CY1116423T1 - Ενωσεις δις(φθοροαλκυλο)-1,4-βενζοδιαζεπινονης - Google Patents
Ενωσεις δις(φθοροαλκυλο)-1,4-βενζοδιαζεπινονηςInfo
- Publication number
- CY1116423T1 CY1116423T1 CY20151100355T CY151100355T CY1116423T1 CY 1116423 T1 CY1116423 T1 CY 1116423T1 CY 20151100355 T CY20151100355 T CY 20151100355T CY 151100355 T CY151100355 T CY 151100355T CY 1116423 T1 CY1116423 T1 CY 1116423T1
- Authority
- CY
- Cyprus
- Prior art keywords
- compounds
- benzodiazepinone
- fluoroalkyl
- bis
- ch2ch2cf3
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
- C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
- C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
- C07D243/24—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Αποκαλύπτονται ενώσεις του τύπου (I) ή προφάρμακα αυτών· όπου: η R1 είναι CH2CF3 ή CH2CH2CF3· η R2 είναι CH2CF3, CH2CH2CF3, ή CH2CH2CH2CF3· η R3 είναι Η ή CH3· έκαστη Ra είναι ανεξαρτήτως F, CI, -CN, -OCH3, και/ή NHCH2CH2OCH3· και z είναι μηδέν, 1 ή 2. Επίσης αποκαλύπτονται μέθοδοι χρήσης τέτοιων ενώσεων για αναστολή του υποδοχέα Notch, και φαρμακευτικές συνθέσεις που περιλαμβάνουν τέτοιες ενώσεις. Οι ενώσεις αυτές είναι χρήσιμες στη θεραπευτική αγωγή, πρόληψη, ή επιβράδυνση της εξέλιξης παθήσεων ή διαταραχών σε ποικιλία θεραπευτικών πεδίων, όπως καρκίνο.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161466238P | 2011-03-22 | 2011-03-22 | |
| EP12711102.9A EP2688873B1 (en) | 2011-03-22 | 2012-03-22 | Bis(fluoroalkyl)-1,4-benzodiazepinone compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1116423T1 true CY1116423T1 (el) | 2017-02-08 |
Family
ID=45894701
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20151100355T CY1116423T1 (el) | 2011-03-22 | 2015-04-17 | Ενωσεις δις(φθοροαλκυλο)-1,4-βενζοδιαζεπινονης |
Country Status (32)
| Country | Link |
|---|---|
| US (2) | US8629136B2 (el) |
| EP (1) | EP2688873B1 (el) |
| JP (1) | JP5873923B2 (el) |
| KR (1) | KR101948347B1 (el) |
| CN (1) | CN103717576B (el) |
| AR (1) | AR085471A1 (el) |
| AU (1) | AU2012230904B2 (el) |
| BR (1) | BR112013024059B1 (el) |
| CA (1) | CA2830902C (el) |
| CL (1) | CL2013002690A1 (el) |
| CO (1) | CO6771446A2 (el) |
| CY (1) | CY1116423T1 (el) |
| DK (1) | DK2688873T3 (el) |
| EA (1) | EA022530B1 (el) |
| ES (1) | ES2534080T3 (el) |
| HK (1) | HK1189218A1 (el) |
| HR (1) | HRP20150273T1 (el) |
| IL (1) | IL228534A (el) |
| MA (1) | MA35036B1 (el) |
| MX (1) | MX2013010420A (el) |
| MY (1) | MY161233A (el) |
| PE (1) | PE20140626A1 (el) |
| PL (1) | PL2688873T3 (el) |
| PT (1) | PT2688873E (el) |
| RS (1) | RS53843B1 (el) |
| SG (1) | SG193555A1 (el) |
| SI (1) | SI2688873T1 (el) |
| SM (1) | SMT201500091B (el) |
| TN (1) | TN2013000372A1 (el) |
| TW (1) | TWI530489B (el) |
| UY (1) | UY33961A (el) |
| WO (1) | WO2012129353A1 (el) |
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| CN1386118A (zh) | 2000-06-01 | 2002-12-18 | 布里斯托尔-迈尔斯斯奎布药品公司 | 作为Aβ蛋白产生抑制剂的被环状琥珀酸酯取代的内酰胺类化合物 |
| US7001901B2 (en) | 2002-08-27 | 2006-02-21 | Bristol-Myers Squibb Company | Tetrazolylpropionamides as inhibitors of Aβ protein production |
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| ATE402934T1 (de) | 2003-02-04 | 2008-08-15 | Hoffmann La Roche | Malonamidderivate als gamma-secretaseinhibitoren |
| GB0312365D0 (en) | 2003-05-30 | 2003-07-02 | Univ Aston | Novel 3-substituted-1, 4-benzodiazepines |
| EP1711470B1 (en) | 2003-09-09 | 2009-04-15 | F. Hoffmann-La Roche Ag | Malonamide derivatives blocking the activtiy of gamma-secretase |
| EP1795198A1 (en) | 2005-12-09 | 2007-06-13 | Hubrecht Laboratorium | Treatment of Barret's esophagus |
| EP1996182A4 (en) | 2006-02-27 | 2009-08-12 | Univ Johns Hopkins | CANCER TREATMENT WITH GAMMA SECRETASE INHIBITORS |
| MX2008012136A (es) | 2006-03-27 | 2008-10-03 | Hoffmann La Roche | Derivados de malonamida como inhibidores de gama secretasa. |
| JP5001372B2 (ja) | 2006-09-20 | 2012-08-15 | エフ．ホフマン−ラ ロシュ アーゲー | ４−オキソ−２，３，４，５−テトラヒドロ−ベンゾ［ｂ］［１，４］ジアゼピン誘導体 |
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| MA33076B1 (fr) | 2008-01-11 | 2012-03-01 | Hoffmann La Roche | Utilisation d'un inhibiteur de la gamma-secretase pour le traitement du cancer |
| US8637493B2 (en) | 2009-11-12 | 2014-01-28 | University Of Massachusetts | Methods for treating glioblastoma |
| US20120225860A1 (en) | 2011-03-02 | 2012-09-06 | John Frederick Boylan | Method for administration of a gamma secretase inhibitor |
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