MA41449A - Polythérapies pour le traitement de cancers - Google Patents

Polythérapies pour le traitement de cancers

Info

Publication number
MA41449A
MA41449A MA041449A MA41449A MA41449A MA 41449 A MA41449 A MA 41449A MA 041449 A MA041449 A MA 041449A MA 41449 A MA41449 A MA 41449A MA 41449 A MA41449 A MA 41449A
Authority
MA
Morocco
Prior art keywords
polytherapies
cancers
treatment
Prior art date
Application number
MA041449A
Other languages
English (en)
Inventor
Paolo Julie A Di
Randall Mark Jones
Daniel B Tumas
Original Assignee
Gilead Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=55398445&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA41449(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc
Publication of MA41449A publication Critical patent/MA41449A/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
MA041449A 2015-02-03 2016-01-28 Polythérapies pour le traitement de cancers MA41449A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201562111604P 2015-02-03 2015-02-03

Publications (1)

Publication Number Publication Date
MA41449A true MA41449A (fr) 2017-12-12

Family

ID=55398445

Family Applications (1)

Application Number Title Priority Date Filing Date
MA041449A MA41449A (fr) 2015-02-03 2016-01-28 Polythérapies pour le traitement de cancers

Country Status (25)

Country Link
US (2) US20160220573A1 (fr)
EP (1) EP3253385A1 (fr)
JP (1) JP2018503653A (fr)
KR (1) KR20170104616A (fr)
CN (1) CN107205992A (fr)
AU (1) AU2016215643A1 (fr)
BR (1) BR112017016019A2 (fr)
CA (1) CA2974828A1 (fr)
CL (1) CL2017001943A1 (fr)
CO (1) CO2017007662A2 (fr)
CR (1) CR20170352A (fr)
CU (1) CU20170099A7 (fr)
EA (1) EA201791516A1 (fr)
EC (1) ECSP17048849A (fr)
GT (1) GT201700167A (fr)
IL (1) IL253573A0 (fr)
MA (1) MA41449A (fr)
MD (1) MD20170073A2 (fr)
MX (1) MX2017009724A (fr)
PE (1) PE20171241A1 (fr)
PH (1) PH12017550063A1 (fr)
SG (1) SG11201706107SA (fr)
SV (1) SV2017005489A (fr)
TW (1) TW201639573A (fr)
WO (1) WO2016126552A1 (fr)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102307581B (zh) 2008-12-08 2016-08-17 吉利德康涅狄格股份有限公司 咪唑并哌嗪syk抑制剂
ES2530449T3 (es) 2010-03-11 2015-03-02 Gilead Connecticut Inc Inhibidores de Syk de imidazopiridinas
PL3027618T3 (pl) 2013-07-30 2021-04-19 Kronos Bio, Inc. Polimorf inhibitorów syk
US9376441B2 (en) 2013-07-31 2016-06-28 Gilead Sciences, Inc. Substituted pyrrolidines as SYK inhibitors
CN105764516A (zh) 2013-12-04 2016-07-13 吉利德科学公司 治疗癌症的方法
UY35898A (es) 2013-12-23 2015-07-31 Gilead Sciences Inc ?compuestos inhibidores de syk y composiciones que los comprenden?.
KR20170029580A (ko) 2014-07-14 2017-03-15 길리애드 사이언시즈, 인코포레이티드 암을 치료하기 위한 조합물
TWI808055B (zh) 2016-05-11 2023-07-11 美商滬亞生物國際有限公司 Hdac 抑制劑與 pd-1 抑制劑之組合治療
TWI794171B (zh) 2016-05-11 2023-03-01 美商滬亞生物國際有限公司 Ｈｄａｃ抑制劑與ｐｄ-ｌ１抑制劑之組合治療
US10111882B2 (en) 2016-09-14 2018-10-30 Gilead Sciences, Inc. SYK inhibitors
WO2018049634A1 (fr) * 2016-09-14 2018-03-22 杭州领业医药科技有限公司 Sel d'addition abt-199 et sa forme cristalline, son procédé de préparation et composition pharmaceutique associée
WO2018200841A1 (fr) * 2017-04-28 2018-11-01 Actinium Pharmaceuticals, Inc. Méthode de traitement du cancer à l'aide d'un inhibiteur de bcl-2 en association avec une radioimmunothérapie à émission alpha
KR102399996B1 (ko) 2017-08-25 2022-05-20 길리애드 사이언시즈, 인코포레이티드 Syk 억제제의 다형체
AU2019207608B2 (en) 2018-01-10 2024-03-28 Recurium Ip Holdings, Llc Benzamide compounds
EP3927708A1 (fr) 2019-02-22 2021-12-29 Kronos Bio, Inc. Formes solides de pyrazines condensées en tant qu'inhibiteur de syk
SG11202113356XA (en) 2019-06-12 2021-12-30 Juno Therapeutics Inc Combination therapy of a cell-mediated cytotoxic therapy and an inhibitor of a prosurvival bcl2 family protein
WO2021110136A1 (fr) * 2019-12-04 2021-06-10 Ascentage Pharma (Suzhou) Co., Ltd. Association pharmaceutique et son utilisation
WO2022133030A1 (fr) 2020-12-16 2022-06-23 Juno Therapeutics, Inc. Polythérapie de thérapie cellulaire et d'inhibiteur de bcl2
EP4316494A1 (fr) * 2021-04-05 2024-02-07 Pinotbio, Inc. Polythérapie à basede 4'-thio-5-aza-2'-désoxycytidine et de vénétoclax
WO2023220655A1 (fr) 2022-05-11 2023-11-16 Celgene Corporation Méthodes pour surmonter la résistance aux médicaments par ré-sensibilisation de cellules cancéreuses à un traitement avec une thérapie antérieure par l'intermédiaire d'un traitement avec une thérapie par lymphocytes t

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4965288A (en) 1988-02-25 1990-10-23 Merrell Dow Pharmaceuticals Inc. Inhibitors of lysyl oxidase
US5252608A (en) 1988-02-25 1993-10-12 Merrell Dow Pharmaceuticals Inc. Inhibitors of lysyl oxidase
US4943593A (en) 1988-02-25 1990-07-24 Merrell Dow Pharmaceuticals Inc. Inhibitors of lysyl oxidase
US5021456A (en) 1988-02-25 1991-06-04 Merrell Dow Pharmaceuticals Inc. Inhibitors of lysyl oxidase
US5182297A (en) 1988-02-25 1993-01-26 Merrell Dow Pharmaceuticals Inc. Inhibitors of lysyl oxidase
US5059714A (en) 1988-02-25 1991-10-22 Merrell Dow Pharmaceuticals Inc. Inhibitors of lysyl oxidase
US5120764A (en) 1988-11-01 1992-06-09 Merrell Dow Pharmaceuticals Inc. Inhibitors of lysyl oxidase
US4997854A (en) 1989-08-25 1991-03-05 Trustees Of Boston University Anti-fibrotic agents and methods for inhibiting the activity of lysyl oxidase in-situ using adjacently positioned diamine analogue substrates
FR2828206B1 (fr) 2001-08-03 2004-09-24 Centre Nat Rech Scient Utilisation d'inhibiteurs des lysyl oxydases pour la culture cellulaire et le genie tissulaire
US7973161B2 (en) 2003-11-13 2011-07-05 Abbott Laboratories Apoptosis promoters
HUE030950T2 (en) 2004-05-13 2017-06-28 Icos Corp Quinazolinones as 3-kinase delta inhibitors of human phosphatidylinositol
US20090142345A1 (en) 2005-03-15 2009-06-04 Takeda Pharmaceutical Company Limited Prophylactic/therapeutic agent for cancer
PT1888550E (pt) 2005-05-12 2014-09-03 Abbvie Bahamas Ltd Promotores de apoptose
SI2185198T1 (sl) 2007-08-02 2015-04-30 Gilead Biologics, Inc. Inhibitorji LOX in LOXL2 ter njihova uporaba
WO2010019702A2 (fr) 2008-08-12 2010-02-18 Oncomed Pharmaceuticals, Inc. Agents de liaison à ddr1 et leurs méthodes d'utilisation
US8450321B2 (en) * 2008-12-08 2013-05-28 Gilead Connecticut, Inc. 6-(1H-indazol-6-yl)-N-[4-(morpholin-4-yl)phenyl]imidazo-[1,2-A]pyrazin-8-amine, or a pharmaceutically acceptable salt thereof, as a SYK inhibitor
RS55055B1 (sr) * 2008-12-08 2016-12-30 Gilead Connecticut Inc Imidazopirazin syk inhibitori
US8362013B2 (en) 2009-04-30 2013-01-29 Abbvie Inc. Salt of ABT-263 and solid-state forms thereof
US8546399B2 (en) 2009-05-26 2013-10-01 Abbvie Inc. Apoptosis inducing agents for the treatment of cancer and immune and autoimmune diseases
TWI598347B (zh) 2009-07-13 2017-09-11 基利科學股份有限公司 調節細胞凋亡信號之激酶的抑制劑
KR20120085781A (ko) 2009-09-20 2012-08-01 아보트 러보러터리즈 Ｂｃｌ-２ 단백질 관련 질환을 치료하는데 사용하기 위한 ａｂｔ-２６３ 결정 형태 및 용매화물
CA2789022A1 (fr) 2010-02-04 2011-08-11 Gilead Biologics, Inc. Anticorps qui se lient a loxl2 (lysyl oxydase-like 2) et procedes d'utilisation de ceux-ci
WO2011133668A2 (fr) * 2010-04-20 2011-10-27 President And Fellows Of Harvard College Méthodes et compositions utilisées pour le traitement du cancer
KR101930179B1 (ko) 2010-08-27 2018-12-17 길리아드 바이오로직스, 인크. 매트릭스 메탈로프로테이나제 ９에 대한 항체
JP6141188B2 (ja) 2010-11-23 2017-06-07 アッヴィ・インコーポレイテッド アポトーシス誘導剤の塩および結晶の形態
JP6101205B2 (ja) 2011-08-23 2017-03-22 中外製薬株式会社 抗腫瘍活性を有する新規な抗ｄｄｒ１抗体
GB201115529D0 (en) 2011-09-08 2011-10-26 Imp Innovations Ltd Antibodies, uses and methods
WO2013052699A2 (fr) 2011-10-04 2013-04-11 Gilead Calistoga Llc Nouveaux inhibiteurs de quinoxaline de la voie pi3k
UY34573A (es) 2012-01-27 2013-06-28 Gilead Sciences Inc Inhibidor de la quinasa que regula la señal de la apoptosis
WO2013116562A1 (fr) 2012-02-03 2013-08-08 Gilead Calistoga Llc Compositions et procédés de traitement d'une maladie avec (s)-4 amino-6-((1-(5-chloro-4-oxo-3-phényl-3,4-dihydroquinazoline-2-yl)éthyl)amino)pyrimidine-5-carbonitrile
EP2884980A1 (fr) * 2012-08-14 2015-06-24 Gilead Calistoga LLC Polythérapies pour le traitement du cancer
KR102158467B1 (ko) * 2012-09-07 2020-09-25 제넨테크, 인크. Ｉｉ형 항-ｃｄ20 항체와 선택적 ｂｃｌ-2 억제제와의 병용 치료요법
UY35044A (es) 2012-09-24 2014-04-30 Gilead Sciences Inc ANTICUERPOS ANTI-dDr1
CA2895782C (fr) 2012-12-21 2017-08-22 Gilead Calistoga Llc Pyrimidine aminoalkyl-quinazolones substituees en tant qu'inhibiteurs de phosphatidylinositol 3-kinase
JP6207100B2 (ja) 2012-12-21 2017-10-04 ギリアード カリストガ エルエルシー イソキノリノンまたはキナゾリノンホスファチジルイノシトール３−キナーゼ阻害剤
JP6030783B2 (ja) 2013-06-14 2016-11-24 ギリアード サイエンシーズ， インコーポレイテッド ホスファチジルイノシトール３−キナーゼ阻害剤
PL3027171T3 (pl) * 2013-07-30 2020-08-24 Gilead Connecticut, Inc. Formulacja inhibitorów syk
PL3027618T3 (pl) 2013-07-30 2021-04-19 Kronos Bio, Inc. Polimorf inhibitorów syk
EP2886146A1 (fr) * 2013-12-20 2015-06-24 Sanofi-Aventis Deutschland GmbH Dispositif de sécurité d'aiguille et dispositif d'administration de médicament

Also Published As

Publication number Publication date
CL2017001943A1 (es) 2018-03-02
CN107205992A (zh) 2017-09-26
AU2016215643A1 (en) 2017-08-10
BR112017016019A2 (pt) 2018-03-20
CO2017007662A2 (es) 2017-10-20
US20160220573A1 (en) 2016-08-04
SG11201706107SA (en) 2017-08-30
GT201700167A (es) 2017-11-02
US20180117052A1 (en) 2018-05-03
CU20170099A7 (es) 2018-03-13
PH12017550063A1 (en) 2018-02-05
ECSP17048849A (es) 2017-10-31
CA2974828A1 (fr) 2016-08-11
MX2017009724A (es) 2017-11-17
PE20171241A1 (es) 2017-08-24
WO2016126552A1 (fr) 2016-08-11
IL253573A0 (en) 2017-09-28
EA201791516A1 (ru) 2018-01-31
SV2017005489A (es) 2017-10-17
TW201639573A (zh) 2016-11-16
CR20170352A (es) 2017-09-29
MD20170073A2 (ro) 2018-02-28
EP3253385A1 (fr) 2017-12-13
JP2018503653A (ja) 2018-02-08
KR20170104616A (ko) 2017-09-15

Similar Documents

Publication Publication Date Title
MA49144A (fr) Polythérapies pour le traitement du cancer
MA41449A (fr) Polythérapies pour le traitement de cancers
MA47501A (fr) Dérivé de di-nucléotides cycliques pour le traitement du cancer
HK1251257A1 (zh) 用於醫治疾病的外泌體的用途
HK1247202A1 (zh) 用於治療癌症的化合物
MA43746A (fr) Dérivés de 2-cyanoisoindoline pour le traitement du cancer
MA47719A (fr) Esketamine pour le traitement de la dépression
MA43135A (fr) Compositions et méthodes pour le du traitement du cancer
MA45146A (fr) Dérivés de pyrazolopyridine pour le traitement du cancer
MA39748A (fr) Cenicriviroc pour le traitement de la fibrose
IL264674B1 (en) Antibodies to siglec7 for cancer treatment
MA50409A (fr) Polythérapies pour le traitement du cancer
MA43000A (fr) Polythérapie pour le traitement de tumeurs malignes
MA48637A (fr) Polythérapies pour le traitement du cancer
MA45429A (fr) Polythérapie pour le traitement du cancer
MA41555A (fr) Polythérapie pour le traitement du cancer
IL259996A (en) Combinations for cancer treatment
SI3122358T1 (sl) Kombinacije FGFR- in CMET-inhibitorjev za zdravljenje raka
MA42999A (fr) Polythérapie pour le traitement de malignités
MA41123A (fr) Polythérapie pour le traitement du cancer
MA47408A (fr) Traitement du cancer
HUE050567T2 (hu) Triciklusos heterociklusok rák kezelésére
GB201618424D0 (en) Treatment of antibody mediated disease
MA44378A (fr) Protéines de fusion immunogènes pour le traitement du cancer
MA46086A (fr) Schéma posologique pour le traitement de tumeurs solides