JP2009536188A5 - - Google Patents

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Publication number

JP2009536188A5

JP2009536188A5 JP2009508479A JP2009508479A JP2009536188A5 JP 2009536188 A5 JP2009536188 A5 JP 2009536188A5 JP 2009508479 A JP2009508479 A JP 2009508479A JP 2009508479 A JP2009508479 A JP 2009508479A JP 2009536188 A5 JP2009536188 A5 JP 2009536188A5

Authority

JP

Japan

Prior art keywords

compound

valine

formula

compound according

pharmaceutically acceptable

Prior art date

2007-05-09

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

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• 150000001875 compounds Chemical class 0.000 claims 11
• 238000000034 method Methods 0.000 claims 5
• KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims 4
• KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims 4
• 229940024606 amino acid Drugs 0.000 claims 4
• 235000001014 amino acid Nutrition 0.000 claims 4
• 150000001413 amino acids Chemical class 0.000 claims 4
• 229960004295 valine Drugs 0.000 claims 4
• 230000007935 neutral effect Effects 0.000 claims 3
• 229910052760 oxygen Inorganic materials 0.000 claims 3
• 229910052717 sulfur Inorganic materials 0.000 claims 3
• 239000004474 valine Substances 0.000 claims 3
• VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 2
• 208000036142 Viral infection Diseases 0.000 claims 2
• 125000000217 alkyl group Chemical group 0.000 claims 2
• 238000005886 esterification reaction Methods 0.000 claims 2
• 150000002148 esters Chemical class 0.000 claims 2
• 238000004519 manufacturing process Methods 0.000 claims 2
• -1 n- pentyl Chemical group 0.000 claims 2
• 239000008194 pharmaceutical composition Substances 0.000 claims 2
• 239000000546 pharmaceutical excipient Substances 0.000 claims 2
• 150000003839 salts Chemical class 0.000 claims 2
• 230000009385 viral infection Effects 0.000 claims 2
• 125000003088 (fluoren-9-ylmethoxy)carbonyl group Chemical group 0.000 claims 1
• QCQCHGYLTSGIGX-GHXANHINSA-N 4-[[(3ar,5ar,5br,7ar,9s,11ar,11br,13as)-5a,5b,8,8,11a-pentamethyl-3a-[(5-methylpyridine-3-carbonyl)amino]-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3h-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid Chemical compound N([C@@]12CC[C@@]3(C)[C@]4(C)CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(O)=O)CC[C@]5(C)[C@H]4CC[C@@H]3C1=C(C(C2)=O)C(C)C)C(=O)C1=CN=CC(C)=C1 QCQCHGYLTSGIGX-GHXANHINSA-N 0.000 claims 1
• KZSNJWFQEVHDMF-SCSAIBSYSA-N D-valine Chemical compound CC(C)[C@@H](N)C(O)=O KZSNJWFQEVHDMF-SCSAIBSYSA-N 0.000 claims 1
• 229930182831 D-valine Natural products 0.000 claims 1
• QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 1
• AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 claims 1
• ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 1
• 125000003580 L-valyl group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(C([H])([H])[H])(C([H])([H])[H])[H] 0.000 claims 1
• ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 1
• 239000002253 acid Substances 0.000 claims 1
• 235000004279 alanine Nutrition 0.000 claims 1
• 229960003767 alanine Drugs 0.000 claims 1
• 229940126214 compound 3 Drugs 0.000 claims 1
• 229940125898 compound 5 Drugs 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• 230000032050 esterification Effects 0.000 claims 1
• 229960000310 isoleucine Drugs 0.000 claims 1
• AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 claims 1
• 229960003136 leucine Drugs 0.000 claims 1
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
• 125000001280 n-hexyl group Chemical group C(CCCCC)* 0.000 claims 1
• 125000000740 n-pentyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
• 230000002265 prevention Effects 0.000 claims 1
• 125000006239 protecting group Chemical group 0.000 claims 1