ATE154029T1 - 7-deazapurin modifizierte oligonukleotide - Google Patents

7-deazapurin modifizierte oligonukleotide

Info

Publication number
ATE154029T1
ATE154029T1 AT94913923T AT94913923T ATE154029T1 AT E154029 T1 ATE154029 T1 AT E154029T1 AT 94913923 T AT94913923 T AT 94913923T AT 94913923 T AT94913923 T AT 94913923T AT E154029 T1 ATE154029 T1 AT E154029T1
Authority
AT
Austria
Prior art keywords
modified oligonucleotides
deazapurine modified
deazapurine
oligonucleotides
deazanucleosides
Prior art date
Application number
AT94913923T
Other languages
English (en)
Inventor
Phillip D Cook
Daniel J Delecki
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Application granted granted Critical
Publication of ATE154029T1 publication Critical patent/ATE154029T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
AT94913923T 1993-03-30 1994-03-21 7-deazapurin modifizierte oligonukleotide ATE154029T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US4015893A 1993-03-30 1993-03-30

Publications (1)

Publication Number Publication Date
ATE154029T1 true ATE154029T1 (de) 1997-06-15

Family

ID=21909441

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94913923T ATE154029T1 (de) 1993-03-30 1994-03-21 7-deazapurin modifizierte oligonukleotide

Country Status (11)

Country Link
EP (1) EP0691980B1 (de)
JP (1) JPH08508493A (de)
AT (1) ATE154029T1 (de)
AU (1) AU6589094A (de)
CA (1) CA2159630A1 (de)
DE (1) DE69403642T2 (de)
DK (1) DK0691980T3 (de)
ES (1) ES2105698T3 (de)
GR (1) GR3024597T3 (de)
HU (1) HU9501963D0 (de)
WO (1) WO1994022892A1 (de)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4438918A1 (de) * 1994-11-04 1996-05-09 Hoechst Ag Modifizierte Oligonukleotide, deren Herstellung sowie deren Verwendung
US6150510A (en) * 1995-11-06 2000-11-21 Aventis Pharma Deutschland Gmbh Modified oligonucleotides, their preparation and their use
GB2323357B (en) * 1997-03-20 1999-09-29 Amersham Pharm Biotech Inc Derivatives of 7-deaza-2-deoxy-guanosine-5'-triphosphate, preparation and use thereof
US6906185B1 (en) 1997-03-20 2005-06-14 Amersham Biosciences Corp. Derivatives of 7-deaza -2′-deoxyguanosine-5'-triphosphate, preparation and use thereof
US6660845B1 (en) * 1999-11-23 2003-12-09 Epoch Biosciences, Inc. Non-aggregating, non-quenching oligomers comprising nucleotide analogues; methods of synthesis and use thereof
AU2001247414A1 (en) 2000-03-14 2001-09-24 Active Motif Oligonucleotide analogues, methods of synthesis and methods of use
US6962906B2 (en) 2000-03-14 2005-11-08 Active Motif Oligonucleotide analogues, methods of synthesis and methods of use
EP1322656B1 (de) * 2000-09-26 2008-01-16 Idera Pharmaceuticals, Inc. Modulation der immunostimulatorischen aktivität von immunostimulierenden oligonukleotidanaloga durch positionelle chemische veränderungen
WO2008157696A2 (en) 2007-06-19 2008-12-24 Stratos Genomics Inc. High throughput nucleic acid sequencing by expansion
CN102365367A (zh) 2009-01-29 2012-02-29 斯特拉托斯基因公司 通过展开进行高通量核酸测序和相关方法
US8586301B2 (en) 2010-06-30 2013-11-19 Stratos Genomics, Inc. Multiplexed identification of nucleic acid sequences
US9212392B2 (en) 2012-09-25 2015-12-15 Exact Sciences Corporation Normalization of polymerase activity
WO2014152937A1 (en) 2013-03-14 2014-09-25 Ibis Biosciences, Inc. Nucleic acid control panels
AU2015349730C1 (en) 2014-11-20 2020-04-30 F. Hoffmann-La Roche Ag Nulceoside phosphoroamidate esters and derivatives thereof, use and synthesis thereof
CN108350485A (zh) 2015-10-30 2018-07-31 精密科学发展有限责任公司 血浆dna的多重扩增检测测定以及分离和检测
CA3004883A1 (en) 2015-11-16 2017-05-26 Stratos Genomics, Inc. Dp04 polymerase variants
CA3022911A1 (en) 2016-05-05 2017-11-09 Exact Sciences Development Company, Llc Detection of lung neoplasia by analysis of methylated dna
US11118228B2 (en) 2017-01-27 2021-09-14 Exact Sciences Development Company, Llc Detection of colon neoplasia by analysis of methylated DNA
EP3587576A4 (de) * 2017-02-21 2021-01-06 Osaka University Antisense-oligonukleinsäure
EP3619321A4 (de) 2017-05-04 2020-10-28 Stratos Genomics Inc. Dp04-polymerase-varianten
CN111655846A (zh) 2017-12-11 2020-09-11 斯特拉托斯基因公司 具有改进的精确度的dpo4聚合酶变体
US10648025B2 (en) 2017-12-13 2020-05-12 Exact Sciences Development Company, Llc Multiplex amplification detection assay II
US20220403450A1 (en) 2021-06-03 2022-12-22 Illumina Software, Inc. Systems and methods for sequencing nucleotides using two optical channels
AU2022303381A1 (en) 2021-07-01 2024-01-18 Illumina, Inc. Device having horizontal nanochannel for nanopore sequencing
WO2023034079A1 (en) 2021-09-01 2023-03-09 Illumina Software, Inc. Amplitude modulation for accelerated base calling
WO2023049682A1 (en) 2021-09-22 2023-03-30 Illumina, Inc. Sequencing polynucleotides using nanopores
US20230112203A1 (en) 2021-09-30 2023-04-13 Illumina, Inc. Isolation of cells in a nanopore sensor array
WO2023086391A1 (en) 2021-11-15 2023-05-19 Illumina, Inc. Nanopore systems and methods of fabrication
US20230183799A1 (en) 2021-12-10 2023-06-15 Illumina, Inc. Parallel sample and index sequencing
WO2023175026A1 (en) 2022-03-15 2023-09-21 Illumina, Inc. Methods of determining sequence information
US20230357307A1 (en) 2022-05-04 2023-11-09 Illumina, Inc. Cleavable cyclic loop nucleotides for nanopore sequencing
WO2023239660A1 (en) 2022-06-07 2023-12-14 Illumina Software, Inc. Methods and systems for identifying gene variants
WO2024010809A2 (en) 2022-07-07 2024-01-11 Illumina Software, Inc. Methods and systems for detecting recombination events
WO2024010812A2 (en) 2022-07-07 2024-01-11 Illumina Software, Inc. Methods and systems for determining copy number variant genotypes
WO2024073278A1 (en) 2022-09-26 2024-04-04 Illumina, Inc. Detecting and genotyping variable number tandem repeats
US20240110889A1 (en) 2022-09-28 2024-04-04 Illumina, Inc. Fast pulsing for nanopore sensors

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3739366A1 (de) * 1987-04-10 1988-10-27 Boehringer Mannheim Gmbh Desaza-purin-nucleosid-derivate, verfahren zu deren herstellung sowie deren verwendung bei der nucleinsaeure-sequenzierung sowie als antivirale mittel

Also Published As

Publication number Publication date
HU9501963D0 (en) 1995-08-28
DE69403642D1 (de) 1997-07-10
JPH08508493A (ja) 1996-09-10
DK0691980T3 (da) 1997-12-29
EP0691980A1 (de) 1996-01-17
ES2105698T3 (es) 1997-10-16
EP0691980B1 (de) 1997-06-04
CA2159630A1 (en) 1994-10-13
AU6589094A (en) 1994-10-24
GR3024597T3 (en) 1997-12-31
WO1994022892A1 (en) 1994-10-13
DE69403642T2 (de) 1998-01-08

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Legal Events

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UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee