JP2011506274A5 - - Google Patents
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- Publication number
- JP2011506274A5 JP2011506274A5 JP2010534970A JP2010534970A JP2011506274A5 JP 2011506274 A5 JP2011506274 A5 JP 2011506274A5 JP 2010534970 A JP2010534970 A JP 2010534970A JP 2010534970 A JP2010534970 A JP 2010534970A JP 2011506274 A5 JP2011506274 A5 JP 2011506274A5
- Authority
- JP
- Japan
- Prior art keywords
- fastin
- inhibitor
- thr318
- amino acids
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- NCAIGTHBQTXTLR-UHFFFAOYSA-N phentermine hydrochloride Chemical compound [Cl-].CC(C)([NH3+])CC1=CC=CC=C1 NCAIGTHBQTXTLR-UHFFFAOYSA-N 0.000 claims description 123
- 239000003112 inhibitor Substances 0.000 claims description 60
- 238000000034 method Methods 0.000 claims description 55
- -1 Fastin amino acids Chemical class 0.000 claims description 38
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 30
- 102000002151 Microfilament Proteins Human genes 0.000 claims description 29
- 108010040897 Microfilament Proteins Proteins 0.000 claims description 29
- 229920001184 polypeptide Polymers 0.000 claims description 24
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 24
- 239000003795 chemical substances by application Substances 0.000 claims description 21
- 230000002401 inhibitory effect Effects 0.000 claims description 21
- 239000012634 fragment Substances 0.000 claims description 20
- 102000039446 nucleic acids Human genes 0.000 claims description 15
- 108020004707 nucleic acids Proteins 0.000 claims description 15
- 150000007523 nucleic acids Chemical class 0.000 claims description 15
- 102000004169 proteins and genes Human genes 0.000 claims description 14
- 108090000623 proteins and genes Proteins 0.000 claims description 14
- 102000007469 Actins Human genes 0.000 claims description 13
- 108010085238 Actins Proteins 0.000 claims description 13
- 208000037819 metastatic cancer Diseases 0.000 claims description 10
- 208000011575 metastatic malignant neoplasm Diseases 0.000 claims description 10
- 201000011510 cancer Diseases 0.000 claims description 9
- 210000004027 cell Anatomy 0.000 claims description 8
- 206010028980 Neoplasm Diseases 0.000 claims description 7
- 150000001413 amino acids Chemical class 0.000 claims description 6
- 125000004429 atom Chemical group 0.000 claims description 6
- 150000001875 compounds Chemical class 0.000 claims description 6
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 4
- 208000035143 Bacterial infection Diseases 0.000 claims description 4
- 206010009944 Colon cancer Diseases 0.000 claims description 4
- 208000017604 Hodgkin disease Diseases 0.000 claims description 4
- 208000010747 Hodgkins lymphoma Diseases 0.000 claims description 4
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims description 4
- 208000012902 Nervous system disease Diseases 0.000 claims description 4
- 208000025966 Neurological disease Diseases 0.000 claims description 4
- 206010033128 Ovarian cancer Diseases 0.000 claims description 4
- 206010061535 Ovarian neoplasm Diseases 0.000 claims description 4
- 208000005718 Stomach Neoplasms Diseases 0.000 claims description 4
- 208000036142 Viral infection Diseases 0.000 claims description 4
- 125000000217 alkyl group Chemical group 0.000 claims description 4
- 208000022362 bacterial infectious disease Diseases 0.000 claims description 4
- 208000029742 colonic neoplasm Diseases 0.000 claims description 4
- 201000010099 disease Diseases 0.000 claims description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 4
- 239000013604 expression vector Substances 0.000 claims description 4
- 206010017758 gastric cancer Diseases 0.000 claims description 4
- 125000005843 halogen group Chemical group 0.000 claims description 4
- 206010020718 hyperplasia Diseases 0.000 claims description 4
- 230000004968 inflammatory condition Effects 0.000 claims description 4
- 208000028867 ischemia Diseases 0.000 claims description 4
- 201000005202 lung cancer Diseases 0.000 claims description 4
- 208000020816 lung neoplasm Diseases 0.000 claims description 4
- 201000001441 melanoma Diseases 0.000 claims description 4
- 230000004770 neurodegeneration Effects 0.000 claims description 4
- 150000003384 small molecules Chemical class 0.000 claims description 4
- 201000011549 stomach cancer Diseases 0.000 claims description 4
- 230000000451 tissue damage Effects 0.000 claims description 4
- 231100000827 tissue damage Toxicity 0.000 claims description 4
- 230000009385 viral infection Effects 0.000 claims description 4
- 230000000694 effects Effects 0.000 claims description 3
- 206010003571 Astrocytoma Diseases 0.000 claims description 2
- 206010005003 Bladder cancer Diseases 0.000 claims description 2
- 206010006187 Breast cancer Diseases 0.000 claims description 2
- 208000026310 Breast neoplasm Diseases 0.000 claims description 2
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims description 2
- 208000008839 Kidney Neoplasms Diseases 0.000 claims description 2
- 206010025323 Lymphomas Diseases 0.000 claims description 2
- 206010027406 Mesothelioma Diseases 0.000 claims description 2
- 206010027476 Metastases Diseases 0.000 claims description 2
- 241001465754 Metazoa Species 0.000 claims description 2
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims description 2
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims description 2
- 206010060862 Prostate cancer Diseases 0.000 claims description 2
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims description 2
- 206010038389 Renal cancer Diseases 0.000 claims description 2
- 206010039491 Sarcoma Diseases 0.000 claims description 2
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims description 2
- 125000003545 alkoxy group Chemical group 0.000 claims description 2
- 210000004102 animal cell Anatomy 0.000 claims description 2
- 230000015572 biosynthetic process Effects 0.000 claims description 2
- 201000007455 central nervous system cancer Diseases 0.000 claims description 2
- 201000004101 esophageal cancer Diseases 0.000 claims description 2
- 201000010982 kidney cancer Diseases 0.000 claims description 2
- 208000032839 leukemia Diseases 0.000 claims description 2
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims description 2
- 230000001404 mediated effect Effects 0.000 claims description 2
- 230000009401 metastasis Effects 0.000 claims description 2
- 201000002528 pancreatic cancer Diseases 0.000 claims description 2
- 208000008443 pancreatic carcinoma Diseases 0.000 claims description 2
- 150000003839 salts Chemical class 0.000 claims description 2
- 230000002194 synthesizing effect Effects 0.000 claims description 2
- 201000005112 urinary bladder cancer Diseases 0.000 claims description 2
- 210000002700 urine Anatomy 0.000 claims description 2
- 239000003814 drug Substances 0.000 description 4
- IOJLFLBSAYDJAK-OMKFUYFESA-N C[C@@H]([C@@H]([C@H](/C=C/CCCC1)OC)O)/C=C(/C)\CNC1=O Chemical compound C[C@@H]([C@@H]([C@H](/C=C/CCCC1)OC)O)/C=C(/C)\CNC1=O IOJLFLBSAYDJAK-OMKFUYFESA-N 0.000 description 2
- 0 C[C@@]([C@@]([C@@](*)C=CCCCC1)O)C=C(C)CCC1(C(F)(F)F)O Chemical compound C[C@@]([C@@]([C@@](*)C=CCCCC1)O)C=C(C)CCC1(C(F)(F)F)O 0.000 description 2
- 241000124008 Mammalia Species 0.000 description 2
- 230000005764 inhibitory process Effects 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US98960907P | 2007-11-21 | 2007-11-21 | |
| PCT/US2008/012988 WO2009070244A2 (en) | 2007-11-21 | 2008-11-21 | Methods for inhibiting fascin |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011506274A JP2011506274A (ja) | 2011-03-03 |
| JP2011506274A5 true JP2011506274A5 (enExample) | 2012-11-29 |
Family
ID=40679192
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010534970A Withdrawn JP2011506274A (ja) | 2007-11-21 | 2008-11-21 | ファスチンを阻害するための方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US20100297109A1 (enExample) |
| EP (1) | EP2222343A4 (enExample) |
| JP (1) | JP2011506274A (enExample) |
| CN (1) | CN101918036A (enExample) |
| CA (1) | CA2707009A1 (enExample) |
| WO (1) | WO2009070244A2 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4719671B2 (ja) | 2003-03-28 | 2011-07-06 | コーネル・リサーチ・ファンデーション・インコーポレイテッド | ミグラスタチンアナログ組成物およびその使用 |
| JP5149001B2 (ja) | 2004-05-25 | 2013-02-20 | スローン−ケッタリング・インスティテュート・フォー・キャンサー・リサーチ | 癌の処置におけるマイグラスタチンアナログ |
| EP1805161B1 (en) | 2004-09-23 | 2014-05-07 | Sloan-Kettering Institute For Cancer Research | Isomigrastatin analogs in the treatment of cancer |
| JP5744560B2 (ja) * | 2011-02-21 | 2015-07-08 | シーシーアイ株式会社 | ファスシン（Ｆａｓｃｉｎ）遺伝子の働きを抑える短鎖ＲＮＡを含有する癌の予防、治療剤 |
| JP5975581B2 (ja) | 2011-04-07 | 2016-08-23 | スローン − ケタリング・インスティテュート・フォー・キャンサー・リサーチ | ミグラスタチンおよびその使用 |
| JP5806168B2 (ja) * | 2012-06-19 | 2015-11-10 | 国立大学法人 岡山大学 | 抗浸潤薬の新規スクリーニング法 |
| US10208043B2 (en) | 2012-08-22 | 2019-02-19 | Cornell University | Methods for inhibiting fascin |
| CA2940144C (en) | 2014-02-20 | 2023-06-13 | Cornell University | Substituted indazol-3-yl derivatives and pharmaceutical compositions thereof useful as inhibitor of fascin |
| US11974574B2 (en) * | 2017-02-24 | 2024-05-07 | Flagship Pioneering Innovations V, Inc. | Compositions and related methods for modulating endosymbionts |
| CN107446949A (zh) * | 2017-07-25 | 2017-12-08 | 国家纳米科学中心 | Pls3重组蛋白真核表达质粒及其构建方法和应用 |
| CN111655259A (zh) * | 2017-11-22 | 2020-09-11 | 康奈尔大学 | 包括转移抑制剂的共疗法 |
| CN112080499A (zh) * | 2020-08-12 | 2020-12-15 | 南京医科大学 | 一种降低fascin-1基因表达的siRNA及其应用 |
| GB202012761D0 (en) * | 2020-08-14 | 2020-09-30 | Univ Oxford Brookes | Metastatis treatment or prevention |
| CN111944812A (zh) * | 2020-08-17 | 2020-11-17 | 南通大学 | 靶向Fascin基因的siRNA分子及其应用 |
| CN112243955B (zh) * | 2020-10-23 | 2022-09-30 | 中国医学科学院北京协和医院 | 新型pls3基因敲除大鼠动物模型的构建方法和应用 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030194702A1 (en) * | 2000-12-22 | 2003-10-16 | Engelhard Eric K. | Novel compositions and methods for cancer |
| JP5149001B2 (ja) * | 2004-05-25 | 2013-02-20 | スローン−ケッタリング・インスティテュート・フォー・キャンサー・リサーチ | 癌の処置におけるマイグラスタチンアナログ |
| US8178505B2 (en) * | 2005-01-05 | 2012-05-15 | Sloan-Kettering Institute For Cancer Research | Method of predicting and reducing risk of metastasis of breast cancer to lung |
| US7829066B2 (en) * | 2006-12-27 | 2010-11-09 | Memorial Sloan-Kettering Cancer Center | Assay for anti-metastatic agents |
-
2008
- 2008-11-21 CA CA2707009A patent/CA2707009A1/en not_active Abandoned
- 2008-11-21 US US12/743,962 patent/US20100297109A1/en not_active Abandoned
- 2008-11-21 WO PCT/US2008/012988 patent/WO2009070244A2/en not_active Ceased
- 2008-11-21 JP JP2010534970A patent/JP2011506274A/ja not_active Withdrawn
- 2008-11-21 CN CN200880124192XA patent/CN101918036A/zh active Pending
- 2008-11-21 EP EP08855277A patent/EP2222343A4/en not_active Withdrawn
-
2013
- 2013-03-15 US US13/840,287 patent/US20130259857A1/en not_active Abandoned