JP2015521189A5 - - Google Patents
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- JP2015521189A5 JP2015521189A5 JP2015513183A JP2015513183A JP2015521189A5 JP 2015521189 A5 JP2015521189 A5 JP 2015521189A5 JP 2015513183 A JP2015513183 A JP 2015513183A JP 2015513183 A JP2015513183 A JP 2015513183A JP 2015521189 A5 JP2015521189 A5 JP 2015521189A5
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- JP
- Japan
- Prior art keywords
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- alkyl
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- cycloalkyl
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261650725P | 2012-05-23 | 2012-05-23 | |
| US61/650,725 | 2012-05-23 | ||
| PCT/EP2013/060634 WO2013174931A1 (en) | 2012-05-23 | 2013-05-23 | 7-oxo-4,7 -dihydro- pyrazolo [1, 5 -a] pyrimidine derivatives which are useful in the treatment, amelioration or prevention of a viral disease |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015521189A JP2015521189A (ja) | 2015-07-27 |
| JP2015521189A5 true JP2015521189A5 (enExample) | 2016-07-14 |
Family
ID=48669866
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015513183A Pending JP2015521189A (ja) | 2012-05-23 | 2013-05-23 | ウイルス性疾患の治療、改善又は予防に有用な７−オキソ−４，７−ジヒドロ−ピラゾロ［１，５−ａ］ピリミジン誘導体 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US20130317021A1 (enExample) |
| EP (1) | EP2861232A1 (enExample) |
| JP (1) | JP2015521189A (enExample) |
| KR (1) | KR20150014506A (enExample) |
| CN (1) | CN104507481B (enExample) |
| BR (1) | BR112014029006A2 (enExample) |
| CA (1) | CA2874253A1 (enExample) |
| HK (1) | HK1204987A1 (enExample) |
| MX (1) | MX2014014109A (enExample) |
| RU (1) | RU2014146778A (enExample) |
| WO (1) | WO2013174931A1 (enExample) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2723746A1 (en) | 2011-06-22 | 2014-04-30 | Vertex Pharmaceuticals Inc. | Compounds useful as inhibitors of atr kinase |
| CN104334563B (zh) * | 2012-05-23 | 2017-03-08 | 萨维拉制药有限公司 | 7‑氧代‑噻唑并吡啶碳酸衍生物和它们在治疗、改善或预防病毒疾病中的用途 |
| LT3486245T (lt) | 2012-12-07 | 2021-08-25 | Vertex Pharmaceuticals Incorporated | 2-amino-n-(piperidin-1-il-piridin-3-il)pirazolo[1,5alfa]pirimidin-3-karboksamidas, kaip atr kinazės inhibitorius |
| US20140275092A1 (en) | 2013-03-13 | 2014-09-18 | Constellation Pharmaceuticals, Inc. | Pyrazolo compounds and uses thereof |
| JP2016512815A (ja) | 2013-03-15 | 2016-05-09 | バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ | Ａｔｒキナーゼの阻害剤として有用な縮合ピラゾロピリミジン誘導体 |
| WO2014143241A1 (en) | 2013-03-15 | 2014-09-18 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of atr kinase |
| EP2970288A1 (en) | 2013-03-15 | 2016-01-20 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of atr kinase |
| CA2932757C (en) | 2013-12-06 | 2023-10-31 | Vertex Pharmaceuticals Incorporated | 2-amino-6-fluoro-n-[5-fluoro-pyridin-3-yl]pyrazolo[1,5-a]pyrimidin-3-carboxamide compound useful as atr kinase inhibitor, its preparation, different solid forms and radiolabelled derivatives thereof |
| AU2015271030B2 (en) | 2014-06-05 | 2019-05-16 | Vertex Pharmaceuticals Incorporated | Radiolabelled derivatives of a 2-amino-6-fluoro-n-[5-fluoro-pyridin-3-yl]- pyrazolo [1,5-a] pyrimidin-3-carboxamide compound useful as ATR kinase inhibitor, the preparation of said compound and different solid forms thereof |
| LT3157566T (lt) | 2014-06-17 | 2019-08-12 | Vertex Pharmaceuticals Incorporated | Vėžio gydymo būdas, panaudojant chk1 ir atr inhibitorių derinį |
| KR20170024087A (ko) | 2014-07-01 | 2017-03-06 | 렘펙스 파머수티클스 인코퍼레이티드 | 보론산 유도체 및 그의 치료적 용도 |
| EP3166951A1 (en) | 2014-07-07 | 2017-05-17 | Savira Pharmaceuticals GmbH | Dihydropyridopyrazine-1,8-diones and their use in the treatment, amelioration or prevention of viral diseases |
| CN112876473A (zh) | 2015-04-28 | 2021-06-01 | 盐野义制药株式会社 | 经取代的多环性吡啶酮衍生物及其前药 |
| US20170081331A1 (en) * | 2015-09-18 | 2017-03-23 | F. Hoffmann-La Roche Ag | Pyrazolopyrazines and their use in the treatment, amelioration or prevention of a viral disease |
| WO2017059357A1 (en) | 2015-09-30 | 2017-04-06 | Vertex Pharmaceuticals Incorporated | Method for treating cancer using a combination of dna damaging agents and atr inhibitors |
| KR102084109B1 (ko) | 2015-12-15 | 2020-03-03 | 시오노기세야쿠 가부시키가이샤 | 캡 의존적 엔도뉴클레아제 저해제 및 항인플루엔자 약을 조합하는 것을 특징으로 하는 인플루엔자 치료용 의약 |
| JP6957535B2 (ja) | 2016-06-29 | 2021-11-02 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | ピリダジノンベースの広域スペクトル抗インフルエンザ阻害剤 |
| MX390287B (es) | 2016-08-10 | 2025-03-20 | Shionogi & Co | Composiciones farmacéuticas que contienen derivados de piridona policíclicos sustituidos y profármacos de los mismos. |
| WO2018071282A1 (en) * | 2016-10-12 | 2018-04-19 | Merck Sharp & Dohme Corp. | Kdm5 inhibitors |
| US10975084B2 (en) | 2016-10-12 | 2021-04-13 | Merck Sharp & Dohme Corp. | KDM5 inhibitors |
| TW201920185A (zh) | 2017-09-15 | 2019-06-01 | 美商艾杜諾生物科技公司 | 吡唑并嘧啶酮化合物及其用途 |
| CN111670189A (zh) * | 2018-01-31 | 2020-09-15 | 爱尔兰詹森科学公司 | 对rsv具有活性的环烷基取代的吡唑并嘧啶 |
| CN113620977B (zh) * | 2021-08-24 | 2024-02-02 | 江苏弘和药物研发有限公司 | 一种噻唑烷并嘧啶酮乙酸的合成方法 |
| CN117304133A (zh) * | 2023-09-26 | 2023-12-29 | 华南农业大学 | 一种具有噻唑侧链的截短侧耳素衍生物及其制备方法和应用 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5475109A (en) | 1994-10-17 | 1995-12-12 | Merck & Co., Inc. | Dioxobutanoic acid derivatives as inhibitors of influenza endonuclease |
| US6559145B2 (en) * | 2000-07-12 | 2003-05-06 | Pharmacia & Upjohn Company | Heterocycle carboxamides as antiviral agents |
| ATE389656T1 (de) * | 2002-06-04 | 2008-04-15 | Neogenesis Pharmaceuticals Inc | Pyrazolo(1,5-a)pyrimidin-verbindungen als antivirale agentien |
| JP4953297B2 (ja) | 2004-09-15 | 2012-06-13 | 塩野義製薬株式会社 | Ｈｉｖインテグラーゼ阻害活性を有するカルバモイルピリドン誘導体 |
| AR057023A1 (es) | 2005-05-16 | 2007-11-14 | Gilead Sciences Inc | Compuestos heterociclicos con propiedades inhibidoras de hiv-integrasa |
| US20110112086A1 (en) * | 2006-06-08 | 2011-05-12 | Cylene Pharmaceuticals, Inc. | Pyridinone analogs |
| TWI518084B (zh) | 2009-03-26 | 2016-01-21 | 鹽野義製藥股份有限公司 | 哌喃酮與吡啶酮衍生物之製造方法 |
| EP2412708A4 (en) | 2009-03-26 | 2014-07-23 | Shionogi & Co | SUBSTITUTED 3-HYDROXY-4-PYRIDONE DERIVATIVE |
| WO2011000566A2 (en) | 2009-06-30 | 2011-01-06 | Savira Pharmaceuticals Gmbh | Compounds and pharmaceutical compositions for the treatment of negative-sense ssrna virus infections |
| CN101671336B (zh) * | 2009-09-23 | 2013-11-13 | 辽宁利锋科技开发有限公司 | 芳杂环并嘧啶衍生物和类似物及其制备方法和用途 |
| CN104334563B (zh) * | 2012-05-23 | 2017-03-08 | 萨维拉制药有限公司 | 7‑氧代‑噻唑并吡啶碳酸衍生物和它们在治疗、改善或预防病毒疾病中的用途 |
-
2013
- 2013-05-23 CN CN201380025121.5A patent/CN104507481B/zh not_active Expired - Fee Related
- 2013-05-23 HK HK15105893.0A patent/HK1204987A1/xx unknown
- 2013-05-23 WO PCT/EP2013/060634 patent/WO2013174931A1/en not_active Ceased
- 2013-05-23 RU RU2014146778A patent/RU2014146778A/ru not_active Application Discontinuation
- 2013-05-23 EP EP13730131.3A patent/EP2861232A1/en not_active Withdrawn
- 2013-05-23 US US13/900,940 patent/US20130317021A1/en not_active Abandoned
- 2013-05-23 JP JP2015513183A patent/JP2015521189A/ja active Pending
- 2013-05-23 CA CA2874253A patent/CA2874253A1/en not_active Abandoned
- 2013-05-23 KR KR1020147035547A patent/KR20150014506A/ko not_active Withdrawn
- 2013-05-23 MX MX2014014109A patent/MX2014014109A/es unknown
- 2013-05-23 BR BR112014029006A patent/BR112014029006A2/pt not_active IP Right Cessation
-
2016
- 2016-06-24 US US15/191,865 patent/US20160367557A1/en not_active Abandoned
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