CN111447949B - 免疫刺激寡核苷酸 - Google Patents

免疫刺激寡核苷酸 Download PDF

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Publication number
CN111447949B
CN111447949B CN201880080814.7A CN201880080814A CN111447949B CN 111447949 B CN111447949 B CN 111447949B CN 201880080814 A CN201880080814 A CN 201880080814A CN 111447949 B CN111447949 B CN 111447949B
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oligonucleotide
immunostimulatory
cholesteryl
immunostimulatory oligonucleotide
linker
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Chinese (zh)
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CN111447949A (zh
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T.伊尔格
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Lilan Animal Health Care Co ltd
Bayer Animal Health GmbH
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Lilan Animal Health Care Co ltd
Bayer Animal Health GmbH
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/117—Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/17—Immunomodulatory nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/33—Chemical structure of the base
    • C12N2310/334—Modified C
    • C12N2310/3341—5-Methylcytosine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate
    • C12N2310/3515—Lipophilic moiety, e.g. cholesterol
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications
    • C12N2320/31—Combination therapy

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201880080814.7A 2017-12-15 2018-12-07 免疫刺激寡核苷酸 Active CN111447949B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202510619819.4A CN120519464A (zh) 2017-12-15 2018-12-07 免疫刺激寡核苷酸

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
EP17207746 2017-12-15
EP17207746.3 2017-12-15
EP17207740 2017-12-15
EP17207750 2017-12-15
EP17207750.5 2017-12-15
EP17207740.6 2017-12-15
PCT/EP2018/084019 WO2019115402A1 (en) 2017-12-15 2018-12-07 Immunostimulatory oligonucleotides

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CN111447949A CN111447949A (zh) 2020-07-24
CN111447949B true CN111447949B (zh) 2025-07-11

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CN201880080814.7A Active CN111447949B (zh) 2017-12-15 2018-12-07 免疫刺激寡核苷酸
CN201880089469.3A Pending CN111801419A (zh) 2017-12-15 2018-12-07 免疫刺激性寡核苷酸
CN201880089491.8A Active CN111801116B (zh) 2017-12-15 2018-12-07 免疫刺激性组合物
CN202510619819.4A Pending CN120519464A (zh) 2017-12-15 2018-12-07 免疫刺激寡核苷酸
CN202411608245.2A Pending CN119656298A (zh) 2017-12-15 2018-12-07 免疫刺激性组合物

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CN201880089469.3A Pending CN111801419A (zh) 2017-12-15 2018-12-07 免疫刺激性寡核苷酸
CN201880089491.8A Active CN111801116B (zh) 2017-12-15 2018-12-07 免疫刺激性组合物
CN202510619819.4A Pending CN120519464A (zh) 2017-12-15 2018-12-07 免疫刺激寡核苷酸
CN202411608245.2A Pending CN119656298A (zh) 2017-12-15 2018-12-07 免疫刺激性组合物

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US (7) US11932857B2 (enExample)
EP (4) EP3701032A1 (enExample)
JP (5) JP7458977B2 (enExample)
KR (4) KR20250048594A (enExample)
CN (5) CN111447949B (enExample)
AU (5) AU2018385257B2 (enExample)
BR (2) BR112020011815A2 (enExample)
CA (3) CA3085661A1 (enExample)
CL (3) CL2020001560A1 (enExample)
CO (3) CO2020007102A2 (enExample)
CR (1) CR20200260A (enExample)
DK (1) DK3700564T3 (enExample)
DO (3) DOP2020000113A (enExample)
IL (3) IL274975A (enExample)
MX (4) MX2020006243A (enExample)
PE (3) PE20200933A1 (enExample)
PH (3) PH12020550904A1 (enExample)
SG (3) SG11202004773SA (enExample)
TW (2) TW201940192A (enExample)
UY (3) UY38014A (enExample)
WO (3) WO2019115402A1 (enExample)
ZA (1) ZA202004317B (enExample)

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CN113493790A (zh) * 2020-04-01 2021-10-12 南京华普生物技术股份有限公司 具有免疫调节功能的CpG ODN及其应用
EP3892260A1 (en) * 2020-04-10 2021-10-13 Bayer Animal Health GmbH Immunostimulatory compositions based on liposomes with zwiterionic and cationic lipids
EP4295917A3 (en) 2020-08-07 2024-02-28 Tambo, Inc. Trans-cyclooctene bioorthogonal agents and uses in cancer and immunotherapy
CN112159814B (zh) * 2020-10-29 2023-05-16 中国农业科学院兰州兽医研究所 一种CpG寡聚脱氧核苷酸及制备与其用途
CN113797329A (zh) * 2021-10-19 2021-12-17 启锰生物科技(江苏)有限公司 一种二价锰佐剂和CpG佐剂的疫苗佐剂组合物及其制作方法
CN116218852A (zh) * 2023-02-22 2023-06-06 中国人民解放军陆军军医大学 一种靶向基因启动子G-四联体区域的sgRNA及其用途
WO2025149000A1 (zh) * 2024-01-09 2025-07-17 康希诺(上海)生物研发有限公司 一种免疫刺激序列截断多聚a尾的序列构建及其应用

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CA3085657A1 (en) 2019-06-20
RU2020122553A (ru) 2022-01-17
JP2023156485A (ja) 2023-10-24
PH12020550903A1 (en) 2021-05-17
BR112020011838A2 (pt) 2020-11-24
PE20210636A1 (es) 2021-03-23
US20230332162A1 (en) 2023-10-19
SG11202004773SA (en) 2020-06-29
US20230174990A1 (en) 2023-06-08
KR20200098638A (ko) 2020-08-20
TW201936924A (zh) 2019-09-16
EP3694549A1 (en) 2020-08-19
AU2018385257B2 (en) 2025-04-10
JP7760560B2 (ja) 2025-10-27
DOP2020000106A (es) 2020-08-31
CR20200260A (es) 2020-08-01
CN119656298A (zh) 2025-03-21
DK3700564T3 (da) 2025-11-10
SG11202004952UA (en) 2020-06-29
AU2018382419B2 (en) 2025-04-10
CL2020001562A1 (es) 2020-11-06
JP2021506246A (ja) 2021-02-22
BR112020011815A2 (pt) 2020-11-17
WO2019115386A1 (en) 2019-06-20
CA3085661A1 (en) 2019-06-20
TW201936923A (zh) 2019-09-16
JP7770769B2 (ja) 2025-11-17
JP7273040B2 (ja) 2023-05-12
AU2025204678A1 (en) 2025-07-17
EP3700564A1 (en) 2020-09-02
US11932857B2 (en) 2024-03-19
CN111801116B (zh) 2024-11-26
US20210062192A1 (en) 2021-03-04
CN111447949A (zh) 2020-07-24
AU2018385257A1 (en) 2020-06-18
EP3701032A1 (en) 2020-09-02
RU2020122545A3 (enExample) 2022-05-04
US20210170020A1 (en) 2021-06-10
WO2019115402A1 (en) 2019-06-20
TW201940192A (zh) 2019-10-16
US12305173B2 (en) 2025-05-20
CN120519464A (zh) 2025-08-22
CN111801116A (zh) 2020-10-20
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