|
US586935A
(en)
*
|
|
1897-07-20 |
|
Albert j |
|
US4522811A
(en)
|
1982-07-08 |
1985-06-11 |
Syntex (U.S.A.) Inc. |
Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
|
|
US5240848A
(en)
|
1988-11-21 |
1993-08-31 |
Monsanto Company |
Dna sequences encoding human vascular permeability factor having 189 amino acids
|
|
US5328470A
(en)
|
1989-03-31 |
1994-07-12 |
The Regents Of The University Of Michigan |
Treatment of diseases by site-specific instillation of cells or site-specific transformation of cells and kits therefor
|
|
US5332671A
(en)
|
1989-05-12 |
1994-07-26 |
Genetech, Inc. |
Production of vascular endothelial cell growth factor and DNA encoding same
|
|
US5194596A
(en)
|
1989-07-27 |
1993-03-16 |
California Biotechnology Inc. |
Production of vascular endothelial cell growth factor
|
|
US5219739A
(en)
|
1989-07-27 |
1993-06-15 |
Scios Nova Inc. |
DNA sequences encoding bVEGF120 and hVEGF121 and methods for the production of bovine and human vascular endothelial cell growth factors, bVEGF120 and hVEGF121
|
|
EP0500799B1
(en)
|
1989-11-16 |
1998-01-14 |
Duke University |
Particle mediated transformation of animal skin tissue cells
|
|
US5610289A
(en)
|
1990-07-27 |
1997-03-11 |
Isis Pharmaceuticals, Inc. |
Backbone modified oligonucleotide analogues
|
|
US5672697A
(en)
|
1991-02-08 |
1997-09-30 |
Gilead Sciences, Inc. |
Nucleoside 5'-methylene phosphonates
|
|
US5252479A
(en)
|
1991-11-08 |
1993-10-12 |
Research Corporation Technologies, Inc. |
Safe vector for gene therapy
|
|
US5587308A
(en)
|
1992-06-02 |
1996-12-24 |
The United States Of America As Represented By The Department Of Health & Human Services |
Modified adeno-associated virus vector capable of expression from a novel promoter
|
|
JPH0641183A
(ja)
|
1992-07-23 |
1994-02-15 |
Mitsubishi Kasei Corp |
オリゴヌクレオチド単分子膜
|
|
US5985558A
(en)
|
1997-04-14 |
1999-11-16 |
Isis Pharmaceuticals Inc. |
Antisense oligonucleotide compositions and methods for the inibition of c-Jun and c-Fos
|
|
US6291438B1
(en)
|
1993-02-24 |
2001-09-18 |
Jui H. Wang |
Antiviral anticancer poly-substituted phenyl derivatized oligoribonucleotides and methods for their use
|
|
US5858988A
(en)
|
1993-02-24 |
1999-01-12 |
Wang; Jui H. |
Poly-substituted-phenyl-oligoribo nucleotides having enhanced stability and membrane permeability and methods of use
|
|
HU9501994D0
(en)
|
1993-03-31 |
1995-09-28 |
Sterling Winthrop Inc |
Novel 5'-substituted nucleosides and oligomers produced therefrom
|
|
TW404844B
(en)
|
1993-04-08 |
2000-09-11 |
Oxford Biosciences Ltd |
Needleless syringe
|
|
KR970703357A
(ko)
*
|
1994-06-01 |
1997-07-03 |
다알렌 반스톤 |
병원체-저해제로서의, 측쇄를 가지는 올리고누클레오티드(branched oligonu-cleotides as pathogen-inhibitory agents)
|
|
AU2991295A
(en)
|
1994-07-26 |
1996-02-22 |
Kaken Pharmaceutical Co., Ltd. |
Sustance with antiviral activity
|
|
US6383814B1
(en)
|
1994-12-09 |
2002-05-07 |
Genzyme Corporation |
Cationic amphiphiles for intracellular delivery of therapeutic molecules
|
|
WO1996033761A1
(en)
|
1995-04-28 |
1996-10-31 |
Medtronic, Inc. |
Intraparenchymal infusion catheter system
|
|
US6025335A
(en)
|
1995-09-21 |
2000-02-15 |
Lipitek International, Inc. |
L-Nucleoside Dimer Compounds and therapeutic uses
|
|
US5684143A
(en)
|
1996-02-21 |
1997-11-04 |
Lynx Therapeutics, Inc. |
Oligo-2'-fluoronucleotide N3'->P5' phosphoramidates
|
|
US5735814A
(en)
|
1996-04-30 |
1998-04-07 |
Medtronic, Inc. |
Techniques of treating neurodegenerative disorders by brain infusion
|
|
US5898031A
(en)
|
1996-06-06 |
1999-04-27 |
Isis Pharmaceuticals, Inc. |
Oligoribonucleotides for cleaving RNA
|
|
US5849902A
(en)
|
1996-09-26 |
1998-12-15 |
Oligos Etc. Inc. |
Three component chimeric antisense oligonucleotides
|
|
US6177403B1
(en)
|
1996-10-21 |
2001-01-23 |
The Trustees Of The University Of Pennsylvania |
Compositions, methods, and apparatus for delivery of a macromolecular assembly to an extravascular tissue of an animal
|
|
US6042820A
(en)
|
1996-12-20 |
2000-03-28 |
Connaught Laboratories Limited |
Biodegradable copolymer containing α-hydroxy acid and α-amino acid units
|
|
US6472375B1
(en)
|
1998-04-16 |
2002-10-29 |
John Wayne Cancer Institute |
DNA vaccine and methods for its use
|
|
US6242589B1
(en)
|
1998-07-14 |
2001-06-05 |
Isis Pharmaceuticals, Inc. |
Phosphorothioate oligonucleotides having modified internucleoside linkages
|
|
EP1016726A1
(en)
|
1998-12-30 |
2000-07-05 |
Introgene B.V. |
Gene therapy to promote angiogenesis
|
|
ES2270893T3
(es)
|
1999-12-24 |
2007-04-16 |
Genentech, Inc. |
Procedimiento y composiciones para prolongar la vida media de compuestos bioactivos.
|
|
US20070026394A1
(en)
|
2000-02-11 |
2007-02-01 |
Lawrence Blatt |
Modulation of gene expression associated with inflammation proliferation and neurite outgrowth using nucleic acid based technologies
|
|
US8273866B2
(en)
|
2002-02-20 |
2012-09-25 |
Merck Sharp & Dohme Corp. |
RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (SINA)
|
|
US8202979B2
(en)
|
2002-02-20 |
2012-06-19 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid
|
|
KR100909681B1
(ko)
|
2000-12-01 |
2009-07-29 |
막스-플랑크-게젤샤프트 츄어 푀르더룽 데어 비쎈샤프텐 에.파우. |
Ｒｎａ 간섭을 매개하는 작은 ｒｎａ 분자
|
|
JP4371812B2
(ja)
|
2001-09-28 |
2009-11-25 |
マックス−プランク−ゲゼルシャフト・ツア・フェルデルング・デア・ヴィッセンシャフテン・エー・ファオ |
マイクロｒｎａ分子
|
|
AU2002366803A1
(en)
|
2001-12-19 |
2003-07-09 |
Millennium Pharmaceuticals, Inc. |
Human diacylglycerol acyltransferase 2 (dgat2) family members and uses therefor
|
|
US20060009409A1
(en)
|
2002-02-01 |
2006-01-12 |
Woolf Tod M |
Double-stranded oligonucleotides
|
|
US20100240730A1
(en)
|
2002-02-20 |
2010-09-23 |
Merck Sharp And Dohme Corp. |
RNA Interference Mediated Inhibition of Gene Expression Using Chemically Modified Short Interfering Nucleic Acid (siNA)
|
|
US9181551B2
(en)
|
2002-02-20 |
2015-11-10 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
|
|
US20050096284A1
(en)
|
2002-02-20 |
2005-05-05 |
Sirna Therapeutics, Inc. |
RNA interference mediated treatment of polyglutamine (polyQ) repeat expansion diseases using short interfering nucleic acid (siNA)
|
|
US7858367B2
(en)
|
2002-04-30 |
2010-12-28 |
Duke University |
Viral vectors and methods for producing and using the same
|
|
DK2308507T3
(da)
|
2002-07-19 |
2015-04-20 |
Beth Israel Hospital |
Fremgangsmåder til behandling af præeklampsi
|
|
US20050106731A1
(en)
|
2002-08-05 |
2005-05-19 |
Davidson Beverly L. |
siRNA-mediated gene silencing with viral vectors
|
|
US20040241854A1
(en)
|
2002-08-05 |
2004-12-02 |
Davidson Beverly L. |
siRNA-mediated gene silencing
|
|
US7923547B2
(en)
*
|
2002-09-05 |
2011-04-12 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
|
|
AU2003285071A1
(en)
|
2002-10-30 |
2004-06-07 |
Nikolaos Avlonitis |
Antiprotozoal ring-substituted phospholipids
|
|
AU2003295387A1
(en)
|
2002-11-05 |
2004-06-03 |
Isis Parmaceuticals, Inc. |
Modified oligonucleotides for use in rna interference
|
|
US7250496B2
(en)
|
2002-11-14 |
2007-07-31 |
Rosetta Genomics Ltd. |
Bioinformatically detectable group of novel regulatory genes and uses thereof
|
|
WO2006006948A2
(en)
|
2002-11-14 |
2006-01-19 |
Dharmacon, Inc. |
METHODS AND COMPOSITIONS FOR SELECTING siRNA OF IMPROVED FUNCTIONALITY
|
|
US8090542B2
(en)
|
2002-11-14 |
2012-01-03 |
Dharmacon Inc. |
Functional and hyperfunctional siRNA
|
|
US7217807B2
(en)
|
2002-11-26 |
2007-05-15 |
Rosetta Genomics Ltd |
Bioinformatically detectable group of novel HIV regulatory genes and uses thereof
|
|
US6913890B2
(en)
|
2002-12-18 |
2005-07-05 |
Palo Alto Research Center Incorporated |
Process for preparing albumin protein conjugated oligonucleotide probes
|
|
US20080188429A1
(en)
|
2002-12-27 |
2008-08-07 |
Iyer Radhakrishnan P |
Synthetic siRNA compounds and methods for the downregulation of gene expression
|
|
US20040198640A1
(en)
|
2003-04-02 |
2004-10-07 |
Dharmacon, Inc. |
Stabilized polynucleotides for use in RNA interference
|
|
EP2669377A3
(en)
|
2003-04-17 |
2015-10-14 |
Alnylam Pharmaceuticals Inc. |
Modified iRNA agents
|
|
US7851615B2
(en)
|
2003-04-17 |
2010-12-14 |
Alnylam Pharmaceuticals, Inc. |
Lipophilic conjugated iRNA agents
|
|
ATE485394T1
(de)
|
2003-06-02 |
2010-11-15 |
Univ Massachusetts |
Verfahren und zusammensetzungen zur verbesserung der wirksamkeit und spezifität von fnai
|
|
US7459547B2
(en)
|
2003-06-02 |
2008-12-02 |
University Of Massachusetts |
Methods and compositions for controlling efficacy of RNA silencing
|
|
US7750144B2
(en)
|
2003-06-02 |
2010-07-06 |
University Of Massachusetts |
Methods and compositions for enhancing the efficacy and specificity of RNA silencing
|
|
DE10326302A1
(de)
|
2003-06-11 |
2004-12-30 |
Gnothis Holding Sa |
Bi-Fluorophor-markierte Sonden zum Nachweis von Nukleinsäuren
|
|
US8680063B2
(en)
|
2003-09-12 |
2014-03-25 |
University Of Massachusetts |
RNA interference for the treatment of gain-of-function disorders
|
|
WO2008005562A2
(en)
|
2006-07-07 |
2008-01-10 |
University Of Massachusetts |
Rna silencing compositions and methods for the treatment of huntington's disease
|
|
NZ545134A
(en)
|
2003-09-18 |
2009-06-26 |
Lilly Co Eli |
Modulation of eIF4E expression
|
|
CN1906308B
(zh)
|
2003-12-19 |
2011-09-14 |
诺华疫苗和诊断公司 |
小干扰rna的细胞转染制剂、相关组合物以及制备和使用方法
|
|
US20050176045A1
(en)
|
2004-02-06 |
2005-08-11 |
Dharmacon, Inc. |
SNP discriminatory siRNA
|
|
WO2005077333A2
(en)
|
2004-02-10 |
2005-08-25 |
University Of Florida Research Foundation, Inc. |
Gel-based delivery of recombinant adeno-associated virus vectors
|
|
WO2005089224A2
(en)
|
2004-03-12 |
2005-09-29 |
Alnylam Pharmaceuticals, Inc. |
iRNA AGENTS TARGETING VEGF
|
|
KR101147147B1
(ko)
|
2004-04-01 |
2012-05-25 |
머크 샤프 앤드 돔 코포레이션 |
Ｒｎａ 간섭의 오프 타겟 효과 감소를 위한 변형된폴리뉴클레오타이드
|
|
CA2564616C
(en)
|
2004-04-20 |
2016-08-30 |
Nastech Pharmaceutical Company Inc. |
Methods and compositions for enhancing delivery of double-stranded rna or a double-stranded hybrid nucleic acid to regulate gene expression in mammalian cells
|
|
AU2005248147A1
(en)
|
2004-05-11 |
2005-12-08 |
Alphagen Co., Ltd. |
Polynucleotides for causing RNA interference and method for inhibiting gene expression using the same
|
|
CA2569419A1
(en)
|
2004-06-03 |
2005-12-22 |
Isis Pharmaceuticals, Inc. |
Double strand compositions comprising differentially modified strands for use in gene modulation
|
|
EP1789553B1
(en)
|
2004-06-30 |
2014-03-26 |
Alnylam Pharmaceuticals Inc. |
Oligonucleotides comprising a non-phosphate backbone linkage
|
|
US7892809B2
(en)
|
2004-12-15 |
2011-02-22 |
The University Of North Carolina At Chapel Hill |
Chimeric vectors
|
|
WO2007022470A2
(en)
|
2005-08-18 |
2007-02-22 |
Alnylam Pharmaceuticals, Inc. |
Methods and compositions for treating neurological disease
|
|
US20090203893A1
(en)
|
2005-08-29 |
2009-08-13 |
Regulus Therapeutics, Llc |
Antisense compounds having enhanced anti-microrna activity
|
|
CN101365801B
(zh)
|
2005-10-28 |
2013-03-27 |
阿尔尼拉姆医药品有限公司 |
抑制亨廷顿基因表达的组合物和方法
|
|
CN101346393B
(zh)
|
2005-11-02 |
2015-07-22 |
普洛体维生物治疗公司 |
修饰的siRNA分子及其应用
|
|
AU2006311912A1
(en)
|
2005-11-04 |
2007-05-18 |
Mdrna, Inc. |
Peptide-dicer substrate RNA conjugates as delivery vehicles for siRNA
|
|
WO2007087451A2
(en)
|
2006-01-25 |
2007-08-02 |
University Of Massachusetts |
Compositions and methods for enhancing discriminatory rna interference
|
|
US9198981B2
(en)
|
2006-02-01 |
2015-12-01 |
The University Of Kentucky |
Modulation of angiogenesis
|
|
EP1989307B1
(en)
*
|
2006-02-08 |
2012-08-08 |
Quark Pharmaceuticals, Inc. |
NOVEL TANDEM siRNAS
|
|
JPWO2007094218A1
(ja)
|
2006-02-16 |
2009-07-02 |
国立大学法人岐阜大学 |
修飾オリゴヌクレオチド
|
|
EP1986697B1
(en)
|
2006-02-17 |
2016-06-29 |
GE Healthcare Dharmacon, Inc. |
Compositions and methods for inhibiting gene silencing by rna interference
|
|
WO2007112414A2
(en)
|
2006-03-27 |
2007-10-04 |
Isis Pharmaceuticals, Inc. |
Conjugated double strand compositions for use in gene modulation
|
|
US20080039415A1
(en)
|
2006-08-11 |
2008-02-14 |
Gregory Robert Stewart |
Retrograde transport of sirna and therapeutic uses to treat neurologic disorders
|
|
WO2008036841A2
(en)
|
2006-09-22 |
2008-03-27 |
Dharmacon, Inc. |
Tripartite oligonucleotide complexes and methods for gene silencing by rna interference
|
|
US8906874B2
(en)
|
2006-11-09 |
2014-12-09 |
Gradalis, Inc. |
Bi-functional shRNA targeting Stathmin 1 and uses thereof
|
|
WO2008109381A2
(en)
|
2007-03-02 |
2008-09-12 |
Mdrna, Inc. |
Nucleic acid compounds for inhibiting hif1a gene expression and uses thereof
|
|
WO2008154482A2
(en)
|
2007-06-08 |
2008-12-18 |
Sirnaomics, Inc. |
Sirna compositions and methods of use in treatment of ocular diseases
|
|
EP2173358B1
(en)
|
2007-06-22 |
2015-10-21 |
Isis Pharmaceuticals, Inc. |
Double strand compositions comprising differentially modified strands for use in gene modulation
|
|
DK2193140T3
(en)
|
2007-08-27 |
2017-01-23 |
Iglobe Health Inst Llc |
COMPOSITIONS OF ASYMMETRIC INTERFERRING RNA AND ITS APPLICATIONS
|
|
CN101199858A
(zh)
|
2007-10-18 |
2008-06-18 |
广州拓谱基因技术有限公司 |
治疗眼科疾病的多靶点小干扰rna鸡尾酒制剂及制备方法
|
|
TW200927177A
(en)
|
2007-10-24 |
2009-07-01 |
Nat Inst Of Advanced Ind Scien |
Lipid-modified double-stranded RNA having potent RNA interference effect
|
|
CA2910760C
(en)
|
2007-12-04 |
2019-07-09 |
Muthiah Manoharan |
Targeting lipids
|
|
US9029524B2
(en)
|
2007-12-10 |
2015-05-12 |
California Institute Of Technology |
Signal activated RNA interference
|
|
US20110081362A1
(en)
|
2008-01-31 |
2011-04-07 |
The Brigham And Women's Hospital, Inc. |
Treatment of cancer
|
|
US10131904B2
(en)
|
2008-02-11 |
2018-11-20 |
Rxi Pharmaceuticals Corporation |
Modified RNAi polynucleotides and uses thereof
|
|
US9217155B2
(en)
|
2008-05-28 |
2015-12-22 |
University Of Massachusetts |
Isolation of novel AAV'S and uses thereof
|
|
US8815818B2
(en)
|
2008-07-18 |
2014-08-26 |
Rxi Pharmaceuticals Corporation |
Phagocytic cell delivery of RNAI
|
|
EP2318528A1
(en)
|
2008-07-24 |
2011-05-11 |
Rxi Pharmaceuticals Corporation |
Rnai constructs and uses therof
|
|
WO2010011895A1
(en)
|
2008-07-25 |
2010-01-28 |
Alnylam Pharmaceuticals, Inc. |
Enhancement of sirna silencing activity using universal bases or mismatches in the sense strand
|
|
US8796443B2
(en)
|
2008-09-22 |
2014-08-05 |
Rxi Pharmaceuticals Corporation |
Reduced size self-delivering RNAi compounds
|
|
JP2012505644A
(ja)
|
2008-10-15 |
2012-03-08 |
エフ．ホフマン−ラ ロシュ アーゲー |
オリゴヌクレオチド検出法
|
|
US8987435B2
(en)
|
2008-10-24 |
2015-03-24 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds and methods
|
|
WO2010059226A2
(en)
|
2008-11-19 |
2010-05-27 |
Rxi Pharmaceuticals Corporation |
Inhibition of map4k4 through rnai
|
|
US9493774B2
(en)
|
2009-01-05 |
2016-11-15 |
Rxi Pharmaceuticals Corporation |
Inhibition of PCSK9 through RNAi
|
|
US9023820B2
(en)
|
2009-01-26 |
2015-05-05 |
Protiva Biotherapeutics, Inc. |
Compositions and methods for silencing apolipoprotein C-III expression
|
|
WO2010090762A1
(en)
|
2009-02-04 |
2010-08-12 |
Rxi Pharmaceuticals Corporation |
Rna duplexes with single stranded phosphorothioate nucleotide regions for additional functionality
|
|
KR101141544B1
(ko)
|
2009-03-13 |
2012-05-03 |
한국과학기술원 |
에스아이알엔에이 다중 접합체 및 이의 제조방법
|
|
US8309356B2
(en)
|
2009-04-01 |
2012-11-13 |
Yale University |
Pseudocomplementary oligonucleotides for targeted gene therapy
|
|
US8987222B2
(en)
|
2009-04-08 |
2015-03-24 |
University Of Massachusetts |
Single nucleotide polymorphism (SNP) targeting therapies for the treatment of huntington'S disease
|
|
WO2010138263A2
(en)
|
2009-05-28 |
2010-12-02 |
University Of Massachusetts |
Novel aav 's and uses thereof
|
|
GB0910723D0
(en)
|
2009-06-22 |
2009-08-05 |
Sylentis Sau |
Novel drugs for inhibition of gene expression
|
|
HRP20150566T1
(hr)
|
2009-08-27 |
2015-07-17 |
Idera Pharmaceuticals, Inc. |
Kompozicija za inhibiciju ekspresije gena i njegova upotreba
|
|
US20150025122A1
(en)
|
2009-10-12 |
2015-01-22 |
Larry J. Smith |
Methods and Compositions for Modulating Gene Expression Using Oligonucleotide Based Drugs Administered in vivo or in vitro
|
|
US8877439B2
(en)
|
2009-12-17 |
2014-11-04 |
Sirna Therapeutics, Inc. |
Method for rapidly evaluating performance of short interfering RNA with novel chemical modifications
|
|
EP3561060A1
(en)
|
2010-02-08 |
2019-10-30 |
Ionis Pharmaceuticals, Inc. |
Selective reduction of allelic variants
|
|
WO2011109698A1
(en)
|
2010-03-04 |
2011-09-09 |
Rxi Pharmaceuticals Corporation |
Formulations and methods for targeted delivery to phagocyte cells
|
|
RU2615143C2
(ru)
|
2010-03-24 |
2017-04-04 |
Адвирна |
Самодоставляющие PHKi соединения уменьшенного размера
|
|
IL265674B2
(en)
|
2010-03-24 |
2024-05-01 |
Phio Pharm Corp |
Rana disorder in cutaneous and fibrotic symptoms
|
|
US9095504B2
(en)
|
2010-03-24 |
2015-08-04 |
Rxi Pharmaceuticals Corporation |
RNA interference in ocular indications
|
|
WO2011125943A1
(ja)
|
2010-04-01 |
2011-10-13 |
日本新薬株式会社 |
修飾オリゴヌクレオチド
|
|
EP2601204B1
(en)
|
2010-04-28 |
2016-09-07 |
Ionis Pharmaceuticals, Inc. |
Modified nucleosides and oligomeric compounds prepared therefrom
|
|
WO2012005898A2
(en)
|
2010-06-15 |
2012-01-12 |
Alnylam Pharmaceuticals, Inc. |
Chinese hamster ovary (cho) cell transcriptome, corresponding sirnas and uses thereof
|
|
CN102946908B
(zh)
|
2010-06-18 |
2015-04-22 |
Lsip基金运营联合公司 |
显性等位基因表达抑制剂
|
|
WO2012003330A2
(en)
*
|
2010-06-30 |
2012-01-05 |
Stratos Genomics, Inc |
Multiplexed identification of nucleic acid sequences
|
|
JP2013545818A
(ja)
|
2010-12-16 |
2013-12-26 |
バーテックス ファーマシューティカルズ インコーポレイテッド |
インフルエンザウイルス複製阻害物質
|
|
CN103492381A
(zh)
|
2010-12-16 |
2014-01-01 |
沃泰克斯药物股份有限公司 |
流感病毒复制的抑制剂
|
|
EP2651941A1
(en)
|
2010-12-16 |
2013-10-23 |
Vertex Pharmaceuticals Incorporated |
Inhibitors of influenza viruses replication
|
|
CA2816155C
(en)
|
2010-12-17 |
2020-10-27 |
Arrowhead Research Corporation |
Galactose cluster-pharmacokinetic modulator targeting moiety for sirna
|
|
EP2681315B1
(en)
|
2011-03-03 |
2017-05-03 |
Quark Pharmaceuticals, Inc. |
Oligonucleotide modulators of the toll-like receptor pathway
|
|
GB201105137D0
(en)
|
2011-03-28 |
2011-05-11 |
Isis Innovation |
Therapeutic molecules for use in the suppression of Parkinson's disease
|
|
KR102104125B1
(ko)
|
2011-04-21 |
2020-05-29 |
재단법인 한국파스퇴르연구소 |
소염 화합물
|
|
EP3564393A1
(en)
|
2011-06-21 |
2019-11-06 |
Alnylam Pharmaceuticals, Inc. |
Assays and methods for determining activity of a therapeutic agent in a subject
|
|
EP2844261B1
(en)
|
2012-05-02 |
2018-10-17 |
Sirna Therapeutics, Inc. |
SHORT INTERFERING NUCLEIC ACID (siNA) COMPOSITIONS
|
|
US10125362B2
(en)
|
2012-05-22 |
2018-11-13 |
Olix Pharmaceuticals, Inc. |
RNA-interference-inducing nucleic acid molecule able to penetrate into cells, and use therefor
|
|
US9480752B2
(en)
|
2012-07-10 |
2016-11-01 |
Baseclick Gmbh |
Anandamide-modified nucleic acid molecules
|
|
EP2895200B1
(en)
|
2012-09-14 |
2019-11-06 |
Translate Bio MA, Inc. |
Multimeric oligonucleotide compounds
|
|
WO2014047649A1
(en)
|
2012-09-24 |
2014-03-27 |
The Regents Of The University Of California |
Methods for arranging and packing nucleic acids for unusual resistance to nucleases and targeted delivery for gene therapy
|
|
JP6452614B2
(ja)
|
2012-11-15 |
2019-01-16 |
ロシュ イノベーション センター コペンハーゲン エーエス |
オリゴヌクレオチドコンジュゲート
|
|
PT2929031T
(pt)
|
2012-12-05 |
2018-01-19 |
Alnylam Pharmaceuticals Inc |
Composições de irna de pcsk9 e métodos de seu uso
|
|
US20140200124A1
(en)
|
2013-01-15 |
2014-07-17 |
Karen Michelle JAMES |
Physical Therapy Device and Methods for Use Thereof
|
|
PE20152002A1
(es)
*
|
2013-05-01 |
2016-01-21 |
Isis Pharmaceuticals Inc |
Composiciones y metodos para modular la expresion de ttr y vhb
|
|
TWI727917B
(zh)
|
2013-05-22 |
2021-05-21 |
美商阿尼拉製藥公司 |
ＴＭＰＲＳＳ６ｉＲＮＡ 組成物及其使用方法
|
|
US20160367587A1
(en)
|
2013-06-12 |
2016-12-22 |
Oncoimmunin, Inc. |
Systemic In Vivo Delivery of Oligonucleotides
|
|
CA2915443A1
(en)
|
2013-06-16 |
2014-12-24 |
National University Corporation Tokyo Medical And Dental University |
Double-stranded antisense nucleic acid with exon-skipping effect
|
|
US9862350B2
(en)
|
2013-08-12 |
2018-01-09 |
Tk Holdings Inc. |
Dual chambered passenger airbag
|
|
GB201315141D0
(en)
|
2013-08-23 |
2013-10-09 |
Logicor R & D Ltd |
Improvements to electric heating systems and method of use thereof
|
|
WO2015070173A1
(en)
|
2013-11-08 |
2015-05-14 |
Isis Pharmaceuticals, Inc. |
Compounds and methods for detecting oligonucleotides
|
|
WO2015113004A2
(en)
|
2014-01-27 |
2015-07-30 |
The Board Of Trustee Of The Leland Stanford Junior University |
Oligonucleotides and methods for treatment of cardiomyopathy using rna interference
|
|
EP3733856A1
(en)
*
|
2014-04-18 |
2020-11-04 |
University of Massachusetts |
Exosomal loading using hydrophobically modified oligonucleotides
|
|
WO2015168661A1
(en)
|
2014-05-01 |
2015-11-05 |
Smith Larry J |
METHODS AND MODIFICATIONS THAT PRODUCE ssRNAi COMPOUNDS WITH ENHANCED ACTIVITY, POTENCY AND DURATION OF EFFECT
|
|
MX382901B
(es)
|
2014-05-22 |
2025-03-13 |
Alnylam Pharmaceuticals Inc |
Composiciones de angiotensinogeno (agt) arni y métodos de uso de las mismas.
|
|
US10588980B2
(en)
|
2014-06-23 |
2020-03-17 |
Novartis Ag |
Fatty acids and their use in conjugation to biomolecules
|
|
IL316808A
(en)
|
2014-08-20 |
2025-01-01 |
Alnylam Pharmaceuticals Inc |
Modified double-stranded RNA materials and their uses
|
|
CN106795200B
(zh)
|
2014-10-10 |
2020-06-19 |
豪夫迈·罗氏有限公司 |
Galnac亚磷酰胺、其核酸缀合物及其用途
|
|
JOP20200092A1
(ar)
|
2014-11-10 |
2017-06-16 |
Alnylam Pharmaceuticals Inc |
تركيبات iRNA لفيروس الكبد B (HBV) وطرق لاستخدامها
|
|
WO2016149331A2
(en)
|
2015-03-17 |
2016-09-22 |
Arrowhead Research Corporation |
Compositions and methods for inhibiting gene expression of factor xii
|
|
CN107980062B
(zh)
|
2015-04-03 |
2022-11-25 |
马萨诸塞大学 |
用于靶向亨廷汀mRNA的寡核苷酸化合物
|
|
WO2016161388A1
(en)
|
2015-04-03 |
2016-10-06 |
University Of Massachusetts |
Fully stabilized asymmetric sirna
|
|
DK3277815T3
(da)
|
2015-04-03 |
2021-12-13 |
Univ Massachusetts |
Oligonukleotidforbindelser til behandling af præeklampsi og andre angiogene lidelser
|
|
US10480023B2
(en)
|
2015-04-10 |
2019-11-19 |
Hudsonalpha Institute For Biotechnology |
Method for blocking miRNA
|
|
IL316159A
(en)
*
|
2015-06-15 |
2024-12-01 |
Mpeg La Llc |
Defined Oligonucleotide Multimers and Methods for Manufacture Thereof
|
|
CN108025089A
(zh)
|
2015-07-22 |
2018-05-11 |
波涛生命科学有限公司 |
寡核苷酸组合物及其方法
|
|
TW201718024A
(zh)
|
2015-08-06 |
2017-06-01 |
世代好公司 |
治療性細胞內化結合物
|
|
EP3334499A4
(en)
|
2015-08-14 |
2019-04-17 |
University of Massachusetts |
BIOACTIVE CONJUGATES FOR THE RELEASE OF OLIGONUCLEOTIDES
|
|
SG10201912902TA
(en)
|
2015-10-09 |
2020-02-27 |
Wave Life Sciences Ltd |
Oligonucleotide compositions and methods thereof
|
|
CN105194689A
(zh)
|
2015-10-10 |
2015-12-30 |
湖南中楚博生物科技有限公司 |
一种基于siRNA的双偶联复合物
|
|
US10478503B2
(en)
|
2016-01-31 |
2019-11-19 |
University Of Massachusetts |
Branched oligonucleotides
|
|
KR102775461B1
(ko)
|
2016-04-01 |
2025-02-28 |
어비디티 바이오사이언시스 인크. |
핵산-폴리펩타이드 조성물 및 이의 용도
|
|
WO2017174572A1
(en)
|
2016-04-04 |
2017-10-12 |
F. Hoffmann-La Roche Ag |
Nucleic acid sample preparation methods
|
|
US10036024B2
(en)
|
2016-06-03 |
2018-07-31 |
Purdue Research Foundation |
siRNA compositions that specifically downregulate expression of a variant of the PNPLA3 gene and methods of use thereof for treating a chronic liver disease or alcoholic liver disease (ALD)
|
|
WO2018031933A2
(en)
|
2016-08-12 |
2018-02-15 |
University Of Massachusetts |
Conjugated oligonucleotides
|
|
EP3507366B1
(en)
|
2016-09-01 |
2020-10-07 |
ProQR Therapeutics II B.V. |
Chemically modified single-stranded rna-editing oligonucleotides
|
|
RS63836B1
(sr)
|
2017-04-05 |
2023-01-31 |
Silence Therapeutics Gmbh |
Proizvodi i sastavi
|
|
WO2018223056A1
(en)
|
2017-06-02 |
2018-12-06 |
Wave Life Sciences Ltd. |
Oligonucleotide compositions and methods of use thereof
|
|
CN110799647A
(zh)
|
2017-06-23 |
2020-02-14 |
马萨诸塞大学 |
双尾自递送sirna及相关的方法
|
|
CA3071086A1
(en)
|
2017-08-18 |
2019-02-21 |
The Procter & Gamble Company |
Cleaning agent
|
|
EP3550021A1
(en)
|
2018-04-05 |
2019-10-09 |
Silence Therapeutics GmbH |
Products and compositions for inhibiting expression of a target gene
|
|
AU2019316640B2
(en)
|
2018-08-10 |
2026-03-12 |
University Of Massachusetts |
Modified oligonucleotides targeting SNPs
|
|
EP3840759A4
(en)
|
2018-08-23 |
2022-06-01 |
University Of Massachusetts |
O-METHYL RICH FULLY STABILIZED OLIGONUCLEOTIDES
|
|
AU2020207935A1
(en)
|
2019-01-18 |
2021-08-26 |
University Of Massachusetts |
Dynamic pharmacokinetic-modifying anchors
|
|
JP2022528840A
(ja)
|
2019-03-26 |
2022-06-16 |
ユニバーシティ・オブ・マサチューセッツ |
安定性が増加した修飾オリゴヌクレオチド
|
|
US20210115442A1
(en)
|
2019-08-23 |
2021-04-22 |
University Of Massachusetts |
O-methyl rich fully stabilized oligonucleotides
|
|
EP4090744A4
(en)
|
2020-01-17 |
2024-04-10 |
Anastasia Khvorova |
UNIVERSAL DYNAMIC PHARMACOKINETIC MODIFYING ANCHORS
|
|
EP4126070A4
(en)
|
2020-03-26 |
2024-07-24 |
University Of Massachusetts |
Synthesis of modified oligonucleotides with increased stability
|
|
BR112022019202A2
(pt)
|
2020-03-26 |
2022-11-08 |
Nutrivert Llc |
Oligopeptídeo, composição farmacêutica, composição, e, método para reduzir a inflamação intestinal em um ser humano, para promover crescimento em um animal e para realçar conversão de alimento em um animal
|
|
US12534724B2
(en)
|
2020-05-26 |
2026-01-27 |
University Of Massachusetts |
Synthetic oligonucleotides having regions of block and cluster modifications
|
|
US20220228141A1
(en)
|
2020-11-23 |
2022-07-21 |
University Of Massachusetts |
Oligonucleotides for dgat2 modulation
|
|
IL309334A
(en)
|
2021-06-23 |
2024-02-01 |
Univ Massachusetts |
Anti-FLT1 optimized oligonucleotide compounds for the treatment of preeclampsia and other angiogenic disorders
|