JP2014530838A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2014530838A5 JP2014530838A5 JP2014536253A JP2014536253A JP2014530838A5 JP 2014530838 A5 JP2014530838 A5 JP 2014530838A5 JP 2014536253 A JP2014536253 A JP 2014536253A JP 2014536253 A JP2014536253 A JP 2014536253A JP 2014530838 A5 JP2014530838 A5 JP 2014530838A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- compound
- aryl
- cycloalkyl
- heterocyclyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims 14
- 150000001875 compounds Chemical class 0.000 claims 14
- 201000010099 disease Diseases 0.000 claims 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 6
- 230000003612 virological effect Effects 0.000 claims 6
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 239000003446 ligand Substances 0.000 claims 4
- 206010022000 influenza Diseases 0.000 claims 3
- 125000001424 substituent group Chemical group 0.000 claims 3
- 241000712892 Arenaviridae Species 0.000 claims 2
- 241000711573 Coronaviridae Species 0.000 claims 2
- 241000711950 Filoviridae Species 0.000 claims 2
- 241000710781 Flaviviridae Species 0.000 claims 2
- 241000700586 Herpesviridae Species 0.000 claims 2
- 241000712464 Orthomyxoviridae Species 0.000 claims 2
- 241000711504 Paramyxoviridae Species 0.000 claims 2
- 241000150350 Peribunyaviridae Species 0.000 claims 2
- 241000709664 Picornaviridae Species 0.000 claims 2
- 241000712907 Retroviridae Species 0.000 claims 2
- 241000711931 Rhabdoviridae Species 0.000 claims 2
- 241000710924 Togaviridae Species 0.000 claims 2
- 239000000654 additive Substances 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 229940077274 Alpha glucosidase inhibitor Drugs 0.000 claims 1
- 101800004538 Bradykinin Proteins 0.000 claims 1
- QXZGBUJJYSLZLT-UHFFFAOYSA-N H-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-OH Natural products NC(N)=NCCCC(N)C(=O)N1CCCC1C(=O)N1C(C(=O)NCC(=O)NC(CC=2C=CC=CC=2)C(=O)NC(CO)C(=O)N2C(CCC2)C(=O)NC(CC=2C=CC=CC=2)C(=O)NC(CCCN=C(N)N)C(O)=O)CCC1 QXZGBUJJYSLZLT-UHFFFAOYSA-N 0.000 claims 1
- 102100035792 Kininogen-1 Human genes 0.000 claims 1
- 239000000867 Lipoxygenase Inhibitor Substances 0.000 claims 1
- 229940123424 Neuraminidase inhibitor Drugs 0.000 claims 1
- 229940123066 Polymerase inhibitor Drugs 0.000 claims 1
- OFHCOWSQAMBJIW-AVJTYSNKSA-N alfacalcidol Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C OFHCOWSQAMBJIW-AVJTYSNKSA-N 0.000 claims 1
- 239000003888 alpha glucosidase inhibitor Substances 0.000 claims 1
- 239000003242 anti bacterial agent Substances 0.000 claims 1
- 229940121363 anti-inflammatory agent Drugs 0.000 claims 1
- 239000002260 anti-inflammatory agent Substances 0.000 claims 1
- 229940088710 antibiotic agent Drugs 0.000 claims 1
- QXZGBUJJYSLZLT-FDISYFBBSA-N bradykinin Chemical compound NC(=N)NCCC[C@H](N)C(=O)N1CCC[C@H]1C(=O)N1[C@H](C(=O)NCC(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CO)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)CCC1 QXZGBUJJYSLZLT-FDISYFBBSA-N 0.000 claims 1
- 229930003827 cannabinoid Natural products 0.000 claims 1
- 239000003557 cannabinoid Substances 0.000 claims 1
- 239000000969 carrier Substances 0.000 claims 1
- 229940125400 channel inhibitor Drugs 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 125000001072 heteroaryl group Chemical group 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 229940002612 prodrug Drugs 0.000 claims 1
- 239000000651 prodrug Substances 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000002911 sialidase inhibitor Substances 0.000 claims 1
- 239000012453 solvate Substances 0.000 claims 1
- 230000008685 targeting Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161550057P | 2011-10-21 | 2011-10-21 | |
| US61/550,057 | 2011-10-21 | ||
| PCT/EP2012/070760 WO2013057253A1 (en) | 2011-10-21 | 2012-10-19 | Pyrimidin-4-one derivatives and their use in the treatment, amelioration or prevention of a viral disease |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014530838A JP2014530838A (ja) | 2014-11-20 |
| JP2014530838A5 true JP2014530838A5 (enExample) | 2015-12-03 |
| JP6033873B2 JP6033873B2 (ja) | 2016-11-30 |
Family
ID=47189887
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014536253A Expired - Fee Related JP6033873B2 (ja) | 2011-10-21 | 2012-10-19 | ピリミジン−４−オン誘導体及びウイルス性疾患の治療、改善又は予防におけるその使用 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US20130102601A1 (enExample) |
| EP (1) | EP2794616B1 (enExample) |
| JP (1) | JP6033873B2 (enExample) |
| KR (1) | KR20140097197A (enExample) |
| CN (1) | CN103958521B (enExample) |
| BR (1) | BR112014008412A2 (enExample) |
| CA (1) | CA2852843A1 (enExample) |
| ES (1) | ES2589459T3 (enExample) |
| MX (1) | MX342176B (enExample) |
| RU (1) | RU2014120477A (enExample) |
| WO (1) | WO2013057253A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107074880A (zh) | 2014-07-07 | 2017-08-18 | 萨维拉制药有限公司 | 二氢吡啶并吡嗪‑1,8‑二酮和它们在治疗、改善或预防病毒疾病中的用途 |
| EP3186228A4 (en) * | 2014-08-28 | 2018-04-18 | X-Chem, Inc. | Soluble epoxide hydrolase inhibitors and uses thereof |
| WO2016133888A1 (en) * | 2015-02-16 | 2016-08-25 | Biota Pharmaceuticals, Inc. | Compounds for treating respiratory syncytial virus infections |
| HRP20241039T1 (hr) | 2015-04-28 | 2024-11-08 | Shionogi & Co., Ltd | Supstituirani derivat policikličkog piridona i njegov predlijek |
| US20170081331A1 (en) | 2015-09-18 | 2017-03-23 | F. Hoffmann-La Roche Ag | Pyrazolopyrazines and their use in the treatment, amelioration or prevention of a viral disease |
| SG10201911957QA (en) * | 2015-12-15 | 2020-02-27 | Shionogi & Co | Medicine for treating influenza characterized by comprising combination of cap-dependent endonuclease inhibitor with anti-influenza drug |
| CN109415345B (zh) | 2016-06-29 | 2022-01-11 | 豪夫迈·罗氏有限公司 | 基于哒嗪酮的广谱抗流感抑制剂 |
| UA125218C2 (uk) | 2016-08-10 | 2022-02-02 | Сіоногі Енд Ко., Лтд. | Фармацевтичні композиції, що містять заміщені поліциклічні піридонові похідні та їх проліки |
| US10392368B2 (en) | 2017-08-01 | 2019-08-27 | Theravance Biopharma R&D Ip, Llc | Pyrazolo and triazolo bicyclic compounds as JAK kinase inhibitors |
| CA3125039A1 (en) | 2019-01-23 | 2020-07-30 | Theravance Biopharma R&D Ip, Llc | Imidazo[1,5-a]pyridine, 1,2,4-triazolo[4,3-a]pyridine and imidazo[1,5-a]pyrazine as jak inhibitors |
| WO2021207530A1 (en) * | 2020-04-08 | 2021-10-14 | Remix Therapeutics Inc. | Compounds and methods for modulating splicing |
| WO2022194800A1 (en) * | 2021-03-17 | 2022-09-22 | F. Hoffmann-La Roche Ag | New thienopyrimidinone derivatives |
| US11932656B1 (en) | 2023-10-06 | 2024-03-19 | King Faisal University | Thieno[2,3-d]pyrimidines as COX-2 inhibitors |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5475109A (en) | 1994-10-17 | 1995-12-12 | Merck & Co., Inc. | Dioxobutanoic acid derivatives as inhibitors of influenza endonuclease |
| AU2003210388B2 (en) * | 2002-03-07 | 2007-05-17 | F. Hoffmann-La Roche Ag | Bicyclic pyridine and pyrimidine P38 Kinase inhibitors |
| EP1790638B1 (en) | 2004-09-15 | 2013-04-03 | Shionogi Co., Ltd. | Carbamoylpyridone derivative having hiv integrase inhibitory activity |
| US8354408B2 (en) * | 2007-11-15 | 2013-01-15 | Ym Biosciences Australia Pty Ltd | N-containing heterocyclic compounds |
| US8901132B2 (en) | 2009-03-13 | 2014-12-02 | Katholieke Universiteit Leuven, K.U. Leuven R&D | Thiazolopyrimidine modulators as immunosuppressive agents |
| US8835461B2 (en) | 2009-03-26 | 2014-09-16 | Shionogi & Co., Ltd. | Substituted 3-hydroxy-4-pyridone derivative |
| TWI518084B (zh) | 2009-03-26 | 2016-01-21 | 鹽野義製藥股份有限公司 | 哌喃酮與吡啶酮衍生物之製造方法 |
| WO2011000566A2 (en) | 2009-06-30 | 2011-01-06 | Savira Pharmaceuticals Gmbh | Compounds and pharmaceutical compositions for the treatment of negative-sense ssrna virus infections |
-
2012
- 2012-10-18 US US13/655,418 patent/US20130102601A1/en not_active Abandoned
- 2012-10-19 RU RU2014120477/04A patent/RU2014120477A/ru not_active Application Discontinuation
- 2012-10-19 MX MX2014003801A patent/MX342176B/es active IP Right Grant
- 2012-10-19 CA CA2852843A patent/CA2852843A1/en not_active Abandoned
- 2012-10-19 WO PCT/EP2012/070760 patent/WO2013057253A1/en not_active Ceased
- 2012-10-19 JP JP2014536253A patent/JP6033873B2/ja not_active Expired - Fee Related
- 2012-10-19 BR BR112014008412A patent/BR112014008412A2/pt not_active IP Right Cessation
- 2012-10-19 KR KR1020147013721A patent/KR20140097197A/ko not_active Withdrawn
- 2012-10-19 ES ES12787384.2T patent/ES2589459T3/es active Active
- 2012-10-19 CN CN201280051684.7A patent/CN103958521B/zh not_active Expired - Fee Related
- 2012-10-19 EP EP12787384.2A patent/EP2794616B1/en not_active Not-in-force
-
2016
- 2016-06-15 US US15/182,705 patent/US20160376286A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2014530838A5 (enExample) | ||
| JP2015517555A5 (enExample) | ||
| JP2016518305A5 (enExample) | ||
| JP2014530837A5 (enExample) | ||
| JP2015521189A5 (enExample) | ||
| RU2477723C2 (ru) | Ингибиторы протеинкиназ (варианты), их применение для лечения онкологических заболеваний и фармацевтическая композиция на их основе | |
| RU2014143250A (ru) | Производные 7-оксо-тиазолопиридин карбоновой кислоты и их применение при лечении, облегчении или профилактике вирусного заболевания | |
| RU2015107803A (ru) | Производные дигидроксипиримидинкарбоновой кислоты и их применение в лечении, облегчении или предотвращении вирусного заболевания | |
| RU2014120477A (ru) | Производные пиримидин-4-она и их применение в лечении, облегчении или профилактике вирусного заболевания | |
| RU2014120421A (ru) | Производные гетероарилгидроксамовой кислоты и их применение при лечении, облегчении течения или профилактике вирусных заболеваний | |
| JP2016530259A5 (enExample) | ||
| JP2016530314A5 (enExample) | ||
| JP2015524457A5 (enExample) | ||
| JP2016006118A5 (enExample) | ||
| EA201201031A1 (ru) | Ингибиторы вируса гепатита с | |
| ME02321B (me) | Antivirusna jedinjenja | |
| JP2016503797A5 (enExample) | ||
| HRP20181169T4 (hr) | Predlijekovi fumarata i njihova upotreba u liječenju različitih bolesti | |
| JP2016515560A5 (enExample) | ||
| JP2013537203A5 (enExample) | ||
| JP2015505296A5 (enExample) | ||
| JP2015537020A5 (enExample) | ||
| JP2013544860A5 (enExample) | ||
| JP2013512277A5 (enExample) | ||
| JP2014521625A5 (enExample) |