|
CH445129A
(fr)
|
1964-04-29 |
1967-10-15 |
Nestle Sa |
Procédé pour la préparation de composés d'inclusion à poids moléculaire élevé
|
|
US3459731A
(en)
|
1966-12-16 |
1969-08-05 |
Corn Products Co |
Cyclodextrin polyethers and their production
|
|
US3453257A
(en)
|
1967-02-13 |
1969-07-01 |
Corn Products Co |
Cyclodextrin with cationic properties
|
|
US3426011A
(en)
|
1967-02-13 |
1969-02-04 |
Corn Products Co |
Cyclodextrins with anionic properties
|
|
US3453259A
(en)
|
1967-03-22 |
1969-07-01 |
Corn Products Co |
Cyclodextrin polyol ethers and their oxidation products
|
|
US4235871A
(en)
|
1978-02-24 |
1980-11-25 |
Papahadjopoulos Demetrios P |
Method of encapsulating biologically active materials in lipid vesicles
|
|
US5521063A
(en)
|
1985-03-15 |
1996-05-28 |
Antivirals Inc. |
Polynucleotide reagent containing chiral subunits and methods of use
|
|
JP2528107B2
(ja)
|
1985-03-15 |
1996-08-28 |
サマ−トン，ジエ−ムス |
ポリヌクレオチド測定試薬と方法
|
|
US5217866A
(en)
|
1985-03-15 |
1993-06-08 |
Anti-Gene Development Group |
Polynucleotide assay reagent and method
|
|
US5506337A
(en)
|
1985-03-15 |
1996-04-09 |
Antivirals Inc. |
Morpholino-subunit combinatorial library and method
|
|
US5034506A
(en)
|
1985-03-15 |
1991-07-23 |
Anti-Gene Development Group |
Uncharged morpholino-based polymers having achiral intersubunit linkages
|
|
US5166315A
(en)
|
1989-12-20 |
1992-11-24 |
Anti-Gene Development Group |
Sequence-specific binding polymers for duplex nucleic acids
|
|
US4737323A
(en)
|
1986-02-13 |
1988-04-12 |
Liposome Technology, Inc. |
Liposome extrusion method
|
|
KR0166088B1
(ko)
|
1990-01-23 |
1999-01-15 |
. |
수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도
|
|
US5719262A
(en)
|
1993-11-22 |
1998-02-17 |
Buchardt, Deceased; Ole |
Peptide nucleic acids having amino acid side chains
|
|
US5539082A
(en)
|
1993-04-26 |
1996-07-23 |
Nielsen; Peter E. |
Peptide nucleic acids
|
|
US5714331A
(en)
|
1991-05-24 |
1998-02-03 |
Buchardt, Deceased; Ole |
Peptide nucleic acids having enhanced binding affinity, sequence specificity and solubility
|
|
JPH07509133A
(ja)
|
1992-07-17 |
1995-10-12 |
リボザイム・ファーマシューティカルズ・インコーポレイテッド |
動物疾患の処置のための方法および剤
|
|
ATE368107T1
(de)
|
1993-05-11 |
2007-08-15 |
Univ North Carolina |
Antisense oligonukleotide die anomales splicing verhindern und deren verwendung
|
|
US5885613A
(en)
|
1994-09-30 |
1999-03-23 |
The University Of British Columbia |
Bilayer stabilizing components and their use in forming programmable fusogenic liposomes
|
|
US5753613A
(en)
|
1994-09-30 |
1998-05-19 |
Inex Pharmaceuticals Corporation |
Compositions for the introduction of polyanionic materials into cells
|
|
US5820873A
(en)
|
1994-09-30 |
1998-10-13 |
The University Of British Columbia |
Polyethylene glycol modified ceramide lipids and liposome uses thereof
|
|
IL115849A0
(en)
|
1994-11-03 |
1996-01-31 |
Merz & Co Gmbh & Co |
Tangential filtration preparation of liposomal drugs and liposome product thereof
|
|
US7572582B2
(en)
|
1997-09-12 |
2009-08-11 |
Exiqon A/S |
Oligonucleotide analogues
|
|
US6794499B2
(en)
|
1997-09-12 |
2004-09-21 |
Exiqon A/S |
Oligonucleotide analogues
|
|
WO1999042091A2
(en)
|
1998-02-19 |
1999-08-26 |
Massachusetts Institute Of Technology |
Use of polycations as endosomolytic agents
|
|
US6683173B2
(en)
|
1998-04-03 |
2004-01-27 |
Epoch Biosciences, Inc. |
Tm leveling methods
|
|
US6210892B1
(en)
|
1998-10-07 |
2001-04-03 |
Isis Pharmaceuticals, Inc. |
Alteration of cellular behavior by antisense modulation of mRNA processing
|
|
JP2000125448A
(ja)
|
1998-10-14 |
2000-04-28 |
Yazaki Corp |
電気接続箱
|
|
JP2000256547A
(ja)
|
1999-03-10 |
2000-09-19 |
Sumitomo Dow Ltd |
耐熱性プラスチックカード用樹脂組成物
|
|
US7084125B2
(en)
|
1999-03-18 |
2006-08-01 |
Exiqon A/S |
Xylo-LNA analogues
|
|
ATE356824T1
(de)
|
1999-05-04 |
2007-04-15 |
Santaris Pharma As |
L-ribo-lna analoge
|
|
JP2000325085A
(ja)
|
1999-05-21 |
2000-11-28 |
Masafumi Matsuo |
デュシェンヌ型筋ジストロフィー治療剤
|
|
US7070807B2
(en)
|
1999-12-29 |
2006-07-04 |
Mixson A James |
Branched histidine copolymers and methods for using same
|
|
CA2394758A1
(en)
|
1999-12-29 |
2001-07-05 |
A. James Mixson |
Histidine-containing copolymers enhance pharmaceutical agent delivery
|
|
US6653467B1
(en)
|
2000-04-26 |
2003-11-25 |
Jcr Pharmaceutical Co., Ltd. |
Medicament for treatment of Duchenne muscular dystrophy
|
|
US6727355B2
(en)
|
2000-08-25 |
2004-04-27 |
Jcr Pharmaceuticals Co., Ltd. |
Pharmaceutical composition for treatment of Duchenne muscular dystrophy
|
|
EP1191097A1
(en)
|
2000-09-21 |
2002-03-27 |
Leids Universitair Medisch Centrum |
Induction of exon skipping in eukaryotic cells
|
|
US7060809B2
(en)
|
2001-09-04 |
2006-06-13 |
Exiqon A/S |
LNA compositions and uses thereof
|
|
KR100464261B1
(ko)
|
2002-01-24 |
2005-01-03 |
주식회사 파나진 |
Ｐｎａ 올리고머를 합성하기 위한 신규한 단량체 및 그의제조방법
|
|
KR20030084444A
(ko)
|
2002-04-26 |
2003-11-01 |
주식회사 파나진 |
Ｐｎａ 올리고머를 합성하기 위한 신규한 단량체 및 그의제조방법
|
|
US7569575B2
(en)
|
2002-05-08 |
2009-08-04 |
Santaris Pharma A/S |
Synthesis of locked nucleic acid derivatives
|
|
AU2003291682A1
(en)
|
2002-11-05 |
2004-06-03 |
Isis Pharmaceuticals, Inc. |
2'-methoxy substituted oligomeric compounds and compositions for use in gene modulations
|
|
EP2530155B1
(en)
|
2002-11-25 |
2016-03-16 |
Masafumi Matsuo |
ENA nucleic acid drugs modifying splicing in mRNA precursor
|
|
AU2003225410A1
(en)
|
2003-03-21 |
2004-10-11 |
Academisch Ziekenhuis Leiden |
Modulation of exon recognition in pre-mrna by interfering with the secondary rna structure
|
|
US7211668B2
(en)
|
2003-07-28 |
2007-05-01 |
Panagene, Inc. |
PNA monomer and precursor
|
|
ES2627917T3
(es)
|
2004-06-28 |
2017-08-01 |
The University Of Western Australia |
Oligonucleótidos no codificantes para la inducción de la omisión exónica y métodos de uso de los mismos
|
|
US20090312532A1
(en)
|
2005-04-22 |
2009-12-17 |
Van Deutekom Judith Christina |
Modulation of exon recognition in pre-mrna by interfering with the binding of sr proteins and by interfering with secodary rna structure
|
|
US8067571B2
(en)
|
2005-07-13 |
2011-11-29 |
Avi Biopharma, Inc. |
Antibacterial antisense oligonucleotide and method
|
|
WO2007058894A2
(en)
|
2005-11-10 |
2007-05-24 |
The University Of North Carolina At Chapel Hill |
Splice switching oligomers for tnf superfamily receptors and their use in treatment of disease
|
|
US20090173556A1
(en)
|
2006-05-17 |
2009-07-09 |
Svetlana Anatolevna Sokolova |
Transport Means
|
|
CA2691673A1
(en)
|
2007-06-29 |
2009-01-08 |
Avi Biopharma, Inc. |
Tissue specific peptide conjugates and methods
|
|
US20100016215A1
(en)
|
2007-06-29 |
2010-01-21 |
Avi Biopharma, Inc. |
Compound and method for treating myotonic dystrophy
|
|
JP2010533170A
(ja)
|
2007-07-12 |
2010-10-21 |
プロセンサ テクノロジーズ ビー．ブイ． |
化合物を種々の選択された臓器、組織又は腫瘍細胞に標的化するための分子
|
|
NZ584793A
(en)
|
2007-10-26 |
2012-05-25 |
Academisch Ziekenhuis Leiden |
Means and methods for counteracting muscle disorders
|
|
US8076476B2
(en)
|
2007-11-15 |
2011-12-13 |
Avi Biopharma, Inc. |
Synthesis of morpholino oligomers using doubly protected guanine morpholino subunits
|
|
US8299206B2
(en)
|
2007-11-15 |
2012-10-30 |
Avi Biopharma, Inc. |
Method of synthesis of morpholino oligomers
|
|
MX2010004955A
(es)
|
2007-11-15 |
2010-06-30 |
Avi Biopharma Inc |
Metodo de sintesis de oligomeros de morfolina.
|
|
WO2009127230A1
(en)
|
2008-04-16 |
2009-10-22 |
Curevac Gmbh |
MODIFIED (m)RNA FOR SUPPRESSING OR AVOIDING AN IMMUNOSTIMULATORY RESPONSE AND IMMUNOSUPPRESSIVE COMPOSITION
|
|
EP2119783A1
(en)
|
2008-05-14 |
2009-11-18 |
Prosensa Technologies B.V. |
Method for efficient exon (44) skipping in Duchenne Muscular Dystrophy and associated means
|
|
US8084601B2
(en)
|
2008-09-11 |
2011-12-27 |
Royal Holloway And Bedford New College Royal Holloway, University Of London |
Oligomers
|
|
EP3133160B1
(en)
|
2008-10-24 |
2018-12-12 |
Sarepta Therapeutics, Inc. |
Exon skipping compositions for dmd
|
|
SI2607484T1
(sl)
|
2008-10-27 |
2016-11-30 |
Biomarin Technologies B.V. |
Metode in sredstva za učinkovito preskakovanje eksona 45 v pre-mRNA Duchennove mišične distrofije
|
|
BRPI0923225A2
(pt)
|
2008-12-02 |
2016-10-04 |
Chiralgen Ltd |
metodo para sintese de acidos nucleicos modificados no atomo de fosforo
|
|
CA2758189C
(en)
|
2009-04-10 |
2020-12-29 |
Association Institut De Myologie |
Tricyclo-dna antisense oligonucleotides, compositions, and methods for the treatment of disease
|
|
CN102459595A
(zh)
|
2009-04-24 |
2012-05-16 |
普罗森那技术公司 |
用于治疗dmd的包含肌苷的寡核苷酸
|
|
EP2451461A4
(en)
|
2009-07-06 |
2013-05-29 |
Ontorii Inc |
NOVEL NUCLEIC ACID PRODRUGS AND METHOD OF USE THEREOF
|
|
EP2479182B8
(en)
|
2009-09-16 |
2016-07-13 |
Wave Life Sciences Japan, Inc. |
Novel protecting group for synthesizing rna and derivative thereof
|
|
HUE040445T2
(hu)
|
2009-11-12 |
2019-03-28 |
Univ Western Australia |
Antiszensz molekulák és eljárások betegségek kezelésére
|
|
KR101981705B1
(ko)
|
2010-05-28 |
2019-05-24 |
사렙타 쎄러퓨틱스, 인코퍼레이티드 |
변형된 서브유니트간 결합 및/또는 말단 그룹을 갖는 올리고뉴클레오타이드 유사체
|
|
TWI541024B
(zh)
|
2010-09-01 |
2016-07-11 |
日本新藥股份有限公司 |
反義核酸
|
|
DK2620428T3
(da)
|
2010-09-24 |
2019-07-01 |
Wave Life Sciences Ltd |
Asymmetrisk hjælpegruppe
|
|
BR112013020273A2
(pt)
|
2011-02-08 |
2016-10-18 |
Charlotte Mecklenburg Hospital |
oligonucleotídeos antissenso
|
|
AU2011367230B2
(en)
|
2011-05-05 |
2017-08-10 |
Sarepta Therapeutics, Inc. |
Peptide oligonucleotide conjugates
|
|
US9161948B2
(en)
|
2011-05-05 |
2015-10-20 |
Sarepta Therapeutics, Inc. |
Peptide oligonucleotide conjugates
|
|
US9607308B2
(en)
|
2011-06-29 |
2017-03-28 |
American Express Travel Related Services Company, Inc. |
Spend based digital ad targeting and measurement
|
|
DK2581448T3
(en)
|
2011-10-13 |
2015-04-27 |
Ass Inst De Myologie |
Tricyclo-DNA phosphorothioate
|
|
ES2727481T3
(es)
|
2011-11-30 |
2019-10-16 |
Sarepta Therapeutics Inc |
Inclusión inducida de exón en atrofia muscular espinal
|
|
CN108588073A
(zh)
|
2011-12-28 |
2018-09-28 |
日本新药株式会社 |
反义核酸
|
|
CA2862628C
(en)
|
2012-01-27 |
2021-08-24 |
Prosensa Technologies B.V. |
Rna modulating oligonucleotides with improved characteristics for the treatment of duchenne and becker muscular dystrophy
|
|
DE102012101676A1
(de)
|
2012-02-29 |
2013-08-29 |
Klaus-Dieter Rösler |
Verfahren und Vorrichtung zum Bearbeiten von Formularen mit einer Datenverarbeitungsanlage
|
|
CN104603271B
(zh)
|
2012-07-03 |
2019-07-19 |
马林生物科技有限公司 |
用于治疗肌肉萎缩症患者的寡核苷酸
|
|
WO2014010250A1
(en)
|
2012-07-13 |
2014-01-16 |
Chiralgen, Ltd. |
Asymmetric auxiliary group
|
|
DK2872147T3
(da)
|
2012-07-13 |
2023-02-20 |
Wave Life Sciences Ltd |
Fremgangsmåde til fremstilling af kirale oligonukleotider
|
|
WO2014052855A1
(en)
|
2012-09-27 |
2014-04-03 |
Population Diagnostics, Inc. |
Methods and compositions for screening and treating developmental disorders
|
|
CN106414739A
(zh)
|
2012-12-20 |
2017-02-15 |
萨雷普塔医疗公司 |
用于治疗肌营养不良症的改良的外显子跳跃组合物
|
|
WO2014113540A1
(en)
*
|
2013-01-16 |
2014-07-24 |
Iowa State University Research Foundation, Inc. |
A deep intronic target for splicing correction on spinal muscular atrophy gene
|
|
EP3760720A1
(en)
|
2013-03-14 |
2021-01-06 |
Sarepta Therapeutics, Inc. |
Exon skipping compositions for treating muscular dystrophy
|
|
US9217148B2
(en)
|
2013-03-14 |
2015-12-22 |
Sarepta Therapeutics, Inc. |
Exon skipping compositions for treating muscular dystrophy
|
|
HK1220154A1
(zh)
|
2013-03-15 |
2017-04-28 |
Sarepta Therapeutics, Inc. |
改进的用於治疗肌营养不良的组合物
|
|
WO2015108046A1
(ja)
|
2014-01-15 |
2015-07-23 |
株式会社新日本科学 |
抗アレルギー作用を有するキラル核酸アジュバンド及び抗アレルギー剤
|
|
EP3095461A4
(en)
|
2014-01-15 |
2017-08-23 |
Shin Nippon Biomedical Laboratories, Ltd. |
Chiral nucleic acid adjuvant having immunity induction activity, and immunity induction activator
|
|
EP3095459A4
(en)
|
2014-01-15 |
2017-08-23 |
Shin Nippon Biomedical Laboratories, Ltd. |
Chiral nucleic acid adjuvant having antitumor effect and antitumor agent
|
|
EP3094728B1
(en)
|
2014-01-16 |
2022-03-09 |
Wave Life Sciences Ltd. |
Chiral design
|
|
US20150329609A1
(en)
|
2014-03-03 |
2015-11-19 |
Sujata Acharjee |
Chimeric dystrophin proteins to treat dystrophinopathies
|
|
BR112016020618B1
(pt)
|
2014-03-12 |
2023-04-04 |
Nippon Shinyaku Co., Ltd. |
Oligômero antissentido, composição farmacêutica, e, uso de um oligômero antissentido
|
|
PT3159409T
(pt)
|
2014-06-17 |
2020-01-21 |
Nippon Shinyaku Co Ltd |
Ácido nucleico anti-sentido para utilização no tratamento da distrofia muscular de duchenne
|
|
WO2016070166A2
(en)
|
2014-11-02 |
2016-05-06 |
Arcturus Therapeutics, Inc. |
Messenger una molecules and uses thereof
|
|
CN117965536A
(zh)
|
2015-07-22 |
2024-05-03 |
波涛生命科学有限公司 |
寡核苷酸组合物及其方法
|
|
MA46427A
(fr)
|
2015-10-09 |
2018-08-15 |
Wave Life Sciences Ltd |
Compositions d'oligonucléotides et procédés associés
|
|
JP2018530560A
(ja)
*
|
2015-10-09 |
2018-10-18 |
サレプタ セラピューティクス， インコーポレイテッド |
デュシェンヌ型筋ジストロフィーおよび関連障害の処置のための組成物および方法
|
|
JP7042255B2
(ja)
*
|
2016-04-29 |
2022-03-25 |
サレプタ セラピューティクス， インコーポレイテッド |
ヒトｌｍｎａを標的にするオリゴヌクレオチド類縁体
|
|
EP3452596A4
(en)
|
2016-05-04 |
2020-03-18 |
Wave Life Sciences Ltd. |
OLIGONUCLEOTIDE COMPOSITIONS AND RELATED METHODS
|
|
JP2019516679A
(ja)
|
2016-05-04 |
2019-06-20 |
ウェイブ ライフ サイエンシズ リミテッドＷａｖｅ Ｌｉｆｅ Ｓｃｉｅｎｃｅｓ Ｌｔｄ． |
生物活性剤に関する方法および組成物
|
|
NZ755416A
(en)
|
2016-12-19 |
2023-05-26 |
Sarepta Therapeutics Inc |
Exon skipping oligomer conjugates for muscular dystrophy
|
|
PT4122497T
(pt)
*
|
2016-12-19 |
2024-06-12 |
Sarepta Therapeutics Inc |
Conjugados oligoméricos de salto de exão para a distrofia muscular
|
|
ES3051834T3
(en)
|
2016-12-19 |
2025-12-30 |
Sarepta Therapeutics Inc |
Exon skipping oligomer conjugates for muscular dystrophy
|
|
EA201991450A1
(ru)
|
2017-09-22 |
2019-12-30 |
Сарепта Терапьютикс, Инк. |
Конъюгаты олигомеров для пропуска экзона при мышечной дистрофии
|