JP2004526737A5 - - Google Patents
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- Publication number
- JP2004526737A5 JP2004526737A5 JP2002576627A JP2002576627A JP2004526737A5 JP 2004526737 A5 JP2004526737 A5 JP 2004526737A5 JP 2002576627 A JP2002576627 A JP 2002576627A JP 2002576627 A JP2002576627 A JP 2002576627A JP 2004526737 A5 JP2004526737 A5 JP 2004526737A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- compound
- compound according
- oligonucleotide
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 19
- 108091034117 Oligonucleotide Proteins 0.000 claims 8
- 229910052760 oxygen Inorganic materials 0.000 claims 8
- 125000000217 alkyl group Chemical group 0.000 claims 5
- 229910052739 hydrogen Inorganic materials 0.000 claims 5
- 229910052717 sulfur Inorganic materials 0.000 claims 5
- 108010017842 Telomerase Proteins 0.000 claims 4
- 125000003118 aryl group Chemical group 0.000 claims 3
- 230000000694 effects Effects 0.000 claims 3
- 229910052736 halogen Inorganic materials 0.000 claims 3
- 150000002367 halogens Chemical class 0.000 claims 3
- 229910052757 nitrogen Inorganic materials 0.000 claims 3
- PTMHPRAIXMAOOB-UHFFFAOYSA-L phosphoramidate Chemical compound NP([O-])([O-])=O PTMHPRAIXMAOOB-UHFFFAOYSA-L 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 230000000295 complement effect Effects 0.000 claims 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 2
- 150000002431 hydrogen Chemical class 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 2
- 108010057210 telomerase RNA Proteins 0.000 claims 2
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- YACKEPLHDIMKIO-UHFFFAOYSA-L methylphosphonate(2-) Chemical compound CP([O-])([O-])=O YACKEPLHDIMKIO-UHFFFAOYSA-L 0.000 claims 1
- 239000002777 nucleoside Substances 0.000 claims 1
- 125000003835 nucleoside group Chemical group 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 150000004713 phosphodiesters Chemical class 0.000 claims 1
- RYYWUUFWQRZTIU-UHFFFAOYSA-K thiophosphate Chemical compound [O-]P([O-])([O-])=S RYYWUUFWQRZTIU-UHFFFAOYSA-K 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US27832201P | 2001-03-23 | 2001-03-23 | |
| US60/278,322 | 2001-03-23 | ||
| PCT/US2002/009138 WO2002077184A2 (en) | 2001-03-23 | 2002-03-21 | Oligonucleotide conjugates |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004526737A JP2004526737A (ja) | 2004-09-02 |
| JP2004526737A5 true JP2004526737A5 (enExample) | 2005-12-22 |
| JP4854913B2 JP4854913B2 (ja) | 2012-01-18 |
Family
ID=23064542
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002576627A Expired - Lifetime JP4854913B2 (ja) | 2001-03-23 | 2002-03-21 | オリゴヌクレオチド結合体 |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP1379689B1 (enExample) |
| JP (1) | JP4854913B2 (enExample) |
| AU (1) | AU2002245717A1 (enExample) |
| CA (1) | CA2440322C (enExample) |
| WO (1) | WO2002077184A2 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7563618B2 (en) | 2001-03-23 | 2009-07-21 | Geron Corporation | Oligonucleotide conjugates |
| DK3342425T3 (da) | 2003-09-09 | 2020-03-16 | Geron Corp | Modificerede oligonukleotider til inhibering af telomerase |
| WO2005116207A1 (ja) * | 2004-05-28 | 2005-12-08 | Sankyo Company, Limited | テロメラーゼ阻害ｅｎａオリゴヌクレオチド |
| RS61840B1 (sr) | 2004-07-02 | 2021-06-30 | Geron Corp | Sinteza zaštićenih 3'-amino 5'-fosforamidit nukleozidnih monomera |
| US9228189B2 (en) | 2012-10-26 | 2016-01-05 | Geron Corporation | C-myc antisense oligonucleotides and methods for using the same to treat cell-proliferative disorders |
| US9200327B2 (en) | 2012-11-30 | 2015-12-01 | Geron Corporation | Diagnostic markers for treating cell proliferative disorders with telomerase inhibitors |
| US9375485B2 (en) | 2012-12-07 | 2016-06-28 | Geron Corporation | Use of telomerase inhibitors for the treatment of myeloproliferative disorders and myeloproliferative neoplasms |
| EP3052512A4 (en) | 2013-09-30 | 2017-02-22 | Geron Corporation | Phosphorodiamidate backbone linkage for oligonucleotides |
| JOP20200257A1 (ar) * | 2014-05-01 | 2017-06-16 | Geron Corp | تركيبات أوليجو نوكليوتيد وطرق لتحضيرها |
| JP2018513127A (ja) | 2015-04-23 | 2018-05-24 | ジェロン・コーポレーションＧｅｒｏｎ Ｃｏｒｐｏｒａｔｉｏｎ | 多価カチオン塩組成物を用いたポリヌクレオチド調製方法 |
| EP3658156B1 (en) | 2017-07-28 | 2026-03-25 | Geron Corporation | Telomerase inhibitor for use in treating a myelodysplastic syndrome |
| CN113631719A (zh) | 2018-11-29 | 2021-11-09 | 美国杰龙生物医药公司 | 治疗骨髓增生异常综合征的方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4965349A (en) * | 1987-12-24 | 1990-10-23 | Applied Biosystems, Inc. | Method of synthesizing oligonucleotides labeled with ammonia-labile groups on solid phase supports |
| US5352803A (en) * | 1992-03-30 | 1994-10-04 | Abbott Laboratories | 5(6)-methyl substituted fluorescein derivatives |
| US5863726A (en) * | 1993-11-12 | 1999-01-26 | Geron Corporation | Telomerase activity assays |
| JP3189000B2 (ja) * | 1994-12-01 | 2001-07-16 | 東ソー株式会社 | 特定核酸配列の検出方法 |
| WO2000050279A1 (en) * | 1999-02-23 | 2000-08-31 | Recreational Technologies International Llc | Vehicle leveling assembly |
| HK1049339B (en) * | 1999-09-10 | 2008-06-27 | Geron Corporation | Oligonucleotide n3'-p5' thiophosphoramidates: their synthesis and use |
-
2002
- 2002-03-21 AU AU2002245717A patent/AU2002245717A1/en not_active Abandoned
- 2002-03-21 JP JP2002576627A patent/JP4854913B2/ja not_active Expired - Lifetime
- 2002-03-21 WO PCT/US2002/009138 patent/WO2002077184A2/en not_active Ceased
- 2002-03-21 CA CA2440322A patent/CA2440322C/en not_active Expired - Lifetime
- 2002-03-21 EP EP02713894A patent/EP1379689B1/en not_active Expired - Lifetime