|
US2515483A
(en)
*
|
1946-08-10 |
1950-07-18 |
Merck & Co Inc |
Diacylated pteroic acid and process for preparing same
|
|
US2816110A
(en)
*
|
1956-11-23 |
1957-12-10 |
Merck & Co Inc |
Methods for the production of substituted pteridines
|
|
US3392173A
(en)
*
|
1964-03-09 |
1968-07-09 |
Lilly Co Eli |
Novel acyl derivatives of desacetyl-vincaleukoblastine and processes for their preparation
|
|
US3387001A
(en)
*
|
1964-10-19 |
1968-06-04 |
Lilly Co Eli |
Novel aminoacyl esters of desacetyl vincaleukoblastine
|
|
US3641109A
(en)
|
1968-09-04 |
1972-02-08 |
Carl D Emerson |
Alkyl and aryl esters of polyhalo-dithio alcohols
|
|
US3632622A
(en)
|
1969-04-01 |
1972-01-04 |
Chevron Res |
Polyhaloalkylpolythioalkyl sulfite esters
|
|
US4203898A
(en)
*
|
1977-08-29 |
1980-05-20 |
Eli Lilly And Company |
Amide derivatives of VLB, leurosidine, leurocristine and related dimeric alkaloids
|
|
US4166810A
(en)
*
|
1978-04-20 |
1979-09-04 |
Eli Lilly And Company |
Derivatives of 4-desacetyl VLB C-3 carboxyhydrazide
|
|
US4337339A
(en)
*
|
1979-04-30 |
1982-06-29 |
Baker Instruments Corp. |
Process for preparation of folic acid derivatives
|
|
US4639456A
(en)
|
1980-06-10 |
1987-01-27 |
Omnichem S.A. |
Vinblastin-23-oyl amino acid derivatives
|
|
US4316885A
(en)
|
1980-08-25 |
1982-02-23 |
Ayerst, Mckenna And Harrison, Inc. |
Acyl derivatives of rapamycin
|
|
US4713249A
(en)
*
|
1981-11-12 |
1987-12-15 |
Schroeder Ulf |
Crystallized carbohydrate matrix for biologically active substances, a process of preparing said matrix, and the use thereof
|
|
US5140104A
(en)
*
|
1982-03-09 |
1992-08-18 |
Cytogen Corporation |
Amine derivatives of folic acid analogs
|
|
US4687808A
(en)
|
1982-08-12 |
1987-08-18 |
Biospecific Technologies, Inc. |
Activation of biocompatible polymers with biologicals whose binding complements are pathological effectors
|
|
JPS59175493A
(ja)
|
1983-03-25 |
1984-10-04 |
Kyowa Hakko Kogyo Co Ltd |
マイトマイシン誘導体
|
|
DE116208T1
(de)
|
1982-12-07 |
1985-02-28 |
Kyowa Hakko Kogyo Co., Ltd., Tokio/Tokyo |
Mitomycin-analoge.
|
|
GR81790B
(enExample)
|
1983-04-29 |
1984-12-12 |
Omnichem Sa |
|
|
JPS59175493U
(ja)
|
1983-05-12 |
1984-11-22 |
株式会社小松製作所 |
レ−ザ加工装置
|
|
US4866180A
(en)
*
|
1984-02-24 |
1989-09-12 |
Bristol-Myers Company |
Amino disulfide thiol exchange products
|
|
GB8413849D0
(en)
|
1984-05-31 |
1984-07-04 |
Amersham Int Plc |
Nmr contrast agents
|
|
JPS60255789A
(ja)
|
1984-06-01 |
1985-12-17 |
Kyowa Hakko Kogyo Co Ltd |
マイトマイシン誘導体,その製造法および抗腫瘍剤
|
|
US5266333A
(en)
*
|
1985-03-06 |
1993-11-30 |
American Cyanamid Company |
Water dispersible and water soluble carbohydrate polymer compositions for parenteral administration of growth hormone
|
|
US4650803A
(en)
|
1985-12-06 |
1987-03-17 |
University Of Kansas |
Prodrugs of rapamycin
|
|
IL82579A0
(en)
|
1986-05-27 |
1987-11-30 |
Lilly Co Eli |
Immunoglobulin conjugates
|
|
US4801688A
(en)
*
|
1986-05-27 |
1989-01-31 |
Eli Lilly And Company |
Hydrazone immunoglobulin conjugates
|
|
DE3750846T2
(de)
|
1986-08-29 |
1995-05-11 |
Kyowa Hakko Kogyo Kk |
Mitomycin-derivate.
|
|
US5006652A
(en)
*
|
1988-08-08 |
1991-04-09 |
Eli Lilly And Company |
Intermediates for antibody-vinca drug conjugates
|
|
US5094849A
(en)
*
|
1988-08-08 |
1992-03-10 |
Eli Lilly And Company |
Cytotoxic antibody conjugates of hydrazide derivatized vinca analogs via simple organic linkers
|
|
US5108921A
(en)
|
1989-04-03 |
1992-04-28 |
Purdue Research Foundation |
Method for enhanced transmembrane transport of exogenous molecules
|
|
US5688488A
(en)
*
|
1989-04-03 |
1997-11-18 |
Purdue Research Foundation |
Composition and method for tumor imaging
|
|
WO1991007418A1
(en)
|
1989-11-13 |
1991-05-30 |
Xoma Corporation |
Chimeric mouse-human a10 antibody with specificity to a human tumor cell antigen
|
|
US5627165A
(en)
|
1990-06-13 |
1997-05-06 |
Drug Innovation & Design, Inc. |
Phosphorous prodrugs and therapeutic delivery systems using same
|
|
US5998603A
(en)
*
|
1994-09-29 |
1999-12-07 |
Isis Pharmaceuticals, Inc. |
4'-desmethyl nucleoside analogs, and oligomers thereof
|
|
JPH06502301A
(ja)
|
1990-08-29 |
1994-03-17 |
サントル オスピタリエ レジオナル デ ナント |
安定タンパク質コアに結合されたタンパク質ポリリガンド
|
|
US5130307A
(en)
|
1990-09-28 |
1992-07-14 |
American Home Products Corporation |
Aminoesters of rapamycin
|
|
US5378696A
(en)
|
1990-09-19 |
1995-01-03 |
American Home Products Corporation |
Rapamycin esters
|
|
US5221670A
(en)
|
1990-09-19 |
1993-06-22 |
American Home Products Corporation |
Rapamycin esters
|
|
US5233036A
(en)
|
1990-10-16 |
1993-08-03 |
American Home Products Corporation |
Rapamycin alkoxyesters
|
|
US5120842A
(en)
|
1991-04-01 |
1992-06-09 |
American Home Products Corporation |
Silyl ethers of rapamycin
|
|
US5100883A
(en)
|
1991-04-08 |
1992-03-31 |
American Home Products Corporation |
Fluorinated esters of rapamycin
|
|
US5118678A
(en)
|
1991-04-17 |
1992-06-02 |
American Home Products Corporation |
Carbamates of rapamycin
|
|
US5194447A
(en)
|
1992-02-18 |
1993-03-16 |
American Home Products Corporation |
Sulfonylcarbamates of rapamycin
|
|
US5138051A
(en)
|
1991-08-07 |
1992-08-11 |
American Home Products Corporation |
Rapamycin analogs as immunosuppressants and antifungals
|
|
US5118677A
(en)
|
1991-05-20 |
1992-06-02 |
American Home Products Corporation |
Amide esters of rapamycin
|
|
US5169851A
(en)
|
1991-08-07 |
1992-12-08 |
American Home Products Corporation |
Rapamycin analog as immunosuppressants and antifungals
|
|
US6335434B1
(en)
*
|
1998-06-16 |
2002-01-01 |
Isis Pharmaceuticals, Inc., |
Nucleosidic and non-nucleosidic folate conjugates
|
|
US5151413A
(en)
|
1991-11-06 |
1992-09-29 |
American Home Products Corporation |
Rapamycin acetals as immunosuppressant and antifungal agents
|
|
US5159079A
(en)
*
|
1991-12-20 |
1992-10-27 |
Eli Lilly And Company |
2-piperidones as intermediates for 5-deaza-10-oxo- and 5-deaza-10-thio-5,6,7,8-tetrahydrofolic acids
|
|
US6004555A
(en)
*
|
1992-03-05 |
1999-12-21 |
Board Of Regents, The University Of Texas System |
Methods for the specific coagulation of vasculature
|
|
US6022966A
(en)
|
1993-11-22 |
2000-02-08 |
Neorx Corporation |
Pretargeting methods and compounds
|
|
US5302584A
(en)
|
1992-10-13 |
1994-04-12 |
American Home Products Corporation |
Carbamates of rapamycin
|
|
US5258389A
(en)
|
1992-11-09 |
1993-11-02 |
Merck & Co., Inc. |
O-aryl, O-alkyl, O-alkenyl and O-alkynylrapamycin derivatives
|
|
US5260300A
(en)
|
1992-11-19 |
1993-11-09 |
American Home Products Corporation |
Rapamycin carbonate esters as immuno-suppressant agents
|
|
US5583020A
(en)
|
1992-11-24 |
1996-12-10 |
Ribozyme Pharmaceuticals, Inc. |
Permeability enhancers for negatively charged polynucleotides
|
|
US7279561B1
(en)
|
1993-04-23 |
2007-10-09 |
Wyeth |
Anti-rapamycin monoclonal antibodies
|
|
DE69430060T2
(de)
*
|
1993-04-23 |
2002-11-07 |
Abbott Laboratories, Abbott Park |
Antikörper von rapamycinen mit offenem ring
|
|
US5562907A
(en)
|
1993-05-14 |
1996-10-08 |
Arnon; Stephen S. |
Method to prevent side-effects and insensitivity to the therapeutic uses of toxins
|
|
US5391730A
(en)
|
1993-10-08 |
1995-02-21 |
American Home Products Corporation |
Phosphorylcarbamates of rapamycin and oxime derivatives thereof
|
|
US5385910A
(en)
|
1993-11-22 |
1995-01-31 |
American Home Products Corporation |
Gem-distributed esters of rapamycin
|
|
US5385908A
(en)
|
1993-11-22 |
1995-01-31 |
American Home Products Corporation |
Hindered esters of rapamycin
|
|
US5385909A
(en)
|
1993-11-22 |
1995-01-31 |
American Home Products Corporation |
Heterocyclic esters of rapamycin
|
|
US5389639A
(en)
|
1993-12-29 |
1995-02-14 |
American Home Products Company |
Amino alkanoic esters of rapamycin
|
|
US5417982A
(en)
|
1994-02-17 |
1995-05-23 |
Modi; Pankaj |
Controlled release of drugs or hormones in biodegradable polymer microspheres
|
|
IL112873A
(en)
*
|
1994-03-08 |
2005-03-20 |
Wyeth Corp |
Rapamycin-fkbp12 binding proteins, their isolation and their use
|
|
US6171859B1
(en)
*
|
1994-03-30 |
2001-01-09 |
Mitokor |
Method of targeting conjugate molecules to mitochondria
|
|
US5362718A
(en)
|
1994-04-18 |
1994-11-08 |
American Home Products Corporation |
Rapamycin hydroxyesters
|
|
US5463048A
(en)
|
1994-06-14 |
1995-10-31 |
American Home Products Corporation |
Rapamycin amidino carbamates
|
|
US5574018A
(en)
|
1994-07-29 |
1996-11-12 |
Amgen Inc. |
Conjugates of vitamin B12 and proteins
|
|
US5491231A
(en)
|
1994-11-28 |
1996-02-13 |
American Home Products Corporation |
Hindered N-oxide esters of rapamycin
|
|
US5547668A
(en)
*
|
1995-05-05 |
1996-08-20 |
The Board Of Trustees Of The University Of Illinois |
Conjugates of folate anti-effector cell antibodies
|
|
AUPN449295A0
(en)
|
1995-07-28 |
1995-08-24 |
Inner And Eastern Health Care Network, The |
Radioprotectors
|
|
US6207157B1
(en)
*
|
1996-04-23 |
2001-03-27 |
The United States Of America As Represented By The Department Of Health And Human Services |
Conjugate vaccine for nontypeable Haemophilus influenzae
|
|
US6030941A
(en)
*
|
1996-05-01 |
2000-02-29 |
Avi Biopharma, Inc. |
Polymer composition for delivering substances in living organisms
|
|
AU717020B2
(en)
*
|
1996-05-03 |
2000-03-16 |
Immunomedics Inc. |
Targeted combination immunotherapy of cancer
|
|
DE19621133A1
(de)
*
|
1996-05-24 |
1997-11-27 |
Boehringer Mannheim Gmbh |
Bestimmungsverfahren mit oligomerisierten Rezeptoren
|
|
ATE298344T1
(de)
|
1996-08-27 |
2005-07-15 |
Univ Utah Res Found |
Biokonjugate und verabreichung von bioaktiven substanzen
|
|
EP0923287A4
(en)
|
1996-08-30 |
2001-08-01 |
Lilly Co Eli |
NON-CLASSIC PYRROLO (2,3-D) PYRIMIDINE ANTIFOLATE
|
|
AU715632B2
(en)
|
1996-09-12 |
2000-02-03 |
Merck & Co., Inc. |
Conjugates useful in the treatment of prostate cancer
|
|
US6056973A
(en)
*
|
1996-10-11 |
2000-05-02 |
Sequus Pharmaceuticals, Inc. |
Therapeutic liposome composition and method of preparation
|
|
US6177404B1
(en)
*
|
1996-10-15 |
2001-01-23 |
Merck & Co., Inc. |
Conjugates useful in the treatment of benign prostatic hyperplasia
|
|
US6071532A
(en)
*
|
1996-10-15 |
2000-06-06 |
Emory University |
Synthesis of glycophospholipid and peptide-phospholipid conjugates and uses thereof
|
|
WO1999020626A1
(en)
|
1997-10-17 |
1999-04-29 |
Purdue Research Foundation |
Folic acid derivatives
|
|
GB9723669D0
(en)
*
|
1997-11-07 |
1998-01-07 |
Univ Aberdeen |
Skin penetration enhancing components
|
|
US6380395B1
(en)
*
|
1998-04-21 |
2002-04-30 |
Bristol-Myers Squibb Company |
12, 13-cyclopropane epothilone derivatives
|
|
US6093382A
(en)
*
|
1998-05-16 |
2000-07-25 |
Bracco Research Usa Inc. |
Metal complexes derivatized with folate for use in diagnostic and therapeutic applications
|
|
WO1999061055A1
(en)
|
1998-05-22 |
1999-12-02 |
The Board Of Trustees Of The Leland Stanford Junior University |
Bifunctional molecules and therapies based thereon
|
|
JP2000026434A
(ja)
|
1998-06-05 |
2000-01-25 |
Zeria Pharmaceut Co Ltd |
新規1,5−ベンゾジアゼピン誘導体
|
|
US6589503B1
(en)
|
1998-06-20 |
2003-07-08 |
Washington University |
Membrane-permeant peptide complexes for medical imaging, diagnostics, and pharmaceutical therapy
|
|
ES2302391T3
(es)
|
1998-12-18 |
2008-07-01 |
HADASIT MEDICAL RESEARCH SERVICES & DEVELOPMENT COMPANY, LTD. |
Procedimiento de administracion de un compuesto a celulas resistentes a multi-farmacos.
|
|
US6291684B1
(en)
*
|
1999-03-29 |
2001-09-18 |
Bristol-Myers Squibb Company |
Process for the preparation of aziridinyl epothilones from oxiranyl epothilones
|
|
US7238368B2
(en)
|
1999-04-23 |
2007-07-03 |
Alza Corporation |
Releasable linkage and compositions containing same
|
|
CA2369595C
(en)
|
1999-04-23 |
2010-10-05 |
Alza Corporation |
Conjugate having a cleavable linkage for use in a liposome
|
|
AUPQ014799A0
(en)
|
1999-05-04 |
1999-05-27 |
Access Pharmaceuticals Australia Pty Limited |
Amplification of folate-mediated targeting to tumor cells using polymers
|
|
AUPQ071299A0
(en)
|
1999-06-02 |
1999-06-24 |
Access Pharmaceuticals Australia Pty Limited |
Vitamin directed dual targeting therapy
|
|
US6822086B1
(en)
|
1999-08-09 |
2004-11-23 |
The General Hospital Corporation |
Drug-carrier complexes and methods of use thereof
|
|
JP4813712B2
(ja)
|
1999-08-09 |
2011-11-09 |
ザ ジェネラル ホスピタル コーポレーション |
薬物−担体複合体およびその使用方法
|
|
US7229961B2
(en)
|
1999-08-24 |
2007-06-12 |
Cellgate, Inc. |
Compositions and methods for enhancing drug delivery across and into ocular tissues
|
|
EP2269654A3
(en)
|
1999-08-24 |
2011-04-13 |
Cellgate Inc. |
Enhancing drug delivery across and into epithelial tissues using oligo arginine moieties
|
|
EP1231942A1
(en)
*
|
1999-10-15 |
2002-08-21 |
Mayo Foundation For Medical Education And Research |
Cobalamin conjugates useful as imaging agents and as antitumor agents
|
|
US7067111B1
(en)
*
|
1999-10-25 |
2006-06-27 |
Board Of Regents, University Of Texas System |
Ethylenedicysteine (EC)-drug conjugates, compositions and methods for tissue specific disease imaging
|
|
DK1242401T3
(da)
|
1999-11-24 |
2007-05-07 |
Immunogen Inc |
Cytotoksiske midler, der omfatter taxaner, og den terapeutiske anvendelse deraf
|
|
AU776283B2
(en)
|
1999-12-02 |
2004-09-02 |
Zeria Pharmaceutical Co., Ltd. |
Calcium salts of 1,5-benzodiazepine derivatives, process for producing the salts and drugs containing the same
|
|
CA2405299C
(en)
*
|
2000-03-31 |
2014-07-22 |
Purdue Research Foundation |
Method of treatment using ligand-immunogen conjugates
|
|
US6670355B2
(en)
*
|
2000-06-16 |
2003-12-30 |
Wyeth |
Method of treating cardiovascular disease
|
|
US6290929B1
(en)
|
2000-07-28 |
2001-09-18 |
The Procter & Gamble Company |
Cancer treatment
|
|
ATE278421T1
(de)
*
|
2000-08-11 |
2004-10-15 |
Wyeth Corp |
Verfahren zur behandlung eines östrogenrezeptor positives karzinoms
|
|
DK1319008T3
(da)
*
|
2000-09-19 |
2009-02-09 |
Wyeth Corp |
Vandoplöselige rapamycinestere
|
|
US6399625B1
(en)
*
|
2000-09-27 |
2002-06-04 |
Wyeth |
1-oxorapamycins
|
|
US6399626B1
(en)
*
|
2000-10-02 |
2002-06-04 |
Wyeth |
Hydroxyesters of 7-desmethylrapamycin
|
|
US6440991B1
(en)
*
|
2000-10-02 |
2002-08-27 |
Wyeth |
Ethers of 7-desmethlrapamycin
|
|
MXPA03004688A
(es)
*
|
2000-11-28 |
2003-09-05 |
Wyeth Corp |
Analisis de expresion de acidos nucleicos y polipeptidos fkbp utiles en diagnostico.
|
|
US20020168737A1
(en)
|
2001-01-24 |
2002-11-14 |
Cornish Virginia W. |
Binding and catalysis screen for high throughput determination of protein function using chemical inducers of dimerization
|
|
AR036993A1
(es)
*
|
2001-04-02 |
2004-10-20 |
Wyeth Corp |
Uso de agentes que modulan la interaccion entre pd-1 y sus ligandos en la submodulacion de respuestas inmunologicas
|
|
EP2388590A1
(en)
*
|
2001-04-02 |
2011-11-23 |
Dana Farber Cancer Institute |
PD-1, a receptor for B7-4, and uses thereof
|
|
DE60231868D1
(de)
|
2001-04-24 |
2009-05-20 |
Purdue Research Foundation |
Folat-mimetika und deren folatrezeptorbindende konjugate
|
|
KR20040015234A
(ko)
|
2001-05-02 |
2004-02-18 |
펄듀 리서치 파운데이션 |
대식세포 매개된 질환의 치료와 진단
|
|
US7109165B2
(en)
*
|
2001-05-18 |
2006-09-19 |
Sirna Therapeutics, Inc. |
Conjugates and compositions for cellular delivery
|
|
CA2449077A1
(en)
*
|
2001-06-01 |
2002-12-12 |
Gregory D. Vite |
Epothilone derivatives
|
|
US20040018203A1
(en)
*
|
2001-06-08 |
2004-01-29 |
Ira Pastan |
Pegylation of linkers improves antitumor activity and reduces toxicity of immunoconjugates
|
|
UA77200C2
(en)
*
|
2001-08-07 |
2006-11-15 |
Wyeth Corp |
Antineoplastic combination of cci-779 and bkb-569
|
|
MXPA04001523A
(es)
*
|
2001-08-22 |
2004-05-31 |
Wyeth Corp |
Dialdehidos de rapamicina.
|
|
ES2246409T3
(es)
*
|
2001-08-22 |
2006-02-16 |
Wyeth |
29-enoles de rapamicina.
|
|
WO2003028634A2
(en)
*
|
2001-09-28 |
2003-04-10 |
Purdue Research Foundation |
Method of treatment using ligand-immunogen conjugates
|
|
GR1004163B
(el)
*
|
2001-11-01 |
2003-02-21 |
|
Πολυκυκλικα παραγωγα τροποποιησης των οπτικων ιδιοτητων και των ιδιοτητων αντοχης στο πλασμα των πολυμερων λιθογραφιας
|
|
AU2002364566B2
(en)
*
|
2001-12-12 |
2009-03-26 |
Conforma Therapeutics Corporation |
Assays and implements for determining and modulating HSP90 binding activity
|
|
US20030194409A1
(en)
*
|
2002-01-17 |
2003-10-16 |
Rothman James E. |
Conjugate heat shock protein-binding peptides
|
|
US8043602B2
(en)
*
|
2002-02-07 |
2011-10-25 |
Endocyte, Inc. |
Folate targeted enhanced tumor and folate receptor positive tissue optical imaging technology
|
|
US7000695B2
(en)
*
|
2002-05-02 |
2006-02-21 |
Halliburton Energy Services, Inc. |
Expanding wellbore junction
|
|
EP1501551B1
(en)
*
|
2002-05-06 |
2009-11-18 |
Endocyte, Inc. |
Folate-receptor targeted imaging agents
|
|
US6596757B1
(en)
*
|
2002-05-14 |
2003-07-22 |
Immunogen Inc. |
Cytotoxic agents comprising polyethylene glycol-containing taxanes and their therapeutic use
|
|
DE60326833D1
(de)
*
|
2002-05-15 |
2009-05-07 |
Endocyte Inc |
Vitamin-mitomycin-konjugate
|
|
US7816377B2
(en)
*
|
2002-07-09 |
2010-10-19 |
R&D-Biopharmaceuticals Gmbh |
Tubulysin analogues
|
|
US7776814B2
(en)
|
2002-07-09 |
2010-08-17 |
R&D-Biopharmaceuticals Gmbh |
Tubulysin conjugates
|
|
ES2369542T3
(es)
|
2002-07-31 |
2011-12-01 |
Seattle Genetics, Inc. |
Conjugados de auristatina y su uso para tratar cáncer, una enfermedad autoinmune o una enfermedad infecciosa.
|
|
IL166039A0
(en)
|
2002-07-31 |
2006-01-15 |
Schering Ag |
New effector conjugates process for their production and their pharmaceutical use
|
|
DE10241152A1
(de)
|
2002-09-05 |
2004-03-18 |
GESELLSCHAFT FüR BIOTECHNOLOGISCHE FORSCHUNG MBH (GBF) |
Tubulysin-Biosynthese-Gene
|
|
US20040047917A1
(en)
|
2002-09-06 |
2004-03-11 |
Stephen Wilson |
Drug delivery and targeting with vitamin B12 conjugates
|
|
JP2006502301A
(ja)
|
2002-09-06 |
2006-01-19 |
インサート セラピューティクス インコーポレイテッド |
治療剤配送のためのシクロデキストリン基材重合体
|
|
CA2501752A1
(en)
*
|
2002-10-10 |
2004-04-22 |
Wyeth |
Compositions, organisms and methodologies employing a novel human kinase
|
|
WO2004037210A2
(en)
|
2002-10-24 |
2004-05-06 |
Research Corporation Technologies |
Functional mri agents for cancer imaging
|
|
AU2003294438A1
(en)
*
|
2002-11-21 |
2004-06-18 |
Wyeth |
Composition and method for treating lupus nephritis
|
|
DE10254439A1
(de)
*
|
2002-11-21 |
2004-06-03 |
GESELLSCHAFT FüR BIOTECHNOLOGISCHE FORSCHUNG MBH (GBF) |
Tubulysine, Herstellungsverfahren und Tubulysin-Mittel
|
|
CA2508831C
(en)
|
2002-12-13 |
2012-05-01 |
Immunomedics, Inc. |
Immunoconjugates with an intracellularly-cleavable linkage
|
|
CN101239190B
(zh)
*
|
2003-01-27 |
2013-09-25 |
恩多塞特公司 |
维生素受体结合递药缀合物
|
|
TWI367096B
(en)
|
2003-01-27 |
2012-07-01 |
Endocyte Inc |
Vitamin-receptor binding drug delivery conjugates and pharmaceutical compositions
|
|
AR042938A1
(es)
*
|
2003-02-06 |
2005-07-06 |
Wyeth Corp |
Uso del cci-779 en el tratamiento de la fibrosis hepatica
|
|
WO2004084805A2
(en)
|
2003-03-19 |
2004-10-07 |
The J. David Gladstone Institutes |
Acetylated tat polypeptides and methods of use thereof
|
|
EP2660322A3
(en)
*
|
2003-04-17 |
2013-11-13 |
Alnylam Pharmaceuticals Inc. |
Modified iRNA agents
|
|
JP2007526238A
(ja)
|
2003-05-06 |
2007-09-13 |
パーデュー・リサーチ・ファウンデーション |
マクロファージまたは葉酸受容体を標的とする狼瘡治療法
|
|
WO2004101803A2
(en)
*
|
2003-05-12 |
2004-11-25 |
Wyeth Holdings Corporation |
Process for producing anticancer agent ll-d45042
|
|
MXPA06000407A
(es)
*
|
2003-07-16 |
2006-03-17 |
Wyeth Corp |
Isomero c cci-779.
|
|
KR20060057605A
(ko)
*
|
2003-08-07 |
2006-05-26 |
와이어쓰 |
Cci-779의 위치선택적 합성 방법
|
|
JP2007519681A
(ja)
|
2004-01-30 |
2007-07-19 |
バイエル・シエーリング・ファーマ アクチエンゲゼルシャフト |
新規なエフェクター複合体、それらを製造する方法およびそれらの薬学上の使用
|
|
US7612071B2
(en)
|
2004-03-12 |
2009-11-03 |
Syntrix Biosystems, Inc. |
Compositions and methods employing aminopterin
|
|
WO2005111238A2
(en)
|
2004-04-19 |
2005-11-24 |
Archemix Corporation |
Aptamer-mediated intracellular delivery of therapeutic oligonucleotides
|
|
EP1747021B1
(en)
|
2004-05-19 |
2015-09-09 |
E. R. Squibb & Sons, L.L.C. |
Self-immolative linkers and drug conjugates
|
|
WO2005115912A1
(ja)
|
2004-05-25 |
2005-12-08 |
Matsushita Electric Industrial Co., Ltd. |
水素生成装置及びそれを用いた燃料電池システム
|
|
WO2006012527A1
(en)
*
|
2004-07-23 |
2006-02-02 |
Endocyte, Inc. |
Bivalent linkers and conjugates thereof
|
|
CA2576233C
(en)
*
|
2004-08-10 |
2016-03-15 |
Alnylam Pharmaceuticals, Inc. |
Conjugate comprising an antagomir and a ligand
|
|
TW200616604A
(en)
|
2004-08-26 |
2006-06-01 |
Nicholas Piramal India Ltd |
Nitric oxide releasing prodrugs containing bio-cleavable linker
|
|
JP2008515915A
(ja)
|
2004-10-07 |
2008-05-15 |
エモリー ユニバーシティー |
多機能性ナノ粒子結合体およびそれらの使用
|
|
WO2007001457A2
(en)
|
2004-11-12 |
2007-01-04 |
Xencor, Inc. |
Antibodies operably linked to selected chemoattractants
|
|
US20110166319A1
(en)
|
2005-02-11 |
2011-07-07 |
Immunogen, Inc. |
Process for preparing purified drug conjugates
|
|
TW200640493A
(en)
|
2005-02-16 |
2006-12-01 |
Insert Therapeutics Inc |
Cyclodextrin-based polymers for therapeutics delivery
|
|
US7312217B2
(en)
|
2005-03-11 |
2007-12-25 |
Syntrix Biosystems, Inc. |
Aminopterin dosage forms and methods for inflammatory disorders
|
|
CN101175757B
(zh)
|
2005-03-16 |
2012-11-14 |
恩多塞特公司 |
蝶酸及其缀合物的合成和纯化
|
|
CA2602585A1
(en)
|
2005-03-30 |
2006-10-05 |
Purdue Research Foundation |
Method for cancer prognosis using cellular folate vitamin receptor quantification
|
|
US20070160617A1
(en)
|
2005-06-20 |
2007-07-12 |
Psma Development Company, Llc |
PSMA antibody-drug conjugates
|
|
WO2007006041A2
(en)
*
|
2005-07-05 |
2007-01-11 |
Purdue Research Foundation |
Imaging and therapeutic method using monocytes
|
|
WO2007022493A2
(en)
|
2005-08-19 |
2007-02-22 |
Endocyte, Inc. |
Ligand conjugates of vinca alkaloids, analogs, and derivatives
|
|
US8465724B2
(en)
|
2005-08-19 |
2013-06-18 |
Endocyte, Inc. |
Multi-drug ligand conjugates
|
|
AU2006280932A1
(en)
|
2005-08-19 |
2007-02-22 |
Novo Nordisk A/S |
Glycopegylated factor VII and factor Vila
|
|
DE102005039651B4
(de)
*
|
2005-08-22 |
2008-04-03 |
Airbus Deutschland Gmbh |
Illumination im Bereich von Flugzeugkabinen
|
|
CN101267841B
(zh)
|
2005-08-24 |
2012-10-10 |
免疫原公司 |
制备美登木素生物碱抗体缀合物的方法
|
|
WO2008048298A2
(en)
|
2005-11-21 |
2008-04-24 |
Medivas, Llc |
Polymer particles for delivery of macromolecules and methods of use
|
|
AR062448A1
(es)
|
2006-05-25 |
2008-11-12 |
Endocyte Inc |
Conjugados de analogos de aziridinil-epotilona y composiciones farmaceuticas que comprenden los mismos
|
|
CA2668197A1
(en)
|
2006-11-03 |
2008-05-15 |
Philip S. Low |
Ex vivo flow cytometry method and device
|
|
JP2010516625A
(ja)
|
2007-01-24 |
2010-05-20 |
インサート セラピューティクス, インコーポレイテッド |
制御された薬物送達のためのテザー基を有するポリマー−薬物コンジュゲート
|
|
CA2678427C
(en)
|
2007-02-16 |
2016-06-07 |
Ktb Tumorforschungsgesellschaft Mbh |
Dual acting prodrugs
|
|
WO2008101231A2
(en)
|
2007-02-16 |
2008-08-21 |
Endocyte, Inc. |
Methods and compositions for treating and diagnosing kidney disease
|
|
EP2489372A3
(en)
*
|
2007-03-14 |
2013-01-02 |
Endocyte, Inc. |
Binding ligand linked drug delivery conjugates of tubulysins
|
|
WO2008138561A1
(en)
|
2007-05-10 |
2008-11-20 |
R & D Biopharmaceuticals Gmbh |
Tubulysine derivatives
|
|
US9877965B2
(en)
|
2007-06-25 |
2018-01-30 |
Endocyte, Inc. |
Vitamin receptor drug delivery conjugates for treating inflammation
|
|
RU2523909C2
(ru)
|
2007-06-25 |
2014-07-27 |
Эндосайт, Инк. |
Конъюгаты, содержащие гидрофильные спейсеры линкеров
|
|
US8476451B2
(en)
|
2007-07-20 |
2013-07-02 |
The Regents Of The University Of California |
Tubulysin D analogues
|
|
NZ600085A
(en)
|
2007-08-17 |
2013-12-20 |
Purdue Research Foundation |
Psma binding ligand-linker conjugates and methods for using
|
|
CN101909441B
(zh)
|
2007-10-25 |
2015-05-13 |
恩多塞特公司 |
微管蛋白抑制剂及其制备方法
|
|
AU2008340354B2
(en)
|
2007-12-04 |
2014-04-17 |
Alnylam Pharmaceuticals, Inc. |
Folate-iRNA conjugates
|
|
US8609105B2
(en)
|
2008-03-18 |
2013-12-17 |
Seattle Genetics, Inc. |
Auristatin drug linker conjugates
|
|
US8236319B2
(en)
|
2008-04-30 |
2012-08-07 |
Immunogen, Inc. |
Cross-linkers and their uses
|
|
MX2010011808A
(es)
|
2008-04-30 |
2011-03-04 |
Immunogen Inc |
Conjugados potentes y enlazadores hidrofilicos.
|
|
US20100040669A1
(en)
|
2008-08-12 |
2010-02-18 |
Higuchi John W |
Non-Invasive Ocular Delivery of Rapamycin
|
|
NZ592255A
(en)
|
2008-09-17 |
2013-07-26 |
Endocyte Inc |
Folate receptor binding conjugates of antifolates
|
|
US20100074863A1
(en)
|
2008-09-17 |
2010-03-25 |
Yat Sun Or |
Anti-infective pyrrolidine derivatives and analogs
|
|
EP2174947A1
(en)
|
2008-09-25 |
2010-04-14 |
Universität des Saarlandes |
Bioactive pre-tubulysins and use thereof
|
|
WO2010045584A1
(en)
|
2008-10-17 |
2010-04-22 |
Endocyte, Inc. |
Folate targeting of nucleotides
|
|
US20110288152A1
(en)
|
2008-10-17 |
2011-11-24 |
Purdue Research Foundation |
Psma binding ligand-linker conjugates and methods for using
|
|
IT1394860B1
(it)
|
2009-07-22 |
2012-07-20 |
Kemotech S R L |
Composti farmaceutici
|
|
US8394922B2
(en)
|
2009-08-03 |
2013-03-12 |
Medarex, Inc. |
Antiproliferative compounds, conjugates thereof, methods therefor, and uses thereof
|
|
EP2322537A1
(en)
|
2009-11-12 |
2011-05-18 |
R & D Biopharmaceuticals Gmbh |
Tubulin inhibitors
|
|
WO2011057805A1
(en)
|
2009-11-12 |
2011-05-19 |
R&D Biopharmaceuticals Gmbh |
Tubulin inhibitors
|
|
WO2011069116A1
(en)
|
2009-12-04 |
2011-06-09 |
Endocyte, Inc. |
Binding ligand linked drug delivery conjugates of tubulysins
|
|
US20120258905A1
(en)
|
2009-12-23 |
2012-10-11 |
Endocyte, Inc. |
Vitamin receptor drug delivery conjugates for treating inflammation
|
|
US20120322741A1
(en)
|
2010-02-25 |
2012-12-20 |
Purdue Research Foundation |
Psma binding ligand-linker conjugates and methods for using
|
|
CN102933236B
(zh)
|
2010-04-15 |
2014-10-08 |
斯皮罗根有限公司 |
吡咯并苯二氮卓类及其结合物
|
|
EP2409983A1
(en)
|
2010-07-19 |
2012-01-25 |
Leibniz-Institut für Pflanzenbiochemie (IPB) |
Tubulysin analogues
|
|
AU2011285532B2
(en)
|
2010-08-06 |
2015-09-10 |
Endocyte, Inc. |
Processes for preparing tubulysins
|
|
US20130203680A1
(en)
|
2010-09-27 |
2013-08-08 |
Endocyte, Inc. |
Folate conjugates for treating inflammation of the eye
|
|
AU2011325989C1
(en)
|
2010-11-12 |
2015-04-23 |
Endocyte, Inc. |
Methods of treating cancer
|
|
WO2012090104A1
(en)
|
2010-12-31 |
2012-07-05 |
Kareus Therapeutics, Sa |
Methods and compositions for designing novel conjugate therapeutics
|
|
PT2675480T
(pt)
|
2011-02-15 |
2019-04-15 |
Immunogen Inc |
Métodos para preparação de conjugados
|
|
MX339927B
(es)
|
2011-03-29 |
2016-06-16 |
Immunogen Inc |
Preparacion de conjugados de maitansinoides y anticuerpos mediante un proceso de una etapa.
|
|
MX2013011201A
(es)
|
2011-03-29 |
2013-12-16 |
Immunogen Inc |
Proceso para la elaboracion de conjugados de mejor homogeneidad.
|
|
BR112013032928A2
(pt)
|
2011-06-21 |
2017-01-24 |
Immunogen Inc |
"derivados de maitansinoide com ligante de peptídeo e conjugados dos mesmos, composição farmacêutica que os compreende e uso dos mesmos"
|
|
IN2014CN04961A
(enExample)
|
2011-12-05 |
2015-09-18 |
Igenica Biotherapeutics Inc |
|
|
WO2013126797A1
(en)
|
2012-02-24 |
2013-08-29 |
Purdue Research Foundation |
Cholecystokinin b receptor targeting for imaging and therapy
|
|
CA2807707A1
(en)
|
2012-02-29 |
2013-08-29 |
Christopher P. Leamon |
Compositions and methods for treating cancer
|
|
EP2822386B1
(en)
|
2012-02-29 |
2021-05-05 |
Purdue Research Foundation |
Folate receptor alpha binding ligands
|
|
US20140080175A1
(en)
|
2012-03-29 |
2014-03-20 |
Endocyte, Inc. |
Processes for preparing tubulysin derivatives and conjugates thereof
|
|
EP2850201A4
(en)
|
2012-05-11 |
2016-08-31 |
Alexander Krantz |
Site-specific labeling and targeted administration of proteins for the treatment of cancer
|
|
JP6280103B2
(ja)
|
2012-05-15 |
2018-02-14 |
ソレント・セラピューティクス・インコーポレイテッドSorrento Therapeutics, Inc. |
薬物コンジュゲート、コンジュゲーション方法およびその使用
|
|
ES2781523T3
(es)
|
2012-07-12 |
2020-09-02 |
Hangzhou Dac Biotech Co Ltd |
Conjugados de moléculas de unión celular con agentes citotóxicos
|
|
EP2708243A1
(en)
|
2012-09-17 |
2014-03-19 |
OntoChem GmbH |
Receptor ligand linked cytotoxic molecules
|
|
US20140107316A1
(en)
|
2012-10-16 |
2014-04-17 |
Endocyte, Inc. |
Drug delivery conjugates containing unnatural amino acids and methods for using
|
|
IN2015DN04147A
(enExample)
|
2012-10-16 |
2015-10-16 |
Endocyte Inc |
|
|
KR102575825B1
(ko)
|
2012-11-15 |
2023-09-06 |
엔도사이트, 인코포레이티드 |
Psma 발현 세포에 의해 야기되는 질병을 치료하기 위한 컨쥬게이트
|
|
JP6133431B2
(ja)
|
2012-11-24 |
2017-05-24 |
ハンジョウ ディーエーシー バイオテック シーオー.,エルティディ.Hangzhou Dac Biotech Co.,Ltd. |
親水性連結体及び薬物分子と細胞結合分子との共役反応における親水性連結体の使用
|
|
US20140154702A1
(en)
|
2012-11-30 |
2014-06-05 |
Endocyte, Inc. |
Methods For Treating Cancer Using Combination Therapies
|
|
PT2935259T
(pt)
|
2012-12-21 |
2019-04-04 |
Abgenomics Int Inc |
Ligantes de autoimolação hidrofílicos e conjugados dos mesmos
|
|
ES2628156T3
(es)
|
2013-02-14 |
2017-08-01 |
Bristol-Myers Squibb Company |
Compuestos de tubulisina, métodos para su fabricación y su uso
|
|
US20140249315A1
(en)
|
2013-03-01 |
2014-09-04 |
Endocyte, Inc. |
Processes for preparing tubulysins
|
|
US9295731B2
(en)
|
2013-04-01 |
2016-03-29 |
Mark Quang Nguyen |
Cleavable drug conjugates, compositions thereof and methods of use
|
|
CN104784699B
(zh)
|
2014-01-20 |
2019-05-03 |
博瑞生物医药(苏州)股份有限公司 |
叶酸受体结合配体-药物偶联物
|
|
CA2962440A1
(en)
|
2014-09-25 |
2016-03-31 |
Endocyte, Inc. |
Methods of treating cancer with tubulysin conjugates
|
|
WO2016080626A2
(en)
|
2014-11-20 |
2016-05-26 |
Pharosgen |
Prodrugs activated by caspase
|
|
US10456479B2
(en)
|
2015-03-19 |
2019-10-29 |
Hangzhou Dac Biotech Co., Ltd. |
Hydrophilic linkers and ligand-drug conjugates thereof
|
|
US10975112B2
(en)
|
2015-06-16 |
2021-04-13 |
Hangzhou Dac Biotech Co., Ltd. |
Linkers for conjugation of cell-binding molecules
|