JP2022528840A5 - - Google Patents
Info
- Publication number
- JP2022528840A5 JP2022528840A5 JP2021557374A JP2021557374A JP2022528840A5 JP 2022528840 A5 JP2022528840 A5 JP 2022528840A5 JP 2021557374 A JP2021557374 A JP 2021557374A JP 2021557374 A JP2021557374 A JP 2021557374A JP 2022528840 A5 JP2022528840 A5 JP 2022528840A5
- Authority
- JP
- Japan
- Prior art keywords
- formula
- modified
- bond
- group
- subunit
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2025015181A JP2025072451A (ja) | 2019-03-26 | 2025-01-31 | 安定性が増加した修飾オリゴヌクレオチド |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962824136P | 2019-03-26 | 2019-03-26 | |
| US62/824,136 | 2019-03-26 | ||
| US201962826454P | 2019-03-29 | 2019-03-29 | |
| US62/826,454 | 2019-03-29 | ||
| US201962864792P | 2019-06-21 | 2019-06-21 | |
| US62/864,792 | 2019-06-21 | ||
| PCT/US2020/025017 WO2020198509A2 (en) | 2019-03-26 | 2020-03-26 | Modified oligonucleotides with increased stability |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025015181A Division JP2025072451A (ja) | 2019-03-26 | 2025-01-31 | 安定性が増加した修飾オリゴヌクレオチド |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2022528840A JP2022528840A (ja) | 2022-06-16 |
| JP2022528840A5 true JP2022528840A5 (enExample) | 2023-04-03 |
Family
ID=72609530
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021557374A Pending JP2022528840A (ja) | 2019-03-26 | 2020-03-26 | 安定性が増加した修飾オリゴヌクレオチド |
| JP2025015181A Pending JP2025072451A (ja) | 2019-03-26 | 2025-01-31 | 安定性が増加した修飾オリゴヌクレオチド |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025015181A Pending JP2025072451A (ja) | 2019-03-26 | 2025-01-31 | 安定性が増加した修飾オリゴヌクレオチド |
Country Status (4)
| Country | Link |
|---|---|
| US (2) | US11820985B2 (enExample) |
| EP (1) | EP3946369A4 (enExample) |
| JP (2) | JP2022528840A (enExample) |
| WO (1) | WO2020198509A2 (enExample) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20160319278A1 (en) | 2015-04-03 | 2016-11-03 | University Of Massachusetts | Fully stabilized asymmetric sirna |
| WO2017030973A1 (en) | 2015-08-14 | 2017-02-23 | University Of Massachusetts | Bioactive conjugates for oligonucleotide delivery |
| US10478503B2 (en) | 2016-01-31 | 2019-11-19 | University Of Massachusetts | Branched oligonucleotides |
| CA3033368A1 (en) | 2016-08-12 | 2018-02-15 | University Of Massachusetts | Conjugated oligonucleotides |
| CN106987604B (zh) * | 2017-03-29 | 2021-05-28 | 北京希诺谷生物科技有限公司 | 一种制备动脉粥样硬化疾病模型犬的方法 |
| JP7406793B2 (ja) | 2017-06-23 | 2023-12-28 | ユニバーシティー オブ マサチューセッツ | ２テイル自己デリバリー型ｓｉＲＮＡおよび関連方法 |
| EP3781677A4 (en) | 2018-04-16 | 2022-01-19 | University of Massachusetts | COMPOSITIONS AND METHODS FOR IMPROVED GENE EDITTING |
| US11279930B2 (en) | 2018-08-23 | 2022-03-22 | University Of Massachusetts | O-methyl rich fully stabilized oligonucleotides |
| CN113614232A (zh) | 2019-01-18 | 2021-11-05 | 马萨诸塞大学 | 动态药代动力学修饰锚 |
| US11820985B2 (en) | 2019-03-26 | 2023-11-21 | University Of Massachusetts | Modified oligonucleotides with increased stability |
| KR20220047989A (ko) | 2019-08-09 | 2022-04-19 | 유니버시티 오브 매사추세츠 | Snp를 표적화하는 화학적으로 변형된 올리고뉴클레오타이드 |
| US12365894B2 (en) | 2019-09-16 | 2025-07-22 | University Of Massachusetts | Branched lipid conjugates of siRNA for specific tissue delivery |
| US12339155B2 (en) | 2020-03-25 | 2025-06-24 | Kuwana Metals, Ltd. | Sensor |
| JP7837560B2 (ja) | 2020-03-26 | 2026-03-31 | ユニバーシティー オブ マサチューセッツ | 安定性の向上を有する修飾オリゴヌクレオチドの合成 |
| WO2021242883A1 (en) | 2020-05-26 | 2021-12-02 | University Of Massachusetts | Synthetic oligonucleotides having regions of block and cluster modifications |
| EP4158028A4 (en) | 2020-05-28 | 2024-10-02 | University Of Massachusetts | OLIGONUCLEOTIDES FOR THE MODULATION OF SARS-COV-2 |
| EP4314296A2 (en) | 2021-03-29 | 2024-02-07 | Alnylam Pharmaceuticals, Inc. | Huntingtin (htt) irna agent compositions and methods of use thereof |
| CN117677699A (zh) | 2021-06-23 | 2024-03-08 | 马萨诸塞大学 | 用于治疗先兆子痫和其他血管生成病症的优化抗flt1寡核苷酸化合物 |
| WO2023069495A1 (en) * | 2021-10-19 | 2023-04-27 | Alnylam Pharmaceuticals, Inc. | Oligonucleotides with 2'-deoxy-2'-f-2'-c-methyl nucleotides |
| WO2023114989A2 (en) * | 2021-12-17 | 2023-06-22 | University Of Massachusetts | Oligonucleotides for mlh3 modulation |
| US20240052344A1 (en) * | 2022-05-04 | 2024-02-15 | University Of Massachusetts | Oligonucleotides for pms1 modulation |
| US20250388617A1 (en) * | 2022-06-27 | 2025-12-25 | Rona Bioscience, Limited | Double-stranded rna comprising nucleotide analog capable of reducing off-target toxicity |
| WO2025264952A2 (en) * | 2024-06-21 | 2025-12-26 | Eli Lilly And Company | Novel rna therapeutics and uses thereof |
| WO2026006109A2 (en) * | 2024-06-24 | 2026-01-02 | Eli Lilly And Company | Novel rna therapeutics and uses thereof |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5610289A (en) | 1990-07-27 | 1997-03-11 | Isis Pharmaceuticals, Inc. | Backbone modified oligonucleotide analogues |
| US5672697A (en) * | 1991-02-08 | 1997-09-30 | Gilead Sciences, Inc. | Nucleoside 5'-methylene phosphonates |
| JPH0641183A (ja) | 1992-07-23 | 1994-02-15 | Mitsubishi Kasei Corp | オリゴヌクレオチド単分子膜 |
| US6291438B1 (en) | 1993-02-24 | 2001-09-18 | Jui H. Wang | Antiviral anticancer poly-substituted phenyl derivatized oligoribonucleotides and methods for their use |
| WO1994022890A1 (en) | 1993-03-31 | 1994-10-13 | Sterling Winthop Inc. | Novel 5'-substituted nucleosides and oligomers produced therefrom |
| WO1996003500A1 (en) | 1994-07-26 | 1996-02-08 | Ltt Institute Co., Ltd. | Sustance with antiviral activity |
| US6025335A (en) | 1995-09-21 | 2000-02-15 | Lipitek International, Inc. | L-Nucleoside Dimer Compounds and therapeutic uses |
| US6242589B1 (en) | 1998-07-14 | 2001-06-05 | Isis Pharmaceuticals, Inc. | Phosphorothioate oligonucleotides having modified internucleoside linkages |
| US20100240730A1 (en) * | 2002-02-20 | 2010-09-23 | Merck Sharp And Dohme Corp. | RNA Interference Mediated Inhibition of Gene Expression Using Chemically Modified Short Interfering Nucleic Acid (siNA) |
| AU2003285071A1 (en) | 2002-10-30 | 2004-06-07 | Nikolaos Avlonitis | Antiprotozoal ring-substituted phospholipids |
| DE10326302A1 (de) | 2003-06-11 | 2004-12-30 | Gnothis Holding Sa | Bi-Fluorophor-markierte Sonden zum Nachweis von Nukleinsäuren |
| US20050176045A1 (en) | 2004-02-06 | 2005-08-11 | Dharmacon, Inc. | SNP discriminatory siRNA |
| EP1789553B1 (en) | 2004-06-30 | 2014-03-26 | Alnylam Pharmaceuticals Inc. | Oligonucleotides comprising a non-phosphate backbone linkage |
| EP2342340A1 (en) * | 2008-09-22 | 2011-07-13 | Rxi Pharmaceuticals Corporation | Rna interference in skin indications |
| US8309356B2 (en) * | 2009-04-01 | 2012-11-13 | Yale University | Pseudocomplementary oligonucleotides for targeted gene therapy |
| WO2010118263A1 (en) | 2009-04-08 | 2010-10-14 | University Of Massachusetts | Single-nucleotide polymorphism (snp) targeting therapies for the treatment of huntington's disease |
| US8957040B2 (en) | 2010-02-08 | 2015-02-17 | Isis Pharmaceuticals, Inc. | Selective reduction of allelic variants |
| WO2011125943A1 (ja) | 2010-04-01 | 2011-10-13 | 日本新薬株式会社 | 修飾オリゴヌクレオチド |
| RU2013132681A (ru) | 2010-12-16 | 2015-01-27 | Вертекс Фармасьютикалз Инкорпорейтед | Ингибиторы репликации вирусов гриппа |
| CA2822059A1 (en) | 2010-12-16 | 2012-06-21 | Vertex Pharmaceuticals Incorporated | Inhibitors of influenza viruses replication |
| CN103562205A (zh) | 2010-12-16 | 2014-02-05 | 沃泰克斯药物股份有限公司 | 流感病毒复制的抑制剂 |
| GB201105137D0 (en) | 2011-03-28 | 2011-05-11 | Isis Innovation | Therapeutic molecules for use in the suppression of Parkinson's disease |
| KR102104125B1 (ko) | 2011-04-21 | 2020-05-29 | 재단법인 한국파스퇴르연구소 | 소염 화합물 |
| EP3007705A4 (en) * | 2013-06-12 | 2017-02-15 | Oncoimmunin, Inc. | Systemic in vivo delivery of oligonucleotides |
| WO2015113004A2 (en) | 2014-01-27 | 2015-07-30 | The Board Of Trustee Of The Leland Stanford Junior University | Oligonucleotides and methods for treatment of cardiomyopathy using rna interference |
| US20170051286A1 (en) | 2014-05-01 | 2017-02-23 | Larry J. Smith | METHODS AND MODIFICATIONS THAT PRODUCE ssRNAi COMPOUNDS WITH ENHANCED ACTIVITY, POTENCY AND DURATION OF EFFECT |
| PL3277814T3 (pl) | 2015-04-03 | 2020-11-30 | University Of Massachusetts | Związki oligonukleotydowe ukierunkowane na mrna huntingtyny |
| US10478503B2 (en) * | 2016-01-31 | 2019-11-19 | University Of Massachusetts | Branched oligonucleotides |
| CN110352244B (zh) * | 2016-09-01 | 2023-03-21 | ProQR治疗上市公司Ⅱ | 化学修饰的编辑rna的单链寡核苷酸 |
| JP2020522510A (ja) | 2017-06-02 | 2020-07-30 | ウェイブ ライフ サイエンシズ リミテッドＷａｖｅ Ｌｉｆｅ Ｓｃｉｅｎｃｅｓ Ｌｔｄ． | オリゴヌクレオチド組成物及びその使用方法 |
| WO2020033899A1 (en) * | 2018-08-10 | 2020-02-13 | University Of Massachusetts | Modified oligonucleotides targeting snps |
| US11820985B2 (en) | 2019-03-26 | 2023-11-21 | University Of Massachusetts | Modified oligonucleotides with increased stability |
| ES3014076T3 (en) | 2020-03-26 | 2025-04-16 | Nutrivert Inc | Lipophilic enantiomers of desacetylglucosamine muramyl dipeptide with anti-inflammatory and growth promoting activity |
| JP7837560B2 (ja) | 2020-03-26 | 2026-03-31 | ユニバーシティー オブ マサチューセッツ | 安定性の向上を有する修飾オリゴヌクレオチドの合成 |
-
2020
- 2020-03-26 US US16/831,470 patent/US11820985B2/en active Active
- 2020-03-26 WO PCT/US2020/025017 patent/WO2020198509A2/en not_active Ceased
- 2020-03-26 JP JP2021557374A patent/JP2022528840A/ja active Pending
- 2020-03-26 EP EP20777915.8A patent/EP3946369A4/en active Pending
-
2023
- 2023-09-01 US US18/459,992 patent/US20240141362A1/en active Pending
-
2025
- 2025-01-31 JP JP2025015181A patent/JP2025072451A/ja active Pending
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