MX2022012676A - Compuestos y metodos para modular el empalme. - Google Patents

Compuestos y metodos para modular el empalme.

Info

Publication number
MX2022012676A
MX2022012676A MX2022012676A MX2022012676A MX2022012676A MX 2022012676 A MX2022012676 A MX 2022012676A MX 2022012676 A MX2022012676 A MX 2022012676A MX 2022012676 A MX2022012676 A MX 2022012676A MX 2022012676 A MX2022012676 A MX 2022012676A
Authority
MX
Mexico
Prior art keywords
methods
compounds
splicing
modulating splicing
modulating
Prior art date
Application number
MX2022012676A
Other languages
English (en)
Inventor
Peter Smith
Dominic Reynolds
Serge Leger
Michael W Seiler
Anant A Agrawal
Frederic Vaillancourt
Original Assignee
Remix Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Remix Therapeutics Inc filed Critical Remix Therapeutics Inc
Publication of MX2022012676A publication Critical patent/MX2022012676A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Replacement Of Web Rolls (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Saccharide Compounds (AREA)

Abstract

La presente divulgación presenta compuestos y composiciones relacionadas que, entre otras cosas, modulan el empalme de ácidos nucleicos, p. ej., el empalme de un pre-ARNm, así como métodos de uso de estos.
MX2022012676A 2020-04-08 2021-04-08 Compuestos y metodos para modular el empalme. MX2022012676A (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202063007327P 2020-04-08 2020-04-08
US202063043920P 2020-06-25 2020-06-25
US202063072873P 2020-08-31 2020-08-31
US202063126493P 2020-12-16 2020-12-16
PCT/US2021/026435 WO2021207530A1 (en) 2020-04-08 2021-04-08 Compounds and methods for modulating splicing

Publications (1)

Publication Number Publication Date
MX2022012676A true MX2022012676A (es) 2023-01-11

Family

ID=75747105

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2022012676A MX2022012676A (es) 2020-04-08 2021-04-08 Compuestos y metodos para modular el empalme.
MX2022012677A MX2022012677A (es) 2020-04-08 2021-04-08 Compuestos y metodos para modular el empalme.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2022012677A MX2022012677A (es) 2020-04-08 2021-04-08 Compuestos y metodos para modular el empalme.

Country Status (14)

Country Link
US (2) US20240279239A1 (es)
EP (2) EP4132936A1 (es)
JP (2) JP2023520924A (es)
KR (2) KR20230005210A (es)
CN (2) CN116134036A (es)
AU (2) AU2021253571A1 (es)
BR (2) BR112022020418A2 (es)
CA (2) CA3175205A1 (es)
CL (1) CL2022002779A1 (es)
CO (1) CO2022015926A2 (es)
CR (1) CR20220567A (es)
IL (1) IL297149A (es)
MX (2) MX2022012676A (es)
WO (2) WO2021207530A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019028440A1 (en) 2017-08-04 2019-02-07 Skyhawk Therapeutics, Inc. METHODS AND COMPOSITIONS FOR MODULATING SPLICING
TW202208358A (zh) 2020-05-13 2022-03-01 美商Ｃｈｄｉ基金會股份有限公司 用於治療亨汀頓舞蹈症之htt調節劑
JP2024510487A (ja) * 2021-03-17 2024-03-07 エフ． ホフマン－ラ ロシュ アーゲー 新規なチアジアゾロピリミドン誘導体
EP4308576A1 (en) * 2021-03-17 2024-01-24 F. Hoffmann-La Roche AG New thiazolopyrimidinone derivatives
TW202330552A (zh) * 2021-10-13 2023-08-01 美商雷密克斯醫療公司 調節剪接之化合物及方法
AU2022398247A1 (en) * 2021-11-24 2024-06-13 Remix Therapeutics Inc. Compounds and methods for modulating splicing
CN115112899B (zh) * 2022-06-15 2024-08-16 四川大学华西医院 检测羧肽酶a4的试剂和/或系统在制备恶性胸腔积液筛查产品中的用途

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US7745447B2 (en) * 2005-10-26 2010-06-29 Bristol-Myers Squibb Company Substituted thieno[3,2-D]pyrimidines as non-basic melanin concentrating hormone receptor-1 antagonists
US8173661B2 (en) * 2006-11-08 2012-05-08 The Rockefeller University Alpha-IIB-beta-3 inhibitors and uses thereof
WO2012009688A1 (en) * 2010-07-16 2012-01-19 Rockefeller University Organic compounds
EP2804610B1 (en) * 2012-01-16 2018-10-31 The Rockefeller University Organic compounds
WO2013119916A2 (en) 2012-02-10 2013-08-15 Ptc Therapeutics, Inc. Compounds for treating spinal muscular atrophy
US8729263B2 (en) 2012-08-13 2014-05-20 Novartis Ag 1,4-disubstituted pyridazine analogs there of and methods for treating SMN-deficiency-related conditions
CA2946702C (en) * 2014-04-23 2022-06-28 Mitsubishi Tanabe Pharma Corporation Bicyclic or tricyclic heterocyclic compound
EP3256126B1 (en) 2015-02-09 2024-03-27 F. Hoffmann-La Roche AG Compounds for the treatment of cancer
EP4249472A3 (en) 2015-05-30 2023-12-13 PTC Therapeutics, Inc. Methods for modulating rna splicing
ES2879995T3 (es) 2015-12-10 2021-11-23 Ptc Therapeutics Inc Métodos para el tratamiento de la enfermedad de Huntington
JP2019529452A (ja) * 2016-09-23 2019-10-17 バイエル・アクチエンゲゼルシヤフト Ｎ３−環状置換チエノウラシルおよびその使用
CN110352007A (zh) 2016-11-28 2019-10-18 Ptc医疗公司 用于调节rna剪接的方法
BR112019026508A2 (pt) 2017-06-14 2020-07-14 Ptc Therapeutics, Inc. métodos para modificar o splicing do rna
EP4331679A3 (en) * 2017-06-21 2024-04-03 Shy Therapeutics LLC Compounds that interact with the ras superfamily for the treatment of cancers, inflammatory diseases, rasopathies, and fibrotic disease
WO2019028440A1 (en) 2017-08-04 2019-02-07 Skyhawk Therapeutics, Inc. METHODS AND COMPOSITIONS FOR MODULATING SPLICING
WO2019060917A2 (en) 2017-09-25 2019-03-28 Skyhawk Therapeutics, Inc. METHODS AND COMPOSITIONS FOR SCREENING AND IDENTIFYING SPREADING MODULATORS
KR20200142039A (ko) 2018-04-10 2020-12-21 스카이호크 테라퓨틱스, 인코포레이티드 암 치료용 화합물
CR20210050A (es) * 2018-06-27 2021-06-10 Reborna Biosciences Inc Agente profiláctico o terapéutico para atrofia muscular espinal
EP4308576A1 (en) * 2021-03-17 2024-01-24 F. Hoffmann-La Roche AG New thiazolopyrimidinone derivatives
JP2024510487A (ja) * 2021-03-17 2024-03-07 エフ． ホフマン－ラ ロシュ アーゲー 新規なチアジアゾロピリミドン誘導体

Also Published As

Publication number Publication date
AU2021253571A1 (en) 2022-11-10
JP2023520924A (ja) 2023-05-22
AU2021251220A1 (en) 2022-11-03
WO2021207530A1 (en) 2021-10-14
EP4132935A1 (en) 2023-02-15
CA3175205A1 (en) 2021-10-14
MX2022012677A (es) 2023-01-11
CN116134036A (zh) 2023-05-16
WO2021207550A1 (en) 2021-10-14
BR112022020418A2 (pt) 2023-05-02
CA3175193A1 (en) 2021-10-14
EP4132936A1 (en) 2023-02-15
IL297149A (en) 2022-12-01
KR20230005210A (ko) 2023-01-09
CL2022002779A1 (es) 2023-04-28
WO2021207530A8 (en) 2021-12-02
US20240287097A1 (en) 2024-08-29
CN116096725A (zh) 2023-05-09
CR20220567A (es) 2023-01-13
CO2022015926A2 (es) 2022-11-29
BR112022020337A2 (pt) 2022-12-13
US20240279239A1 (en) 2024-08-22
JP2023520925A (ja) 2023-05-22
KR20230004575A (ko) 2023-01-06

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