BR0314236A - Formulação de oligonucleotìdeo, composição farmacêutica, kit, composto antiviral, preparação de oligonucleotìdeo e métodos para seleção de um oligonucleotìdeo antiviral para uso como um agente antiviral, para profilaxia ou tratamento de uma infecção viral em um paciente, para tratamento profilático de câncer causado por oncovìrus, para identificação de um composto que altera a ligação de um oligonucleotìdeo a pelo menos um componente viral, para purificação da ligação de oligonucleotìdeos a pelo menos um componente viral e para enriquecimento de oligonucleotìdeos a partir de um agrupamento de oligonucleotìdeos - Google Patents
Formulação de oligonucleotìdeo, composição farmacêutica, kit, composto antiviral, preparação de oligonucleotìdeo e métodos para seleção de um oligonucleotìdeo antiviral para uso como um agente antiviral, para profilaxia ou tratamento de uma infecção viral em um paciente, para tratamento profilático de câncer causado por oncovìrus, para identificação de um composto que altera a ligação de um oligonucleotìdeo a pelo menos um componente viral, para purificação da ligação de oligonucleotìdeos a pelo menos um componente viral e para enriquecimento de oligonucleotìdeos a partir de um agrupamento de oligonucleotìdeosInfo
- Publication number
- BR0314236A BR0314236A BR0314236-1A BR0314236A BR0314236A BR 0314236 A BR0314236 A BR 0314236A BR 0314236 A BR0314236 A BR 0314236A BR 0314236 A BR0314236 A BR 0314236A
- Authority
- BR
- Brazil
- Prior art keywords
- oligonucleotide
- antiviral
- compound
- binding
- treatment
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
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- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
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- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
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- C12N2310/00—Structure or type of the nucleic acid
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- C12N2310/351—Conjugate
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- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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Abstract
"FORMULAçãO DE OLIGONUCLEOTìDEO, COMPOSIçãO FARMACêUTICA, KIT, COMPOSTO ANTIVIRAL, PREPARAçãO DE OLIGONUCLEOTìDEO E MéTODOS PARA SELEçãO DE UM OLIGONUCLEOTìDEO ANTIVIRAL PARA USO COMO UM AGENTE ANTIVIRAL, PARA PROFILAXIA OU TRATAMENTO DE UMA INFECçãO VIRAL EM UM PACIENTE, PARA TRATAMENTO PROFILáTICO DE CâNCER CAUSADO POR ONCOVìRUS, PARA IDENTIFICAçãO DE UM COMPOSTO QUE ALTERA A LIGAçãO DE UM OLIGONUCLEOTìDEO A PELO MENOS UM COMPONENTE VIRAL, PARA PURIFICAçãO DA LIGAçãO DE OLIGONUCLEOTìDEOS A PELO MENOS UM COMPONENTE VIRAL E PARA ENRIQUECIMENTO DE OLIGONUCLEOTìDEOS A PARTIR DE UM AGRUPAMENTO DE OLIGONUCLEOTìDEOS". Os oligonucleotídeos de seq³ência aleatória que têm atividade antiviral são descritos, junto com seu uso como agentes antivirais. Em muitos casos, os oligonucleotídeos são maiores do que 40 nucleotídeos no comprimento. Também são descritos métodos para a profilaxia ou tratamento de uma infecção viral em um ser humano ou animal e um método para a tratamento profilático do câncer causado pelos oncovírus em um ser humano ou animal. Os métodos tipicamente envolve administrar a um ser humano ou animal em necessidade de tal tratamento, uma quantidade farmacologicamente aceitável, terapeuticamente eficaz de pelo menos um oligonucleotídeo que não atue por um modo complementar de seq³ência de ação.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US41026402P | 2002-09-13 | 2002-09-13 | |
US43093402P | 2002-12-05 | 2002-12-05 | |
PCT/IB2003/004573 WO2004024919A1 (en) | 2002-09-13 | 2003-09-11 | Non-sequence complementary antiviral oligonucleotides |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0314236A true BR0314236A (pt) | 2005-08-09 |
Family
ID=31997929
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0314236-1A BR0314236A (pt) | 2002-09-13 | 2003-09-11 | Formulação de oligonucleotìdeo, composição farmacêutica, kit, composto antiviral, preparação de oligonucleotìdeo e métodos para seleção de um oligonucleotìdeo antiviral para uso como um agente antiviral, para profilaxia ou tratamento de uma infecção viral em um paciente, para tratamento profilático de câncer causado por oncovìrus, para identificação de um composto que altera a ligação de um oligonucleotìdeo a pelo menos um componente viral, para purificação da ligação de oligonucleotìdeos a pelo menos um componente viral e para enriquecimento de oligonucleotìdeos a partir de um agrupamento de oligonucleotìdeos |
Country Status (12)
Country | Link |
---|---|
US (13) | US20040162253A1 (pt) |
EP (2) | EP1537208A1 (pt) |
JP (4) | JP2005538186A (pt) |
KR (1) | KR101360955B1 (pt) |
CN (1) | CN1694959B (pt) |
AU (1) | AU2003267785C1 (pt) |
BR (1) | BR0314236A (pt) |
CA (1) | CA2498777C (pt) |
EA (1) | EA008940B1 (pt) |
MX (1) | MXPA05002791A (pt) |
NZ (1) | NZ538719A (pt) |
WO (1) | WO2004024919A1 (pt) |
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- 2003-09-11 KR KR1020057004380A patent/KR101360955B1/ko active IP Right Grant
- 2003-09-12 US US10/661,088 patent/US20040162253A1/en not_active Abandoned
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