ATE334657T1 - Hemmung der bcl-2 protein expression durch liposomale antisense-oligodeoxynukleotide - Google Patents

Hemmung der bcl-2 protein expression durch liposomale antisense-oligodeoxynukleotide

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Publication number
ATE334657T1
ATE334657T1 AT97910067T AT97910067T ATE334657T1 AT E334657 T1 ATE334657 T1 AT E334657T1 AT 97910067 T AT97910067 T AT 97910067T AT 97910067 T AT97910067 T AT 97910067T AT E334657 T1 ATE334657 T1 AT E334657T1
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Austria
Prior art keywords
bcl
inhibition
protein expression
antisense oligodeoxynucleotides
liposomal antisense
Prior art date
Application number
AT97910067T
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English (en)
Inventor
Mar Tormo
Ana M Tara
Gabriel Lopez-Berestein
Timothy J Mcdonnel
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Univ Texas
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Publication of ATE334657T1 publication Critical patent/ATE334657T1/de

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/312—Phosphonates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/322—2'-R Modification

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Wood Science & Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Oncology (AREA)
  • Dispersion Chemistry (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
AT97910067T 1996-10-04 1997-10-03 Hemmung der bcl-2 protein expression durch liposomale antisense-oligodeoxynukleotide ATE334657T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/726,211 US6977244B2 (en) 1996-10-04 1996-10-04 Inhibition of Bcl-2 protein expression by liposomal antisense oligodeoxynucleotides

Publications (1)

Publication Number Publication Date
ATE334657T1 true ATE334657T1 (de) 2006-08-15

Family

ID=24917657

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97910067T ATE334657T1 (de) 1996-10-04 1997-10-03 Hemmung der bcl-2 protein expression durch liposomale antisense-oligodeoxynukleotide

Country Status (8)

Country Link
US (2) US6977244B2 (de)
EP (1) EP0939621B1 (de)
JP (2) JP4402746B2 (de)
AT (1) ATE334657T1 (de)
CA (2) CA2677176C (de)
DE (1) DE69736432T2 (de)
ES (1) ES2270454T3 (de)
WO (1) WO1998014172A1 (de)

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EP0939621A1 (de) 1999-09-08
EP0939621A4 (de) 2005-02-02
DE69736432T2 (de) 2007-03-01
CA2677176A1 (en) 1998-04-09
CA2266584A1 (en) 1998-04-09
JP2008069161A (ja) 2008-03-27
EP0939621B1 (de) 2006-08-02
WO1998014172A1 (en) 1998-04-09
CA2266584C (en) 2009-12-08
JP2001502172A (ja) 2001-02-20
US20030012812A1 (en) 2003-01-16
ES2270454T3 (es) 2007-04-01
JP4402746B2 (ja) 2010-01-20
CA2677176C (en) 2013-01-08
DE69736432D1 (de) 2006-09-14
US6977244B2 (en) 2005-12-20
US20030219474A1 (en) 2003-11-27

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