JP2011506274A5 - - Google Patents
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- Publication number
- JP2011506274A5 JP2011506274A5 JP2010534970A JP2010534970A JP2011506274A5 JP 2011506274 A5 JP2011506274 A5 JP 2011506274A5 JP 2010534970 A JP2010534970 A JP 2010534970A JP 2010534970 A JP2010534970 A JP 2010534970A JP 2011506274 A5 JP2011506274 A5 JP 2011506274A5
- Authority
- JP
- Japan
- Prior art keywords
- fastin
- inhibitor
- thr318
- amino acids
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- IOJLFLBSAYDJAK-OMKFUYFESA-N C[C@@H]([C@@H]([C@H](/C=C/CCCC1)OC)O)/C=C(/C)\CNC1=O Chemical compound C[C@@H]([C@@H]([C@H](/C=C/CCCC1)OC)O)/C=C(/C)\CNC1=O IOJLFLBSAYDJAK-OMKFUYFESA-N 0.000 description 2
- 0 C[C@@]([C@@]([C@@](*)C=CCCCC1)O)C=C(C)CCC1(C(F)(F)F)O Chemical compound C[C@@]([C@@]([C@@](*)C=CCCCC1)O)C=C(C)CCC1(C(F)(F)F)O 0.000 description 2
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US98960907P | 2007-11-21 | 2007-11-21 | |
| PCT/US2008/012988 WO2009070244A2 (en) | 2007-11-21 | 2008-11-21 | Methods for inhibiting fascin |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011506274A JP2011506274A (ja) | 2011-03-03 |
| JP2011506274A5 true JP2011506274A5 (enExample) | 2012-11-29 |
Family
ID=40679192
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010534970A Withdrawn JP2011506274A (ja) | 2007-11-21 | 2008-11-21 | ファスチンを阻害するための方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US20100297109A1 (enExample) |
| EP (1) | EP2222343A4 (enExample) |
| JP (1) | JP2011506274A (enExample) |
| CN (1) | CN101918036A (enExample) |
| CA (1) | CA2707009A1 (enExample) |
| WO (1) | WO2009070244A2 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4928937B2 (ja) | 2003-03-28 | 2012-05-09 | スローン−ケッタリング・インスティテュート・フォー・キャンサー・リサーチ | ミグラスタチンアナログおよびその使用 |
| WO2006001967A2 (en) | 2004-05-25 | 2006-01-05 | Sloan-Kettering Institute For Cancer Research | Migrastatin analogs in the treatment of cancer |
| US8188141B2 (en) | 2004-09-23 | 2012-05-29 | Sloan-Kettering Institute For Cancer Research | Isomigrastatin analogs in the treatment of cancer |
| JP5744560B2 (ja) * | 2011-02-21 | 2015-07-08 | シーシーアイ株式会社 | ファスシン（Ｆａｓｃｉｎ）遺伝子の働きを抑える短鎖ＲＮＡを含有する癌の予防、治療剤 |
| WO2012139074A2 (en) | 2011-04-07 | 2012-10-11 | Sloan-Kettering Institute For Cancer Research | Migrastatins and uses thereof |
| JP5806168B2 (ja) * | 2012-06-19 | 2015-11-10 | 国立大学法人 岡山大学 | 抗浸潤薬の新規スクリーニング法 |
| CN113679717A (zh) | 2012-08-22 | 2021-11-23 | 康奈尔大学 | 用于抑制肌成束蛋白的方法 |
| CA2940144C (en) | 2014-02-20 | 2023-06-13 | Cornell University | Substituted indazol-3-yl derivatives and pharmaceutical compositions thereof useful as inhibitor of fascin |
| JP7231551B2 (ja) * | 2017-02-24 | 2023-03-01 | フラグシップ パイオニアリング イノベーションズ ブイ，インコーポレーテッド | 内部共生体を調節するための組成物及び関連方法 |
| CN107446949A (zh) * | 2017-07-25 | 2017-12-08 | 国家纳米科学中心 | Pls3重组蛋白真核表达质粒及其构建方法和应用 |
| EP3713570A4 (en) * | 2017-11-22 | 2021-08-04 | Cornell University | CO THERAPIES WITH A METASTASIS INHIBITOR |
| CN112080499A (zh) * | 2020-08-12 | 2020-12-15 | 南京医科大学 | 一种降低fascin-1基因表达的siRNA及其应用 |
| GB202012761D0 (en) * | 2020-08-14 | 2020-09-30 | Univ Oxford Brookes | Metastatis treatment or prevention |
| CN111944812A (zh) * | 2020-08-17 | 2020-11-17 | 南通大学 | 靶向Fascin基因的siRNA分子及其应用 |
| CN112243955B (zh) * | 2020-10-23 | 2022-09-30 | 中国医学科学院北京协和医院 | 新型pls3基因敲除大鼠动物模型的构建方法和应用 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030194702A1 (en) * | 2000-12-22 | 2003-10-16 | Engelhard Eric K. | Novel compositions and methods for cancer |
| WO2006001967A2 (en) * | 2004-05-25 | 2006-01-05 | Sloan-Kettering Institute For Cancer Research | Migrastatin analogs in the treatment of cancer |
| WO2006074367A2 (en) * | 2005-01-05 | 2006-07-13 | Sloan-Kettering Institute For Cancer Research | Method of predicting and reducing risk of metastasis of breast cancer to lung |
| US7829066B2 (en) * | 2006-12-27 | 2010-11-09 | Memorial Sloan-Kettering Cancer Center | Assay for anti-metastatic agents |
-
2008
- 2008-11-21 EP EP08855277A patent/EP2222343A4/en not_active Withdrawn
- 2008-11-21 JP JP2010534970A patent/JP2011506274A/ja not_active Withdrawn
- 2008-11-21 CA CA2707009A patent/CA2707009A1/en not_active Abandoned
- 2008-11-21 CN CN200880124192XA patent/CN101918036A/zh active Pending
- 2008-11-21 WO PCT/US2008/012988 patent/WO2009070244A2/en not_active Ceased
- 2008-11-21 US US12/743,962 patent/US20100297109A1/en not_active Abandoned
-
2013
- 2013-03-15 US US13/840,287 patent/US20130259857A1/en not_active Abandoned