BR112018068565A2 - combinações de inibidores de lsd1 para uso no tratamento de tumores sólidos - Google Patents

combinações de inibidores de lsd1 para uso no tratamento de tumores sólidos

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Publication number
BR112018068565A2
BR112018068565A2 BR112018068565-8A BR112018068565A BR112018068565A2 BR 112018068565 A2 BR112018068565 A2 BR 112018068565A2 BR 112018068565 A BR112018068565 A BR 112018068565A BR 112018068565 A2 BR112018068565 A2 BR 112018068565A2
Authority
BR
Brazil
Prior art keywords
solid tumors
treating solid
lsd1 inhibitor
inhibitor combinations
combinations
Prior art date
Application number
BR112018068565-8A
Other languages
English (en)
Inventor
Demario Mark
Pierceall William
MACK Fiona
Maes Tamara
Lunardi Serena
Original Assignee
Oryzon Genomics, S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oryzon Genomics, S.A. filed Critical Oryzon Genomics, S.A.
Publication of BR112018068565A2 publication Critical patent/BR112018068565A2/pt

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/12—Ketones
    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
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    • A61K31/19—Carboxylic acids, e.g. valproic acid
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    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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Abstract

a presente invenção refere-se a combinações terapêuticas de inibidores de lsd1 e um ou mais outros ingredientes farmacêuticos ativos ou sais farmaceuticamente aceitáveis dos mesmos. as combinações são particularmente úteis para o tratamento de doenças neoplásicas, tal como o câncer, particularmente câncer de pulmão de célula pequena (sclc).
BR112018068565-8A 2016-03-15 2017-03-13 combinações de inibidores de lsd1 para uso no tratamento de tumores sólidos BR112018068565A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662308529P 2016-03-15 2016-03-15
US62/308,529 2016-03-15
PCT/EP2017/055784 WO2017157825A1 (en) 2016-03-15 2017-03-13 Combinations of lsd1 inhibitors for use in the treatment of solid tumors

Publications (1)

Publication Number Publication Date
BR112018068565A2 true BR112018068565A2 (pt) 2019-02-12

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BR112018068565-8A BR112018068565A2 (pt) 2016-03-15 2017-03-13 combinações de inibidores de lsd1 para uso no tratamento de tumores sólidos

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US (2) US10265279B2 (pt)
EP (1) EP3429571A1 (pt)
JP (2) JP7158023B2 (pt)
KR (2) KR102511024B1 (pt)
CN (1) CN109195593A (pt)
AR (1) AR107871A1 (pt)
AU (2) AU2017233898B2 (pt)
BR (1) BR112018068565A2 (pt)
CA (1) CA3017411A1 (pt)
EA (1) EA201892075A1 (pt)
IL (1) IL261721B (pt)
MX (2) MX2018011102A (pt)
SG (2) SG10201913331VA (pt)
WO (1) WO2017157825A1 (pt)

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CN107266345B (zh) 2011-10-20 2021-08-17 奥瑞泽恩基因组学股份有限公司 作为lsd1抑制剂的(杂)芳基环丙胺化合物
EP3090998A1 (en) 2015-05-06 2016-11-09 F. Hoffmann-La Roche AG Solid forms
SG11201807972YA (en) 2016-03-15 2018-10-30 Oryzon Genomics Sa Combinations of lsd1 inhibitors for the treatment of hematological malignancies
CA3017411A1 (en) 2016-03-15 2017-09-21 Oryzon Genomics, S.A. Combinations of lsd1 inhibitors for use in the treatment of solid tumors
ES2732669T3 (es) 2016-06-10 2019-11-25 Oryzon Genomics Sa Tratamiento de la esclerosis múltiple
WO2019083971A1 (en) 2017-10-23 2019-05-02 Children's Medical Center Corporation METHODS OF TREATING CANCER USING LSD1 INHIBITORS IN COMBINATION WITH IMMUNOTHERAPY
WO2019108789A1 (en) * 2017-11-29 2019-06-06 The Trustees Of Columbia University In The City Of New York Combination therapy of lymphoma
JP2021522305A (ja) * 2018-05-04 2021-08-30 オリソン ヘノミクス，ソシエダ アノニマ 安定した医薬製剤
MX2020011826A (es) * 2018-05-06 2021-01-15 Ayala Pharmaceuticals Inc Composiciones de combinacion que comprenden compuestos de bisfluoroalquil-1,4-benzodiazepinona y metodos de uso de las mismas.
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CN114341366A (zh) * 2019-07-05 2022-04-12 奥莱松基因组股份有限公司 用于使用kdm1a抑制剂个体化治疗小细胞肺癌的生物标志物和方法
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