EA201791516A1 - Способы комбинированного лечения злокачественных опухолей - Google Patents

Способы комбинированного лечения злокачественных опухолей

Info

Publication number
EA201791516A1
EA201791516A1 EA201791516A EA201791516A EA201791516A1 EA 201791516 A1 EA201791516 A1 EA 201791516A1 EA 201791516 A EA201791516 A EA 201791516A EA 201791516 A EA201791516 A EA 201791516A EA 201791516 A1 EA201791516 A1 EA 201791516A1
Authority
EA
Eurasian Patent Office
Prior art keywords
malignant tumors
methods
combined treatment
treatment
venethoclax
Prior art date
Application number
EA201791516A
Other languages
English (en)
Inventor
Паоло Джули А. Ди
Рэндалл Марк Джонс
Дэниел Б. Тумас
Original Assignee
Джилид Сайэнс, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=55398445&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201791516(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Джилид Сайэнс, Инк. filed Critical Джилид Сайэнс, Инк.
Publication of EA201791516A1 publication Critical patent/EA201791516A1/ru

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

В настоящей заявке предложены способы, которые относятся к терапевтической стратегии лечения злокачественных опухолей, включая гематологические злокачественные опухоли. В частности, способы включают введение энтосплетиниба и ингибитора Bcl-2, такого как венетоклакс, навитоклакс и ABT-737.
EA201791516A 2015-02-03 2016-01-29 Способы комбинированного лечения злокачественных опухолей EA201791516A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562111604P 2015-02-03 2015-02-03
PCT/US2016/015727 WO2016126552A1 (en) 2015-02-03 2016-01-29 Combination therapies for treating cancers

Publications (1)

Publication Number Publication Date
EA201791516A1 true EA201791516A1 (ru) 2018-01-31

Family

ID=55398445

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201791516A EA201791516A1 (ru) 2015-02-03 2016-01-29 Способы комбинированного лечения злокачественных опухолей

Country Status (25)

Country Link
US (2) US20160220573A1 (ru)
EP (1) EP3253385A1 (ru)
JP (1) JP2018503653A (ru)
KR (1) KR20170104616A (ru)
CN (1) CN107205992A (ru)
AU (1) AU2016215643A1 (ru)
BR (1) BR112017016019A2 (ru)
CA (1) CA2974828A1 (ru)
CL (1) CL2017001943A1 (ru)
CO (1) CO2017007662A2 (ru)
CR (1) CR20170352A (ru)
CU (1) CU20170099A7 (ru)
EA (1) EA201791516A1 (ru)
EC (1) ECSP17048849A (ru)
GT (1) GT201700167A (ru)
IL (1) IL253573A0 (ru)
MA (1) MA41449A (ru)
MD (1) MD20170073A2 (ru)
MX (1) MX2017009724A (ru)
PE (1) PE20171241A1 (ru)
PH (1) PH12017550063A1 (ru)
SG (1) SG11201706107SA (ru)
SV (1) SV2017005489A (ru)
TW (1) TW201639573A (ru)
WO (1) WO2016126552A1 (ru)

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TWI794171B (zh) 2016-05-11 2023-03-01 美商滬亞生物國際有限公司 Ｈｄａｃ抑制劑與ｐｄ-ｌ１抑制劑之組合治療
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Also Published As

Publication number Publication date
CL2017001943A1 (es) 2018-03-02
CN107205992A (zh) 2017-09-26
AU2016215643A1 (en) 2017-08-10
BR112017016019A2 (pt) 2018-03-20
CO2017007662A2 (es) 2017-10-20
US20160220573A1 (en) 2016-08-04
SG11201706107SA (en) 2017-08-30
GT201700167A (es) 2017-11-02
US20180117052A1 (en) 2018-05-03
CU20170099A7 (es) 2018-03-13
PH12017550063A1 (en) 2018-02-05
ECSP17048849A (es) 2017-10-31
CA2974828A1 (en) 2016-08-11
MX2017009724A (es) 2017-11-17
PE20171241A1 (es) 2017-08-24
WO2016126552A1 (en) 2016-08-11
MA41449A (fr) 2017-12-12
IL253573A0 (en) 2017-09-28
SV2017005489A (es) 2017-10-17
TW201639573A (zh) 2016-11-16
CR20170352A (es) 2017-09-29
MD20170073A2 (ru) 2018-02-28
EP3253385A1 (en) 2017-12-13
JP2018503653A (ja) 2018-02-08
KR20170104616A (ko) 2017-09-15

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