JP2011512336A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2011512336A5 JP2011512336A5 JP2010546197A JP2010546197A JP2011512336A5 JP 2011512336 A5 JP2011512336 A5 JP 2011512336A5 JP 2010546197 A JP2010546197 A JP 2010546197A JP 2010546197 A JP2010546197 A JP 2010546197A JP 2011512336 A5 JP2011512336 A5 JP 2011512336A5
- Authority
- JP
- Japan
- Prior art keywords
- acid
- pharmaceutically acceptable
- acceptable salt
- group
- csf
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000003839 salts Chemical class 0.000 claims 11
- 150000001875 compounds Chemical class 0.000 claims 6
- 108010017080 Granulocyte Colony-Stimulating Factor Proteins 0.000 claims 4
- 102000004269 Granulocyte Colony-Stimulating Factor Human genes 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 3
- 208000030507 AIDS Diseases 0.000 claims 2
- 208000035143 Bacterial infection Diseases 0.000 claims 2
- FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Chemical compound CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 claims 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 2
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 claims 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims 2
- DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 208000022362 bacterial infectious disease Diseases 0.000 claims 2
- 238000002512 chemotherapy Methods 0.000 claims 2
- 238000004581 coalescence Methods 0.000 claims 2
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 201000002364 leukopenia Diseases 0.000 claims 2
- 231100001022 leukopenia Toxicity 0.000 claims 2
- 150000007522 mineralic acids Chemical class 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 150000007524 organic acids Chemical class 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 238000001959 radiotherapy Methods 0.000 claims 2
- 125000003396 thiol group Chemical group [H]S* 0.000 claims 2
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 claims 2
- ASUGWWOMVNVWAW-UHFFFAOYSA-N 1-(2-methoxyethyl)pyrrole-2,5-dione Chemical compound COCCN1C(=O)C=CC1=O ASUGWWOMVNVWAW-UHFFFAOYSA-N 0.000 claims 1
- 206010064571 Gene mutation Diseases 0.000 claims 1
- 101000746367 Homo sapiens Granulocyte colony-stimulating factor Proteins 0.000 claims 1
- 238000006845 Michael addition reaction Methods 0.000 claims 1
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 claims 1
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims 1
- 125000003277 amino group Chemical group 0.000 claims 1
- 239000002131 composite material Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 208000003669 immune deficiency disease Diseases 0.000 claims 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 claims 1
- 239000011976 maleic acid Substances 0.000 claims 1
- 229940098779 methanesulfonic acid Drugs 0.000 claims 1
- 235000019260 propionic acid Nutrition 0.000 claims 1
- 125000001501 propionyl group Chemical group O=C([*])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 claims 1
- 238000006268 reductive amination reaction Methods 0.000 claims 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims 1
- 125000002221 trityl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C([*])(C1=C(C(=C(C(=C1[H])[H])[H])[H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 claims 1
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/CN2008/070320 WO2009103199A1 (zh) | 2008-02-18 | 2008-02-18 | 水溶性聚合物修饰的g-csf偶联物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011512336A JP2011512336A (ja) | 2011-04-21 |
| JP2011512336A5 true JP2011512336A5 (enExample) | 2011-06-02 |
| JP5225393B2 JP5225393B2 (ja) | 2013-07-03 |
Family
ID=40985048
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010546197A Expired - Fee Related JP5225393B2 (ja) | 2008-02-18 | 2008-02-18 | 水溶性高分子修飾ｇ−ｃｓｆ複合体 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US8629104B2 (enExample) |
| EP (1) | EP2248832B1 (enExample) |
| JP (1) | JP5225393B2 (enExample) |
| ES (1) | ES2523030T3 (enExample) |
| WO (1) | WO2009103199A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3045187B1 (en) | 2011-10-14 | 2019-04-10 | Amgen Inc. | Injector and method of assembly |
| ES2853748T3 (es) | 2013-03-22 | 2021-09-17 | Amgen Inc | Inyector y método de montaje |
| EP3060275B1 (en) | 2013-10-24 | 2019-07-03 | Amgen Inc. | Injector and method of assembly |
| JP2021509805A (ja) * | 2017-12-27 | 2021-04-08 | カウンシル オブ サイエンティフィック アンド インダストリアル リサーチ | 顆粒球コロニー刺激因子活性を示すポリペプチド |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5214132A (en) | 1986-12-23 | 1993-05-25 | Kyowa Hakko Kogyo Co., Ltd. | Polypeptide derivatives of human granulocyte colony stimulating factor |
| US5362853A (en) | 1986-12-23 | 1994-11-08 | Kyowa Hakko Kogyo Co., Ltd. | Polypeptide derivatives of human granulocyte colony stimulating factor |
| US4904584A (en) | 1987-12-23 | 1990-02-27 | Genetics Institute, Inc. | Site-specific homogeneous modification of polypeptides |
| CA1340810C (en) | 1988-03-31 | 1999-11-02 | Motoo Yamasaki | Polypeptide derivatives of human granulocyte colony stimulating factor |
| EP0401384B1 (en) | 1988-12-22 | 1996-03-13 | Kirin-Amgen, Inc. | Chemically modified granulocyte colony stimulating factor |
| US5581476A (en) | 1993-01-28 | 1996-12-03 | Amgen Inc. | Computer-based methods and articles of manufacture for preparing G-CSF analogs |
| US5824784A (en) * | 1994-10-12 | 1998-10-20 | Amgen Inc. | N-terminally chemically modified protein compositions and methods |
| WO2000044785A1 (en) | 1999-01-29 | 2000-08-03 | F. Hoffmann-La Roche Ag | Gcsf conjugates |
| HUP0203751A3 (en) | 2000-01-10 | 2005-01-28 | Maxygen Holdings Ltd Redwood C | G-csf conjugates |
| ES2422187T3 (es) * | 2003-12-03 | 2013-09-09 | Biogenerix Ag | Factor estimulante de colonias de granulocitos glicopegilados |
| WO2006063055A2 (en) * | 2004-12-06 | 2006-06-15 | Bolder Biotechnology, Inc. | Enzyme conjugates for use as detoxifying agents |
| JP5243041B2 (ja) * | 2004-12-21 | 2013-07-24 | ネクター セラピューティックス | 安定化ポリマーチオール試薬 |
| KR100694994B1 (ko) * | 2005-06-13 | 2007-03-14 | 씨제이 주식회사 | 사람 과립구 콜로니 형성인자 동종체 |
| BRPI0614257A2 (pt) | 2005-08-04 | 2011-03-15 | Nektar Therapeutics Al Corp | conjugados de uma porção de g-csf e um polìmero |
| CN101172161B (zh) | 2006-10-30 | 2010-04-21 | 江苏恒瑞医药股份有限公司 | 水溶性聚合物修饰的g-csf偶联物 |
-
2008
- 2008-02-18 WO PCT/CN2008/070320 patent/WO2009103199A1/zh not_active Ceased
- 2008-02-18 US US12/918,280 patent/US8629104B2/en not_active Expired - Fee Related
- 2008-02-18 EP EP08706693.2A patent/EP2248832B1/en not_active Not-in-force
- 2008-02-18 ES ES08706693.2T patent/ES2523030T3/es active Active
- 2008-02-18 JP JP2010546197A patent/JP5225393B2/ja not_active Expired - Fee Related
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP5064024B2 (ja) | イマチニブの製造方法、及び該方法により製造されたイマチニブ | |
| JP5465666B2 (ja) | 抗ウイルス化合物 | |
| JP2010531363A5 (enExample) | ||
| CN1426418A (zh) | 膦酸酯核苷酸化合物 | |
| JP2004529963A5 (enExample) | ||
| JP2011523952A5 (enExample) | ||
| EA020244B1 (ru) | Урацильные циклопропилнуклеотиды | |
| US20250177542A1 (en) | Preparation method for drug linker conjugate | |
| CN1751058A (zh) | 生产3'－核苷前体药物的方法 | |
| WO2020194160A1 (en) | Macrocyclic compounds as sting agonists | |
| WO2014169216A2 (en) | TEMPLATE-DIRECTED γPNA SYNTHESIS AND γPNA TARGETING COMPOUNDS | |
| WO1997000262A1 (fr) | Nucleotides derives de phosphonates | |
| JP2014525939A5 (enExample) | ||
| TWI385172B (zh) | 新穎化合物 | |
| AU2016340093A1 (en) | Epothilone analogs, methods of synthesis, methods of treatment, and drug conjugates thereof | |
| AU2008286742B2 (en) | Protein-polymer conjugates | |
| TWI491410B (zh) | 水溶性聚合物修飾的ｇ－ｃｓｆ偶聯物 | |
| JP2009536188A5 (enExample) | ||
| JP5225393B2 (ja) | 水溶性高分子修飾ｇ−ｃｓｆ複合体 | |
| US20230113948A1 (en) | Synthetic processes and intermediates | |
| US9951093B2 (en) | Chiral compounds substituted with phosphonic acid ester functions or phosphonic acid functions | |
| JP2008534537A5 (enExample) | ||
| TW200927147A (en) | Improvements in or relating to compositions for the treatment or prophylaxis of viral infections | |
| CN106083856A (zh) | 一种可用于肿瘤治疗的嘌呤类丙氨酸衍生物及其制备方法和应用 | |
| US20100009895A1 (en) | Method for selective localization of active agents at and in mitochondria and corresponding active agents |