ATE154029T1 - 7-deazapurin modifizierte oligonukleotide - Google Patents
7-deazapurin modifizierte oligonukleotideInfo
- Publication number
- ATE154029T1 ATE154029T1 AT94913923T AT94913923T ATE154029T1 AT E154029 T1 ATE154029 T1 AT E154029T1 AT 94913923 T AT94913923 T AT 94913923T AT 94913923 T AT94913923 T AT 94913923T AT E154029 T1 ATE154029 T1 AT E154029T1
- Authority
- AT
- Austria
- Prior art keywords
- modified oligonucleotides
- deazapurine modified
- deazapurine
- oligonucleotides
- deazanucleosides
- Prior art date
Links
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Chemical class Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 title abstract 2
- 108091034117 Oligonucleotide Proteins 0.000 abstract 1
- 230000000692 anti-sense effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4015893A | 1993-03-30 | 1993-03-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE154029T1 true ATE154029T1 (de) | 1997-06-15 |
Family
ID=21909441
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT94913923T ATE154029T1 (de) | 1993-03-30 | 1994-03-21 | 7-deazapurin modifizierte oligonukleotide |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP0691980B1 (de) |
| JP (1) | JPH08508493A (de) |
| AT (1) | ATE154029T1 (de) |
| AU (1) | AU6589094A (de) |
| CA (1) | CA2159630A1 (de) |
| DE (1) | DE69403642T2 (de) |
| DK (1) | DK0691980T3 (de) |
| ES (1) | ES2105698T3 (de) |
| GR (1) | GR3024597T3 (de) |
| HU (1) | HU9501963D0 (de) |
| WO (1) | WO1994022892A1 (de) |
Families Citing this family (67)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4438918A1 (de) | 1994-11-04 | 1996-05-09 | Hoechst Ag | Modifizierte Oligonukleotide, deren Herstellung sowie deren Verwendung |
| US6150510A (en) | 1995-11-06 | 2000-11-21 | Aventis Pharma Deutschland Gmbh | Modified oligonucleotides, their preparation and their use |
| US6906185B1 (en) | 1997-03-20 | 2005-06-14 | Amersham Biosciences Corp. | Derivatives of 7-deaza -2′-deoxyguanosine-5'-triphosphate, preparation and use thereof |
| EP0866070A1 (de) * | 1997-03-20 | 1998-09-23 | Amersham Pharmacia Biotech Inc | Derivate von 7-Deaza-2'-Deoxy-Guanosin-5'-Triphosphate, Herstellung und Verwendung davon |
| US6660845B1 (en) * | 1999-11-23 | 2003-12-09 | Epoch Biosciences, Inc. | Non-aggregating, non-quenching oligomers comprising nucleotide analogues; methods of synthesis and use thereof |
| AU2001247414A1 (en) | 2000-03-14 | 2001-09-24 | Active Motif | Oligonucleotide analogues, methods of synthesis and methods of use |
| US6962906B2 (en) | 2000-03-14 | 2005-11-08 | Active Motif | Oligonucleotide analogues, methods of synthesis and methods of use |
| JP2004509970A (ja) * | 2000-09-26 | 2004-04-02 | ハイブリドン・インコーポレイテッド | 位置的化学変化による免疫刺激オリゴヌクレオチドアナログの免疫刺激活性の調節 |
| DK2171088T3 (en) | 2007-06-19 | 2016-01-25 | Stratos Genomics Inc | Nucleic acid sequencing in a high yield by expansion |
| EP2391726B1 (de) | 2009-01-29 | 2015-09-23 | Stratos Genomics Inc. | Hochdurchsatz-nukleinsäuresequenzierung mittels expansion und zugehörige verfahren |
| WO2012003330A2 (en) | 2010-06-30 | 2012-01-05 | Stratos Genomics, Inc | Multiplexed identification of nucleic acid sequences |
| US8916344B2 (en) | 2010-11-15 | 2014-12-23 | Exact Sciences Corporation | Methylation assay |
| US8361720B2 (en) | 2010-11-15 | 2013-01-29 | Exact Sciences Corporation | Real time cleavage assay |
| US9212392B2 (en) | 2012-09-25 | 2015-12-15 | Exact Sciences Corporation | Normalization of polymerase activity |
| US20140287946A1 (en) | 2013-03-14 | 2014-09-25 | Ibis Biosciences, Inc. | Nucleic acid control panels |
| US10184154B2 (en) | 2014-09-26 | 2019-01-22 | Mayo Foundation For Medical Education And Research | Detecting cholangiocarcinoma |
| HK1244813A1 (zh) | 2014-11-20 | 2018-08-17 | F. Hoffmann-La Roche Ag | 氰脲酸酯磷醯胺酯及其衍生物，其用途和合成 |
| EP3274440B1 (de) | 2015-03-27 | 2026-03-04 | Exact Sciences Corporation | Nachweis von erkrankungen der speiseröhre |
| KR102811214B1 (ko) | 2015-10-30 | 2025-05-27 | 이그잭트 사이언시즈 코포레이션 | 복합 증폭 검출 분석 및 혈장으로부터 dna의 분리 및 검출 방법 |
| EP3904528A1 (de) | 2015-11-16 | 2021-11-03 | Stratos Genomics Inc. | Dp04-polymerase-varianten |
| CA3022911A1 (en) | 2016-05-05 | 2017-11-09 | Exact Sciences Development Company, Llc | Detection of lung neoplasia by analysis of methylated dna |
| JP7289264B2 (ja) | 2017-01-27 | 2023-06-09 | エグザクト サイエンシーズ コーポレーション | メチル化ｄｎａの分析による結腸腫瘍の検出 |
| US11261440B2 (en) | 2017-02-21 | 2022-03-01 | Osaka University | Antisense oligonucleic acid |
| ES2987024T3 (es) | 2017-05-04 | 2024-11-13 | Hoffmann La Roche | Variantes de polimerasa DP04 |
| US11530392B2 (en) | 2017-12-11 | 2022-12-20 | Stratos Genomics, Inc. | DPO4 polymerase variants with improved accuracy |
| US10648025B2 (en) | 2017-12-13 | 2020-05-12 | Exact Sciences Development Company, Llc | Multiplex amplification detection assay II |
| CN114651070A (zh) | 2019-09-16 | 2022-06-21 | 精密科学公司 | 结构和温度依赖性瓣状核酸内切酶底物 |
| US20220403450A1 (en) | 2021-06-03 | 2022-12-22 | Illumina Software, Inc. | Systems and methods for sequencing nucleotides using two optical channels |
| US20240293816A1 (en) | 2021-07-01 | 2024-09-05 | Illumina, Inc. | Device having horizontal nanochannel for nanopore sequencing |
| WO2023034079A1 (en) | 2021-09-01 | 2023-03-09 | Illumina Software, Inc. | Amplitude modulation for accelerated base calling |
| JP2024534436A (ja) | 2021-09-22 | 2024-09-20 | イルミナ インコーポレイテッド | ナノポアを使用したポリヌクレオチドの配列決定 |
| US12455277B2 (en) | 2021-09-30 | 2025-10-28 | Illumina, Inc. | Isolation of cells in a nanopore sensor array |
| WO2023086391A1 (en) | 2021-11-15 | 2023-05-19 | Illumina, Inc. | Nanopore systems and methods of fabrication |
| US20230183799A1 (en) | 2021-12-10 | 2023-06-15 | Illumina, Inc. | Parallel sample and index sequencing |
| KR20240161668A (ko) | 2022-03-15 | 2024-11-12 | 일루미나, 인코포레이티드 | 페어드-엔드 시퀀싱 |
| US20230357307A1 (en) | 2022-05-04 | 2023-11-09 | Illumina, Inc. | Cleavable cyclic loop nucleotides for nanopore sequencing |
| WO2023239660A1 (en) | 2022-06-07 | 2023-12-14 | Illumina Software, Inc. | Methods and systems for identifying gene variants |
| KR20250034300A (ko) | 2022-07-07 | 2025-03-11 | 일루미나, 인코포레이티드 | 재조합 이벤트를 검출하기 위한 방법 및 시스템 |
| EP4552124A2 (de) | 2022-07-07 | 2025-05-14 | Illumina, Inc. | Verfahren und systeme zur bestimmung von kopienzahlvariantengenotypen |
| US20260011403A1 (en) | 2022-09-26 | 2026-01-08 | Illumina, Inc. | Detecting and genotyping variable number tandem repeats |
| EP4594749A1 (de) | 2022-09-28 | 2025-08-06 | Illumina, Inc. | Schnelle pulsierung für nanoporensensoren |
| WO2024163233A1 (en) | 2023-01-31 | 2024-08-08 | Illumina, Inc. | Copy number variant calling and recovery |
| EP4677598A1 (de) | 2023-03-10 | 2026-01-14 | Illumina, Inc. | K-mer-basierte verfahren zur montage von polynukleotidsequenzen |
| CN121285637A (zh) | 2023-05-03 | 2026-01-06 | 伊鲁米纳公司 | 纳米孔测序中的受控多核苷酸易位 |
| WO2024249253A1 (en) | 2023-05-31 | 2024-12-05 | Illumina, Inc. | Detecting tandem repeats and determining copy numbers thereof |
| WO2025006464A1 (en) | 2023-06-30 | 2025-01-02 | Illumina, Inc. | Systems and methods of sequencing polynucleotides with alternative scatterplots |
| WO2025006466A1 (en) | 2023-06-30 | 2025-01-02 | Illumina, Inc. | Systems and methods of sequencing polynucleotides with four labeled nucleotides |
| WO2025006460A1 (en) | 2023-06-30 | 2025-01-02 | Illumina, Inc. | Systems and methods of sequencing polynucleotides with modified bases |
| WO2025061942A1 (en) | 2023-09-20 | 2025-03-27 | Illumina, Inc. | Sequencing error identification and correction |
| WO2025061922A1 (en) | 2023-09-20 | 2025-03-27 | Illumina, Inc. | Methods for sequencing |
| US20250109433A1 (en) | 2023-09-22 | 2025-04-03 | Illumina, Inc. | Macromolecule blocks for nanopore sequencing |
| WO2025072047A1 (en) | 2023-09-29 | 2025-04-03 | Illumina, Inc. | Methods and systems for determining a cyp2a6 genotype |
| WO2025072468A1 (en) | 2023-09-29 | 2025-04-03 | Illumina, Inc. | Methods and systems for estimating copy numbers and detecting variants |
| WO2025072861A1 (en) | 2023-09-29 | 2025-04-03 | Illumina, Inc. | Cleavable cyclic loop nucleotides for nanopore sequencing |
| WO2025082960A1 (en) | 2023-10-18 | 2025-04-24 | F. Hoffmann-La Roche Ag | Dpo4 polymerase variants with improved properties |
| WO2025149478A1 (en) | 2024-01-12 | 2025-07-17 | F. Hoffmann-La Roche Ag | Compositions of modified nucleoside triphosphates |
| WO2025149479A1 (en) | 2024-01-12 | 2025-07-17 | Roche Diagnostics Gmbh | Synthesis of modified nucleoside triphosphates |
| WO2025159980A1 (en) | 2024-01-23 | 2025-07-31 | Illumina, Inc. | Ratchet-chelators as unique barcodes for nanopore sequencing |
| WO2025174659A1 (en) | 2024-02-12 | 2025-08-21 | Illumina, Inc. | Net-zero current scheme for nanopore system |
| WO2025174660A1 (en) | 2024-02-12 | 2025-08-21 | Illumina, Inc. | Recharging for nanopore system |
| WO2025183909A1 (en) | 2024-03-01 | 2025-09-04 | Illumina, Inc. | Ribose-mediated cyclic loop opening for nanopore sequencing |
| WO2025184183A1 (en) | 2024-03-01 | 2025-09-04 | Illumina, Inc. | Designer peptide cyclic loops for nanopore sequencing |
| WO2025190902A1 (en) | 2024-03-13 | 2025-09-18 | Illumina, Inc. | Improving base calling quality scores |
| WO2025245014A1 (en) | 2024-05-24 | 2025-11-27 | Illumina, Inc. | Nuclease assisted nanopore sequencing |
| WO2025250322A1 (en) | 2024-05-31 | 2025-12-04 | Illumina, Inc. | Genotyping for tandem repeats |
| WO2025254714A1 (en) | 2024-06-03 | 2025-12-11 | Illumina, Inc. | System and method for assembling a polynucleotide sequence |
| WO2026043922A1 (en) | 2024-08-21 | 2026-02-26 | Illumina, Inc. | Modified nucleotides and related methods for nanopore sequencing |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3739366A1 (de) * | 1987-04-10 | 1988-10-27 | Boehringer Mannheim Gmbh | Desaza-purin-nucleosid-derivate, verfahren zu deren herstellung sowie deren verwendung bei der nucleinsaeure-sequenzierung sowie als antivirale mittel |
-
1994
- 1994-03-21 DK DK94913923.2T patent/DK0691980T3/da active
- 1994-03-21 DE DE69403642T patent/DE69403642T2/de not_active Expired - Fee Related
- 1994-03-21 JP JP6522134A patent/JPH08508493A/ja active Pending
- 1994-03-21 WO PCT/US1994/002996 patent/WO1994022892A1/en not_active Ceased
- 1994-03-21 AT AT94913923T patent/ATE154029T1/de not_active IP Right Cessation
- 1994-03-21 AU AU65890/94A patent/AU6589094A/en not_active Abandoned
- 1994-03-21 HU HU9501963A patent/HU9501963D0/hu unknown
- 1994-03-21 EP EP94913923A patent/EP0691980B1/de not_active Expired - Lifetime
- 1994-03-21 CA CA002159630A patent/CA2159630A1/en not_active Abandoned
- 1994-03-21 ES ES94913923T patent/ES2105698T3/es not_active Expired - Lifetime
-
1997
- 1997-09-02 GR GR970402241T patent/GR3024597T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0691980B1 (de) | 1997-06-04 |
| HU9501963D0 (en) | 1995-08-28 |
| DE69403642T2 (de) | 1998-01-08 |
| DK0691980T3 (da) | 1997-12-29 |
| EP0691980A1 (de) | 1996-01-17 |
| JPH08508493A (ja) | 1996-09-10 |
| WO1994022892A1 (en) | 1994-10-13 |
| GR3024597T3 (en) | 1997-12-31 |
| ES2105698T3 (es) | 1997-10-16 |
| AU6589094A (en) | 1994-10-24 |
| DE69403642D1 (de) | 1997-07-10 |
| CA2159630A1 (en) | 1994-10-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |