JP2011092201A5 - - Google Patents
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- JP2011092201A5 JP2011092201A5 JP2010286755A JP2010286755A JP2011092201A5 JP 2011092201 A5 JP2011092201 A5 JP 2011092201A5 JP 2010286755 A JP2010286755 A JP 2010286755A JP 2010286755 A JP2010286755 A JP 2010286755A JP 2011092201 A5 JP2011092201 A5 JP 2011092201A5
- Authority
- JP
- Japan
- Prior art keywords
- compound according
- compound
- oligonucleotide
- inhibiting
- component
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000001875 compounds Chemical class 0.000 claims 21
- 108091034117 Oligonucleotide Proteins 0.000 claims 8
- 230000002401 inhibitory effect Effects 0.000 claims 6
- 108010017842 Telomerase Proteins 0.000 claims 5
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerol Natural products OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 4
- 230000000694 effects Effects 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- 235000014113 dietary fatty acids Nutrition 0.000 claims 3
- 229930195729 fatty acid Natural products 0.000 claims 3
- 239000000194 fatty acid Substances 0.000 claims 3
- 150000004665 fatty acids Chemical class 0.000 claims 3
- 238000000338 in vitro Methods 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 230000005907 cancer growth Effects 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 230000003834 intracellular effect Effects 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- PTMHPRAIXMAOOB-UHFFFAOYSA-L phosphoramidate Chemical compound NP([O-])([O-])=O PTMHPRAIXMAOOB-UHFFFAOYSA-L 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US50150903P | 2003-09-09 | 2003-09-09 | |
| US60/501,509 | 2003-09-09 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006526347A Division JP4690324B2 (ja) | 2003-09-09 | 2004-09-09 | テロメラーゼ阻害のための改変オリゴヌクレオチド |
Related Child Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011274595A Division JP2012085648A (ja) | 2003-09-09 | 2011-12-15 | テロメラーゼ阻害のための改変オリゴヌクレオチド |
| JP2014087190A Division JP2014158490A (ja) | 2003-09-09 | 2014-04-21 | テロメラーゼ阻害のための改変オリゴヌクレオチド |
| JP2016014128A Division JP6158966B2 (ja) | 2003-09-09 | 2016-01-28 | テロメラーゼ阻害のための改変オリゴヌクレオチド |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011092201A JP2011092201A (ja) | 2011-05-12 |
| JP2011092201A5 true JP2011092201A5 (enExample) | 2012-02-16 |
| JP5923241B2 JP5923241B2 (ja) | 2016-05-24 |
Family
ID=34273050
Family Applications (10)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006526347A Expired - Lifetime JP4690324B2 (ja) | 2003-09-09 | 2004-09-09 | テロメラーゼ阻害のための改変オリゴヌクレオチド |
| JP2010286755A Expired - Lifetime JP5923241B2 (ja) | 2003-09-09 | 2010-12-22 | テロメラーゼ阻害のための改変オリゴヌクレオチド |
| JP2011274595A Pending JP2012085648A (ja) | 2003-09-09 | 2011-12-15 | テロメラーゼ阻害のための改変オリゴヌクレオチド |
| JP2014087190A Pending JP2014158490A (ja) | 2003-09-09 | 2014-04-21 | テロメラーゼ阻害のための改変オリゴヌクレオチド |
| JP2016014128A Expired - Lifetime JP6158966B2 (ja) | 2003-09-09 | 2016-01-28 | テロメラーゼ阻害のための改変オリゴヌクレオチド |
| JP2016137263A Withdrawn JP2016214248A (ja) | 2003-09-09 | 2016-07-12 | テロメラーゼ阻害のための改変オリゴヌクレオチド |
| JP2018025362A Expired - Lifetime JP6758335B2 (ja) | 2003-09-09 | 2018-02-15 | テロメラーゼ阻害のための改変オリゴヌクレオチド |
| JP2019131757A Withdrawn JP2019170400A (ja) | 2003-09-09 | 2019-07-17 | テロメラーゼ阻害のための改変オリゴヌクレオチド |
| JP2021110558A Withdrawn JP2021169466A (ja) | 2003-09-09 | 2021-07-02 | テロメラーゼ阻害のための改変オリゴヌクレオチド |
| JP2023086871A Withdrawn JP2023099808A (ja) | 2003-09-09 | 2023-05-26 | テロメラーゼ阻害のための改変オリゴヌクレオチド |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006526347A Expired - Lifetime JP4690324B2 (ja) | 2003-09-09 | 2004-09-09 | テロメラーゼ阻害のための改変オリゴヌクレオチド |
Family Applications After (8)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011274595A Pending JP2012085648A (ja) | 2003-09-09 | 2011-12-15 | テロメラーゼ阻害のための改変オリゴヌクレオチド |
| JP2014087190A Pending JP2014158490A (ja) | 2003-09-09 | 2014-04-21 | テロメラーゼ阻害のための改変オリゴヌクレオチド |
| JP2016014128A Expired - Lifetime JP6158966B2 (ja) | 2003-09-09 | 2016-01-28 | テロメラーゼ阻害のための改変オリゴヌクレオチド |
| JP2016137263A Withdrawn JP2016214248A (ja) | 2003-09-09 | 2016-07-12 | テロメラーゼ阻害のための改変オリゴヌクレオチド |
| JP2018025362A Expired - Lifetime JP6758335B2 (ja) | 2003-09-09 | 2018-02-15 | テロメラーゼ阻害のための改変オリゴヌクレオチド |
| JP2019131757A Withdrawn JP2019170400A (ja) | 2003-09-09 | 2019-07-17 | テロメラーゼ阻害のための改変オリゴヌクレオチド |
| JP2021110558A Withdrawn JP2021169466A (ja) | 2003-09-09 | 2021-07-02 | テロメラーゼ阻害のための改変オリゴヌクレオチド |
| JP2023086871A Withdrawn JP2023099808A (ja) | 2003-09-09 | 2023-05-26 | テロメラーゼ阻害のための改変オリゴヌクレオチド |
Country Status (19)
| Country | Link |
|---|---|
| US (8) | US7494982B2 (enExample) |
| EP (3) | EP3682903A1 (enExample) |
| JP (10) | JP4690324B2 (enExample) |
| KR (3) | KR101298493B1 (enExample) |
| CN (2) | CN101293908B (enExample) |
| AU (2) | AU2004271215B2 (enExample) |
| BR (1) | BRPI0414222B8 (enExample) |
| CA (1) | CA2536015C (enExample) |
| CY (2) | CY1120113T1 (enExample) |
| DK (2) | DK3342425T3 (enExample) |
| ES (2) | ES2775525T3 (enExample) |
| HU (2) | HUE036593T2 (enExample) |
| IL (1) | IL173747A (enExample) |
| MX (1) | MXPA06002660A (enExample) |
| NZ (1) | NZ545516A (enExample) |
| PL (2) | PL3342425T3 (enExample) |
| PT (2) | PT1667522T (enExample) |
| SI (2) | SI1667522T1 (enExample) |
| WO (1) | WO2005023994A2 (enExample) |
Families Citing this family (64)
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| KR101298493B1 (ko) * | 2003-09-09 | 2013-08-21 | 제론 코포레이션 | 텔로머라제 억제를 위한 변형 올리고뉴클레오티드 |
| US9133233B2 (en) | 2003-11-04 | 2015-09-15 | Geron Corporation | RNA amidates and thioamidates for RNAi |
| ME02933B (me) | 2004-07-02 | 2018-04-20 | Geron Corp | Sinteza zaštićenih 3'-amino nukleozionih monomera |
| US7998938B2 (en) | 2005-04-15 | 2011-08-16 | Geron Corporation | Cancer treatment by combined inhibition of proteasome and telomerase activities |
| US8252756B2 (en) | 2005-06-14 | 2012-08-28 | Northwestern University | Nucleic acid functionalized nanoparticles for therapeutic applications |
| US8153604B2 (en) * | 2006-04-24 | 2012-04-10 | Geron Corporation | CNS-tumor treatment method and composition |
| US9506056B2 (en) | 2006-06-08 | 2016-11-29 | Northwestern University | Nucleic acid functionalized nanoparticles for therapeutic applications |
| EP4474480A2 (en) | 2006-10-30 | 2024-12-11 | Geron Corporation | Combined telomerase inhibitor and gemcitabine for the treatment of cancer |
| US8785409B2 (en) * | 2007-01-30 | 2014-07-22 | Geron Corporation | Compounds having anti-adhesive effects on cancer cells |
| CA2691066C (en) | 2007-02-09 | 2018-07-31 | Northwestern University | Particles for detecting intracellular targets |
| ES2407957T3 (es) | 2007-03-09 | 2013-06-17 | Geron Corporation | Tratamiento de carcinomas con una combinación de inhibidores de la vía EGF y de la telomerasa |
| CN101784556B (zh) | 2007-05-10 | 2014-07-09 | 安捷伦科技有限公司 | 用于rna合成的硫代碳保护基团 |
| TW200927177A (en) * | 2007-10-24 | 2009-07-01 | Nat Inst Of Advanced Ind Scien | Lipid-modified double-stranded RNA having potent RNA interference effect |
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| EP2175023A1 (en) * | 2008-07-31 | 2010-04-14 | The University of Zurich | Anti-tumor activity of small double-stranded oligodeoxynucleotides targeting telomerase RNA |
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| CN102281872A (zh) | 2008-11-24 | 2011-12-14 | 西北大学 | 多价rna纳米颗粒组合物 |
| US9394333B2 (en) | 2008-12-02 | 2016-07-19 | Wave Life Sciences Japan | Method for the synthesis of phosphorus atom modified nucleic acids |
| US20100233270A1 (en) | 2009-01-08 | 2010-09-16 | Northwestern University | Delivery of Oligonucleotide-Functionalized Nanoparticles |
| MX342945B (es) | 2009-07-06 | 2016-10-18 | Ontorii Inc * | Profármacos de ácido nucleico novedosos y métodos de uso de los mismos. |
| KR20120136345A (ko) | 2009-10-30 | 2012-12-18 | 노오쓰웨스턴 유니버시티 | 주형화된 나노컨쥬게이트 |
| US20130178610A1 (en) * | 2009-12-24 | 2013-07-11 | Chad A. Mirkin | Oligonucleotide specific uptake of nanoconjugates |
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| ES2856091T3 (es) | 2011-09-14 | 2021-09-27 | Univ Northwestern | Nanoconjugados capaces de atravesar la barrera hematoencefálica |
| KR20240148947A (ko) | 2012-07-13 | 2024-10-11 | 웨이브 라이프 사이언시스 리미티드 | 키랄 제어 |
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| CA3201145A1 (en) | 2012-10-26 | 2014-05-01 | Geron Corporation | C-myc antisense oligonucleotides and methods for using the same to treat cell-proliferative disorders |
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2004
- 2004-09-09 KR KR1020137007201A patent/KR101298493B1/ko not_active Expired - Lifetime
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- 2004-09-09 HU HUE17200625A patent/HUE048359T2/hu unknown
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- 2004-09-09 CN CNB2004800259754A patent/CN100393209C/zh not_active Expired - Lifetime
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