KR101447522B1 - 항바이러스성 피리미딘 뉴클레오시드 유도체 - Google Patents

항바이러스성 피리미딘 뉴클레오시드 유도체 Download PDF

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KR101447522B1
KR101447522B1 KR1020087029280A KR20087029280A KR101447522B1 KR 101447522 B1 KR101447522 B1 KR 101447522B1 KR 1020087029280 A KR1020087029280 A KR 1020087029280A KR 20087029280 A KR20087029280 A KR 20087029280A KR 101447522 B1 KR101447522 B1 KR 101447522B1
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compound
valine
formula
compound according
alkyl
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KR20090042204A (ko
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크리스토퍼 맥귀간
잔 발자리니
마르코 미글리오레
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유니버시티 칼리지 카디프 컨설턴츠 리미티드
카트호리이케 유니버시타이트 로이펜
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
KR1020087029280A 2006-05-09 2007-05-09 항바이러스성 피리미딘 뉴클레오시드 유도체 Expired - Fee Related KR101447522B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0609178.9A GB0609178D0 (en) 2006-05-09 2006-05-09 Novel compounds
GB0609178.9 2006-05-09
PCT/GB2007/001677 WO2007129083A1 (en) 2006-05-09 2007-05-09 Anti-viral pyrimidine nucleoside derivatives

Publications (2)

Publication Number Publication Date
KR20090042204A KR20090042204A (ko) 2009-04-29
KR101447522B1 true KR101447522B1 (ko) 2014-10-06

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KR1020087029280A Expired - Fee Related KR101447522B1 (ko) 2006-05-09 2007-05-09 항바이러스성 피리미딘 뉴클레오시드 유도체

Country Status (22)

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US (3) US8329664B2 (enExample)
EP (1) EP2016081B1 (enExample)
JP (1) JP5261374B2 (enExample)
KR (1) KR101447522B1 (enExample)
CN (1) CN101443332B (enExample)
AT (1) ATE506367T1 (enExample)
AU (1) AU2007246814B2 (enExample)
BR (1) BRPI0711354A2 (enExample)
CA (1) CA2656780C (enExample)
CY (1) CY1111711T1 (enExample)
DE (1) DE602007014030D1 (enExample)
DK (1) DK2016081T3 (enExample)
EA (1) EA015178B1 (enExample)
ES (1) ES2365057T3 (enExample)
GB (1) GB0609178D0 (enExample)
IL (1) IL194806A (enExample)
NZ (1) NZ573377A (enExample)
PL (1) PL2016081T3 (enExample)
PT (1) PT2016081E (enExample)
SI (1) SI2016081T1 (enExample)
TW (1) TWI385172B (enExample)
WO (1) WO2007129083A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0009486D0 (en) * 2000-04-17 2000-06-07 Univ Cardiff Chemical compounds
GB2452556A (en) * 2007-09-07 2009-03-11 Univ Leuven Kath Nucleoside analogues esterified at 3 and/or 5 positions by neutral non-polar amino acid, or oligopeptide thereof, for combating Varicella Zoster virus
US9260469B2 (en) * 2010-10-09 2016-02-16 Contravir Pharmaceuticals, Inc. Method of preparation of antiviral compounds and useful intermediates thereof
CN105037468A (zh) * 2010-10-09 2015-11-11 英希比泰克斯公司 制备抗病毒组合物的方法及其中间体的应用
MD4110C1 (ro) * 2010-10-21 2011-12-31 Валериу РУДИК Preparat antiherpetiс
KR101875997B1 (ko) * 2015-05-04 2018-07-06 엔 앤드 엔 파마세우티칼스 인크. 엔-메탄노카르바티미딘을 이용한 대상포진의 치료방법

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001083501A1 (en) 2000-04-17 2001-11-08 University College Cardiff Consultants Limited Anti-viral pyrimidine nucleoside analogues
US20030083306A1 (en) 2000-06-15 2003-05-01 Jean-Louis Imbach 3'-prodrugs of 2'-deoxy-beta-L-nucleosides
US20050137141A1 (en) 2003-10-24 2005-06-23 John Hilfinger Prodrug composition

Family Cites Families (15)

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Publication number Priority date Publication date Assignee Title
JPS62255499A (ja) 1986-04-28 1987-11-07 Teijin Ltd 螢光性ヌクレオシド又はヌクレオチド
EP0346108A3 (en) 1988-06-09 1991-04-24 The Wellcome Foundation Limited Anti-infective nucleosides
YU43193A (sh) 1992-06-22 1997-01-08 Eli Lilly And Company 2'-deoksi-2',2'-difluoro(4-supstituisani)pirimidinski nukleozidi antivirusnog i antikancerogenog dejstva i međuproizvodi
GB9505025D0 (en) 1995-03-13 1995-05-03 Medical Res Council Chemical compounds
US6022876A (en) * 1996-11-15 2000-02-08 Yale University L-β-dioxolane uridine analogs and methods for treating and preventing Epstein-Barr virus infections
GB9708611D0 (en) 1997-04-28 1997-06-18 Univ Cardiff Chemical compounds
GB9716231D0 (en) 1997-07-31 1997-10-08 Amersham Int Ltd Base analogues
MXPA02000763A (es) 1999-07-22 2002-08-12 Newbiotics Inc Activacion terapeutica catalizada por enzima.
MXPA02000761A (es) 1999-07-22 2002-08-12 Newbiotics Inc Agentes terapeuticos anti-infecciosos catalizados por enzima.
CN1391486A (zh) 1999-07-22 2003-01-15 新生物公司 治疗对治疗有抗性的肿瘤的方法
GB0011203D0 (en) * 2000-05-09 2000-06-28 Univ Cardiff Chemical compounds
MY141594A (en) * 2000-06-15 2010-05-14 Novirio Pharmaceuticals Ltd 3'-PRODRUGS OF 2'-DEOXY-ß-L-NUCLEOSIDES
CA2490191C (en) 2002-06-28 2010-08-03 Idenix (Cayman) Limited Modified 2' and 3' -nucleoside prodrugs for treating flaviviridae infections
EP1745573A4 (en) * 2003-03-20 2010-05-26 Microbiol Quimica Farmaceutica PROCESS FOR PREPARING 2-DEOXY-BETA-L-NUCLEOSIDES
JP4856638B2 (ja) 2004-06-07 2012-01-18 アナディス・ファーマシューティカルズ・インコーポレイテッド ３−β−Ｄ−リボフラノシルチアゾロ［４，５−ｄ］ピリミジンヌクレオシドおよびその使用

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001083501A1 (en) 2000-04-17 2001-11-08 University College Cardiff Consultants Limited Anti-viral pyrimidine nucleoside analogues
US20030083306A1 (en) 2000-06-15 2003-05-01 Jean-Louis Imbach 3'-prodrugs of 2'-deoxy-beta-L-nucleosides
US20050137141A1 (en) 2003-10-24 2005-06-23 John Hilfinger Prodrug composition

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Publication number Publication date
EA200870505A1 (ru) 2009-04-28
IL194806A (en) 2015-08-31
CA2656780A1 (en) 2007-11-15
US20150072948A1 (en) 2015-03-12
SI2016081T1 (sl) 2011-09-30
DK2016081T3 (da) 2011-06-20
JP2009536188A (ja) 2009-10-08
US8859512B2 (en) 2014-10-14
EA015178B1 (ru) 2011-06-30
US20130096079A1 (en) 2013-04-18
DE602007014030D1 (de) 2011-06-01
IL194806A0 (en) 2009-09-22
PT2016081E (pt) 2011-06-28
CN101443332B (zh) 2011-11-09
KR20090042204A (ko) 2009-04-29
BRPI0711354A2 (pt) 2011-09-27
EP2016081A1 (en) 2009-01-21
PL2016081T3 (pl) 2011-12-30
US8329664B2 (en) 2012-12-11
TW200813066A (en) 2008-03-16
US20100222295A1 (en) 2010-09-02
NZ573377A (en) 2011-03-31
AU2007246814B2 (en) 2012-07-19
CY1111711T1 (el) 2015-10-07
JP5261374B2 (ja) 2013-08-14
ATE506367T1 (de) 2011-05-15
WO2007129083A1 (en) 2007-11-15
CN101443332A (zh) 2009-05-27
GB0609178D0 (en) 2006-06-21
CA2656780C (en) 2015-04-28
US9427447B2 (en) 2016-08-30
EP2016081B1 (en) 2011-04-20
ES2365057T3 (es) 2011-09-21
AU2007246814A1 (en) 2007-11-15
TWI385172B (zh) 2013-02-11

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