SI1667522T1 - Modified oligonucleotides for the inhibition of telomerase - Google Patents

Modified oligonucleotides for the inhibition of telomerase Download PDF

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Publication number
SI1667522T1
SI1667522T1 SI200432432T SI200432432T SI1667522T1 SI 1667522 T1 SI1667522 T1 SI 1667522T1 SI 200432432 T SI200432432 T SI 200432432T SI 200432432 T SI200432432 T SI 200432432T SI 1667522 T1 SI1667522 T1 SI 1667522T1
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Slovenia
Prior art keywords
compound
cancer
pharmaceutically acceptable
pharmaceutical composition
cell
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SI200432432T
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English (en)
Slovenian (sl)
Inventor
Sergei Gryaznov
Krisztina Pongracz
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Geron Corporation
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Publication of SI1667522T1 publication Critical patent/SI1667522T1/en

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    • A61K47/544—Phospholipids
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    • C07C233/18—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
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    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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SI200432432T 2003-09-09 2004-09-09 Modified oligonucleotides for the inhibition of telomerase SI1667522T1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US50150903P 2003-09-09 2003-09-09
EP04783801.6A EP1667522B1 (en) 2003-09-09 2004-09-09 Modified oligonucleotides for telomerase inhibition
PCT/US2004/029718 WO2005023994A2 (en) 2003-09-09 2004-09-09 Modified oligonucleotides for telomerase inhibition

Publications (1)

Publication Number Publication Date
SI1667522T1 true SI1667522T1 (en) 2018-04-30

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ID=34273050

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Application Number Title Priority Date Filing Date
SI200432432T SI1667522T1 (en) 2003-09-09 2004-09-09 Modified oligonucleotides for the inhibition of telomerase
SI200432487T SI3342425T1 (sl) 2003-09-09 2004-09-09 Modificirani oligonukleotidi za inhibicijo telomeraze

Family Applications After (1)

Application Number Title Priority Date Filing Date
SI200432487T SI3342425T1 (sl) 2003-09-09 2004-09-09 Modificirani oligonukleotidi za inhibicijo telomeraze

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US (8) US7494982B2 (enExample)
EP (3) EP3682903A1 (enExample)
JP (10) JP4690324B2 (enExample)
KR (3) KR101298493B1 (enExample)
CN (2) CN101293908B (enExample)
AU (2) AU2004271215B2 (enExample)
BR (1) BRPI0414222B8 (enExample)
CA (1) CA2536015C (enExample)
CY (2) CY1120113T1 (enExample)
DK (2) DK3342425T3 (enExample)
ES (2) ES2775525T3 (enExample)
HU (2) HUE036593T2 (enExample)
IL (1) IL173747A (enExample)
MX (1) MXPA06002660A (enExample)
NZ (1) NZ545516A (enExample)
PL (2) PL3342425T3 (enExample)
PT (2) PT1667522T (enExample)
SI (2) SI1667522T1 (enExample)
WO (1) WO2005023994A2 (enExample)

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US9133233B2 (en) 2003-11-04 2015-09-15 Geron Corporation RNA amidates and thioamidates for RNAi
ME02933B (me) 2004-07-02 2018-04-20 Geron Corp Sinteza zaštićenih 3'-amino nukleozionih monomera
US7998938B2 (en) 2005-04-15 2011-08-16 Geron Corporation Cancer treatment by combined inhibition of proteasome and telomerase activities
US8252756B2 (en) 2005-06-14 2012-08-28 Northwestern University Nucleic acid functionalized nanoparticles for therapeutic applications
US8153604B2 (en) * 2006-04-24 2012-04-10 Geron Corporation CNS-tumor treatment method and composition
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CA2691066C (en) 2007-02-09 2018-07-31 Northwestern University Particles for detecting intracellular targets
ES2407957T3 (es) 2007-03-09 2013-06-17 Geron Corporation Tratamiento de carcinomas con una combinación de inhibidores de la vía EGF y de la telomerasa
CN101784556B (zh) 2007-05-10 2014-07-09 安捷伦科技有限公司 用于rna合成的硫代碳保护基团
TW200927177A (en) * 2007-10-24 2009-07-01 Nat Inst Of Advanced Ind Scien Lipid-modified double-stranded RNA having potent RNA interference effect
US8440809B2 (en) * 2008-07-02 2013-05-14 Santaris Pharma A/S RNA antagonists targeting Hsp27
EP2175023A1 (en) * 2008-07-31 2010-04-14 The University of Zurich Anti-tumor activity of small double-stranded oligodeoxynucleotides targeting telomerase RNA
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CN102281872A (zh) 2008-11-24 2011-12-14 西北大学 多价rna纳米颗粒组合物
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US20100233270A1 (en) 2009-01-08 2010-09-16 Northwestern University Delivery of Oligonucleotide-Functionalized Nanoparticles
MX342945B (es) 2009-07-06 2016-10-18 Ontorii Inc * Profármacos de ácido nucleico novedosos y métodos de uso de los mismos.
KR20120136345A (ko) 2009-10-30 2012-12-18 노오쓰웨스턴 유니버시티 주형화된 나노컨쥬게이트
US20130178610A1 (en) * 2009-12-24 2013-07-11 Chad A. Mirkin Oligonucleotide specific uptake of nanoconjugates
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