RU95104940A - Способ введения в олигонуклеотид алкилфосфонотиоатной или арилфосфонотиоатной межнуклеотидной связи, способ получения олигонуклеотида, олигонуклеотиды, способ ингибирования генной экспрессии, способ лечения - Google Patents

Способ введения в олигонуклеотид алкилфосфонотиоатной или арилфосфонотиоатной межнуклеотидной связи, способ получения олигонуклеотида, олигонуклеотиды, способ ингибирования генной экспрессии, способ лечения

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Publication number
RU95104940A
RU95104940A RU95104940/04A RU95104940A RU95104940A RU 95104940 A RU95104940 A RU 95104940A RU 95104940/04 A RU95104940/04 A RU 95104940/04A RU 95104940 A RU95104940 A RU 95104940A RU 95104940 A RU95104940 A RU 95104940A
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Russia
Prior art keywords
oligonucleotide
alkylphosphonothioate
incorporation
gene expression
internucleotide linkage
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RU95104940/04A
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English (en)
Inventor
А.Падмаприя
Lk]
Агравал Судхир
In]
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Хайбрайдон
Хайбрайдон, Инк.
Инк. (US)
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Publication of RU95104940A publication Critical patent/RU95104940A/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

В изобретении предложены усовершенствованные олигонуклеотиды, которые обладают повышенной устойчивостью к нуклеолитическому расщеплению за счет наличия алкилфосфонотиоатных или арилфосфонотиоатных межнуклеотидных связей.

Claims (1)

  1. В изобретении предложены усовершенствованные олигонуклеотиды, которые обладают повышенной устойчивостью к нуклеолитическому расщеплению за счет наличия алкилфосфонотиоатных или арилфосфонотиоатных межнуклеотидных связей.
RU95104940/04A 1992-07-27 1993-07-26 Способ введения в олигонуклеотид алкилфосфонотиоатной или арилфосфонотиоатной межнуклеотидной связи, способ получения олигонуклеотида, олигонуклеотиды, способ ингибирования генной экспрессии, способ лечения RU95104940A (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US91996792A 1992-07-27 1992-07-27
US07/919,967 1992-07-27

Publications (1)

Publication Number Publication Date
RU95104940A true RU95104940A (ru) 1997-01-10

Family

ID=25442953

Family Applications (1)

Application Number Title Priority Date Filing Date
RU95104940/04A RU95104940A (ru) 1992-07-27 1993-07-26 Способ введения в олигонуклеотид алкилфосфонотиоатной или арилфосфонотиоатной межнуклеотидной связи, способ получения олигонуклеотида, олигонуклеотиды, способ ингибирования генной экспрессии, способ лечения

Country Status (9)

Country Link
US (1) US5929226A (ru)
EP (1) EP0652890B1 (ru)
JP (1) JPH08502723A (ru)
AT (1) ATE162198T1 (ru)
AU (1) AU678769B2 (ru)
CA (1) CA2140542A1 (ru)
DE (1) DE69316369D1 (ru)
RU (1) RU95104940A (ru)
WO (1) WO1994002499A1 (ru)

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