JP2016530314A5 - - Google Patents
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- Publication number
- JP2016530314A5 JP2016530314A5 JP2016542073A JP2016542073A JP2016530314A5 JP 2016530314 A5 JP2016530314 A5 JP 2016530314A5 JP 2016542073 A JP2016542073 A JP 2016542073A JP 2016542073 A JP2016542073 A JP 2016542073A JP 2016530314 A5 JP2016530314 A5 JP 2016530314A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- pharmaceutically acceptable
- acceptable salt
- optionally substituted
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361877151P | 2013-09-12 | 2013-09-12 | |
| US61/877,151 | 2013-09-12 | ||
| US201462011784P | 2014-06-13 | 2014-06-13 | |
| US62/011,784 | 2014-06-13 | ||
| US201462031673P | 2014-07-31 | 2014-07-31 | |
| US62/031,673 | 2014-07-31 | ||
| PCT/US2014/055012 WO2015038655A1 (en) | 2013-09-12 | 2014-09-10 | Aza-pyridone compounds and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016530314A JP2016530314A (ja) | 2016-09-29 |
| JP2016530314A5 true JP2016530314A5 (enExample) | 2017-10-26 |
| JP6448647B2 JP6448647B2 (ja) | 2019-01-09 |
Family
ID=52626171
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016542073A Expired - Fee Related JP6448647B2 (ja) | 2013-09-12 | 2014-09-10 | アザ−ピリドン化合物およびその用途 |
Country Status (18)
| Country | Link |
|---|---|
| US (5) | US9328119B2 (enExample) |
| EP (2) | EP3030566B1 (enExample) |
| JP (1) | JP6448647B2 (enExample) |
| KR (2) | KR102323515B1 (enExample) |
| CN (1) | CN105764904B (enExample) |
| AU (2) | AU2014318832B2 (enExample) |
| BR (1) | BR112016005270B1 (enExample) |
| CA (1) | CA2923075C (enExample) |
| CL (1) | CL2016000539A1 (enExample) |
| EA (1) | EA037949B1 (enExample) |
| ES (1) | ES2821394T3 (enExample) |
| IL (2) | IL244432B (enExample) |
| MX (2) | MX377396B (enExample) |
| PE (1) | PE20160661A1 (enExample) |
| PH (1) | PH12016500486A1 (enExample) |
| TW (1) | TWI652269B (enExample) |
| UA (1) | UA121199C2 (enExample) |
| WO (1) | WO2015038655A1 (enExample) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GEP20207129B (en) | 2009-06-17 | 2020-07-10 | Vertex Pharma | Inhibitors of influenza viruses replication |
| UA118010C2 (uk) | 2011-08-01 | 2018-11-12 | Вертекс Фармасьютікалз Інкорпорейтед | Інгібітори реплікації вірусів грипу |
| US9243022B2 (en) | 2012-12-21 | 2016-01-26 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
| AU2014318837B2 (en) | 2013-09-12 | 2019-05-30 | Janssen Biopharma, Inc. | Pyridazinone compounds and uses thereof |
| CN105764904B (zh) | 2013-09-12 | 2020-02-11 | 詹森生物制药有限公司 | 氮杂-吡啶酮化合物及其用途 |
| WO2016145103A1 (en) * | 2015-03-11 | 2016-09-15 | Alios Biopharma, Inc. | Aza-pyridone compounds and uses thereof |
| CN107709321A (zh) | 2015-04-28 | 2018-02-16 | 盐野义制药株式会社 | 经取代的多环性吡啶酮衍生物及其前药 |
| WO2016183120A1 (en) * | 2015-05-13 | 2016-11-17 | Vertex Pharmaceuticals Incorporated | Inhibitors of influenza viruses replication |
| EP3294717B1 (en) | 2015-05-13 | 2020-07-29 | Vertex Pharmaceuticals Inc. | Methods of preparing inhibitors of influenza viruses replication |
| US9988390B2 (en) | 2015-10-30 | 2018-06-05 | F. Hoffmann-La Roche Ag | Pyrimidone derivatives and their use in the treatment, amelioration or prevention of a viral disease |
| HK1254961A1 (en) | 2015-12-15 | 2019-08-02 | Shionogi & Co., Ltd. | Medicine for treating influenza characterized by comprising combination of cap-dependent endonuclease inhibitor with anti-influenza drug |
| ES2881776T3 (es) | 2016-03-08 | 2021-11-30 | Novartis Ag | Compuestos tricíclicos útiles para tratar las infecciones por ortomixovirus |
| WO2017156407A1 (en) * | 2016-03-10 | 2017-09-14 | Alios Biopharma, Inc. | Method of preparing aza-pyridone compounds |
| CN121974842A (zh) | 2016-05-10 | 2026-05-05 | C4医药公司 | 用于靶蛋白降解的胺连接的c3-戊二酰亚胺降解决定子体 |
| CN109562113A (zh) | 2016-05-10 | 2019-04-02 | C4医药公司 | 用于靶蛋白降解的螺环降解决定子体 |
| CN109562107A (zh) | 2016-05-10 | 2019-04-02 | C4医药公司 | 用于靶蛋白降解的杂环降解决定子体 |
| WO2017197046A1 (en) | 2016-05-10 | 2017-11-16 | C4 Therapeutics, Inc. | C3-carbon linked glutarimide degronimers for target protein degradation |
| WO2017223231A1 (en) | 2016-06-21 | 2017-12-28 | Alios Biopharma, Inc. | (s)-8-(benzhydryl )-6-isopropyl-3,5-dioxo- 5, 6,7,8,-tetrahydro-3h-pyrazino-[1,2-b]pyridazin-yl-isobutyrate antiviral agent for use in treating influenza |
| US10759814B2 (en) | 2016-08-10 | 2020-09-01 | Shionogi & Co., Ltd. | Pharmaceutical compositions containing substituted polycyclic pyridone derivatives and prodrug thereof |
| JOP20170169A1 (ar) * | 2016-08-29 | 2019-01-30 | Novartis Ag | مركبات بيريدازين ثلاثية الحلقة مندمجة تفيد في علاج العدوى بفيروس أورثوميكسو |
| EP4717317A3 (en) | 2017-06-20 | 2026-06-03 | C4 Therapeutics, Inc. | N/o-linked degrons and degronimers for protein degradation |
| CN111848615B (zh) * | 2018-01-17 | 2022-05-17 | 江西彩石医药科技有限公司 | 吡啶酮衍生物及包含其的抗流感病毒药物组合物 |
| HUE069183T2 (hu) * | 2018-02-28 | 2025-02-28 | Novartis Ag | 10-(di(fenil)metil)-4-hidroxi-8,9,9a,10-tetrahidro-7H--pirrolo[1',2':4,5]pirazino[1,2-b]piridazin-3,5-dion származékok és kapcsolódó vegyületek mint orthomyxovírus repikáció gátlók influenza kezelésére |
| EP3849978B1 (en) | 2018-09-10 | 2022-11-02 | Cocrystal Pharma, Inc. | Pyridopyrazine and pyridotriazine inhibitors of influenza virus replication |
| CN111909174B (zh) | 2019-05-08 | 2022-01-21 | 江西彩石医药科技有限公司 | 吡啶酮衍生物的晶型及制备方法和应用 |
| WO2021188949A1 (en) | 2020-03-20 | 2021-09-23 | Atux Iskay Llc | 3-diarylmethylenes and uses thereof |
| KR20230121063A (ko) | 2020-12-14 | 2023-08-17 | 더 스쿨 코포레이션 칸사이 유니버시티 | 전기 화학 디바이스용 전극 및 비수 전해질 이차전지 |
| CN117126044B (zh) * | 2023-04-12 | 2024-01-26 | 延边大学 | 一种微波辅助的甲基酮类化合物的合成方法 |
Family Cites Families (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AUPM354694A0 (en) * | 1994-01-27 | 1994-02-17 | Biota Scientific Management Pty Ltd | Chemical compounds |
| TW200510425A (en) | 2003-08-13 | 2005-03-16 | Japan Tobacco Inc | Nitrogen-containing fused ring compound and use thereof as HIV integrase inhibitor |
| CN100357284C (zh) * | 2003-09-11 | 2007-12-26 | 浙江海正药业股份有限公司 | 抗流感病毒化合物及其制备方法和用途 |
| AU2005221864A1 (en) | 2004-03-09 | 2005-09-22 | Istituto Di Ricerche Di Biologia Molecolare P Angeletti Spa | HIV integrase inhibitors |
| WO2005099699A1 (en) | 2004-04-07 | 2005-10-27 | Sepracor Inc. | Combination of (s)-amlodipine and a beta-blocker, and methods for reducing hypertension |
| JP4790703B2 (ja) | 2004-04-07 | 2011-10-12 | 武田薬品工業株式会社 | 環式化合物 |
| WO2006028963A2 (en) | 2004-09-03 | 2006-03-16 | Celgene Corporation | Substituted heterocyclic compounds and uses thereof |
| AR057623A1 (es) | 2005-11-28 | 2007-12-05 | Omega Bio Pharma H K Ltd | Materiales y metodos para el tratamiento de las infecciones virales |
| ZA200805191B (en) * | 2005-11-28 | 2009-08-26 | Hk Omega Biopharma Ltd | Materials and methods for treating viral infections with a cysteamine compound |
| FR2909090B1 (fr) | 2006-11-23 | 2009-01-09 | Sanofi Aventis Sa | Derives de 2,5-dihydro-3h-pyrazolo[4,3-c]pyridazin-3-one substitues,leur preparation et leur application en therapeutique. |
| AR064517A1 (es) | 2006-12-22 | 2009-04-08 | Avexa Ltd | Pirimidinionas biciclicas y sus usos |
| FR2921505B1 (fr) | 2007-09-25 | 2014-01-31 | Alstom Transport Sa | Dispositif de communication radioelectrique |
| JP2009096991A (ja) | 2007-09-27 | 2009-05-07 | Fujifilm Corp | 硬化性組成物、画像形成材料及び平版印刷版原版 |
| WO2009053799A1 (en) | 2007-10-24 | 2009-04-30 | Glenmark Pharmaceuticals, S.A. | Novel cannabinoid receptor ligands, pharmaceutical compositions containing them, and process for their preparation |
| JP5587790B2 (ja) | 2008-01-09 | 2014-09-10 | アミュラ セラピューティクス リミティド | 化合物 |
| UY32306A (es) | 2008-12-09 | 2010-07-30 | Gilead Sciences Inc | Derivados de pteridinona y pirimidinodiazepinona y composiciones farmacéuticas que modulan en forma selectiva los receptores tipo toll, métodos y usos |
| JP5683489B2 (ja) | 2009-01-12 | 2015-03-11 | アレイ バイオファーマ、インコーポレイテッド | ピペリジン含有化合物およびその用途 |
| BRPI1008498B8 (pt) | 2009-02-05 | 2021-05-25 | Takeda Pharmaceuticals Co | compostos de piridazinona úteis como inibidores da fosfodiesterase 10a, composição farmacêutica, e, uso de um composto |
| JP2012518640A (ja) | 2009-02-23 | 2012-08-16 | メルク・シャープ・エンド・ドーム・コーポレイション | ピラゾロ［４，３−ｃ］シンノリン−３−オンＭ１受容体陽性アロステリックモジュレーター |
| TW201038572A (en) | 2009-03-25 | 2010-11-01 | Gruenenthal Gmbh | Substituted spiro-amide compounds |
| TWI518084B (zh) * | 2009-03-26 | 2016-01-21 | 鹽野義製藥股份有限公司 | 哌喃酮與吡啶酮衍生物之製造方法 |
| US8835461B2 (en) | 2009-03-26 | 2014-09-16 | Shionogi & Co., Ltd. | Substituted 3-hydroxy-4-pyridone derivative |
| WO2010138419A2 (en) * | 2009-05-23 | 2010-12-02 | Obio Pharmaceutical (H.K.) Ltd. | Materials and methods for treating viral infections |
| JP5737691B2 (ja) * | 2009-06-15 | 2015-06-17 | 塩野義製薬株式会社 | 置換された多環性カルバモイルピリドン誘導体 |
| WO2011084371A1 (en) | 2009-12-21 | 2011-07-14 | Merck Sharp & Dohme Corp. | Aminobenzoquinazolinone m1 receptor positive allosteric modulators |
| CN102858771A (zh) * | 2010-02-26 | 2013-01-02 | 日本烟草产业株式会社 | 1,3,4,8-四氢-2H-吡啶并[1,2-a]吡嗪衍生物及其作为HIV整合酶抑制剂的用途 |
| WO2011120153A1 (en) | 2010-04-01 | 2011-10-06 | Critical Outcome Technologies Inc. | Compounds and method for treatment of hiv |
| EP2593107A1 (en) | 2010-07-12 | 2013-05-22 | Merck Sharp & Dohme Corp. | Tyrosine kinase inhibitors |
| LT2620436T (lt) | 2010-09-24 | 2018-08-10 | Shionogi & Co., Ltd. | Pakeistojo policiklinio karbamoilpiridono darinio provaistas |
| JP2014528410A (ja) | 2011-09-30 | 2014-10-27 | キネタ・インコーポレイテツド | 抗ウイルス化合物 |
| EA201591291A1 (ru) | 2013-01-08 | 2015-12-30 | Савира Фармасьютикалз Гмбх | Производные пиримидона и их применение в лечении, облегчении или профилактике вирусного заболевания |
| AU2014318837B2 (en) | 2013-09-12 | 2019-05-30 | Janssen Biopharma, Inc. | Pyridazinone compounds and uses thereof |
| CN105764904B (zh) | 2013-09-12 | 2020-02-11 | 詹森生物制药有限公司 | 氮杂-吡啶酮化合物及其用途 |
| CR20160557A (es) | 2014-05-29 | 2017-01-20 | Glaxosmithkline Ip Dev Ltd | Compuestos derivados de 1-(ciclopent-2-en-1-il)-3-(2-hidroxi-3-(arilsulfonil)fenil)urea como inhibidores cxcr2 |
| WO2016145103A1 (en) * | 2015-03-11 | 2016-09-15 | Alios Biopharma, Inc. | Aza-pyridone compounds and uses thereof |
| WO2017156407A1 (en) | 2016-03-10 | 2017-09-14 | Alios Biopharma, Inc. | Method of preparing aza-pyridone compounds |
| WO2017223231A1 (en) | 2016-06-21 | 2017-12-28 | Alios Biopharma, Inc. | (s)-8-(benzhydryl )-6-isopropyl-3,5-dioxo- 5, 6,7,8,-tetrahydro-3h-pyrazino-[1,2-b]pyridazin-yl-isobutyrate antiviral agent for use in treating influenza |
| JOP20170169A1 (ar) * | 2016-08-29 | 2019-01-30 | Novartis Ag | مركبات بيريدازين ثلاثية الحلقة مندمجة تفيد في علاج العدوى بفيروس أورثوميكسو |
-
2014
- 2014-09-10 CN CN201480061771.XA patent/CN105764904B/zh not_active Expired - Fee Related
- 2014-09-10 WO PCT/US2014/055012 patent/WO2015038655A1/en not_active Ceased
- 2014-09-10 CA CA2923075A patent/CA2923075C/en active Active
- 2014-09-10 AU AU2014318832A patent/AU2014318832B2/en not_active Ceased
- 2014-09-10 ES ES14844961T patent/ES2821394T3/es active Active
- 2014-09-10 BR BR112016005270-6A patent/BR112016005270B1/pt not_active IP Right Cessation
- 2014-09-10 KR KR1020167009194A patent/KR102323515B1/ko not_active Expired - Fee Related
- 2014-09-10 EA EA201690372A patent/EA037949B1/ru unknown
- 2014-09-10 MX MX2016003199A patent/MX377396B/es active IP Right Grant
- 2014-09-10 KR KR1020217035836A patent/KR102468319B1/ko active Active
- 2014-09-10 UA UAA201602294A patent/UA121199C2/uk unknown
- 2014-09-10 EP EP14844961.4A patent/EP3030566B1/en active Active
- 2014-09-10 PE PE2016000369A patent/PE20160661A1/es unknown
- 2014-09-10 JP JP2016542073A patent/JP6448647B2/ja not_active Expired - Fee Related
- 2014-09-10 EP EP20184298.6A patent/EP3778603A1/en not_active Withdrawn
- 2014-09-10 US US14/482,886 patent/US9328119B2/en active Active
- 2014-09-12 TW TW103131647A patent/TWI652269B/zh not_active IP Right Cessation
-
2016
- 2016-03-03 IL IL244432A patent/IL244432B/en active IP Right Grant
- 2016-03-09 CL CL2016000539A patent/CL2016000539A1/es unknown
- 2016-03-10 MX MX2020012132A patent/MX2020012132A/es unknown
- 2016-03-11 PH PH12016500486A patent/PH12016500486A1/en unknown
- 2016-04-28 US US15/141,387 patent/US10251882B2/en active Active
-
2019
- 2019-02-28 AU AU2019201403A patent/AU2019201403B2/en not_active Ceased
- 2019-03-01 US US16/290,690 patent/US10702523B2/en active Active
- 2019-08-09 US US16/537,396 patent/US10980805B2/en not_active Expired - Fee Related
-
2020
- 2020-04-30 IL IL274355A patent/IL274355B/en active IP Right Grant
-
2021
- 2021-02-25 US US17/185,750 patent/US20210186969A1/en not_active Abandoned
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