BR112014016870A2 - composições orgânicas para tratar doenças relacionadas com beta-catenina - Google Patents
composições orgânicas para tratar doenças relacionadas com beta-cateninaInfo
- Publication number
- BR112014016870A2 BR112014016870A2 BR112014016870A BR112014016870A BR112014016870A2 BR 112014016870 A2 BR112014016870 A2 BR 112014016870A2 BR 112014016870 A BR112014016870 A BR 112014016870A BR 112014016870 A BR112014016870 A BR 112014016870A BR 112014016870 A2 BR112014016870 A2 BR 112014016870A2
- Authority
- BR
- Brazil
- Prior art keywords
- cancer
- related diseases
- catenin
- beta
- treating beta
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/713—Double-stranded nucleic acids or oligonucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering N.A.
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/321—2'-O-R Modification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/34—Spatial arrangement of the modifications
- C12N2310/344—Position-specific modifications, e.g. on every purine, at the 3'-end
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physical Education & Sports Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Epidemiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
resumo patente de invenção: "composições orgânicas para tratar doenças relacionadas com beta-catenina". a presente invenção refere-se a agentes de rnai úteis em métodos de tratamento de doenças relacionadas com beta-catenina, tais como polipose adenomatosa do cólon, câncer colorretal, carcinoma de célula basal, câncer de mama, câncer dos rins, tumores wilms, meduloblastoma, câncer ovariano, tumores adrenocorticais, câncer gástrico, câncer do fígado, melanoma, cânceres pancreáticos, câncer da próstata, câncer renal, dentes ectópicos e papilas do paladar, câncer de pele, pilomatrixoma, carcinoma de tireoide anaplástico, e carcinossarcoma uterino, oligodontia, osteoporose, envelhecimento, doenças degenerativas, úlceras de decúbito, ferimentos crônicos e cicatrização de ferimento prejudicado, e doenças similares e relacionadas, usando uma quantidade terapeuticamente eficaz de um agente de rnai para beta-catenina.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261584530P | 2012-01-09 | 2012-01-09 | |
US201261598530P | 2012-02-14 | 2012-02-14 | |
PCT/IB2013/050159 WO2013105022A2 (en) | 2012-01-09 | 2013-01-08 | Organic compositions to treat beta-catenin-related diseases |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112014016870A2 true BR112014016870A2 (pt) | 2017-06-27 |
Family
ID=47720548
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112014016870A BR112014016870A2 (pt) | 2012-01-09 | 2013-01-08 | composições orgânicas para tratar doenças relacionadas com beta-catenina |
Country Status (9)
Country | Link |
---|---|
US (2) | US10023862B2 (pt) |
EP (1) | EP2802658A2 (pt) |
JP (1) | JP6158833B2 (pt) |
CN (1) | CN104302768A (pt) |
AU (1) | AU2013208720A1 (pt) |
BR (1) | BR112014016870A2 (pt) |
CA (1) | CA2860676A1 (pt) |
HK (1) | HK1205758A1 (pt) |
WO (1) | WO2013105022A2 (pt) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3134527B1 (en) * | 2014-04-22 | 2018-12-12 | Medizinische Hochschule Hannover | Lncrnas for therapy and diagnosis of angiogenesis |
CA3017963A1 (en) | 2016-03-16 | 2017-09-21 | Dicerna Pharmaceuticals, Inc. | Compositions and methods for the treatment of a beta-catenin-associated disease or disorder |
US11185553B2 (en) * | 2016-10-31 | 2021-11-30 | Samsung Life Public Welfare Foundation | Pharmaceutical composition for preventing or treating ischemic-reperfusion injury comprising bile acids |
CA3084829A1 (en) | 2018-01-05 | 2019-07-11 | Dicerna Pharmaceuticals, Inc. | Reducing beta-catenin and ido expression to potentiate immunotherapy |
WO2019161105A1 (en) * | 2018-02-14 | 2019-08-22 | Deep Genomics Incorporated | Oligonucleotide therapy for wilson disease |
CN111500694B (zh) * | 2019-01-31 | 2023-02-24 | 中国科学院脑科学与智能技术卓越创新中心 | Baz2b基因作为靶点在缓解衰老中的应用 |
EP4259134A1 (en) * | 2020-12-09 | 2023-10-18 | The Regents Of The University Of Michigan | Compositions and methods for treating wnt-driven cancer |
AU2022228454A1 (en) * | 2021-03-01 | 2023-09-21 | Chelsea Bahney | Compositions comprising catenin mrna and their use for healing bone fractures |
TW202325312A (zh) * | 2021-07-23 | 2023-07-01 | 美商艾拉倫製藥股份有限公司 | β-鏈蛋白(CTNNB1)iRNA組成物及其使用方法 |
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2013
- 2013-01-08 JP JP2014551706A patent/JP6158833B2/ja active Active
- 2013-01-08 EP EP13704633.0A patent/EP2802658A2/en active Pending
- 2013-01-08 AU AU2013208720A patent/AU2013208720A1/en not_active Abandoned
- 2013-01-08 US US14/371,131 patent/US10023862B2/en active Active
- 2013-01-08 CN CN201380013297.9A patent/CN104302768A/zh active Pending
- 2013-01-08 BR BR112014016870A patent/BR112014016870A2/pt not_active IP Right Cessation
- 2013-01-08 CA CA2860676A patent/CA2860676A1/en not_active Abandoned
- 2013-01-08 WO PCT/IB2013/050159 patent/WO2013105022A2/en active Application Filing
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2015
- 2015-07-06 HK HK15106407.7A patent/HK1205758A1/xx unknown
-
2018
- 2018-06-13 US US16/007,517 patent/US20180282728A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
WO2013105022A3 (en) | 2013-10-31 |
EP2802658A2 (en) | 2014-11-19 |
HK1205758A1 (en) | 2015-12-24 |
CN104302768A (zh) | 2015-01-21 |
AU2013208720A1 (en) | 2014-07-24 |
US20180282728A1 (en) | 2018-10-04 |
CA2860676A1 (en) | 2013-07-18 |
JP2015503608A (ja) | 2015-02-02 |
JP6158833B2 (ja) | 2017-07-05 |
US10023862B2 (en) | 2018-07-17 |
WO2013105022A2 (en) | 2013-07-18 |
US20150291954A1 (en) | 2015-10-15 |
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