JP2011092201A5 - - Google Patents
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- Publication number
- JP2011092201A5 JP2011092201A5 JP2010286755A JP2010286755A JP2011092201A5 JP 2011092201 A5 JP2011092201 A5 JP 2011092201A5 JP 2010286755 A JP2010286755 A JP 2010286755A JP 2010286755 A JP2010286755 A JP 2010286755A JP 2011092201 A5 JP2011092201 A5 JP 2011092201A5
- Authority
- JP
- Japan
- Prior art keywords
- compound according
- compound
- oligonucleotide
- inhibiting
- component
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000001875 compounds Chemical class 0.000 claims 21
- 108091034117 Oligonucleotide Proteins 0.000 claims 8
- 230000002401 inhibitory effect Effects 0.000 claims 6
- 108010017842 Telomerase Proteins 0.000 claims 5
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerol Natural products OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 4
- 230000000694 effects Effects 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- 235000014113 dietary fatty acids Nutrition 0.000 claims 3
- 229930195729 fatty acid Natural products 0.000 claims 3
- 239000000194 fatty acid Substances 0.000 claims 3
- 150000004665 fatty acids Chemical class 0.000 claims 3
- 238000000338 in vitro Methods 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 230000005907 cancer growth Effects 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 230000003834 intracellular effect Effects 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- PTMHPRAIXMAOOB-UHFFFAOYSA-L phosphoramidate Chemical compound NP([O-])([O-])=O PTMHPRAIXMAOOB-UHFFFAOYSA-L 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US50150903P | 2003-09-09 | 2003-09-09 | |
| US60/501,509 | 2003-09-09 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006526347A Division JP4690324B2 (ja) | 2003-09-09 | 2004-09-09 | テロメラーゼ阻害のための改変オリゴヌクレオチド |
Related Child Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011274595A Division JP2012085648A (ja) | 2003-09-09 | 2011-12-15 | テロメラーゼ阻害のための改変オリゴヌクレオチド |
| JP2014087190A Division JP2014158490A (ja) | 2003-09-09 | 2014-04-21 | テロメラーゼ阻害のための改変オリゴヌクレオチド |
| JP2016014128A Division JP6158966B2 (ja) | 2003-09-09 | 2016-01-28 | テロメラーゼ阻害のための改変オリゴヌクレオチド |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011092201A JP2011092201A (ja) | 2011-05-12 |
| JP2011092201A5 true JP2011092201A5 (enExample) | 2012-02-16 |
| JP5923241B2 JP5923241B2 (ja) | 2016-05-24 |
Family
ID=34273050
Family Applications (10)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006526347A Expired - Lifetime JP4690324B2 (ja) | 2003-09-09 | 2004-09-09 | テロメラーゼ阻害のための改変オリゴヌクレオチド |
| JP2010286755A Expired - Lifetime JP5923241B2 (ja) | 2003-09-09 | 2010-12-22 | テロメラーゼ阻害のための改変オリゴヌクレオチド |
| JP2011274595A Pending JP2012085648A (ja) | 2003-09-09 | 2011-12-15 | テロメラーゼ阻害のための改変オリゴヌクレオチド |
| JP2014087190A Pending JP2014158490A (ja) | 2003-09-09 | 2014-04-21 | テロメラーゼ阻害のための改変オリゴヌクレオチド |
| JP2016014128A Expired - Lifetime JP6158966B2 (ja) | 2003-09-09 | 2016-01-28 | テロメラーゼ阻害のための改変オリゴヌクレオチド |
| JP2016137263A Withdrawn JP2016214248A (ja) | 2003-09-09 | 2016-07-12 | テロメラーゼ阻害のための改変オリゴヌクレオチド |
| JP2018025362A Expired - Lifetime JP6758335B2 (ja) | 2003-09-09 | 2018-02-15 | テロメラーゼ阻害のための改変オリゴヌクレオチド |
| JP2019131757A Withdrawn JP2019170400A (ja) | 2003-09-09 | 2019-07-17 | テロメラーゼ阻害のための改変オリゴヌクレオチド |
| JP2021110558A Withdrawn JP2021169466A (ja) | 2003-09-09 | 2021-07-02 | テロメラーゼ阻害のための改変オリゴヌクレオチド |
| JP2023086871A Withdrawn JP2023099808A (ja) | 2003-09-09 | 2023-05-26 | テロメラーゼ阻害のための改変オリゴヌクレオチド |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006526347A Expired - Lifetime JP4690324B2 (ja) | 2003-09-09 | 2004-09-09 | テロメラーゼ阻害のための改変オリゴヌクレオチド |
Family Applications After (8)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011274595A Pending JP2012085648A (ja) | 2003-09-09 | 2011-12-15 | テロメラーゼ阻害のための改変オリゴヌクレオチド |
| JP2014087190A Pending JP2014158490A (ja) | 2003-09-09 | 2014-04-21 | テロメラーゼ阻害のための改変オリゴヌクレオチド |
| JP2016014128A Expired - Lifetime JP6158966B2 (ja) | 2003-09-09 | 2016-01-28 | テロメラーゼ阻害のための改変オリゴヌクレオチド |
| JP2016137263A Withdrawn JP2016214248A (ja) | 2003-09-09 | 2016-07-12 | テロメラーゼ阻害のための改変オリゴヌクレオチド |
| JP2018025362A Expired - Lifetime JP6758335B2 (ja) | 2003-09-09 | 2018-02-15 | テロメラーゼ阻害のための改変オリゴヌクレオチド |
| JP2019131757A Withdrawn JP2019170400A (ja) | 2003-09-09 | 2019-07-17 | テロメラーゼ阻害のための改変オリゴヌクレオチド |
| JP2021110558A Withdrawn JP2021169466A (ja) | 2003-09-09 | 2021-07-02 | テロメラーゼ阻害のための改変オリゴヌクレオチド |
| JP2023086871A Withdrawn JP2023099808A (ja) | 2003-09-09 | 2023-05-26 | テロメラーゼ阻害のための改変オリゴヌクレオチド |
Country Status (19)
| Country | Link |
|---|---|
| US (8) | US7494982B2 (enExample) |
| EP (3) | EP3342425B1 (enExample) |
| JP (10) | JP4690324B2 (enExample) |
| KR (3) | KR20060132802A (enExample) |
| CN (2) | CN100393209C (enExample) |
| AU (2) | AU2004271215B2 (enExample) |
| BR (1) | BRPI0414222B8 (enExample) |
| CA (1) | CA2536015C (enExample) |
| CY (2) | CY1120113T1 (enExample) |
| DK (2) | DK1667522T3 (enExample) |
| ES (2) | ES2775525T3 (enExample) |
| HU (2) | HUE048359T2 (enExample) |
| IL (1) | IL173747A (enExample) |
| MX (1) | MXPA06002660A (enExample) |
| NZ (1) | NZ545516A (enExample) |
| PL (2) | PL1667522T3 (enExample) |
| PT (2) | PT3342425T (enExample) |
| SI (2) | SI3342425T1 (enExample) |
| WO (1) | WO2005023994A2 (enExample) |
Families Citing this family (64)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005023994A2 (en) * | 2003-09-09 | 2005-03-17 | Geron Corporation | Modified oligonucleotides for telomerase inhibition |
| DE602004031975D1 (de) | 2003-11-04 | 2011-05-05 | Geron Corp | Rna-amidate und thioamidateur rnai |
| DK3296312T3 (da) | 2004-07-02 | 2021-05-03 | Geron Corp | Syntese af beskyttede 3'-amino-5'-phosphoramidit-nukleosidmonomerer |
| WO2006113470A2 (en) * | 2005-04-15 | 2006-10-26 | Geron Corporation | Cancer treatment by combined inhibition of proteasome and telomerase activities |
| US8252756B2 (en) | 2005-06-14 | 2012-08-28 | Northwestern University | Nucleic acid functionalized nanoparticles for therapeutic applications |
| WO2007127163A2 (en) * | 2006-04-24 | 2007-11-08 | Geron Corporation | Cns-tumor treatment method and composition |
| PT2898887T (pt) | 2006-10-30 | 2018-12-20 | Geron Corp | Inibidor de telomerase combinado e gencitabina para o tratamento de cancro |
| WO2008094640A2 (en) | 2007-01-30 | 2008-08-07 | Geron Corporation | Compounds having anti-adhesive effects on cancer cells |
| CN103966345A (zh) | 2007-02-09 | 2014-08-06 | 西北大学 | 检测细胞内标靶的颗粒 |
| EP2134364B1 (en) * | 2007-03-09 | 2013-02-13 | Geron Corporation | Treatment of carcinomas with a combination of egf-pathway and telomerase inhibitors |
| DK2476689T3 (en) | 2007-05-10 | 2016-01-18 | Agilent Technologies Inc | Thiocarbonbeskyttende groups for RNA synthesis |
| AU2008259907B2 (en) | 2007-05-30 | 2014-12-04 | Northwestern University | Nucleic acid functionalized nanoparticles for therapeutic applications |
| TW200927177A (en) * | 2007-10-24 | 2009-07-01 | Nat Inst Of Advanced Ind Scien | Lipid-modified double-stranded RNA having potent RNA interference effect |
| EA201170127A1 (ru) * | 2008-07-02 | 2011-08-30 | Сантарис Фарма А/С | АНТАГОНИСТЫ РНК, НАЦЕЛЕННЫЕ НА Hsp27 |
| EP2175023A1 (en) * | 2008-07-31 | 2010-04-14 | The University of Zurich | Anti-tumor activity of small double-stranded oligodeoxynucleotides targeting telomerase RNA |
| PL2342360T3 (pl) | 2008-10-17 | 2016-06-30 | Geron Corp | Sposób identyfikacji wrażliwości pacjenta na terapię hamującą telomerazę |
| MX2011005429A (es) | 2008-11-24 | 2011-06-21 | Univ Northwestern | Composiciones de nanoparticulas de arn polivalentes. |
| SG171914A1 (en) | 2008-12-02 | 2011-07-28 | Chiralgen Ltd | Method for the synthesis of phosphorus atom modified nucleic acids |
| US20100233270A1 (en) | 2009-01-08 | 2010-09-16 | Northwestern University | Delivery of Oligonucleotide-Functionalized Nanoparticles |
| US9744183B2 (en) | 2009-07-06 | 2017-08-29 | Wave Life Sciences Ltd. | Nucleic acid prodrugs and methods of use thereof |
| CN102666879B (zh) | 2009-10-30 | 2016-02-24 | 西北大学 | 模板化的纳米缀合物 |
| WO2011079290A1 (en) * | 2009-12-24 | 2011-06-30 | Northwestern University | Oligonucleotide specific uptake of nanoconjugates |
| DK2620428T3 (da) | 2010-09-24 | 2019-07-01 | Wave Life Sciences Ltd | Asymmetrisk hjælpegruppe |
| AU2012236880B2 (en) | 2011-03-28 | 2016-11-17 | Geron Corporation | Telomere length measurement in formalin-fixed, paraffin embedded (FFPE) samples by quantitative PCR |
| RU2014105311A (ru) | 2011-07-19 | 2015-08-27 | Уэйв Лайф Сайенсес Пте. Лтд. | Способы синтеза функционализованных нуклеиновых кислот |
| AU2012308302A1 (en) | 2011-09-14 | 2014-03-20 | Northwestern University | Nanoconjugates able to cross the blood-brain barrier |
| PT2872485T (pt) | 2012-07-13 | 2021-03-05 | Wave Life Sciences Ltd | Grupo auxiliar assimétrico |
| KR102712879B1 (ko) | 2012-07-13 | 2024-10-04 | 웨이브 라이프 사이언시스 리미티드 | 키랄 제어 |
| HK1214293A1 (zh) | 2012-10-26 | 2016-07-22 | Geron Corporation | C-myc反义寡核苷酸和利用其治疗细胞增殖性疾病的方法 |
| US9228189B2 (en) | 2012-10-26 | 2016-01-05 | Geron Corporation | C-myc antisense oligonucleotides and methods for using the same to treat cell-proliferative disorders |
| DK3495495T3 (da) | 2012-11-30 | 2021-03-22 | Geron Corp | Diagnostiske markører til behandling af celleproliferative forstyrrelser med telomeraseinhibitorer |
| US9200327B2 (en) | 2012-11-30 | 2015-12-01 | Geron Corporation | Diagnostic markers for treating cell proliferative disorders with telomerase inhibitors |
| US9375485B2 (en) | 2012-12-07 | 2016-06-28 | Geron Corporation | Use of telomerase inhibitors for the treatment of myeloproliferative disorders and myeloproliferative neoplasms |
| AP2015008504A0 (en) | 2012-12-07 | 2015-06-30 | Geron Corp | Use of telomerase inhibitors for the treatment of myeloproliferative disorders and myeloprolifarative neoplasms |
| CN105164269A (zh) | 2013-02-22 | 2015-12-16 | 里兰斯坦福初级大学理事会 | 与端粒延伸相关的化合物、组合物、方法和试剂盒 |
| KR20160042917A (ko) | 2013-07-25 | 2016-04-20 | 엑시큐어, 인크. | 예방 및 치료 용도를 위한 면역자극제로서의 구형 핵산-기재 구축물 |
| EP3052512A4 (en) | 2013-09-30 | 2017-02-22 | Geron Corporation | Phosphorodiamidate backbone linkage for oligonucleotides |
| JPWO2015108047A1 (ja) | 2014-01-15 | 2017-03-23 | 株式会社新日本科学 | 免疫誘導活性を有するキラル核酸アジュバンド及び免疫誘導活性剤 |
| JPWO2015108048A1 (ja) | 2014-01-15 | 2017-03-23 | 株式会社新日本科学 | 抗腫瘍作用を有するキラル核酸アジュバンド及び抗腫瘍剤 |
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| CN106535876B (zh) | 2014-06-04 | 2020-09-11 | 埃克西奎雷股份有限公司 | 免疫调节剂通过脂质体球形核酸的多价递送以用于预防或治疗应用 |
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| EP3318276A1 (en) | 2016-11-04 | 2018-05-09 | Janssen Biotech, Inc. | Combinations of a telomerase inhibitor and a bcl-2 inhibitor for the treatment of hematological cancers |
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| AU2018307983B2 (en) | 2017-07-28 | 2024-07-18 | Geron Corporation | Methods of treating myelodysplastic syndrome |
| MX2020011570A (es) | 2018-05-07 | 2020-11-24 | Alnylam Pharmaceuticals Inc | Administracion extrahepatica. |
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| EP4032551A4 (en) * | 2019-09-18 | 2023-12-20 | National University Corporation Tokyo Medical and Dental University | NUCLEIC ACID COMPLEX |
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