CA2536015C - Modified oligonucleotides for telomerase inhibition - Google Patents

Modified oligonucleotides for telomerase inhibition Download PDF

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Publication number
CA2536015C
CA2536015C CA2536015A CA2536015A CA2536015C CA 2536015 C CA2536015 C CA 2536015C CA 2536015 A CA2536015 A CA 2536015A CA 2536015 A CA2536015 A CA 2536015A CA 2536015 C CA2536015 C CA 2536015C
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Prior art keywords
oligonucleotide
compounds
telomerase
compound
lipid
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Expired - Lifetime
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CA2536015A
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English (en)
French (fr)
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CA2536015A1 (en
Inventor
Sergei Gryaznov
Krisztina Pongracz
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Geron Corp
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Geron Corp
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    • C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
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    • A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K47/543—Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
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    • A61K47/543—Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
    • A61K47/544—Phospholipids
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    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/17—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/18—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
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    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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    • C12N15/09—Recombinant DNA-technology
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/07—Nucleotidyltransferases (2.7.7)
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CA2536015A 2003-09-09 2004-09-09 Modified oligonucleotides for telomerase inhibition Expired - Lifetime CA2536015C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US50150903P 2003-09-09 2003-09-09
US60/501,509 2003-09-09
PCT/US2004/029718 WO2005023994A2 (en) 2003-09-09 2004-09-09 Modified oligonucleotides for telomerase inhibition

Publications (2)

Publication Number Publication Date
CA2536015A1 CA2536015A1 (en) 2005-03-17
CA2536015C true CA2536015C (en) 2013-12-10

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CA2536015A Expired - Lifetime CA2536015C (en) 2003-09-09 2004-09-09 Modified oligonucleotides for telomerase inhibition

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US (8) US7494982B2 (enExample)
EP (3) EP1667522B1 (enExample)
JP (10) JP4690324B2 (enExample)
KR (3) KR101319388B1 (enExample)
CN (2) CN101293908B (enExample)
AU (2) AU2004271215B2 (enExample)
BR (1) BRPI0414222B8 (enExample)
CA (1) CA2536015C (enExample)
CY (2) CY1120113T1 (enExample)
DK (2) DK3342425T3 (enExample)
ES (2) ES2662196T3 (enExample)
HU (2) HUE036593T2 (enExample)
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MX (1) MXPA06002660A (enExample)
NZ (1) NZ545516A (enExample)
PL (2) PL1667522T3 (enExample)
PT (2) PT3342425T (enExample)
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JP5866119B2 (ja) 2009-10-30 2016-02-17 ノースウェスタン ユニバーシティ 鋳型ナノ複合体
WO2011079290A1 (en) * 2009-12-24 2011-06-30 Northwestern University Oligonucleotide specific uptake of nanoconjugates
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