DE69403642D1 - 7-deazapurin modifizierte oligonukleotide - Google Patents

7-deazapurin modifizierte oligonukleotide

Info

Publication number
DE69403642D1
DE69403642D1 DE69403642T DE69403642T DE69403642D1 DE 69403642 D1 DE69403642 D1 DE 69403642D1 DE 69403642 T DE69403642 T DE 69403642T DE 69403642 T DE69403642 T DE 69403642T DE 69403642 D1 DE69403642 D1 DE 69403642D1
Authority
DE
Germany
Prior art keywords
deazapurin
modified oligonucleotides
oligonucleotides
deazanucleosides
rna
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69403642T
Other languages
English (en)
Other versions
DE69403642T2 (de
Inventor
Phillip Cook
Daniel Delecki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi SA
Original Assignee
Sanofi SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi SA filed Critical Sanofi SA
Publication of DE69403642D1 publication Critical patent/DE69403642D1/de
Application granted granted Critical
Publication of DE69403642T2 publication Critical patent/DE69403642T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
DE69403642T 1993-03-30 1994-03-21 7-deazapurin modifizierte oligonukleotide Expired - Fee Related DE69403642T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4015893A 1993-03-30 1993-03-30
PCT/US1994/002996 WO1994022892A1 (en) 1993-03-30 1994-03-21 7-deazapurine modified oligonucleotides

Publications (2)

Publication Number Publication Date
DE69403642D1 true DE69403642D1 (de) 1997-07-10
DE69403642T2 DE69403642T2 (de) 1998-01-08

Family

ID=21909441

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69403642T Expired - Fee Related DE69403642T2 (de) 1993-03-30 1994-03-21 7-deazapurin modifizierte oligonukleotide

Country Status (11)

Country Link
EP (1) EP0691980B1 (de)
JP (1) JPH08508493A (de)
AT (1) ATE154029T1 (de)
AU (1) AU6589094A (de)
CA (1) CA2159630A1 (de)
DE (1) DE69403642T2 (de)
DK (1) DK0691980T3 (de)
ES (1) ES2105698T3 (de)
GR (1) GR3024597T3 (de)
HU (1) HU9501963D0 (de)
WO (1) WO1994022892A1 (de)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4438918A1 (de) * 1994-11-04 1996-05-09 Hoechst Ag Modifizierte Oligonukleotide, deren Herstellung sowie deren Verwendung
US6150510A (en) 1995-11-06 2000-11-21 Aventis Pharma Deutschland Gmbh Modified oligonucleotides, their preparation and their use
EP0866070A1 (de) * 1997-03-20 1998-09-23 Amersham Pharmacia Biotech Inc Derivate von 7-Deaza-2'-Deoxy-Guanosin-5'-Triphosphate, Herstellung und Verwendung davon
US6906185B1 (en) 1997-03-20 2005-06-14 Amersham Biosciences Corp. Derivatives of 7-deaza -2′-deoxyguanosine-5'-triphosphate, preparation and use thereof
US6660845B1 (en) * 1999-11-23 2003-12-09 Epoch Biosciences, Inc. Non-aggregating, non-quenching oligomers comprising nucleotide analogues; methods of synthesis and use thereof
US6962906B2 (en) 2000-03-14 2005-11-08 Active Motif Oligonucleotide analogues, methods of synthesis and methods of use
CA2402319A1 (en) 2000-03-14 2001-09-20 Active Motif Oligonucleotide analogues, methods of synthesis and methods of use
ES2298269T3 (es) * 2000-09-26 2008-05-16 Idera Pharmaceuticals, Inc. Modulacion de la actividad inmunoestimulante de analogos oligonucleotidicos inmunoestimulantes mediante cambios quimicos posicionales.
JP5745842B2 (ja) 2007-06-19 2015-07-08 ストラトス ゲノミクス インコーポレイテッド 拡張によるハイスループット核酸配列決定
CN102365367A (zh) 2009-01-29 2012-02-29 斯特拉托斯基因公司 通过展开进行高通量核酸测序和相关方法
WO2012003330A2 (en) 2010-06-30 2012-01-05 Stratos Genomics, Inc Multiplexed identification of nucleic acid sequences
US9212392B2 (en) 2012-09-25 2015-12-15 Exact Sciences Corporation Normalization of polymerase activity
WO2014152937A1 (en) 2013-03-14 2014-09-25 Ibis Biosciences, Inc. Nucleic acid control panels
WO2016081871A1 (en) 2014-11-20 2016-05-26 Stratos Genomics, Inc. Nulceoside phosphoroamidate esters and derivatives thereof, use and synthesis thereof
CN108350485A (zh) 2015-10-30 2018-07-31 精密科学发展有限责任公司 血浆dna的多重扩增检测测定以及分离和检测
WO2017087281A1 (en) 2015-11-16 2017-05-26 Stratos Genomics, Inc. Dp04 polymerase variants
US10385406B2 (en) 2016-05-05 2019-08-20 Exact Sciences Development Company, Llc Detection of lung neoplasia by analysis of methylated DNA
US11118228B2 (en) 2017-01-27 2021-09-14 Exact Sciences Development Company, Llc Detection of colon neoplasia by analysis of methylated DNA
WO2018155450A1 (ja) 2017-02-21 2018-08-30 国立大学法人大阪大学 アンチセンスオリゴ核酸
CA3061651A1 (en) 2017-05-04 2018-11-08 Stratos Genomics, Inc. Dp04 polymerase variants
AU2018383610B2 (en) 2017-12-11 2024-09-12 F. Hoffmann-La Roche Ag DPO4 polymerase variants with improved accuracy
US10648025B2 (en) 2017-12-13 2020-05-12 Exact Sciences Development Company, Llc Multiplex amplification detection assay II
US20220403450A1 (en) 2021-06-03 2022-12-22 Illumina Software, Inc. Systems and methods for sequencing nucleotides using two optical channels
WO2023278781A1 (en) 2021-07-01 2023-01-05 Illumina, Inc. Device having horizontal nanochannel for nanopore sequencing
CN117580961A (zh) 2021-09-01 2024-02-20 Illumina公司 用于加速碱基判读的幅度调制
WO2023049682A1 (en) 2021-09-22 2023-03-30 Illumina, Inc. Sequencing polynucleotides using nanopores
US20230112203A1 (en) 2021-09-30 2023-04-13 Illumina, Inc. Isolation of cells in a nanopore sensor array
WO2023086391A1 (en) 2021-11-15 2023-05-19 Illumina, Inc. Nanopore systems and methods of fabrication
US20230183799A1 (en) 2021-12-10 2023-06-15 Illumina, Inc. Parallel sample and index sequencing
EP4341435A1 (de) 2022-03-15 2024-03-27 Illumina, Inc. Verfahren für basenrufende nukleobasen
US20230357307A1 (en) 2022-05-04 2023-11-09 Illumina, Inc. Cleavable cyclic loop nucleotides for nanopore sequencing
WO2023239660A1 (en) 2022-06-07 2023-12-14 Illumina Software, Inc. Methods and systems for identifying gene variants
WO2024010812A2 (en) 2022-07-07 2024-01-11 Illumina Software, Inc. Methods and systems for determining copy number variant genotypes
WO2024010809A2 (en) 2022-07-07 2024-01-11 Illumina Software, Inc. Methods and systems for detecting recombination events
WO2024073278A1 (en) 2022-09-26 2024-04-04 Illumina, Inc. Detecting and genotyping variable number tandem repeats
US20240110889A1 (en) 2022-09-28 2024-04-04 Illumina, Inc. Fast pulsing for nanopore sensors
WO2024163233A1 (en) 2023-01-31 2024-08-08 Illumina, Inc. Copy number variant calling and recovery
WO2024191730A1 (en) 2023-03-10 2024-09-19 Illumina, Inc. K-mer-based methods for assembling polynucleotide sequences

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3739366A1 (de) * 1987-04-10 1988-10-27 Boehringer Mannheim Gmbh Desaza-purin-nucleosid-derivate, verfahren zu deren herstellung sowie deren verwendung bei der nucleinsaeure-sequenzierung sowie als antivirale mittel

Also Published As

Publication number Publication date
GR3024597T3 (en) 1997-12-31
HU9501963D0 (en) 1995-08-28
DK0691980T3 (da) 1997-12-29
EP0691980A1 (de) 1996-01-17
ATE154029T1 (de) 1997-06-15
EP0691980B1 (de) 1997-06-04
JPH08508493A (ja) 1996-09-10
CA2159630A1 (en) 1994-10-13
WO1994022892A1 (en) 1994-10-13
AU6589094A (en) 1994-10-24
DE69403642T2 (de) 1998-01-08
ES2105698T3 (es) 1997-10-16

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Legal Events

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8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee