JP2021506246A5 - - Google Patents
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- Publication number
- JP2021506246A5 JP2021506246A5 JP2020531982A JP2020531982A JP2021506246A5 JP 2021506246 A5 JP2021506246 A5 JP 2021506246A5 JP 2020531982 A JP2020531982 A JP 2020531982A JP 2020531982 A JP2020531982 A JP 2020531982A JP 2021506246 A5 JP2021506246 A5 JP 2021506246A5
- Authority
- JP
- Japan
- Prior art keywords
- immunostimulatory oligonucleotide
- linker
- cholesteryl
- oligonucleotide according
- immunostimulatory
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023128316A JP2023153970A (ja) | 2017-12-15 | 2023-08-07 | 免疫刺激性オリゴヌクレオチド |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17207746 | 2017-12-15 | ||
| EP17207746.3 | 2017-12-15 | ||
| EP17207740 | 2017-12-15 | ||
| EP17207750 | 2017-12-15 | ||
| EP17207750.5 | 2017-12-15 | ||
| EP17207740.6 | 2017-12-15 | ||
| PCT/EP2018/084019 WO2019115402A1 (en) | 2017-12-15 | 2018-12-07 | Immunostimulatory oligonucleotides |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023128316A Division JP2023153970A (ja) | 2017-12-15 | 2023-08-07 | 免疫刺激性オリゴヌクレオチド |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021506246A JP2021506246A (ja) | 2021-02-22 |
| JP2021506246A5 true JP2021506246A5 (enExample) | 2022-01-11 |
| JP7770769B2 JP7770769B2 (ja) | 2025-11-17 |
Family
ID=66818991
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020531988A Active JP7458977B2 (ja) | 2017-12-15 | 2018-12-07 | 免疫刺激性組成物 |
| JP2020531982A Active JP7770769B2 (ja) | 2017-12-15 | 2018-12-07 | 免疫刺激性オリゴヌクレオチド |
| JP2020531972A Active JP7273040B2 (ja) | 2017-12-15 | 2018-12-07 | 免疫刺激性オリゴヌクレオチド |
| JP2023128316A Pending JP2023153970A (ja) | 2017-12-15 | 2023-08-07 | 免疫刺激性オリゴヌクレオチド |
| JP2023134080A Active JP7760560B2 (ja) | 2017-12-15 | 2023-08-21 | 免疫刺激性組成物 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020531988A Active JP7458977B2 (ja) | 2017-12-15 | 2018-12-07 | 免疫刺激性組成物 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020531972A Active JP7273040B2 (ja) | 2017-12-15 | 2018-12-07 | 免疫刺激性オリゴヌクレオチド |
| JP2023128316A Pending JP2023153970A (ja) | 2017-12-15 | 2023-08-07 | 免疫刺激性オリゴヌクレオチド |
| JP2023134080A Active JP7760560B2 (ja) | 2017-12-15 | 2023-08-21 | 免疫刺激性組成物 |
Country Status (22)
| Country | Link |
|---|---|
| US (7) | US11932857B2 (enExample) |
| EP (4) | EP3701032A1 (enExample) |
| JP (5) | JP7458977B2 (enExample) |
| KR (4) | KR20250048594A (enExample) |
| CN (5) | CN111447949B (enExample) |
| AU (5) | AU2018385257B2 (enExample) |
| BR (2) | BR112020011815A2 (enExample) |
| CA (3) | CA3085661A1 (enExample) |
| CL (3) | CL2020001560A1 (enExample) |
| CO (3) | CO2020007102A2 (enExample) |
| CR (1) | CR20200260A (enExample) |
| DK (1) | DK3700564T3 (enExample) |
| DO (3) | DOP2020000113A (enExample) |
| IL (3) | IL274975A (enExample) |
| MX (4) | MX2020006243A (enExample) |
| PE (3) | PE20200933A1 (enExample) |
| PH (3) | PH12020550904A1 (enExample) |
| SG (3) | SG11202004773SA (enExample) |
| TW (2) | TW201940192A (enExample) |
| UY (3) | UY38014A (enExample) |
| WO (3) | WO2019115402A1 (enExample) |
| ZA (1) | ZA202004317B (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3993834A1 (en) | 2019-07-05 | 2022-05-11 | Tambo, Inc. | Trans-cyclooctene bioorthogonal agents and uses in cancer and immunotherapy |
| US20230241196A1 (en) * | 2020-01-27 | 2023-08-03 | Oregon State University | Gonorrhea subunit vaccine |
| CN113493790A (zh) * | 2020-04-01 | 2021-10-12 | 南京华普生物技术股份有限公司 | 具有免疫调节功能的CpG ODN及其应用 |
| EP3892260A1 (en) * | 2020-04-10 | 2021-10-13 | Bayer Animal Health GmbH | Immunostimulatory compositions based on liposomes with zwiterionic and cationic lipids |
| EP4295917A3 (en) | 2020-08-07 | 2024-02-28 | Tambo, Inc. | Trans-cyclooctene bioorthogonal agents and uses in cancer and immunotherapy |
| CN112159814B (zh) * | 2020-10-29 | 2023-05-16 | 中国农业科学院兰州兽医研究所 | 一种CpG寡聚脱氧核苷酸及制备与其用途 |
| CN113797329A (zh) * | 2021-10-19 | 2021-12-17 | 启锰生物科技(江苏)有限公司 | 一种二价锰佐剂和CpG佐剂的疫苗佐剂组合物及其制作方法 |
| CN116218852A (zh) * | 2023-02-22 | 2023-06-06 | 中国人民解放军陆军军医大学 | 一种靶向基因启动子G-四联体区域的sgRNA及其用途 |
| WO2025149000A1 (zh) * | 2024-01-09 | 2025-07-17 | 康希诺(上海)生物研发有限公司 | 一种免疫刺激序列截断多聚a尾的序列构建及其应用 |
Family Cites Families (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5719028A (en) * | 1992-12-07 | 1998-02-17 | Third Wave Technologies Inc. | Cleavase fragment length polymorphism |
| JP3468773B2 (ja) * | 1994-07-15 | 2003-11-17 | ザ ユニバーシティ オブ アイオワ リサーチ ファウンデーション | 免疫調節オリゴヌクレオチド |
| US6693086B1 (en) | 1998-06-25 | 2004-02-17 | National Jewish Medical And Research Center | Systemic immune activation method using nucleic acid-lipid complexes |
| SK287400B6 (sk) * | 1999-09-25 | 2010-08-09 | University Of Iowa Research Foundation | Prostriedok s obsahom imunostimulačnej nukleovej kyseliny a jeho použitie na stimuláciu imunitnej reakcie |
| AU783118B2 (en) * | 1999-09-27 | 2005-09-29 | Coley Pharmaceutical Gmbh | Methods related to immunostimulatory nucleic acid-induced interferon |
| KR100359753B1 (ko) * | 1999-12-21 | 2002-11-09 | 주식회사 제넥신 | 면역조절능력 및 안전성이 증가되고 dG 연속서열이결합된 포스포다이에스터 CpG올리고데옥시뉴클레오티드 변형체 |
| JP2004501666A (ja) | 2000-06-30 | 2004-01-22 | エピゲノミクス アーゲー | 薬理ゲノミクスのメチル化状態分析のための方法及び核酸 |
| AR040996A1 (es) * | 2002-08-19 | 2005-04-27 | Coley Pharm Group Inc | Acidos nucleicos inmunoestimuladores |
| EP1631576A4 (en) * | 2003-06-11 | 2010-08-25 | Idera Pharmaceuticals Inc | STABILIZED IMMUNOMODULATION OLIGONUCLEOTIDES |
| CA2536139A1 (en) | 2003-09-25 | 2005-04-07 | Coley Pharmaceutical Group, Inc. | Nucleic acid-lipophilic conjugates |
| NZ546475A (en) * | 2003-10-30 | 2008-08-29 | Coley Pharm Gmbh | C-Class oligonucleotide analogs with enhanced immunostimulatory potency |
| AU2004291277A1 (en) * | 2003-11-05 | 2005-06-02 | Intercell Ag | Compositions comprising melittin-derved peptides and methods for the potentiation of immune responses against target antigens |
| CN1250737C (zh) * | 2003-11-07 | 2006-04-12 | 深圳市未来海洋科技发展有限公司 | 含CpG DNA畜禽疫苗佐剂的PCR制备方法 |
| KR100558851B1 (ko) * | 2004-01-08 | 2006-03-10 | 학교법인연세대학교 | 면역조절능력이 증가된 CpG 올리고데옥시뉴클레오티드변형체 |
| EP1751612B1 (en) * | 2004-05-06 | 2009-02-25 | The Government of the United States of America, as represented by the Secretary of the Department of Health and Human Services | Methods and compositions for the treatment of uveitis |
| CN101160401A (zh) * | 2005-02-24 | 2008-04-09 | 科勒制药集团公司 | 免疫刺激寡核苷酸 |
| EP1764108A1 (en) * | 2005-09-14 | 2007-03-21 | Gunther Hartmann | Compositions comprising immunostimulatory RNA oligonucleotides and methods for producing said RNA oligonucleotides |
| US8114636B2 (en) * | 2006-02-10 | 2012-02-14 | Life Technologies Corporation | Labeling and detection of nucleic acids |
| JP5473336B2 (ja) | 2006-02-15 | 2014-04-16 | アディウタイド・ファーマスーティカルズ・ゲーエムベーハー | オリゴヌクレオチドの処方に関する組成物および方法 |
| CN100418583C (zh) * | 2006-02-21 | 2008-09-17 | 朱鸿飞 | 预防和治疗乳腺炎的药物组合物 |
| US20080124366A1 (en) | 2006-08-06 | 2008-05-29 | Ohlfest John R | Methods and Compositions for Treating Tumors |
| CN101240271B (zh) * | 2006-08-28 | 2012-08-29 | 长春华普生物技术有限公司 | Toll样受体调节性寡核苷酸及其用途 |
| MX2009003398A (es) | 2006-09-27 | 2009-08-12 | Coley Pharm Gmbh | Analogos de oligonucleotidos cpg que contienen analogos t hidrofobos con actividad inmunoestimuladora mejorada. |
| JP4847609B2 (ja) * | 2007-08-13 | 2011-12-28 | コーリー ファーマシューティカル ゲーエムベーハー | 特異的な免疫修飾プロフィールを誘発する規定されたヌクレオチド間結合との関連におけるrna配列モチーフ |
| WO2010129672A1 (en) | 2009-05-05 | 2010-11-11 | Miragen Therapeutics | Lipophilic polynucleotide conjugates |
| DK2429581T3 (en) | 2009-05-14 | 2015-11-09 | Bayer Ip Gmbh | Improved immune responses in birds |
| CA2800158C (en) | 2010-05-28 | 2020-07-21 | Coley Pharmaceutical Group, Inc. | Vaccines comprising cholesterol and cpg as sole adjuvant-carrier molecules |
| CN101979542B (zh) * | 2010-10-28 | 2011-12-28 | 国家兽用生物制品工程技术研究中心 | 含CpG基序的核酸序列的制备方法及应用 |
| PT2654785T (pt) * | 2010-12-22 | 2019-06-25 | Bayer Ip Gmbh | Resposta imunitária melhorada em espécies bovinas |
| EP2471926A3 (en) * | 2010-12-30 | 2012-07-11 | Intervet International BV | Immunostimulatory oligodeoxynucleotides |
| BR112013029968A2 (pt) * | 2011-05-26 | 2017-01-31 | Intervet Int Bv | oligodesoxinucleotídeo imunoestimulatório não metilado, vetor, vacina para prevenir ou combater uma doença infecciosa, e, método para a detecção de oligodesoxinucleotídeos imunoestimulatórios |
| MX2013013801A (es) * | 2011-05-26 | 2013-12-16 | Intervet Int Bv | Oligodesoxinucleotidos inmunoestimuladores. |
| WO2013151771A1 (en) | 2012-04-05 | 2013-10-10 | Massachusetts Institute Of Technology | Immunostimulatory compositions and methods of use thereof |
| AR091569A1 (es) | 2012-06-28 | 2015-02-11 | Intervet Int Bv | Receptores de tipo toll |
| US20150301058A1 (en) * | 2012-11-26 | 2015-10-22 | Caris Science, Inc. | Biomarker compositions and methods |
| US9506030B2 (en) | 2013-05-01 | 2016-11-29 | Regulus Therapeutics Inc. | Compounds and methods for enhanced cellular uptake |
| WO2015010070A1 (en) * | 2013-07-19 | 2015-01-22 | National Health Research Institutes | Cpg-oligodeoxynucleotide, immunogenic composition comprising the same, and methods for preparing the composition and stimulating immune response thereby |
| AR097029A1 (es) * | 2013-07-26 | 2016-02-17 | Intervet Int Bv | Aceleración de la respuesta inmune inducida por virus vectorial en aves, composición, uso, método para la vacunación y método para acelerar la respuesta inmune |
| GB2517700A (en) * | 2013-08-27 | 2015-03-04 | Lgc Ltd | Oligonucleotides comprising a secondary structure and uses thereof |
| MX2016010993A (es) | 2014-02-28 | 2017-05-01 | Bayer Animal Health Gmbh | Plasmidos inmunoestimuladores. |
| WO2017139570A1 (en) * | 2016-02-12 | 2017-08-17 | Massachusetts Intitute Of Technology | Synergistic tumor treatment with il-2, an integrin-binding-fc fusion protein, and a cancer vaccinne |
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2018
- 2018-12-07 MX MX2020006243A patent/MX2020006243A/es unknown
- 2018-12-07 MX MX2020006246A patent/MX2020006246A/es unknown
- 2018-12-07 PE PE2020000767A patent/PE20200933A1/es unknown
- 2018-12-07 EP EP18811581.0A patent/EP3701032A1/en active Pending
- 2018-12-07 JP JP2020531988A patent/JP7458977B2/ja active Active
- 2018-12-07 KR KR1020257009617A patent/KR20250048594A/ko active Pending
- 2018-12-07 EP EP25202362.7A patent/EP4647437A2/en active Pending
- 2018-12-07 KR KR1020207020349A patent/KR102787688B1/ko active Active
- 2018-12-07 SG SG11202004773SA patent/SG11202004773SA/en unknown
- 2018-12-07 KR KR1020207020350A patent/KR20200099556A/ko active Pending
- 2018-12-07 US US16/772,541 patent/US11932857B2/en active Active
- 2018-12-07 EP EP18829225.4A patent/EP3700564B1/en active Active
- 2018-12-07 PE PE2020000766A patent/PE20210636A1/es unknown
- 2018-12-07 US US16/771,789 patent/US20210062192A1/en not_active Abandoned
- 2018-12-07 AU AU2018385257A patent/AU2018385257B2/en active Active
- 2018-12-07 CN CN201880080814.7A patent/CN111447949B/zh active Active
- 2018-12-07 KR KR1020207020351A patent/KR20200098638A/ko not_active Ceased
- 2018-12-07 CR CR20200260A patent/CR20200260A/es unknown
- 2018-12-07 BR BR112020011815-0A patent/BR112020011815A2/pt unknown
- 2018-12-07 CA CA3085661A patent/CA3085661A1/en active Pending
- 2018-12-07 WO PCT/EP2018/084019 patent/WO2019115402A1/en not_active Ceased
- 2018-12-07 CA CA3085657A patent/CA3085657A1/en active Pending
- 2018-12-07 JP JP2020531982A patent/JP7770769B2/ja active Active
- 2018-12-07 EP EP18829227.0A patent/EP3694549A1/en active Pending
- 2018-12-07 SG SG11202004952UA patent/SG11202004952UA/en unknown
- 2018-12-07 CN CN201880089469.3A patent/CN111801419A/zh active Pending
- 2018-12-07 AU AU2018382419A patent/AU2018382419B2/en active Active
- 2018-12-07 AU AU2018385256A patent/AU2018385256B2/en active Active
- 2018-12-07 PE PE2020000765A patent/PE20210635A1/es unknown
- 2018-12-07 BR BR112020011838-9A patent/BR112020011838A2/pt unknown
- 2018-12-07 JP JP2020531972A patent/JP7273040B2/ja active Active
- 2018-12-07 US US16/772,046 patent/US11542507B2/en active Active
- 2018-12-07 CN CN201880089491.8A patent/CN111801116B/zh active Active
- 2018-12-07 CA CA3085575A patent/CA3085575A1/en active Pending
- 2018-12-07 WO PCT/EP2018/083958 patent/WO2019115386A1/en not_active Ceased
- 2018-12-07 CN CN202510619819.4A patent/CN120519464A/zh active Pending
- 2018-12-07 MX MX2020006244A patent/MX2020006244A/es unknown
- 2018-12-07 SG SG11202004471RA patent/SG11202004471RA/en unknown
- 2018-12-07 DK DK18829225.4T patent/DK3700564T3/da active
- 2018-12-07 CN CN202411608245.2A patent/CN119656298A/zh active Pending
- 2018-12-07 WO PCT/EP2018/083956 patent/WO2019115385A1/en not_active Ceased
- 2018-12-13 TW TW107144946A patent/TW201940192A/zh unknown
- 2018-12-13 TW TW107144947A patent/TWI821224B/zh active
- 2018-12-14 UY UY0001038014A patent/UY38014A/es not_active Application Discontinuation
- 2018-12-14 UY UY0001038016A patent/UY38016A/es not_active Application Discontinuation
- 2018-12-14 UY UY0001038015A patent/UY38015A/es not_active Application Discontinuation
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2020
- 2020-05-27 IL IL274975A patent/IL274975A/en unknown
- 2020-06-03 IL IL275086A patent/IL275086A/en unknown
- 2020-06-08 IL IL275217A patent/IL275217A/en unknown
- 2020-06-10 DO DO2020000113A patent/DOP2020000113A/es unknown
- 2020-06-10 DO DO2020000106A patent/DOP2020000106A/es unknown
- 2020-06-10 DO DO2020000107A patent/DOP2020000107A/es unknown
- 2020-06-11 CO CONC2020/0007102A patent/CO2020007102A2/es unknown
- 2020-06-11 CO CONC2020/0007100A patent/CO2020007100A2/es unknown
- 2020-06-11 CL CL2020001560A patent/CL2020001560A1/es unknown
- 2020-06-11 CO CONC2020/0007120A patent/CO2020007120A2/es unknown
- 2020-06-11 CL CL2020001562A patent/CL2020001562A1/es unknown
- 2020-06-11 CL CL2020001561A patent/CL2020001561A1/es unknown
- 2020-06-15 PH PH12020550904A patent/PH12020550904A1/en unknown
- 2020-06-15 PH PH12020550906A patent/PH12020550906A1/en unknown
- 2020-06-15 PH PH12020550903A patent/PH12020550903A1/en unknown
- 2020-07-13 MX MX2025007909A patent/MX2025007909A/es unknown
- 2020-07-14 ZA ZA2020/04317A patent/ZA202004317B/en unknown
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2022
- 2022-08-08 US US17/883,031 patent/US12305173B2/en active Active
- 2022-11-18 US US18/057,053 patent/US20230332162A1/en active Pending
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2023
- 2023-08-07 JP JP2023128316A patent/JP2023153970A/ja active Pending
- 2023-08-07 US US18/366,306 patent/US20240076681A1/en active Pending
- 2023-08-21 JP JP2023134080A patent/JP7760560B2/ja active Active
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2025
- 2025-01-31 US US19/043,004 patent/US20250215439A1/en active Pending
- 2025-06-20 AU AU2025204678A patent/AU2025204678A1/en active Pending
- 2025-07-03 AU AU2025205082A patent/AU2025205082A1/en active Pending
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