ATE385778T1 - Verfahren zur verabreichung von einer verbindung an mehrfachresistente zellen - Google Patents

Verfahren zur verabreichung von einer verbindung an mehrfachresistente zellen

Info

Publication number
ATE385778T1
ATE385778T1 AT99963103T AT99963103T ATE385778T1 AT E385778 T1 ATE385778 T1 AT E385778T1 AT 99963103 T AT99963103 T AT 99963103T AT 99963103 T AT99963103 T AT 99963103T AT E385778 T1 ATE385778 T1 AT E385778T1
Authority
AT
Austria
Prior art keywords
therapeutic compound
composition
administration
carrier
compound
Prior art date
Application number
AT99963103T
Other languages
English (en)
Inventor
Alberto Gabizon
Samuel Zalipsky
Dorit Goren-Rubel
Aviva Horowitz
Original Assignee
Hadasit Med Res Service
Alza Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hadasit Med Res Service, Alza Corp filed Critical Hadasit Med Res Service
Application granted granted Critical
Publication of ATE385778T1 publication Critical patent/ATE385778T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AT99963103T 1998-12-18 1999-12-17 Verfahren zur verabreichung von einer verbindung an mehrfachresistente zellen ATE385778T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US11300498P 1998-12-18 1998-12-18

Publications (1)

Publication Number Publication Date
ATE385778T1 true ATE385778T1 (de) 2008-03-15

Family

ID=22347057

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99963103T ATE385778T1 (de) 1998-12-18 1999-12-17 Verfahren zur verabreichung von einer verbindung an mehrfachresistente zellen

Country Status (12)

Country Link
US (2) US20040161457A1 (de)
EP (1) EP1140022B8 (de)
JP (1) JP2002532407A (de)
AT (1) ATE385778T1 (de)
AU (1) AU769569B2 (de)
CA (1) CA2353593A1 (de)
DE (1) DE69938148T2 (de)
ES (1) ES2302391T3 (de)
HK (1) HK1040633A1 (de)
IL (1) IL143555A0 (de)
MX (1) MXPA01006201A (de)
WO (1) WO2000035422A2 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AUPQ014799A0 (en) * 1999-05-04 1999-05-27 Access Pharmaceuticals Australia Pty Limited Amplification of folate-mediated targeting to tumor cells using polymers
JP4922824B2 (ja) * 2000-04-03 2012-04-25 参天製薬株式会社 送達性物質およびそれを利用した薬物デリバリーシステム
CA2404737C (en) * 2000-04-03 2010-06-29 Santen Pharmaceutical Co., Ltd. Drug delivering substance containing polyalkylene glycol and phospholipid covalently bonded to drug
KR20050090987A (ko) * 2002-12-19 2005-09-14 알자 코포레이션 혈관신생 조직 성장 치료 방법
EP2529758A3 (de) 2003-01-27 2013-01-02 Endocyte, Inc. Vitaminrezeptorbindende Wirkstofffreisetzungskonjugate
CN100423778C (zh) * 2003-11-25 2008-10-08 上海复旦张江生物医药股份有限公司 用于上载抗肿瘤药物的脂质体载体及其制备方法和应用
WO2006012527A1 (en) 2004-07-23 2006-02-02 Endocyte, Inc. Bivalent linkers and conjugates thereof
WO2007130462A2 (en) * 2006-05-04 2007-11-15 Alza Corporation Treating micrometastases using immunoliposomes comprising a chemotherapeutic agent, a targeting ligand and a hydrophilic polymer
CA2680535C (en) 2007-03-14 2016-09-20 Endocyte, Inc. Binding ligand linked drug delivery conjugates of tubulysins
EP2125024B1 (de) * 2007-03-23 2013-02-13 TO-BBB Holding B.V. Gezielte intrazelluläre abgabe von antiviralen mitteln
US9877965B2 (en) 2007-06-25 2018-01-30 Endocyte, Inc. Vitamin receptor drug delivery conjugates for treating inflammation
WO2009002993A1 (en) 2007-06-25 2008-12-31 Endocyte, Inc. Conjugates containing hydrophilic spacer linkers
AU2008316835B2 (en) 2007-10-25 2015-07-16 Endocyte, Inc. Tubulysins and processes for preparing
EP2440250A1 (de) 2009-06-11 2012-04-18 Yissum Research Development Company of the Hebrew University of Jerusalem, Ltd. Gezielt ausgerichtete liposome mit n-haltigen bisphosphonaten und ihre verwendung
SI2731591T1 (sl) 2011-07-13 2021-02-26 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Liposomi ko-inkapsulirajoči bifosfonat in amfipatično sredstvo
PT2789348T (pt) 2011-12-07 2021-11-11 Univ Do Minho Lipossomas e método de produção correspondente
WO2013126797A1 (en) 2012-02-24 2013-08-29 Purdue Research Foundation Cholecystokinin b receptor targeting for imaging and therapy
GB201215289D0 (en) * 2012-08-28 2012-10-10 Medical Res Council Nanoparticle formulation
US9950074B2 (en) * 2012-10-12 2018-04-24 Georg-August-Universität Göttingen Stiftung Öffenlichen Rechts, Universitätsmedizin Composition and delivery vehicle for active agents and methods therefor
WO2014062697A2 (en) 2012-10-16 2014-04-24 Endocyte, Inc. Drug delivery conjugates containing unnatural amino acids and methods for using
CN106420615B (zh) * 2016-07-05 2021-01-05 广东药科大学 一种靶向脂质体骨架材料及其制备方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5108921A (en) * 1989-04-03 1992-04-28 Purdue Research Foundation Method for enhanced transmembrane transport of exogenous molecules
US6113946A (en) * 1992-04-03 2000-09-05 The Regents Of The University Of California Self-assembling polynucleotide delivery system comprising dendrimer polycations
US5858397A (en) * 1995-10-11 1999-01-12 University Of British Columbia Liposomal formulations of mitoxantrone
US5804445A (en) * 1996-01-11 1998-09-08 Board Of Regents, The University Of Texas System High affinity mutants of nuclear factor-interleukin 6 and methods of use therefor
WO1998013072A1 (en) * 1996-09-24 1998-04-02 Thomas Jefferson University Compositions for and methods of treating multiple drug resistance
US6056973A (en) * 1996-10-11 2000-05-02 Sequus Pharmaceuticals, Inc. Therapeutic liposome composition and method of preparation
TW520297B (en) * 1996-10-11 2003-02-11 Sequus Pharm Inc Fusogenic liposome composition and method
US6162810A (en) * 1997-11-17 2000-12-19 The Regents Of The University Of California Inadone and tetralone compounds for inhibiting cell proliferation
US6426086B1 (en) * 1998-02-03 2002-07-30 The Regents Of The University Of California pH-sensitive, serum-stable liposomes
IT1315253B1 (it) * 1999-10-22 2003-02-03 Novuspharma Spa Preparazione liposomiale di 6,9-bis-(2-amminoetil)ammino|benzog|isochinolin-5,10-dione dimaleato
ES2308256T3 (es) * 2003-09-24 2008-12-01 Wyeth Holdings Corporation 6-aril-7-halo-imidazo(1,2-a)pirimidinas como agentes anticancerosos.

Also Published As

Publication number Publication date
MXPA01006201A (es) 2003-06-06
EP1140022B1 (de) 2008-02-13
US20040161457A1 (en) 2004-08-19
US20060062842A1 (en) 2006-03-23
HK1040633A1 (en) 2002-06-21
AU1940400A (en) 2000-07-03
CA2353593A1 (en) 2000-06-22
JP2002532407A (ja) 2002-10-02
EP1140022A2 (de) 2001-10-10
WO2000035422A2 (en) 2000-06-22
EP1140022B8 (de) 2008-10-15
DE69938148D1 (de) 2008-03-27
AU769569B2 (en) 2004-01-29
IL143555A0 (en) 2002-04-21
ES2302391T3 (es) 2008-07-01
DE69938148T2 (de) 2009-02-26
WO2000035422A3 (en) 2000-10-12

Similar Documents

Publication Publication Date Title
ATE385778T1 (de) Verfahren zur verabreichung von einer verbindung an mehrfachresistente zellen
WO1998016202B1 (en) Fusogenic liposome composition and method
CN107920964B (zh) 融合脂质体包被的多孔硅纳米颗粒
EP0887075A3 (de) Klebstoffmasse zur transdermalen Verabreichung von stark weichmachenden Wirkstoffen
BR9914601A (pt) Inibidor de topoisomerase capturado por lipossoma
Yerushalmi et al. Molecular and cellular studies of hyaluronic acid-modified liposomes as bioadhesive carriers for topical drug delivery in wound healing
Lasic et al. Liposomes and biopolymers in drug and gene delivery
DE69531701D1 (de) Sphingosome mit verbesserter arzneistoffabgage
FI971776A (fi) Yhdisteet ja koostumukset aktiivisten aineiden antamiseksi
EP1163902A3 (de) Einen hydrophilen oder als Salz vorliegenden Arzneiwirkstoff enthaltende transdermale Zubereitung
ATE279210T1 (de) Arzneimittel freisetzendes system enthaltend ein homeobox-peptid und ein zytotoxisches oder antineoplastisches mittel
US20100105139A1 (en) Ligand Targeted Nanocapsules for the delivery of RNAi and other Agents
WO2002083097A3 (en) Drug delivery system for hydrophobic drugs
AU6675198A (en) Transdermal drug delivery system for the administration of tamsulosin, and related compositions and methods of use
EP2382994A1 (de) Durch Liganden gezielrichtete Nanokapseln zur Verabreichung von RNAi und anderen Wirkstoffen
JP2002507571A (ja) アントラサイクリン誘導体とカンプトテシン誘導体の相乗組合せを含有する抗腫瘍組成物
JP2002532407A5 (de)
CA2202531A1 (en) Lyophilizate of lipid complex of water insoluble camptothecins
WO2008038291A1 (en) Combination of liposomal anti-cancer drugs and lysosome/endosome ph increasing agents for therapy
Sharma et al. Modulation of human ovarian tumor cell sensitivity to N-(phosphonacetyl)-L-aspartate (PALA) by liposome drug carriers
WO1998030709A3 (en) Non-immunogenic prodrugs and selectable markers for use in gene therapy
ATE356637T1 (de) Supramolekulare komplexe enthaltende arzneimittel
WO2004112717A3 (en) Conjugate for the specific targeting of anticancer agents to cancer cells and production thereof
ES2202704T3 (es) Agente antitumoral que comprende un complejo de una oxidorreductasa de un polimero y un substrato del enzima.
US20100104622A1 (en) Ligand Targeted Nanocapsules for the delivery of RNAi and other Agents

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties