase inhibitors with a heterobicylic structure |
| WO2003037893A1 (en) | 2001-11-02 | 2003-05-08 | Glaxo Group Limited | Acyl dihydro pyrrole derivatives as hcv inhibitors |
| ATE370137T1 (en) | 2001-11-02 | 2007-09-15 | Glaxo Group Ltd | 4-(6-MEMBED)-HETEROARYL-ACYL-PYRROLIDINE DERIVATIVES AS HCV INHIBITORS |
| US20050043545A1 (en) | 2001-11-02 | 2005-02-24 | Gianpalol Bravi | 4-(5-Membered)-heteroaryl acyl pyrrolidine derivatives as hcv inhibitors |
| JP2005530843A (en) | 2002-06-21 | 2005-10-13 | メルク エンド カムパニー インコーポレーテッド | Nucleoside derivatives as RNA-dependent RNA viral polymerase inhibitors |
| AU2003263978A1 (en) * | 2002-08-01 | 2004-02-23 | Board Of Trustees Of The Leland Stanford Junior University | 2',3'-dideoxynucleoside analogues for the treatment or prevention of flavivitridae infections |
| US20050020884A1 (en) | 2003-02-25 | 2005-01-27 | Hart Charles C. | Surgical access system |
| BRPI0409680A (en) | 2003-04-25 | 2006-04-18 | Gilead Sciences Inc | anti-cancer phosphonate analogs |
| EP1656093A2 (en) | 2003-05-14 | 2006-05-17 | Idenix (Cayman) Limited | Nucleosides for treatment of infection by corona viruses, toga viruses and picorna viruses |
| WO2005007810A2 (en) | 2003-06-16 | 2005-01-27 | Grinstaff Mark W | Functional synthetic molecules and macromolecules for gene delivery |
| GB0317009D0 (en) | 2003-07-21 | 2003-08-27 | Univ Cardiff | Chemical compounds |
| ES2342944T3 (en) | 2004-01-30 | 2010-07-19 | Medivir Ab | INHIBITORS OF NS-3 SERINA PROTEASA of HCV. |
| AU2005313912A1 (en) | 2004-12-10 | 2006-06-15 | Emory University | 2' and 3' - substituted cyclobutyl nucleoside analogs for the treatment of viral infections and abnormal cellular proliferation |
| EP1928475B1 (en) * | 2005-08-15 | 2018-05-23 | Riboscience LLC | Antiviral phosphoramidates of 4'-c-azido-substituted pronucleotides |
| WO2007095269A2 (en) | 2006-02-14 | 2007-08-23 | Merck & Co., Inc. | Nucleoside aryl phosphoramidates for the treatment of rna-dependent rna viral infection |
| US8329159B2 (en) | 2006-08-11 | 2012-12-11 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| GB2442001A (en) | 2006-08-11 | 2008-03-26 | Chembiotech | Nanoparticle - i-motif nucleic acid bioconjugates |
| ATE478084T1 (en) * | 2006-12-11 | 2010-09-15 | Hoffmann La Roche | METHOD FOR PRODUCING 4'-AZIDOCYTIDINE DERIVATIVES |
| JP2010515680A (en) | 2007-01-05 | 2010-05-13 | メルク・シャープ・エンド・ドーム・コーポレイション | Nucleoside aryl phosphoramidates for the treatment of RNA-dependent RNA viral infections |
| US7964580B2 (en) * | 2007-03-30 | 2011-06-21 | Pharmasset, Inc. | Nucleoside phosphoramidate prodrugs |
| GB0709791D0 (en) | 2007-05-22 | 2007-06-27 | Angeletti P Ist Richerche Bio | Antiviral agents |
| US8173621B2 (en) | 2008-06-11 | 2012-05-08 | Gilead Pharmasset Llc | Nucleoside cyclicphosphates |
| US9725479B2 (en) | 2010-04-22 | 2017-08-08 | Ionis Pharmaceuticals, Inc. | 5′-end derivatives |
| CN103052646A (en) | 2010-07-19 | 2013-04-17 | 吉里德科学公司 | Methods for the preparation of diasteromerically pure phosphoramidate prodrugs |
| CA2843885C (en) | 2011-08-01 | 2020-03-10 | Mbc Pharma, Inc. | Vitamin b6 derivatives of nucleotides, acyclonucleotides and acyclonucleoside phosphonates |
-
2012
- 2012-12-17 PL PL12810206T patent/PL2794629T3/en unknown
- 2012-12-17 DK DK12810206.8T patent/DK2794629T3/en active
- 2012-12-17 MX MX2014007023A patent/MX350809B/en active IP Right Grant
- 2012-12-17 PT PT128102068T patent/PT2794629T/en unknown
- 2012-12-17 MY MYPI2014701642A patent/MY171577A/en unknown
- 2012-12-17 PE PE2014000991A patent/PE20141423A1/en active IP Right Grant
- 2012-12-17 CA CA2856179A patent/CA2856179C/en active Active
- 2012-12-17 US US14/365,416 patent/US9108999B2/en active Active
- 2012-12-17 EP EP12810206.8A patent/EP2794629B1/en active Active
- 2012-12-17 KR KR1020147019943A patent/KR101765997B1/en active IP Right Grant
- 2012-12-17 CN CN201280064194.0A patent/CN104011061B/en not_active Expired - Fee Related
- 2012-12-17 RS RS20170808A patent/RS56212B1/en unknown
- 2012-12-17 HU HUE12810206A patent/HUE033727T2/en unknown
- 2012-12-17 SG SG11201403364PA patent/SG11201403364PA/en unknown
- 2012-12-17 EA EA201491179A patent/EA024297B1/en not_active IP Right Cessation
- 2012-12-17 BR BR112014013661-0A patent/BR112014013661B1/en not_active IP Right Cessation
- 2012-12-17 AU AU2012357940A patent/AU2012357940B2/en not_active Ceased
- 2012-12-17 WO PCT/EP2012/075779 patent/WO2013092481A1/en active Application Filing
- 2012-12-17 LT LTEP12810206.8T patent/LT2794629T/en unknown
- 2012-12-17 SI SI201231037T patent/SI2794629T1/en unknown
- 2012-12-17 UA UAA201407326A patent/UA111761C2/en unknown
- 2012-12-17 ES ES12810206.8T patent/ES2636448T3/en active Active
- 2012-12-17 JP JP2014547891A patent/JP5982007B2/en active Active
-
2014
- 2014-05-08 IL IL232505A patent/IL232505B/en active IP Right Grant
- 2014-05-16 CO CO14106193A patent/CO6960551A2/en active IP Right Grant
- 2014-05-21 CR CR20140238A patent/CR20140238A/en unknown
- 2014-05-21 PH PH12014501134A patent/PH12014501134B1/en unknown
- 2014-06-10 ZA ZA2014/04273A patent/ZA201404273B/en unknown
- 2014-06-13 CL CL2014001562A patent/CL2014001562A1/en unknown
- 2014-06-25 MA MA37158A patent/MA35750B1/en unknown
- 2014-12-12 HK HK14112520.8A patent/HK1199036A1/en not_active IP Right Cessation
-
2015
- 2015-02-04 HK HK15101204.3A patent/HK1200836A1/en not_active IP Right Cessation
-
2017
- 2017-07-12 CY CY20171100739T patent/CY1119056T1/en unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL232505A0 (en) | 2', 4'-difluoro-2'-methyl substituted nucleoside derivatives as inhibitors of hcv rna replication | |
| LT2794628T (en) | 4`-azido-3`-fluoro substituted nucleoside derivatives as inhibitors of hcv rna replication | |
| IL272953B (en) | Substituted nucleosides, nucleotides and analogs thereof | |
| FR17C1040I2 (en) | ANTIVIRAL DERIVATIVE OF 2,5-DIBENZIMIDAZOL-5-YL-1-PHENYL-PYRROLIDINE | |
| DK3682905T3 (en) | MODIFIED NUCLEOSIDES, NUCLEOTIDES AND NUCLEIC ACIDS AND USES THEREOF | |
| HK1201518A1 (en) | Compositions, synthesis, and methods of using phenylcycloalkylmethylamine derivatives | |
| RS56101B1 (en) | 4'-azido-3'-fluoro substituted nucleoside derivatives as inhibitors of hcv rna replication | |
| TH1401003558A (en) | Model-substituted nucleoside derivatives 4'-azido,3'-fluoro as an inhibitor of HCV RNA replication | |
| TH1401003474A (en) | Substituted nucleoside derivatives 2',4'-difluoro-2'-methyl as an RNA and HCV replication inhibitor. |