JP2022528840A5 - - Google Patents
Info
- Publication number
- JP2022528840A5 JP2022528840A5 JP2021557374A JP2021557374A JP2022528840A5 JP 2022528840 A5 JP2022528840 A5 JP 2022528840A5 JP 2021557374 A JP2021557374 A JP 2021557374A JP 2021557374 A JP2021557374 A JP 2021557374A JP 2022528840 A5 JP2022528840 A5 JP 2022528840A5
- Authority
- JP
- Japan
- Prior art keywords
- formula
- modified
- bond
- group
- subunit
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2025015181A JP2025072451A (ja) | 2019-03-26 | 2025-01-31 | 安定性が増加した修飾オリゴヌクレオチド |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962824136P | 2019-03-26 | 2019-03-26 | |
| US62/824,136 | 2019-03-26 | ||
| US201962826454P | 2019-03-29 | 2019-03-29 | |
| US62/826,454 | 2019-03-29 | ||
| US201962864792P | 2019-06-21 | 2019-06-21 | |
| US62/864,792 | 2019-06-21 | ||
| PCT/US2020/025017 WO2020198509A2 (en) | 2019-03-26 | 2020-03-26 | Modified oligonucleotides with increased stability |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025015181A Division JP2025072451A (ja) | 2019-03-26 | 2025-01-31 | 安定性が増加した修飾オリゴヌクレオチド |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2022528840A JP2022528840A (ja) | 2022-06-16 |
| JP2022528840A5 true JP2022528840A5 (enExample) | 2023-04-03 |
Family
ID=72609530
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021557374A Pending JP2022528840A (ja) | 2019-03-26 | 2020-03-26 | 安定性が増加した修飾オリゴヌクレオチド |
| JP2025015181A Pending JP2025072451A (ja) | 2019-03-26 | 2025-01-31 | 安定性が増加した修飾オリゴヌクレオチド |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025015181A Pending JP2025072451A (ja) | 2019-03-26 | 2025-01-31 | 安定性が増加した修飾オリゴヌクレオチド |
Country Status (4)
| Country | Link |
|---|---|
| US (2) | US11820985B2 (enExample) |
| EP (1) | EP3946369A4 (enExample) |
| JP (2) | JP2022528840A (enExample) |
| WO (1) | WO2020198509A2 (enExample) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3929293A3 (en) | 2015-04-03 | 2022-03-16 | University Of Massachusetts | Fully stabilized asymmetric sirna |
| WO2017030973A1 (en) | 2015-08-14 | 2017-02-23 | University Of Massachusetts | Bioactive conjugates for oligonucleotide delivery |
| WO2017132669A1 (en) | 2016-01-31 | 2017-08-03 | University Of Massachusetts | Branched oligonucleotides |
| WO2018031933A2 (en) | 2016-08-12 | 2018-02-15 | University Of Massachusetts | Conjugated oligonucleotides |
| CN106987604B (zh) * | 2017-03-29 | 2021-05-28 | 北京希诺谷生物科技有限公司 | 一种制备动脉粥样硬化疾病模型犬的方法 |
| WO2018237245A1 (en) | 2017-06-23 | 2018-12-27 | University Of Massachusetts | TWO TAIL SELF-ADMINISTRATION SIRNA AND ASSOCIATED METHODS |
| EP3781677A4 (en) | 2018-04-16 | 2022-01-19 | University of Massachusetts | COMPOSITIONS AND METHODS FOR IMPROVED GENE EDITTING |
| BR112021002440A2 (pt) | 2018-08-10 | 2021-05-04 | University Of Massachusetts | oligonucleotídeos modificados visando snps |
| WO2020041769A1 (en) | 2018-08-23 | 2020-02-27 | University Of Massachusetts | O-methyl rich fully stabilized oligonucleotides |
| CN113614232A (zh) | 2019-01-18 | 2021-11-05 | 马萨诸塞大学 | 动态药代动力学修饰锚 |
| EP3946369A4 (en) | 2019-03-26 | 2023-10-18 | University Of Massachusetts | MODIFIED OLIGONUCLEOTIDES WITH INCREASED STABILITY |
| KR20220047989A (ko) | 2019-08-09 | 2022-04-19 | 유니버시티 오브 매사추세츠 | Snp를 표적화하는 화학적으로 변형된 올리고뉴클레오타이드 |
| US12365894B2 (en) | 2019-09-16 | 2025-07-22 | University Of Massachusetts | Branched lipid conjugates of siRNA for specific tissue delivery |
| US12339155B2 (en) | 2020-03-25 | 2025-06-24 | Kuwana Metals, Ltd. | Sensor |
| AU2021244600A1 (en) | 2020-03-26 | 2022-11-03 | University Of Massachusetts | Synthesis of modified oligonucleotides with increased stability |
| CA3174079A1 (en) | 2020-05-26 | 2021-12-02 | Anastasia Khvorova | Synthetic oligonucleotides having regions of block and cluster modifications |
| EP4158028A4 (en) | 2020-05-28 | 2024-10-02 | University Of Massachusetts | OLIGONUCLEOTIDES FOR THE MODULATION OF SARS-COV-2 |
| BR112023019981A2 (pt) | 2021-03-29 | 2023-12-12 | Alnylam Pharmaceuticals Inc | Composições do agente irna de huntingtina (htt) e métodos de uso das mesmas |
| IL309334A (en) | 2021-06-23 | 2024-02-01 | Univ Massachusetts | Anti-FLT1 optimized oligonucleotide compounds for the treatment of preeclampsia and other angiogenic disorders |
| US20240425853A1 (en) * | 2021-07-22 | 2024-12-26 | Microbio (Shanghai) Co. Ltd. | Modified small interfering rna molecules with reduced off-target effects |
| CN115819484B (zh) * | 2021-07-23 | 2026-06-02 | 苏州瑞博生物技术股份有限公司 | 双链寡核苷酸、含双链寡核苷酸的组合物与缀合物及制备方法和用途 |
| WO2023069495A1 (en) * | 2021-10-19 | 2023-04-27 | Alnylam Pharmaceuticals, Inc. | Oligonucleotides with 2'-deoxy-2'-f-2'-c-methyl nucleotides |
| WO2023081908A2 (en) | 2021-11-08 | 2023-05-11 | University Of Massachusetts | Oligonucleotides for sod1 modulation |
| WO2023114989A2 (en) * | 2021-12-17 | 2023-06-22 | University Of Massachusetts | Oligonucleotides for mlh3 modulation |
| US20240052344A1 (en) * | 2022-05-04 | 2024-02-15 | University Of Massachusetts | Oligonucleotides for pms1 modulation |
| CN119487046B (zh) * | 2022-06-27 | 2026-08-07 | 大睿生物医药科技(上海)有限公司 | 含有可降低脱靶毒性的核苷酸类似物的双链rna |
| WO2025264952A2 (en) * | 2024-06-21 | 2025-12-26 | Eli Lilly And Company | Novel rna therapeutics and uses thereof |
| WO2026006109A2 (en) * | 2024-06-24 | 2026-01-02 | Eli Lilly And Company | Novel rna therapeutics and uses thereof |
| WO2026080452A1 (en) * | 2024-10-07 | 2026-04-16 | Creyon Bio, Inc. | Fluorosulfonyl phosphoramidate (fsp) backbone modification and uses thereof |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5610289A (en) | 1990-07-27 | 1997-03-11 | Isis Pharmaceuticals, Inc. | Backbone modified oligonucleotide analogues |
| US5672697A (en) * | 1991-02-08 | 1997-09-30 | Gilead Sciences, Inc. | Nucleoside 5'-methylene phosphonates |
| JPH0641183A (ja) | 1992-07-23 | 1994-02-15 | Mitsubishi Kasei Corp | オリゴヌクレオチド単分子膜 |
| US6291438B1 (en) | 1993-02-24 | 2001-09-18 | Jui H. Wang | Antiviral anticancer poly-substituted phenyl derivatized oligoribonucleotides and methods for their use |
| EP0691979A1 (en) | 1993-03-31 | 1996-01-17 | Sanofi | Novel 5'-substituted nucleosides and oligomers produced therefrom |
| WO1996003500A1 (en) | 1994-07-26 | 1996-02-08 | Ltt Institute Co., Ltd. | Sustance with antiviral activity |
| US6025335A (en) | 1995-09-21 | 2000-02-15 | Lipitek International, Inc. | L-Nucleoside Dimer Compounds and therapeutic uses |
| US6242589B1 (en) * | 1998-07-14 | 2001-06-05 | Isis Pharmaceuticals, Inc. | Phosphorothioate oligonucleotides having modified internucleoside linkages |
| US20100240730A1 (en) * | 2002-02-20 | 2010-09-23 | Merck Sharp And Dohme Corp. | RNA Interference Mediated Inhibition of Gene Expression Using Chemically Modified Short Interfering Nucleic Acid (siNA) |
| EP1578754A4 (en) | 2002-10-30 | 2006-07-19 | Makscientific Llc | ROTARY PHOSPHOLIPIDS SUBSTITUTED ANTIPROTOZOOSES |
| DE10326302A1 (de) | 2003-06-11 | 2004-12-30 | Gnothis Holding Sa | Bi-Fluorophor-markierte Sonden zum Nachweis von Nukleinsäuren |
| US20050176045A1 (en) | 2004-02-06 | 2005-08-11 | Dharmacon, Inc. | SNP discriminatory siRNA |
| JP2008504840A (ja) | 2004-06-30 | 2008-02-21 | アルニラム ファーマスーティカルズ インコーポレイテッド | 非リン酸骨格結合を含むオリゴヌクレオチド |
| EP2342340A1 (en) * | 2008-09-22 | 2011-07-13 | Rxi Pharmaceuticals Corporation | Rna interference in skin indications |
| US8309356B2 (en) | 2009-04-01 | 2012-11-13 | Yale University | Pseudocomplementary oligonucleotides for targeted gene therapy |
| US8987222B2 (en) | 2009-04-08 | 2015-03-24 | University Of Massachusetts | Single nucleotide polymorphism (SNP) targeting therapies for the treatment of huntington'S disease |
| ES2733708T3 (es) | 2010-02-08 | 2019-12-02 | Ionis Pharmaceuticals Inc | Reducción selectiva de variantes alélicas |
| WO2011125943A1 (ja) | 2010-04-01 | 2011-10-13 | 日本新薬株式会社 | 修飾オリゴヌクレオチド |
| JP2013545817A (ja) | 2010-12-16 | 2013-12-26 | バーテックス ファーマシューティカルズ インコーポレイテッド | インフルエンザウイルス複製阻害物質 |
| AU2011343647A1 (en) | 2010-12-16 | 2013-05-02 | Vertex Pharmaceuticals Incorporated | Inhibitors of influenza viruses replication |
| RU2013132681A (ru) | 2010-12-16 | 2015-01-27 | Вертекс Фармасьютикалз Инкорпорейтед | Ингибиторы репликации вирусов гриппа |
| GB201105137D0 (en) | 2011-03-28 | 2011-05-11 | Isis Innovation | Therapeutic molecules for use in the suppression of Parkinson's disease |
| WO2012143796A2 (en) | 2011-04-21 | 2012-10-26 | Institut Pasteur Korea | Anti-inflammation compounds |
| EP3007705A4 (en) | 2013-06-12 | 2017-02-15 | Oncoimmunin, Inc. | Systemic in vivo delivery of oligonucleotides |
| CA2938084A1 (en) | 2014-01-27 | 2015-07-30 | The Board Of Trustees Of The Leland Stanford Junior University | Oligonucleotides and methods for treatment of cardiomyopathy using rna interference |
| EP3137606A4 (en) | 2014-05-01 | 2018-04-25 | Larry J. Smith | METHODS AND MODIFICATIONS THAT PRODUCE ssRNAi COMPOUNDS WITH ENHANCED ACTIVITY, POTENCY AND DURATION OF EFFECT |
| RS60762B1 (sr) * | 2015-04-03 | 2020-10-30 | Univ Massachusetts | Oligonukleotidna jedinjenja za ciljane irnk hantingtina |
| WO2017132669A1 (en) * | 2016-01-31 | 2017-08-03 | University Of Massachusetts | Branched oligonucleotides |
| WO2018041973A1 (en) | 2016-09-01 | 2018-03-08 | Proqr Therapeutics Ii B.V. | Chemically modified single-stranded rna-editing oligonucleotides |
| US11603532B2 (en) | 2017-06-02 | 2023-03-14 | Wave Life Sciences Ltd. | Oligonucleotide compositions and methods of use thereof |
| BR112021002440A2 (pt) | 2018-08-10 | 2021-05-04 | University Of Massachusetts | oligonucleotídeos modificados visando snps |
| EP3946369A4 (en) | 2019-03-26 | 2023-10-18 | University Of Massachusetts | MODIFIED OLIGONUCLEOTIDES WITH INCREASED STABILITY |
| CN115605226A (zh) | 2020-03-26 | 2023-01-13 | 纽特莱特公司（Us） | 具有抗炎和生长促进活性的去乙酰基葡糖胺胞壁酰二肽的亲脂对映异构体 |
| AU2021244600A1 (en) | 2020-03-26 | 2022-11-03 | University Of Massachusetts | Synthesis of modified oligonucleotides with increased stability |
-
2020
- 2020-03-26 EP EP20777915.8A patent/EP3946369A4/en active Pending
- 2020-03-26 WO PCT/US2020/025017 patent/WO2020198509A2/en not_active Ceased
- 2020-03-26 JP JP2021557374A patent/JP2022528840A/ja active Pending
- 2020-03-26 US US16/831,470 patent/US11820985B2/en active Active
-
2023
- 2023-09-01 US US18/459,992 patent/US20240141362A1/en active Pending
-
2025
- 2025-01-31 JP JP2025015181A patent/JP2025072451A/ja active Pending
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