EA202092814A1 - Пиридоновое производное, его композиция и применение в качестве противовирусного лекарственного средства - Google Patents
Пиридоновое производное, его композиция и применение в качестве противовирусного лекарственного средстваInfo
- Publication number
- EA202092814A1 EA202092814A1 EA202092814A EA202092814A EA202092814A1 EA 202092814 A1 EA202092814 A1 EA 202092814A1 EA 202092814 A EA202092814 A EA 202092814A EA 202092814 A EA202092814 A EA 202092814A EA 202092814 A1 EA202092814 A1 EA 202092814A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- inhibitor
- influenza
- type
- influenza virus
- diseases
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/20—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
- C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
Abstract
Настоящее изобретение относится к области медицинской химии и касается нового пиридонового производного, имеющего формулу (I), или его стереоизомера, фармацевтически приемлемой соли, сольвата или кристаллической формы и его применения в приготовлении лекарственного средства для предотвращения или лечения таких заболеваний, как вирусная инфекция гриппа типа A и/или вирусная инфекция гриппа типа B, в особенности его применения в качестве ингибитора кэп-зависимой эндонуклеазы субъединицы PA для предотвращения или лечения таких заболеваний, как вирусная инфекция гриппа типа A и/или вирусная инфекция гриппа типа B. Соединения по настоящему изобретению имеют значительную активность в ингибировании эндонуклеазы вируса гриппа и ДНК вируса гриппа, могут применяться в отдельности или в комбинации с ингибитором нейраминидазы, нуклеозидным лекарственным средством, PB2 ингибитором, PB1 ингибитором, M2 ингибитором или другими противогриппозными лекарственными средствами, значительно сокращают время инфекции гриппа, снижают смертность и имеют прекрасные перспективы клинического применения.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201811517425.4A CN111303147A (zh) | 2018-12-12 | 2018-12-12 | 吡啶酮衍生物、其组合物及作为抗流感病毒药物的应用 |
PCT/CN2019/071902 WO2019141179A1 (zh) | 2018-01-17 | 2019-01-16 | 吡啶酮衍生物、其组合物及作为抗流感病毒药物的应用 |
Publications (1)
Publication Number | Publication Date |
---|---|
EA202092814A1 true EA202092814A1 (ru) | 2021-05-14 |
Family
ID=71148820
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA202092814A EA202092814A1 (ru) | 2018-12-12 | 2019-01-16 | Пиридоновое производное, его композиция и применение в качестве противовирусного лекарственного средства |
Country Status (2)
Country | Link |
---|---|
CN (1) | CN111303147A (ru) |
EA (1) | EA202092814A1 (ru) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112898346B (zh) * | 2020-01-23 | 2023-11-10 | 南京知和医药科技有限公司 | 水溶性多环化合物及其药物组合物和用途 |
CN113683613B (zh) * | 2020-09-08 | 2023-06-09 | 知和(山东)大药厂有限公司 | 一种多环吡啶肟基化合物及其药物组合物和用途 |
CN114315827A (zh) * | 2020-12-28 | 2022-04-12 | 维眸生物科技(上海)有限公司 | 多环吡啶并哒嗪酰胺并含肟碳环衍生物及其用途 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TR201810736T4 (tr) * | 2010-09-24 | 2018-08-27 | Shionogi & Co | Substitüe polisiklik karbamoil piridon derivatı ön-ilacı. |
JP5971830B1 (ja) * | 2015-04-28 | 2016-08-17 | 塩野義製薬株式会社 | 置換された多環性ピリドン誘導体およびそのプロドラッグ |
CN108697715A (zh) * | 2015-12-15 | 2018-10-23 | 盐野义制药株式会社 | 包含帽依赖性核酸内切酶抑制剂及抗流感药的组合的流感治疗用药物 |
WO2018030463A1 (ja) * | 2016-08-10 | 2018-02-15 | 塩野義製薬株式会社 | 置換された多環性ピリドン誘導体およびそのプロドラッグを含有する医薬組成物 |
CN110041327B (zh) * | 2018-01-17 | 2022-01-21 | 江西彩石医药科技有限公司 | 吡啶酮衍生物、其组合物及作为抗流感病毒药物的应用 |
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2018
- 2018-12-12 CN CN201811517425.4A patent/CN111303147A/zh active Pending
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2019
- 2019-01-16 EA EA202092814A patent/EA202092814A1/ru unknown
Also Published As
Publication number | Publication date |
---|---|
CN111303147A (zh) | 2020-06-19 |
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