ATE385778T1 - Verfahren zur verabreichung von einer verbindung an mehrfachresistente zellen - Google Patents
Verfahren zur verabreichung von einer verbindung an mehrfachresistente zellenInfo
- Publication number
- ATE385778T1 ATE385778T1 AT99963103T AT99963103T ATE385778T1 AT E385778 T1 ATE385778 T1 AT E385778T1 AT 99963103 T AT99963103 T AT 99963103T AT 99963103 T AT99963103 T AT 99963103T AT E385778 T1 ATE385778 T1 AT E385778T1
- Authority
- AT
- Austria
- Prior art keywords
- therapeutic compound
- composition
- administration
- carrier
- compound
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 2
- 239000003814 drug Substances 0.000 abstract 4
- 230000001225 therapeutic effect Effects 0.000 abstract 4
- 229940079593 drug Drugs 0.000 abstract 3
- 229940014144 folate Drugs 0.000 abstract 2
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 abstract 2
- 235000019152 folic acid Nutrition 0.000 abstract 2
- 239000011724 folic acid Substances 0.000 abstract 2
- 229920001477 hydrophilic polymer Polymers 0.000 abstract 2
- 239000003446 ligand Substances 0.000 abstract 2
- 239000002502 liposome Substances 0.000 abstract 2
- 238000009825 accumulation Methods 0.000 abstract 1
- 239000011248 coating agent Substances 0.000 abstract 1
- 238000000576 coating method Methods 0.000 abstract 1
- 231100000433 cytotoxic Toxicity 0.000 abstract 1
- 230000001472 cytotoxic effect Effects 0.000 abstract 1
- 208000016691 refractory malignant neoplasm Diseases 0.000 abstract 1
- 230000008685 targeting Effects 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Dispersion Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11300498P | 1998-12-18 | 1998-12-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE385778T1 true ATE385778T1 (de) | 2008-03-15 |
Family
ID=22347057
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99963103T ATE385778T1 (de) | 1998-12-18 | 1999-12-17 | Verfahren zur verabreichung von einer verbindung an mehrfachresistente zellen |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US20040161457A1 (de) |
| EP (1) | EP1140022B8 (de) |
| JP (1) | JP2002532407A (de) |
| AT (1) | ATE385778T1 (de) |
| AU (1) | AU769569B2 (de) |
| CA (1) | CA2353593A1 (de) |
| DE (1) | DE69938148T2 (de) |
| ES (1) | ES2302391T3 (de) |
| IL (1) | IL143555A0 (de) |
| MX (1) | MXPA01006201A (de) |
| WO (1) | WO2000035422A2 (de) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AUPQ014799A0 (en) * | 1999-05-04 | 1999-05-27 | Access Pharmaceuticals Australia Pty Limited | Amplification of folate-mediated targeting to tumor cells using polymers |
| EP1279406A4 (de) * | 2000-04-03 | 2007-10-24 | Santen Pharmaceutical Co Ltd | Transporters und arzneimittelabgabesysteme die diese verwenden |
| JP4922824B2 (ja) * | 2000-04-03 | 2012-04-25 | 参天製薬株式会社 | 送達性物質およびそれを利用した薬物デリバリーシステム |
| JP2006517917A (ja) * | 2002-12-19 | 2006-08-03 | アルザ・コーポレーシヨン | 血管新生性の組織増殖の治療方法 |
| JP5576007B2 (ja) | 2003-01-27 | 2014-08-20 | エンドサイト・インコーポレイテッド | ビタミン受容体結合性薬剤送達結合体 |
| CN100423778C (zh) * | 2003-11-25 | 2008-10-08 | 上海复旦张江生物医药股份有限公司 | 用于上载抗肿瘤药物的脂质体载体及其制备方法和应用 |
| JP5149620B2 (ja) | 2004-07-23 | 2013-02-20 | エンドサイト，インコーポレイテッド | ２価リンカーおよびその結合体 |
| US20070292497A1 (en) * | 2006-05-04 | 2007-12-20 | Martin Francis J | Method for treating micrometastatic tumors |
| NZ580132A (en) | 2007-03-14 | 2012-11-30 | Endocyte Inc | Binding ligand linked drug delivery conjugates of tubulysins to vitamins |
| SI2308514T1 (sl) * | 2007-03-23 | 2013-09-30 | To-Bbb Holding B.V. | Konjugati za prenos zdravila preko krvno-moĹľganske pregrade |
| CN104383553A (zh) | 2007-06-25 | 2015-03-04 | 恩多塞特公司 | 含有亲水性间隔区接头的共轭物 |
| US9877965B2 (en) | 2007-06-25 | 2018-01-30 | Endocyte, Inc. | Vitamin receptor drug delivery conjugates for treating inflammation |
| WO2009055562A1 (en) | 2007-10-25 | 2009-04-30 | Endocyte, Inc. | Tubulysins and processes for preparing |
| US20120100206A1 (en) | 2009-06-11 | 2012-04-26 | Yissum Research Development Company Of The Hebrew University Of Jerusalem, Ltd. | Targeted liposomes comprising n-containing bisphosphonates and uses thereof |
| EP2731591B1 (de) | 2011-07-13 | 2020-06-17 | Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. | Liposomen zur gemeinsamen verkapselung eines bisphosphonats und eines amphipatischen stoffes |
| CA2858741C (en) | 2011-12-07 | 2018-07-31 | Universidade Do Minho | Folate-targeted liposomes |
| US10080805B2 (en) | 2012-02-24 | 2018-09-25 | Purdue Research Foundation | Cholecystokinin B receptor targeting for imaging and therapy |
| GB201215289D0 (en) | 2012-08-28 | 2012-10-10 | Medical Res Council | Nanoparticle formulation |
| US9950074B2 (en) * | 2012-10-12 | 2018-04-24 | Georg-August-Universität Göttingen Stiftung Öffenlichen Rechts, Universitätsmedizin | Composition and delivery vehicle for active agents and methods therefor |
| JP2015536323A (ja) | 2012-10-16 | 2015-12-21 | エンドサイト・インコーポレイテッドＥｎｄｏｃｙｔｅ， Ｉｎｃ． | 非天然アミノ酸を含む薬物送達結合体および使用方法 |
| CN106420615B (zh) * | 2016-07-05 | 2021-01-05 | 广东药科大学 | 一种靶向脂质体骨架材料及其制备方法 |
| CN118319859B (zh) * | 2024-04-11 | 2026-02-06 | 中国药科大学 | 一种基于瘤内菌群调控策略的载药脂质体及其制备方法和应用 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5108921A (en) * | 1989-04-03 | 1992-04-28 | Purdue Research Foundation | Method for enhanced transmembrane transport of exogenous molecules |
| US6113946A (en) * | 1992-04-03 | 2000-09-05 | The Regents Of The University Of California | Self-assembling polynucleotide delivery system comprising dendrimer polycations |
| US5858397A (en) * | 1995-10-11 | 1999-01-12 | University Of British Columbia | Liposomal formulations of mitoxantrone |
| US5804445A (en) * | 1996-01-11 | 1998-09-08 | Board Of Regents, The University Of Texas System | High affinity mutants of nuclear factor-interleukin 6 and methods of use therefor |
| WO1998013072A1 (en) * | 1996-09-24 | 1998-04-02 | Thomas Jefferson University | Compositions for and methods of treating multiple drug resistance |
| TW520297B (en) * | 1996-10-11 | 2003-02-11 | Sequus Pharm Inc | Fusogenic liposome composition and method |
| US6056973A (en) * | 1996-10-11 | 2000-05-02 | Sequus Pharmaceuticals, Inc. | Therapeutic liposome composition and method of preparation |
| US6162810A (en) * | 1997-11-17 | 2000-12-19 | The Regents Of The University Of California | Inadone and tetralone compounds for inhibiting cell proliferation |
| US6426086B1 (en) * | 1998-02-03 | 2002-07-30 | The Regents Of The University Of California | pH-sensitive, serum-stable liposomes |
| IT1315253B1 (it) * | 1999-10-22 | 2003-02-03 | Novuspharma Spa | Preparazione liposomiale di 6,9-bis-(2-amminoetil)ammino|benzog|isochinolin-5,10-dione dimaleato |
| JP4695595B2 (ja) * | 2003-09-24 | 2011-06-08 | ワイス・ホールディングズ・コーポレイション | 抗癌剤としての６−アリール−７−ハロ−イミダゾ［１，２−ａ］ピリミジン類 |
-
1999
- 1999-12-17 WO PCT/US1999/030230 patent/WO2000035422A2/en not_active Ceased
- 1999-12-17 IL IL14355599A patent/IL143555A0/xx unknown
- 1999-12-17 DE DE69938148T patent/DE69938148T2/de not_active Expired - Fee Related
- 1999-12-17 AT AT99963103T patent/ATE385778T1/de not_active IP Right Cessation
- 1999-12-17 MX MXPA01006201A patent/MXPA01006201A/es not_active Application Discontinuation
- 1999-12-17 AU AU19404/00A patent/AU769569B2/en not_active Ceased
- 1999-12-17 EP EP99963103A patent/EP1140022B8/de not_active Expired - Lifetime
- 1999-12-17 ES ES99963103T patent/ES2302391T3/es not_active Expired - Lifetime
- 1999-12-17 JP JP2000587743A patent/JP2002532407A/ja not_active Withdrawn
- 1999-12-17 CA CA002353593A patent/CA2353593A1/en not_active Abandoned
-
2004
- 2004-02-13 US US10/778,738 patent/US20040161457A1/en not_active Abandoned
-
2005
- 2005-09-06 US US11/220,901 patent/US20060062842A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU769569B2 (en) | 2004-01-29 |
| JP2002532407A (ja) | 2002-10-02 |
| US20060062842A1 (en) | 2006-03-23 |
| MXPA01006201A (es) | 2003-06-06 |
| EP1140022B1 (de) | 2008-02-13 |
| DE69938148T2 (de) | 2009-02-26 |
| CA2353593A1 (en) | 2000-06-22 |
| WO2000035422A3 (en) | 2000-10-12 |
| AU1940400A (en) | 2000-07-03 |
| HK1040633A1 (en) | 2002-06-21 |
| ES2302391T3 (es) | 2008-07-01 |
| WO2000035422A2 (en) | 2000-06-22 |
| EP1140022A2 (de) | 2001-10-10 |
| EP1140022B8 (de) | 2008-10-15 |
| US20040161457A1 (en) | 2004-08-19 |
| DE69938148D1 (de) | 2008-03-27 |
| IL143555A0 (en) | 2002-04-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |